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There are total 68 rules.

help How to interpret the rules

Id     
    
If Statement Then
Coverage
Positive     
    
Negative     
    
Rank     
    
        Enter a key word:  
develop  retina001_4   modif_polarity(A, polarity_increase) and is_in_site(A, yes) and mut_accessibility(A, buried) and stability(A, decrease). deleterious(A)
73 (11.08%) 
3 (2.05%) 
6
Covers:
+ Positive Examples: deleterious(m_P10619_Met406Thr), deleterious(m_P60484_Ala34Asp), deleterious(m_P07949_Phe174Ser), deleterious(m_P21912_Leu65His), deleterious(m_P60484_Ile67Arg), deleterious(m_P21912_Leu87Ser), deleterious(m_P40337_Phe136Tyr), deleterious(m_O14832_Phe257Ser), deleterious(m_Q14203_Gly59Ser), deleterious(m_P40337_Val166Asp), deleterious(m_P51648_Pro315Ser), deleterious(m_P51648_Leu106Arg), deleterious(m_Q9Y4U1_Gly156Asp), deleterious(m_Q9H0F7_Leu170Trp), deleterious(m_P48637_Leu254Arg), deleterious(m_P60484_Val343Glu), deleterious(m_P40337_Leu101Arg), deleterious(m_Q15465_Phe170Cys), deleterious(m_Q15465_Gly143Asp), deleterious(m_O14832_Gly204Ser), deleterious(m_P40337_Ala149Thr), deleterious(m_O14773_Ala454Glu), deleterious(m_P60484_Phe241Ser), deleterious(m_O15305_Ile132Asn), deleterious(m_Q92968_Ile326Thr), deleterious(m_P40337_Gly93Ser), deleterious(m_P40337_Gly93Cys), deleterious(m_O15305_Ile132Thr), deleterious(m_P40763_Phe384Ser), deleterious(m_P21912_Ile127Asn), deleterious(m_O14773_Pro544Ser), deleterious(m_P35240_Phe62Ser), deleterious(m_P48637_Ala26Asp), deleterious(m_P35240_Leu234Arg), deleterious(m_Q9BZ23_Ile497Thr), deleterious(m_O15305_Leu32Arg), deleterious(m_Q14203_Gly71Glu), deleterious(m_Q15465_Ala110Thr), deleterious(m_Q9Y4U1_Gly147Asp), deleterious(m_O15305_Phe183Ser), deleterious(m_P60484_Gly129Glu), deleterious(m_O15305_Phe157Ser), deleterious(m_P56589_Gly138Glu), deleterious(m_O14773_Gly482Arg), deleterious(m_P40337_Phe76Ser), deleterious(m_P11532_Ala168Asp), deleterious(m_P40337_Leu118Arg), deleterious(m_P40337_Phe136Ser), deleterious(m_P50897_Leu219Gln), deleterious(m_P40337_Pro86His), deleterious(m_P11532_Leu54Arg), deleterious(m_P40337_Phe119Ser), deleterious(m_Q9BZ23_Ile501Thr), deleterious(m_P60484_Met35Arg), deleterious(m_P40337_Pro86Ser), deleterious(m_O15305_Pro69Ser), deleterious(m_Q12948_Phe112Ser), deleterious(m_P02462_Gly1580Arg), deleterious(m_O15305_Phe11Cys), deleterious(m_P40337_Leu188Gln), deleterious(m_Q9BZ23_Ala398Thr), deleterious(m_O15305_Phe206Ser), deleterious(m_O15305_Gly228Arg), deleterious(m_P40337_Pro86Arg), deleterious(m_P40337_Phe136Cys), deleterious(m_P60484_Gly165Glu), deleterious(m_P51648_Val64Asp), deleterious(m_O14773_Val385Asp), deleterious(m_Q15465_Ala110Asp), deleterious(m_O15305_Ile153Thr), deleterious(m_P48637_Leu286Gln), deleterious(m_P10619_Gly439Ser), deleterious(m_P51648_Phe419Ser)

+ Negative Examples: deleterious(m_P42224_Ile30Thr), deleterious(m_O15305_Gly42Arg), deleterious(m_P40763_Phe561Tyr)  
develop  retina001_6   g_or_p(A, g_or_p_unchanged) and secondary_struc(A, sheet) and mut_accessibility(A, buried) and stability(A, decrease). deleterious(A)
91 (13.81%) 
3 (2.05%) 
6
Covers:
+ Positive Examples: deleterious(m_P60484_Ala34Asp), deleterious(m_Q9H0F7_Ala89Val), deleterious(m_P60484_His123Arg), deleterious(m_P40337_Trp88Ser), deleterious(m_P21912_Arg46Gln), deleterious(m_Q15465_Ile84Phe), deleterious(m_P07949_Phe174Ser), deleterious(m_Q15465_Asp147Asn), deleterious(m_P10619_Tyr395Cys), deleterious(m_P60484_Ile67Arg), deleterious(m_P07339_Phe229Ile), deleterious(m_O14832_Phe257Ser), deleterious(m_P40337_Val84Leu), deleterious(m_P60484_Phe347Leu), deleterious(m_P40337_Asn78Thr), deleterious(m_P51648_Leu106Arg), deleterious(m_P48637_Asp469Glu), deleterious(m_P48637_Leu254Arg), deleterious(m_P60484_Val343Glu), deleterious(m_P07949_Cys142Ser), deleterious(m_P40337_Asn78His), deleterious(m_Q15465_Thr150Arg), deleterious(m_Q15465_Thr150Lys), deleterious(m_Q15465_Cys183Phe), deleterious(m_O14773_Arg447His), deleterious(m_P40337_Ala149Thr), deleterious(m_O14773_Ala454Glu), deleterious(m_P51648_Thr184Arg), deleterious(m_P60484_Phe241Ser), deleterious(m_P43080_Leu151Phe), deleterious(m_P40337_Ser111Asn), deleterious(m_Q92968_Ile326Thr), deleterious(m_Q15465_Cys183Arg), deleterious(m_P60484_Tyr68His), deleterious(m_Q9BZ23_Arg286Cys), deleterious(m_P40337_Trp117Cys), deleterious(m_P51648_Asp245Asn), deleterious(m_P40337_Phe119Leu), deleterious(m_P40763_Phe384Ser), deleterious(m_P10619_Phe440Val), deleterious(m_O15305_Cys9Tyr), deleterious(m_P21912_Ile127Asn), deleterious(m_P40337_Phe76Leu), deleterious(m_Q9BZ23_Arg278Cys), deleterious(m_P35240_Phe62Ser), deleterious(m_Q15465_Cys183Tyr), deleterious(m_P35240_Leu234Arg), deleterious(m_O15305_Val44Ala), deleterious(m_P51648_Cys214Tyr), deleterious(m_O15305_Phe172Val), deleterious(m_O15305_Phe183Ser), deleterious(m_P40337_Phe76Ile), deleterious(m_P50897_Tyr247His), deleterious(m_O15305_Tyr76Cys), deleterious(m_O14832_Arg275Gln), deleterious(m_Q15465_Val124Met), deleterious(m_P40337_Phe76Ser), deleterious(m_Q15465_Ser184Leu), deleterious(m_P40337_Ser111Cys), deleterious(m_P40337_Leu116Val), deleterious(m_O14832_Arg275Trp), deleterious(m_P40337_Val130Leu), deleterious(m_P50897_Trp38Cys), deleterious(m_P40337_Leu118Arg), deleterious(m_O15305_Val44Leu), deleterious(m_P50897_Tyr109Asp), deleterious(m_P40337_Phe119Ser), deleterious(m_O15305_Thr226Ser), deleterious(m_P60484_Met35Arg), deleterious(m_P22748_Arg219Ser), deleterious(m_P40337_Asn78Ser), deleterious(m_Q9NRR6_Arg378Cys), deleterious(m_O15305_Val67Met), deleterious(m_O15305_Val129Met), deleterious(m_O15119_Tyr149Ser), deleterious(m_Q9NSU2_Asp73Asn), deleterious(m_Q9BZ23_Leu282Val), deleterious(m_P07339_Trp383Cys), deleterious(m_P40763_Phe384Leu), deleterious(m_O14832_Trp193Arg), deleterious(m_O15305_Phe11Cys), deleterious(m_P40763_Phe621Val), deleterious(m_Q9UMR3_Ile152Met), deleterious(m_Q9Y4U1_Tyr130His), deleterious(m_Q9BZ23_Ala398Thr), deleterious(m_O15305_Phe206Ser), deleterious(m_Q9BZ23_Arg278Leu), deleterious(m_P10619_Gln49Arg), deleterious(m_P10619_Trp65Arg), deleterious(m_P40337_Ser111Arg), deleterious(m_Q9Y4U1_Arg161Gln)

+ Negative Examples: deleterious(m_P22748_Val237Leu), deleterious(m_P51801_Ser660Leu), deleterious(m_P21912_Lys40Glu)  
develop  retina001_1   fold(A, 'HAD-like'). deleterious(A)
68 (10.32%) 
3 (2.05%) 
8
Covers:
+ Positive Examples: deleterious(m_O15305_Tyr229Ser), deleterious(m_O15305_Gln37His), deleterious(m_O15305_Pro20Ser), deleterious(m_O15305_Leu104Val), deleterious(m_O15305_Thr237Met), deleterious(m_O15305_Tyr106Cys), deleterious(m_O15305_Ala108Val), deleterious(m_O15305_His218Leu), deleterious(m_O15305_Arg238Gly), deleterious(m_O15305_Gly228Cys), deleterious(m_O15305_Ile132Asn), deleterious(m_O15305_Gly15Glu), deleterious(m_O15305_Gln177His), deleterious(m_O15305_Phe144Leu), deleterious(m_O15305_Ala233Thr), deleterious(m_O15305_Glu197Ala), deleterious(m_O15305_Ile132Thr), deleterious(m_O15305_Glu139Lys), deleterious(m_O15305_Asp185Gly), deleterious(m_O15305_Cys9Tyr), deleterious(m_O15305_Asp65Tyr), deleterious(m_O15305_Leu32Arg), deleterious(m_O15305_Val44Ala), deleterious(m_O15305_Gly117Arg), deleterious(m_O15305_Tyr64Cys), deleterious(m_O15305_Ile132Phe), deleterious(m_O15305_Val231Met), deleterious(m_O15305_Phe172Val), deleterious(m_O15305_Phe183Ser), deleterious(m_O15305_Cys103Phe), deleterious(m_O15305_Phe157Ser), deleterious(m_O15305_Tyr76Cys), deleterious(m_O15305_Asp148Asn), deleterious(m_O15305_His195Arg), deleterious(m_O15305_Cys192Gly), deleterious(m_O15305_Arg162Trp), deleterious(m_O15305_Gly214Ser), deleterious(m_O15305_Phe119Leu), deleterious(m_O15305_Val44Leu), deleterious(m_O15305_Glu151Gly), deleterious(m_O15305_Gly175Arg), deleterious(m_O15305_Asn216Ser), deleterious(m_O15305_Thr237Arg), deleterious(m_O15305_Arg141Cys), deleterious(m_O15305_Thr226Ser), deleterious(m_O15305_Asn101Lys), deleterious(m_O15305_Pro113Leu), deleterious(m_O15305_Arg123Gln), deleterious(m_O15305_Val67Met), deleterious(m_O15305_Pro69Ser), deleterious(m_O15305_Asp217Glu), deleterious(m_O15305_Val129Met), deleterious(m_O15305_Asp223Glu), deleterious(m_O15305_Pro131Ala), deleterious(m_O15305_Gly208Ala), deleterious(m_O15305_Glu93Ala), deleterious(m_O15305_Asp223Asn), deleterious(m_O15305_Phe11Cys), deleterious(m_O15305_Phe206Ser), deleterious(m_O15305_Gly228Arg), deleterious(m_O15305_Gly176Val), deleterious(m_O15305_Cys241Ser), deleterious(m_O15305_Ile120Thr), deleterious(m_O15305_Ile153Thr), deleterious(m_O15305_Asp188Gly), deleterious(m_O15305_Asn216Ile), deleterious(m_O15305_Arg238Pro), deleterious(m_O15305_Arg141His)

+ Negative Examples: deleterious(m_O15305_Met212Val), deleterious(m_O15305_Gln37Leu), deleterious(m_O15305_Gly42Arg)  
develop  retina001_5   modif_hydrophobicity(A, hydrophobicity_decrease) and mut_accessibility(A, buried) and stability(A, decrease). deleterious(A)
98 (14.87%) 
3 (2.05%) 
8
Covers:
+ Positive Examples: deleterious(m_O14773_Ile287Asn), deleterious(m_P60484_Ala34Asp), deleterious(m_P60484_His123Arg), deleterious(m_P40337_Trp88Ser), deleterious(m_P07949_Phe174Ser), deleterious(m_P21912_Cys192Arg), deleterious(m_P10619_Leu236Pro), deleterious(m_P35240_Leu141Pro), deleterious(m_P07949_Gly93Ser), deleterious(m_P60484_Ile67Arg), deleterious(m_P21912_Leu87Ser), deleterious(m_O14832_Phe257Ser), deleterious(m_Q14203_Gly59Ser), deleterious(m_P40337_Val166Asp), deleterious(m_P40337_Leu188Pro), deleterious(m_P51648_Leu106Arg), deleterious(m_Q9Y4U1_Gly156Asp), deleterious(m_P48637_Leu254Arg), deleterious(m_P60484_Val343Glu), deleterious(m_P07949_Cys142Ser), deleterious(m_P35240_Cys133Arg), deleterious(m_P40337_Leu101Arg), deleterious(m_P54845_Leu160Pro), deleterious(m_Q15465_Thr150Arg), deleterious(m_Q15465_Gly143Asp), deleterious(m_O14832_Gly204Ser), deleterious(m_O15119_Leu143Pro), deleterious(m_P21912_Ala43Pro), deleterious(m_O14773_Ala454Glu), deleterious(m_P51648_Thr184Arg), deleterious(m_P60484_Phe241Ser), deleterious(m_P48637_Leu188Pro), deleterious(m_O15305_Ile132Asn), deleterious(m_P51648_Tyr279Asn), deleterious(m_P50897_His39Gln), deleterious(m_P40337_Tyr175Asp), deleterious(m_Q15465_Cys183Arg), deleterious(m_P40337_Gly93Ser), deleterious(m_P11532_Ala171Pro), deleterious(m_P40763_Phe384Ser), deleterious(m_P60484_Cys124Ser), deleterious(m_P21912_Ile127Asn), deleterious(m_P35240_Phe62Ser), deleterious(m_P48637_Ala26Asp), deleterious(m_P35240_Leu234Arg), deleterious(m_O15305_Leu32Arg), deleterious(m_P40337_His115Gln), deleterious(m_Q14203_Gly71Glu), deleterious(m_P60484_Leu70Pro), deleterious(m_Q9Y4U1_Gly147Asp), deleterious(m_O15305_Phe183Ser), deleterious(m_P60484_Gly129Glu), deleterious(m_O15305_Phe157Ser), deleterious(m_O75916_Trp299Arg), deleterious(m_P56589_Gly138Glu), deleterious(m_O14773_Gly482Arg), deleterious(m_P40337_Phe76Ser), deleterious(m_P11532_Ala168Asp), deleterious(m_Q9Y4U1_Leu116Pro), deleterious(m_P40337_Leu118Arg), deleterious(m_Q15465_Cys102Arg), deleterious(m_P40337_Phe136Ser), deleterious(m_P40337_Leu118Pro), deleterious(m_O94972_Leu76Pro), deleterious(m_P50897_Leu219Gln), deleterious(m_P40337_Leu184Pro), deleterious(m_Q15465_His140Gln), deleterious(m_O15305_Thr237Arg), deleterious(m_P40337_His115Arg), deleterious(m_P50897_Tyr109Asp), deleterious(m_P11532_Leu54Arg), deleterious(m_P40337_Phe119Ser), deleterious(m_O15305_Thr226Ser), deleterious(m_P60484_Met35Arg), deleterious(m_P11532_Tyr231Asn), deleterious(m_P60484_Cys124Arg), deleterious(m_O15119_Tyr149Ser), deleterious(m_P21912_Leu65Pro), deleterious(m_P10619_Tyr249Asn), deleterious(m_Q12948_Phe112Ser), deleterious(m_Q9Y4U1_Leu193Pro), deleterious(m_P40337_Leu89Pro), deleterious(m_P40337_Leu63Pro), deleterious(m_P02462_Gly1580Arg), deleterious(m_O14832_Trp193Arg), deleterious(m_P40337_Leu188Gln), deleterious(m_O15305_Phe206Ser), deleterious(m_O15305_Gly228Arg), deleterious(m_P40337_Leu163Pro), deleterious(m_O15305_Cys241Ser), deleterious(m_P60484_Gly165Glu), deleterious(m_P51648_Val64Asp), deleterious(m_O14773_Val385Asp), deleterious(m_Q15465_Ala110Asp), deleterious(m_P48637_Leu286Gln), deleterious(m_P10619_Gly439Ser), deleterious(m_P51648_Phe419Ser), deleterious(m_P10619_Trp65Arg)

+ Negative Examples: deleterious(m_O00206_Cys246Ser), deleterious(m_P21912_Lys40Glu), deleterious(m_O15305_Gly42Arg)  
develop  retina001_10   modif_size(A, size_increase) and modif_polarity(A, polarity_increase) and wt_accessibility(A, buried). deleterious(A)
64 (9.71%) 
2 (1.37%) 
10
Covers:
+ Positive Examples: deleterious(m_O14773_Gly473Arg), deleterious(m_P60484_Ala34Asp), deleterious(m_P07686_Ala543Thr), deleterious(m_P21912_Leu65His), deleterious(m_P07949_Gly93Ser), deleterious(m_P60484_Ile67Arg), deleterious(m_Q14203_Gly59Ser), deleterious(m_P51648_Leu106Arg), deleterious(m_Q9Y4U1_Gly156Asp), deleterious(m_Q9H0F7_Leu170Trp), deleterious(m_P48637_Leu254Arg), deleterious(m_P60484_Val343Glu), deleterious(m_P40337_Leu101Arg), deleterious(m_Q16678_Ala388Thr), deleterious(m_Q14203_Gly71Arg), deleterious(m_Q15465_Gly143Asp), deleterious(m_O14832_Gly204Ser), deleterious(m_P40337_Ala149Thr), deleterious(m_P40337_Gly114Ser), deleterious(m_O14773_Ala454Glu), deleterious(m_P50897_Gly108Arg), deleterious(m_P40337_Gly93Ser), deleterious(m_O15305_Gly15Glu), deleterious(m_Q16678_Gly232Arg), deleterious(m_P48637_Ala26Asp), deleterious(m_P35240_Leu234Arg), deleterious(m_O15305_Leu32Arg), deleterious(m_O75369_Leu171Arg), deleterious(m_O15305_Gly117Arg), deleterious(m_Q14203_Gly71Glu), deleterious(m_Q15465_Ala110Thr), deleterious(m_P51648_Gly412Arg), deleterious(m_Q9Y4U1_Gly147Asp), deleterious(m_P60484_Gly129Glu), deleterious(m_P06400_Met457Arg), deleterious(m_P56589_Gly138Glu), deleterious(m_O14773_Gly482Arg), deleterious(m_P40337_Gly114Arg), deleterious(m_Q99593_Gly80Arg), deleterious(m_P11532_Ala168Asp), deleterious(m_Q16678_Met132Arg), deleterious(m_P40337_Gly93Asp), deleterious(m_P51648_Gly406Arg), deleterious(m_P51659_Gly16Ser), deleterious(m_P40337_Leu118Arg), deleterious(m_P06400_Val654Glu), deleterious(m_Q9BZ23_Gly521Arg), deleterious(m_O14773_Gly77Arg), deleterious(m_P40337_Pro86His), deleterious(m_P11532_Leu54Arg), deleterious(m_P60484_Met35Arg), deleterious(m_Q16678_Gly466Asp), deleterious(m_P40337_Leu198Arg), deleterious(m_P02462_Gly1580Arg), deleterious(m_O14773_Gly389Glu), deleterious(m_O75369_Gly168Ser), deleterious(m_Q9BZ23_Ala398Thr), deleterious(m_P40337_Pro86Arg), deleterious(m_P60484_Gly165Glu), deleterious(m_P51648_Val64Asp), deleterious(m_O14773_Val385Asp), deleterious(m_Q15465_Ala110Asp), deleterious(m_P40337_Val170Asp), deleterious(m_P10619_Gly439Ser)

+ Negative Examples: deleterious(m_P19087_Gly183Asp), deleterious(m_O15305_Gly42Arg)  
develop  retina001_7   modif_size(A, size_decrease) and conservation_class(A, global_conservation_rank_2). deleterious(A)
62 (9.41%) 
2 (1.37%) 
13
Covers:
+ Positive Examples: deleterious(m_Q9Y2V3_Arg192Gln), deleterious(m_P21912_Arg46Gln), deleterious(m_P40337_Pro81Ser), deleterious(m_P11532_Lys18Asn), deleterious(m_O15305_Leu104Val), deleterious(m_Q92793_Arg1664His), deleterious(m_O15305_Tyr106Cys), deleterious(m_P40337_Arg161Pro), deleterious(m_O15305_His218Leu), deleterious(m_P40337_Val74Gly), deleterious(m_Q16678_Arg444Gln), deleterious(m_O14832_Pro173Ser), deleterious(m_P40337_Arg161Gly), deleterious(m_Q16678_Arg368His), deleterious(m_P40337_Lys159Glu), deleterious(m_P40337_Leu101Gly), deleterious(m_Q92968_Ile326Thr), deleterious(m_P40337_Tyr175Asp), deleterious(m_Q9BZ23_Arg286Cys), deleterious(m_P25054_Ser722Gly), deleterious(m_P40337_Tyr156Cys), deleterious(m_O75369_Met202Val), deleterious(m_O14832_Glu197Gln), deleterious(m_P40337_Arg167Gly), deleterious(m_P60484_Tyr155Cys), deleterious(m_P04198_Arg394His), deleterious(m_O14773_Pro544Ser), deleterious(m_P60484_Arg47Gly), deleterious(m_Q16678_Arg523Thr), deleterious(m_P40337_Tyr156Asp), deleterious(m_Q15465_Glu188Gln), deleterious(m_Q9BZ23_Ile497Thr), deleterious(m_O15305_Val44Ala), deleterious(m_Q15067_Met278Val), deleterious(m_Q9GZT9_Arg371His), deleterious(m_P40337_Arg161Gln), deleterious(m_Q9GZV9_Ser71Gly), deleterious(m_O15305_Phe183Ser), deleterious(m_O15305_Phe157Ser), deleterious(m_P60484_Ile135Val), deleterious(m_Q99714_Leu122Val), deleterious(m_P35555_Asn2144Ser), deleterious(m_O15305_Tyr76Cys), deleterious(m_P28360_Arg196Pro), deleterious(m_P40337_Asn131Thr), deleterious(m_P21912_Arg46Gly), deleterious(m_P40337_Tyr156Asn), deleterious(m_P40337_Arg167Gln), deleterious(m_Q99593_Arg237Gln), deleterious(m_P40337_Val155Gly), deleterious(m_P22748_Arg219Ser), deleterious(m_O14773_Gln278Pro), deleterious(m_Q9NRR6_Arg378Cys), deleterious(m_Q9BZ23_Leu282Val), deleterious(m_P40337_Arg64Pro), deleterious(m_O15305_Glu93Ala), deleterious(m_P40337_Arg79Pro), deleterious(m_O75369_Phe161Cys), deleterious(m_O15305_Ile120Thr), deleterious(m_O15305_Ile153Thr), deleterious(m_P40337_Tyr112Asn), deleterious(m_P60484_Met134Leu)

+ Negative Examples: deleterious(m_P51659_Lys140Asn), deleterious(m_P23219_Arg149Leu)  
develop  retina001_42   modif_polarity(A, polarity_increase) and g_or_p(A, g_or_p_unchanged) and is_in_site(A, yes) and wt_accessibility(A, buried). deleterious(A)
60 (9.1%) 
3 (2.05%) 
25
Covers:
+ Positive Examples: deleterious(m_P60484_Ala34Asp), deleterious(m_P07949_Phe174Ser), deleterious(m_P07686_Ala543Thr), deleterious(m_P21912_Leu65His), deleterious(m_P60484_Ile67Arg), deleterious(m_P21912_Leu87Ser), deleterious(m_P40337_Phe136Tyr), deleterious(m_O14832_Phe257Ser), deleterious(m_P51648_Leu106Arg), deleterious(m_Q9H0F7_Leu170Trp), deleterious(m_P48637_Leu254Arg), deleterious(m_P60484_Val343Glu), deleterious(m_P40337_Leu101Arg), deleterious(m_Q15465_Phe170Cys), deleterious(m_Q16678_Ala388Thr), deleterious(m_P40337_Ala149Thr), deleterious(m_O14773_Ala454Glu), deleterious(m_P60484_Phe241Ser), deleterious(m_O15305_Ile132Asn), deleterious(m_Q92968_Ile326Thr), deleterious(m_O15305_Ile132Thr), deleterious(m_O14773_Phe481Cys), deleterious(m_P40763_Phe384Ser), deleterious(m_P21912_Ile127Asn), deleterious(m_P35240_Phe62Ser), deleterious(m_P48637_Ala26Asp), deleterious(m_P35240_Leu234Arg), deleterious(m_Q9BZ23_Ile497Thr), deleterious(m_O15305_Leu32Arg), deleterious(m_O75369_Leu171Arg), deleterious(m_Q15465_Ala110Thr), deleterious(m_O15305_Phe157Ser), deleterious(m_P06400_Met457Arg), deleterious(m_P40337_Phe76Ser), deleterious(m_P11532_Ala168Asp), deleterious(m_Q16678_Met132Arg), deleterious(m_P40337_Leu198Gln), deleterious(m_P40337_Leu118Arg), deleterious(m_P40337_Phe136Ser), deleterious(m_P50897_Leu219Gln), deleterious(m_P06400_Val654Glu), deleterious(m_P11532_Leu54Arg), deleterious(m_P40337_Phe119Ser), deleterious(m_Q9BZ23_Ile501Thr), deleterious(m_P60484_Met35Arg), deleterious(m_P40337_Leu198Arg), deleterious(m_Q12948_Phe112Ser), deleterious(m_O15305_Phe11Cys), deleterious(m_P40337_Leu188Gln), deleterious(m_Q9BZ23_Ala398Thr), deleterious(m_O15305_Phe206Ser), deleterious(m_O75369_Phe161Cys), deleterious(m_P40337_Phe136Cys), deleterious(m_P51648_Val64Asp), deleterious(m_O14773_Val385Asp), deleterious(m_Q15465_Ala110Asp), deleterious(m_O15305_Ile153Thr), deleterious(m_P48637_Leu286Gln), deleterious(m_P40337_Val170Asp), deleterious(m_P51648_Phe419Ser)

+ Negative Examples: deleterious(m_O00754_Ala250Ser), deleterious(m_P42224_Ile30Thr), deleterious(m_P40763_Phe561Tyr)  
develop  retina001_33   modif_charge(A, charge_decrease) and lost_contact(A, dc). deleterious(A)
43 (6.53%) 
3 (2.05%) 
31
Covers:
+ Positive Examples: deleterious(m_P48637_Arg283Cys), deleterious(m_P40337_Arg82Pro), deleterious(m_P11532_Lys18Asn), deleterious(m_Q9Y4U1_Arg189Ser), deleterious(m_P40337_Arg161Pro), deleterious(m_Q9Y4U1_Arg161Gly), deleterious(m_Q9BZ23_Arg264Trp), deleterious(m_P32243_Arg89Gly), deleterious(m_O15305_Arg238Gly), deleterious(m_P48637_Asp219Ala), deleterious(m_P40337_Arg200Trp), deleterious(m_P40337_Arg161Gly), deleterious(m_Q16678_Asp530Gly), deleterious(m_P40337_Arg107Gly), deleterious(m_Q9BZ23_Arg286Cys), deleterious(m_P40337_Arg167Gly), deleterious(m_O15305_Asp185Gly), deleterious(m_P60484_Asp252Gly), deleterious(m_P60484_Arg47Gly), deleterious(m_Q9BZ23_Arg278Cys), deleterious(m_P43080_Glu155Gly), deleterious(m_P51648_Arg228Cys), deleterious(m_P07949_Arg180Pro), deleterious(m_Q9Y4U1_Arg206Pro), deleterious(m_Q13562_Arg111Leu), deleterious(m_P21912_Arg46Gly), deleterious(m_P60484_Lys342Asn), deleterious(m_P21912_His132Pro), deleterious(m_P60484_Arg130Leu), deleterious(m_P21912_Arg230Cys), deleterious(m_P07949_Arg77Cys), deleterious(m_P40337_Arg167Trp), deleterious(m_P22748_Arg219Ser), deleterious(m_Q9NRR6_Arg378Cys), deleterious(m_Q9BZ23_Arg249Pro), deleterious(m_Q15465_Arg144Pro), deleterious(m_P40337_Arg64Pro), deleterious(m_P40337_Arg107Pro), deleterious(m_P60484_His93Tyr), deleterious(m_P06400_His549Tyr), deleterious(m_O15305_Arg238Pro), deleterious(m_Q16678_Arg469Trp), deleterious(m_Q99714_Arg130Cys)

+ Negative Examples: deleterious(m_P17655_Lys677Gln), deleterious(m_P23219_Lys185Thr), deleterious(m_O14773_Arg185Cys)  
develop  retina001_61   g_or_p(A, g_or_p_apparition) and is_in_site(A, yes) and mut_accessibility(A, buried). deleterious(A)
52 (7.89%) 
3 (2.05%) 
34
Covers:
+ Positive Examples: deleterious(m_P10619_Leu236Pro), deleterious(m_P35240_Leu141Pro), deleterious(m_Q9BZ23_Glu322Gly), deleterious(m_P40337_Leu188Pro), deleterious(m_Q9Y4U1_Arg161Gly), deleterious(m_P54845_Leu160Pro), deleterious(m_O15305_Arg238Gly), deleterious(m_P40337_Val74Gly), deleterious(m_P60484_Asp331Gly), deleterious(m_O15119_Leu143Pro), deleterious(m_P21912_Ala43Pro), deleterious(m_P48637_Leu188Pro), deleterious(m_P40337_Leu101Gly), deleterious(m_P25054_Ser722Gly), deleterious(m_P40337_Asp121Gly), deleterious(m_P11532_Ala171Pro), deleterious(m_P48637_Asp219Gly), deleterious(m_P60484_Ala121Gly), deleterious(m_Q9BZ23_Leu563Pro), deleterious(m_P60484_Asp252Gly), deleterious(m_P06400_His673Pro), deleterious(m_P43080_Glu155Gly), deleterious(m_P50897_Asp79Gly), deleterious(m_P60484_Leu70Pro), deleterious(m_Q9GZV9_Ser71Gly), deleterious(m_P07949_Arg180Pro), deleterious(m_P28360_Arg196Pro), deleterious(m_Q9Y4U1_Leu116Pro), deleterious(m_O15305_Cys192Gly), deleterious(m_Q9Y4U1_Arg206Pro), deleterious(m_P21912_Arg46Gly), deleterious(m_O14773_Ser153Pro), deleterious(m_Q16678_Ala443Gly), deleterious(m_O14832_Asp177Gly), deleterious(m_P40337_Leu118Pro), deleterious(m_O75369_Ser235Pro), deleterious(m_P40337_Leu184Pro), deleterious(m_O14773_Thr353Pro), deleterious(m_P06400_Leu662Pro), deleterious(m_P06400_Leu657Pro), deleterious(m_O14773_Gln278Pro), deleterious(m_P10071_Cys515Gly), deleterious(m_P21912_Leu65Pro), deleterious(m_Q15465_Arg144Pro), deleterious(m_Q9Y4U1_Leu193Pro), deleterious(m_P40337_Leu89Pro), deleterious(m_P06400_Gln685Pro), deleterious(m_P40337_Leu63Pro), deleterious(m_P40337_Leu163Pro), deleterious(m_Q15465_His140Pro), deleterious(m_Q16678_Ala115Pro), deleterious(m_O15305_Arg238Pro)

+ Negative Examples: deleterious(m_Q16678_Val422Gly), deleterious(m_P06400_Ala525Gly), deleterious(m_P06400_Glu746Gly)  
develop  retina001_66   modif_size(A, size_decrease) and modif_charge(A, charge_unchanged) and lost_contact(A, phob) and stability(A, decrease). deleterious(A)
43 (6.53%) 
3 (2.05%) 
36
Covers:
+ Positive Examples: deleterious(m_O15305_Tyr229Ser), deleterious(m_P07949_Phe174Ser), deleterious(m_P10619_Tyr395Cys), deleterious(m_O15305_Leu104Val), deleterious(m_O14832_Phe257Ser), deleterious(m_O15305_Tyr106Cys), deleterious(m_P60484_Phe347Leu), deleterious(m_Q15465_Phe170Cys), deleterious(m_P60484_Phe241Ser), deleterious(m_P40337_Leu101Gly), deleterious(m_P51648_Tyr279Asn), deleterious(m_P40337_Tyr156Cys), deleterious(m_P40763_Tyr657Cys), deleterious(m_P40337_Trp117Cys), deleterious(m_O15305_Ile132Thr), deleterious(m_P40763_Phe384Ser), deleterious(m_P10619_Phe440Val), deleterious(m_P35240_Phe62Ser), deleterious(m_O15305_Tyr64Cys), deleterious(m_O15305_Phe172Val), deleterious(m_O15305_Phe157Ser), deleterious(m_P60484_Ile135Val), deleterious(m_P60484_Phe341Val), deleterious(m_P43080_Tyr99Cys), deleterious(m_P40337_Leu116Val), deleterious(m_P50897_Trp38Cys), deleterious(m_P40337_Tyr156Asn), deleterious(m_P40337_Phe119Ser), deleterious(m_Q9BZ23_Ile501Thr), deleterious(m_P40337_Pro86Ser), deleterious(m_Q15465_Trp117Gly), deleterious(m_Q99593_Ile54Thr), deleterious(m_P11532_Tyr231Asn), deleterious(m_O15119_Tyr149Ser), deleterious(m_P10619_Tyr249Asn), deleterious(m_Q9BZ23_Leu282Val), deleterious(m_P35240_Met77Val), deleterious(m_Q12948_Phe112Ser), deleterious(m_Q9Y4U1_Trp157Cys), deleterious(m_P07339_Trp383Cys), deleterious(m_O15305_Phe11Cys), deleterious(m_O15305_Phe206Ser), deleterious(m_P51648_Phe419Ser)

+ Negative Examples: deleterious(m_O00206_Phe443Leu), deleterious(m_O15305_Met212Val), deleterious(m_O14773_Arg175His)  
develop  retina001_41   modif_charge(A, charge_increase) and g_or_p(A, g_or_p_unchanged) and wt_accessibility(A, buried). deleterious(A)
56 (8.5%) 
2 (1.37%) 
37
Covers:
+ Positive Examples: deleterious(m_P50542_Asn526Lys), deleterious(m_P60484_Ala34Asp), deleterious(m_P21912_Leu65His), deleterious(m_P21912_Cys192Arg), deleterious(m_P60484_Ile67Arg), deleterious(m_P51648_Leu106Arg), deleterious(m_P48637_Leu254Arg), deleterious(m_P60484_Val343Glu), deleterious(m_P40337_Asn78His), deleterious(m_P35240_Cys133Arg), deleterious(m_P40337_Leu101Arg), deleterious(m_Q15465_Thr150Arg), deleterious(m_Q15465_Thr150Lys), deleterious(m_P40337_Gln164His), deleterious(m_P50897_Gln177Glu), deleterious(m_O14773_Ala454Glu), deleterious(m_P51648_Thr184Arg), deleterious(m_O14832_Asn269His), deleterious(m_P60484_Ser170Arg), deleterious(m_P40337_Tyr175Asp), deleterious(m_Q15465_Cys183Arg), deleterious(m_P60484_Tyr68His), deleterious(m_Q16678_Ser239Arg), deleterious(m_P48637_Ala26Asp), deleterious(m_P35240_Leu234Arg), deleterious(m_O15305_Leu32Arg), deleterious(m_O75369_Leu171Arg), deleterious(m_P07686_Ser255Arg), deleterious(m_P50897_Tyr247His), deleterious(m_O14773_Gln422His), deleterious(m_P06400_Met457Arg), deleterious(m_O75916_Trp299Arg), deleterious(m_P11532_Ala168Asp), deleterious(m_Q16678_Met132Arg), deleterious(m_P40337_Leu118Arg), deleterious(m_Q15465_Cys102Arg), deleterious(m_P40337_Ser80Arg), deleterious(m_P06400_Val654Glu), deleterious(m_O15305_Thr237Arg), deleterious(m_P50897_Tyr109Asp), deleterious(m_P11532_Leu54Arg), deleterious(m_P60484_Met35Arg), deleterious(m_P60484_Cys124Arg), deleterious(m_Q92793_Tyr1450His), deleterious(m_P40337_Trp88Arg), deleterious(m_P40337_Leu198Arg), deleterious(m_O14832_Gln176Lys), deleterious(m_O14832_Trp193Arg), deleterious(m_Q9Y4U1_Tyr130His), deleterious(m_P51648_Val64Asp), deleterious(m_O14773_Val385Asp), deleterious(m_Q15465_Ala110Asp), deleterious(m_P06400_Cys712Arg), deleterious(m_P40337_Val170Asp), deleterious(m_P10619_Trp65Arg), deleterious(m_P40337_Ser111Arg)

+ Negative Examples: deleterious(m_P00450_Thr841Arg), deleterious(m_Q16678_Gln144His)  
develop  retina001_50   g_or_p(A, g_or_p_unchanged) and gain_contact(A, dc) and wt_accessibility(A, buried) and stability(A, decrease). deleterious(A)
53 (8.04%) 
3 (2.05%) 
39
Covers:
+ Positive Examples: deleterious(m_P50542_Asn526Lys), deleterious(m_P60484_Ala34Asp), deleterious(m_P50897_Arg122Trp), deleterious(m_P21912_Cys192Arg), deleterious(m_P60484_Ile67Arg), deleterious(m_P07339_Phe229Ile), deleterious(m_P40337_Asn78Thr), deleterious(m_P51648_Leu106Arg), deleterious(m_P07949_Cys142Ser), deleterious(m_P40337_Asn78His), deleterious(m_P35240_Cys133Arg), deleterious(m_O15305_His218Leu), deleterious(m_P48637_Asp219Ala), deleterious(m_P51648_Thr184Arg), deleterious(m_P40337_Tyr175Asp), deleterious(m_Q15465_Cys183Arg), deleterious(m_O14773_Ser475Leu), deleterious(m_O15305_Ile132Thr), deleterious(m_P40337_Leu188Val), deleterious(m_O15305_Asp65Tyr), deleterious(m_Q9BZ23_Arg278Cys), deleterious(m_P35240_Leu234Arg), deleterious(m_Q9BZ23_Ile497Thr), deleterious(m_P40763_Thr622Ile), deleterious(m_P51648_Ser415Asn), deleterious(m_P50897_Val181Met), deleterious(m_O15305_Val231Met), deleterious(m_O15305_Phe172Val), deleterious(m_P10619_Val132Met), deleterious(m_P40337_Phe76Ile), deleterious(m_O14773_Glu343Lys), deleterious(m_O15305_His195Arg), deleterious(m_P50897_Val181Leu), deleterious(m_Q9Y4U1_Gln27Arg), deleterious(m_P60484_Phe341Val), deleterious(m_P40337_Leu198Gln), deleterious(m_Q15465_Cys102Arg), deleterious(m_P40337_Ser80Arg), deleterious(m_O15305_Thr237Arg), deleterious(m_P11532_Leu54Arg), deleterious(m_P60484_Cys124Arg), deleterious(m_Q9NSU2_Asp73Asn), deleterious(m_P40337_Leu198Arg), deleterious(m_O14773_Val277Met), deleterious(m_O15305_Phe11Cys), deleterious(m_P40337_Leu188Gln), deleterious(m_Q9BZ23_Arg278Leu), deleterious(m_Q15465_Asp171His), deleterious(m_P10619_Gln49Arg), deleterious(m_P10619_Trp65Arg), deleterious(m_O14832_His175Arg), deleterious(m_P51648_Met328Ile), deleterious(m_Q9Y4U1_Arg161Gln)

+ Negative Examples: deleterious(m_P22748_Val237Leu), deleterious(m_Q9H6Z9_Val136Leu), deleterious(m_P19087_Val124Met)  
develop  retina001_9   g_or_p(A, g_or_p_unchanged) and freq_at_pos(A, B) and B>=2 and stability(A, decrease). deleterious(A)
127 (19.27%) 
3 (2.05%) 
39
Covers:
+ Positive Examples: deleterious(m_Q15465_Trp117Arg), deleterious(m_P60484_His123Arg), deleterious(m_P40337_Trp88Ser), deleterious(m_P21912_Arg46Gln), deleterious(m_Q15465_Ile111Asn), deleterious(m_O15305_Gln37His), deleterious(m_P21912_Leu65His), deleterious(m_P40337_Asn131Lys), deleterious(m_P40337_Leu178Gln), deleterious(m_P40337_Phe136Tyr), deleterious(m_O15305_Thr237Met), deleterious(m_Q9BZ23_Glu322Asp), deleterious(m_P40337_Tyr112His), deleterious(m_P40337_Val166Asp), deleterious(m_P40337_Asn78Thr), deleterious(m_P40337_Val166Phe), deleterious(m_P40337_Asn78His), deleterious(m_P40337_Val155Met), deleterious(m_P40337_Leu101Arg), deleterious(m_Q15465_Thr150Arg), deleterious(m_P48637_Asp219Ala), deleterious(m_Q15465_Thr150Lys), deleterious(m_Q15465_Cys183Phe), deleterious(m_P40763_Arg382Gln), deleterious(m_P40763_Arg382Leu), deleterious(m_P40337_Gln164His), deleterious(m_O14773_Cys365Arg), deleterious(m_P51648_Thr184Arg), deleterious(m_P40337_Ser111Asn), deleterious(m_Q9H0F7_Thr31Met), deleterious(m_O15305_Ile132Asn), deleterious(m_P40337_Ser80Asn), deleterious(m_Q15465_Cys183Arg), deleterious(m_P40337_Leu184Arg), deleterious(m_P40337_Tyr156Cys), deleterious(m_Q15465_Cys102Tyr), deleterious(m_P60484_His93Arg), deleterious(m_O14773_Cys365Tyr), deleterious(m_P40337_Phe119Leu), deleterious(m_O15305_Ile132Thr), deleterious(m_P40337_Leu188Val), deleterious(m_P40763_Phe384Ser), deleterious(m_P60484_Cys124Ser), deleterious(m_P40337_Gln164Arg), deleterious(m_P40337_Phe76Leu), deleterious(m_Q9BZ23_Arg278Cys), deleterious(m_P40337_Tyr156Asp), deleterious(m_Q15465_Cys183Tyr), deleterious(m_P40337_Ser65Ala), deleterious(m_P48637_Ala26Asp), deleterious(m_O15305_Val44Ala), deleterious(m_P40337_His115Gln), deleterious(m_P40337_Ser80Ile), deleterious(m_Q9H0F7_Thr31Arg), deleterious(m_O15305_Tyr64Cys), deleterious(m_P50897_Val181Met), deleterious(m_Q15465_Ala110Thr), deleterious(m_P40337_Arg161Gln), deleterious(m_O15305_Ile132Phe), deleterious(m_P40763_Val637Leu), deleterious(m_O15305_Cys103Phe), deleterious(m_P04198_Arg393His), deleterious(m_P40337_Phe76Ile), deleterious(m_O14832_Arg275Gln), deleterious(m_P40337_Cys162Phe), deleterious(m_P40337_Phe76Ser), deleterious(m_P40337_Asn131Thr), deleterious(m_P40337_Ser65Leu), deleterious(m_P50897_Val181Leu), deleterious(m_P40337_Ser111Cys), deleterious(m_P40337_Ser65Trp), deleterious(m_O14832_Arg275Trp), deleterious(m_P40337_Leu198Gln), deleterious(m_P40337_Leu158Val), deleterious(m_P40337_Leu118Arg), deleterious(m_Q15465_Cys102Arg), deleterious(m_P40337_Phe136Ser), deleterious(m_P60484_Arg130Leu), deleterious(m_P40337_Ser80Arg), deleterious(m_P40337_Tyr156Asn), deleterious(m_O15305_Val44Leu), deleterious(m_P60484_Asp107Tyr), deleterious(m_P40337_Arg167Gln), deleterious(m_P40337_His115Tyr), deleterious(m_Q15465_His140Gln), deleterious(m_O15305_Thr237Arg), deleterious(m_P40337_His115Arg), deleterious(m_O15305_Arg141Cys), deleterious(m_P40337_Cys162Arg), deleterious(m_Q99593_Arg237Gln), deleterious(m_O14773_Arg206His), deleterious(m_P40337_Phe119Ser), deleterious(m_P40337_Cys162Trp), deleterious(m_Q99593_Arg237Trp), deleterious(m_P40337_Cys162Tyr), deleterious(m_P48637_Tyr270Cys), deleterious(m_P40337_Arg167Trp), deleterious(m_P40337_Asn78Ser), deleterious(m_Q99593_Ile54Thr), deleterious(m_P60484_Cys105Phe), deleterious(m_P11532_Tyr231Asn), deleterious(m_P60484_Cys124Arg), deleterious(m_O15305_Asp223Glu), deleterious(m_Q9NRR6_Arg515Trp), deleterious(m_Q9Y4U1_Arg206Trp), deleterious(m_P40337_Trp88Arg), deleterious(m_P40337_Leu198Arg), deleterious(m_P40763_Phe384Leu), deleterious(m_P40763_Arg382Trp), deleterious(m_O15305_Asp223Asn), deleterious(m_P40337_Leu188Gln), deleterious(m_P04198_Arg393Ser), deleterious(m_P60484_Arg130Gln), deleterious(m_Q9BZ23_Arg278Leu), deleterious(m_P40337_Asp126Tyr), deleterious(m_P40337_Phe136Cys), deleterious(m_O14773_Arg206Cys), deleterious(m_Q15465_Ala110Asp), deleterious(m_P40337_Tyr112Asn), deleterious(m_P40763_Val637Met), deleterious(m_P40337_Val170Asp), deleterious(m_Q15465_Ile111Phe), deleterious(m_P48637_Tyr270His), deleterious(m_O15305_Arg141His), deleterious(m_P40337_Val170Phe), deleterious(m_P40337_Ser111Arg), deleterious(m_Q9Y4U1_Arg161Gln)

+ Negative Examples: deleterious(m_P23219_Arg149Leu), deleterious(m_O15305_Gln37Leu), deleterious(m_P63211_Glu50Lys)  
develop  retina001_15   modif_charge(A, charge_unchanged) and g_or_p(A, g_or_p_disparition) and secondary_struc(A, other). deleterious(A)
41 (6.22%) 
2 (1.37%) 
41
Covers:
+ Positive Examples: deleterious(m_P40337_Pro81Ser), deleterious(m_O15305_Pro20Ser), deleterious(m_Q14203_Gly71Ala), deleterious(m_P07949_Gly93Ser), deleterious(m_P07686_Pro417Leu), deleterious(m_Q16678_Pro437Leu), deleterious(m_P51648_Pro315Ser), deleterious(m_P40337_Pro154Leu), deleterious(m_O14832_Gly204Ser), deleterious(m_O14832_Pro173Ser), deleterious(m_P40337_Gly114Ser), deleterious(m_P51648_Gly185Ala), deleterious(m_P40337_Gly93Ser), deleterious(m_P51648_Pro114Leu), deleterious(m_P40337_Gly93Cys), deleterious(m_P07686_Pro504Ser), deleterious(m_O14773_Pro544Ser), deleterious(m_Q16678_Pro193Leu), deleterious(m_O14773_Gly284Val), deleterious(m_P35240_Gly197Cys), deleterious(m_Q15465_Pro26Leu), deleterious(m_Q15465_Gly27Ala), deleterious(m_P40337_Gly114Cys), deleterious(m_P51659_Gly16Ser), deleterious(m_P48637_Gly464Val), deleterious(m_O15305_Gly214Ser), deleterious(m_Q16678_Gly365Trp), deleterious(m_O14521_Gly148Val), deleterious(m_P07949_Pro64Leu), deleterious(m_P50897_Gly250Val), deleterious(m_O15305_Pro113Leu), deleterious(m_O15305_Pro69Ser), deleterious(m_Q9Y4U1_Gly147Ala), deleterious(m_Q9BZ23_Gly219Val), deleterious(m_O15305_Pro131Ala), deleterious(m_P07949_Pro198Thr), deleterious(m_P40337_Pro192Ser), deleterious(m_O75369_Gly168Ser), deleterious(m_O15305_Gly176Val), deleterious(m_P60484_Gly165Val), deleterious(m_Q9H0F7_Gly169Ala)

+ Negative Examples: deleterious(m_O14832_Gly215Ser), deleterious(m_Q16678_Gly184Ser)  
develop  retina001_30   modif_polarity(A, polarity_unchanged) and g_or_p(A, g_or_p_unchanged) and conservation_class(A, global_conservation_rank_2) and secondary_struc(A, helix). deleterious(A)
35 (5.31%) 
3 (2.05%) 
44
Covers:
+ Positive Examples: deleterious(m_Q9Y2V3_Arg192Gln), deleterious(m_P11532_Lys18Asn), deleterious(m_O15305_Leu104Val), deleterious(m_P60484_Cys136Tyr), deleterious(m_O15305_Tyr106Cys), deleterious(m_Q16678_Ala330Phe), deleterious(m_P40337_Val166Phe), deleterious(m_P40337_Arg200Trp), deleterious(m_P07686_Cys534Tyr), deleterious(m_P40337_Gln164His), deleterious(m_Q16678_Arg444Gln), deleterious(m_P40337_Lys159Glu), deleterious(m_Q15465_Ser156Arg), deleterious(m_Q15465_Gln100His), deleterious(m_P40337_Tyr175Asp), deleterious(m_Q16678_Arg145Trp), deleterious(m_O75369_Met202Val), deleterious(m_P60484_Tyr155Cys), deleterious(m_P04198_Arg394His), deleterious(m_P40337_Gln164Arg), deleterious(m_O75369_Ala173Val), deleterious(m_P40337_Arg161Gln), deleterious(m_P60484_Ile135Val), deleterious(m_Q9BZ23_Ala509Val), deleterious(m_O75369_Glu227Lys), deleterious(m_P40337_Arg167Gln), deleterious(m_O15305_Thr237Arg), deleterious(m_Q99593_Arg237Gln), deleterious(m_O15305_Asn101Lys), deleterious(m_Q99593_Arg237Trp), deleterious(m_P40337_Arg167Trp), deleterious(m_P06400_Lys530Arg), deleterious(m_P06400_Cys712Arg), deleterious(m_Q15465_Ile111Phe), deleterious(m_P60484_Met134Leu)

+ Negative Examples: deleterious(m_P23219_Val481Ile), deleterious(m_P23219_Lys341Arg), deleterious(m_O94788_Ala110Val)  
develop  retina001_39   g_or_p(A, g_or_p_apparition) and secondary_struc(A, helix). deleterious(A)
44 (6.68%) 
3 (2.05%) 
45
Covers:
+ Positive Examples: deleterious(m_O14521_Leu139Pro), deleterious(m_P10619_Leu236Pro), deleterious(m_P35240_Leu141Pro), deleterious(m_Q9BZ23_Glu322Gly), deleterious(m_P40337_Leu188Pro), deleterious(m_P40337_Arg161Pro), deleterious(m_P32243_Arg89Gly), deleterious(m_P54845_Leu160Pro), deleterious(m_Q9Y6K9_Ala323Pro), deleterious(m_O15305_Arg238Gly), deleterious(m_P06400_Arg500Gly), deleterious(m_P60484_Leu112Pro), deleterious(m_P40337_Arg161Gly), deleterious(m_P48637_Leu188Pro), deleterious(m_Q16678_Gln144Pro), deleterious(m_P25054_Ser722Gly), deleterious(m_Q9Y6K9_Ala288Gly), deleterious(m_Q92793_Arg1378Pro), deleterious(m_P11532_Ala171Pro), deleterious(m_P48637_Asp219Gly), deleterious(m_P40337_Arg167Gly), deleterious(m_Q9BZ23_Leu563Pro), deleterious(m_O75369_Ser188Pro), deleterious(m_P43080_Glu155Gly), deleterious(m_Q9BZ23_Ser351Pro), deleterious(m_P50897_Asp79Gly), deleterious(m_Q16678_Leu77Pro), deleterious(m_P28360_Arg196Pro), deleterious(m_O15305_Cys192Gly), deleterious(m_Q9Y4U1_Arg206Pro), deleterious(m_Q16678_Ala443Gly), deleterious(m_O14832_Asp177Gly), deleterious(m_O15305_Glu151Gly), deleterious(m_O94972_Leu76Pro), deleterious(m_P40337_Leu184Pro), deleterious(m_O14773_Gln278Pro), deleterious(m_Q9BZ23_Arg249Pro), deleterious(m_P21912_Leu65Pro), deleterious(m_Q9Y4U1_Leu193Pro), deleterious(m_P35240_Glu106Gly), deleterious(m_P40337_Leu163Pro), deleterious(m_P40337_Leu158Pro), deleterious(m_Q15465_His140Pro), deleterious(m_O15305_Arg238Pro)

+ Negative Examples: deleterious(m_P06400_Ala525Gly), deleterious(m_P11532_Gln133Pro), deleterious(m_P06400_Glu746Gly)  
develop  retina001_40   modif_size(A, size_increase) and secondary_struc(A, other) and mut_accessibility(A, buried) and stability(A, decrease). deleterious(A)
44 (6.68%) 
3 (2.05%) 
47
Covers:
+ Positive Examples: deleterious(m_P07949_Gly93Ser), deleterious(m_Q9Y4U1_Gly156Asp), deleterious(m_P35240_Cys133Arg), deleterious(m_P40337_Leu101Arg), deleterious(m_Q15465_Gly143Asp), deleterious(m_O14832_Gly204Ser), deleterious(m_O14832_Asn269His), deleterious(m_P40337_Ser80Asn), deleterious(m_P40337_Gly93Ser), deleterious(m_P51648_Cys237Tyr), deleterious(m_P07949_Cys197Tyr), deleterious(m_P07949_Ser32Leu), deleterious(m_P40763_Thr622Ile), deleterious(m_O14773_Gly284Val), deleterious(m_P40337_Ser80Ile), deleterious(m_Q14203_Gly71Glu), deleterious(m_P50897_Val181Met), deleterious(m_P21912_Cys196Tyr), deleterious(m_O15305_Ile132Phe), deleterious(m_O15305_Val231Met), deleterious(m_P40763_Val637Leu), deleterious(m_Q9Y4U1_Gly147Asp), deleterious(m_P10619_Val132Met), deleterious(m_P40337_Ser65Leu), deleterious(m_P50897_Val181Leu), deleterious(m_O14773_Ser153Pro), deleterious(m_P40337_Ser65Trp), deleterious(m_P40337_Ser80Arg), deleterious(m_O14521_Gly148Val), deleterious(m_P40337_His115Arg), deleterious(m_P21912_Cys101Tyr), deleterious(m_P40337_Leu128Phe), deleterious(m_P60484_Cys124Arg), deleterious(m_O15305_Asp223Glu), deleterious(m_P40763_Ser611Asn), deleterious(m_P10071_Cys520Tyr), deleterious(m_P51648_Ser365Leu), deleterious(m_O14832_Ile199Phe), deleterious(m_P40337_Asp126Tyr), deleterious(m_Q15465_Asp171His), deleterious(m_P60484_Gly165Glu), deleterious(m_O14773_Val385Asp), deleterious(m_P60484_Gly165Val), deleterious(m_P43080_Asp100Glu)

+ Negative Examples: deleterious(m_O00206_Leu385Phe), deleterious(m_Q9H6Z9_Val136Leu), deleterious(m_P36575_Leu44Phe)  
develop  retina001_8   g_or_p(A, g_or_p_apparition) and mut_accessibility(A, intermediate). deleterious(A)
35 (5.31%) 
3 (2.05%) 
47
Covers:
+ Positive Examples: deleterious(m_P40337_Arg82Pro), deleterious(m_Q16678_Glu499Gly), deleterious(m_O14521_Leu139Pro), deleterious(m_Q14203_Thr72Pro), deleterious(m_P40337_Arg161Pro), deleterious(m_P32243_Arg89Gly), deleterious(m_Q9Y6K9_Ala323Pro), deleterious(m_P06400_Ala635Pro), deleterious(m_P06400_Arg500Gly), deleterious(m_P60484_Leu112Pro), deleterious(m_P40337_Arg161Gly), deleterious(m_Q16678_Gln144Pro), deleterious(m_P40337_Arg107Gly), deleterious(m_Q9Y6K9_Ala288Gly), deleterious(m_Q15465_Leu39Pro), deleterious(m_P40337_Arg167Gly), deleterious(m_O15305_Asp185Gly), deleterious(m_P50897_Thr75Pro), deleterious(m_P60484_Arg47Gly), deleterious(m_P40337_Val170Gly), deleterious(m_Q16678_Leu77Pro), deleterious(m_P35555_Ala2160Pro), deleterious(m_Q9BZ23_Leu413Pro), deleterious(m_P40337_Thr105Pro), deleterious(m_O15305_Glu151Gly), deleterious(m_P40337_Leu178Pro), deleterious(m_Q15465_Trp117Gly), deleterious(m_Q9BZ23_Arg249Pro), deleterious(m_P51692_Ala630Pro), deleterious(m_P40337_Arg64Pro), deleterious(m_P40337_Arg107Pro), deleterious(m_P35240_Glu106Gly), deleterious(m_P40337_Arg79Pro), deleterious(m_P40337_Gln96Pro), deleterious(m_O15305_Asp188Gly)

+ Negative Examples: deleterious(m_P20810_Glu592Gly), deleterious(m_O00206_Asp299Gly), deleterious(m_P17655_Ser68Gly)  
develop  retina001_51   modif_size(A, size_increase) and secondary_struc(A, helix) and mut_accessibility(A, buried) and stability(A, decrease). deleterious(A)
39 (5.92%) 
3 (2.05%) 
48
Covers:
+ Positive Examples: deleterious(m_P50542_Asn526Lys), deleterious(m_P21912_Leu65His), deleterious(m_P21912_Cys192Arg), deleterious(m_O15305_Thr237Met), deleterious(m_P60484_Cys136Tyr), deleterious(m_P40337_Val166Asp), deleterious(m_Q9H0F7_Leu170Trp), deleterious(m_P40337_Gln164His), deleterious(m_P50897_Gln177Glu), deleterious(m_Q9H0F7_Thr31Met), deleterious(m_P60484_Ser170Arg), deleterious(m_Q12948_Leu130Phe), deleterious(m_Q15465_Cys102Tyr), deleterious(m_P11532_Ala171Pro), deleterious(m_P40337_Gln164Arg), deleterious(m_P48637_Ala26Asp), deleterious(m_O15305_Leu32Arg), deleterious(m_P51648_Ser415Asn), deleterious(m_P51648_Ile45Phe), deleterious(m_Q15465_Ala110Thr), deleterious(m_O15305_Cys103Phe), deleterious(m_P60484_Gly129Glu), deleterious(m_O14773_Gln422His), deleterious(m_O14773_Glu343Lys), deleterious(m_P56589_Gly138Glu), deleterious(m_O14773_Gly482Arg), deleterious(m_P11532_Ala168Asp), deleterious(m_Q9BZ23_Ala509Val), deleterious(m_P51648_Cys226Trp), deleterious(m_Q15465_Leu109Phe), deleterious(m_P43080_Gly159Val), deleterious(m_Q15465_Cys102Arg), deleterious(m_O15305_Thr237Arg), deleterious(m_P11532_Leu54Arg), deleterious(m_P60484_Cys105Phe), deleterious(m_O14773_Val277Met), deleterious(m_P57082_Gly248Val), deleterious(m_P51648_Val64Asp), deleterious(m_Q15465_Ala110Asp)

+ Negative Examples: deleterious(m_P00352_Ile177Phe), deleterious(m_P19087_Val124Met), deleterious(m_O94788_Ala110Val)  
develop  retina001_18   conservation_class(A, global_conservation_rank_2) and secondary_struc(A, helix) and stability(A, decrease). deleterious(A)
49 (7.44%) 
3 (2.05%) 
48
Covers:
+ Positive Examples: deleterious(m_Q15465_Ile111Asn), deleterious(m_P11532_Lys18Asn), deleterious(m_P35240_Leu141Pro), deleterious(m_O15305_Leu104Val), deleterious(m_O15305_Thr237Met), deleterious(m_P60484_Cys136Tyr), deleterious(m_O15305_Tyr106Cys), deleterious(m_P40337_Val166Asp), deleterious(m_P40337_Val166Phe), deleterious(m_P40337_Arg161Pro), deleterious(m_P54845_Leu160Pro), deleterious(m_P40337_Arg200Trp), deleterious(m_P40337_Gln164His), deleterious(m_P60484_Leu112Pro), deleterious(m_P40337_Arg161Gly), deleterious(m_P40337_Lys159Glu), deleterious(m_Q15465_Gln100His), deleterious(m_P40337_Tyr175Asp), deleterious(m_P11532_Ala171Pro), deleterious(m_P40337_Arg167Gly), deleterious(m_P60484_Tyr155Cys), deleterious(m_P04198_Arg394His), deleterious(m_P40337_Gln164Arg), deleterious(m_Q9BZ23_Ile497Thr), deleterious(m_P40337_Arg161Gln), deleterious(m_P60484_Gly129Glu), deleterious(m_O15305_Phe157Ser), deleterious(m_P60484_Ile135Val), deleterious(m_P56589_Gly138Glu), deleterious(m_O14773_Gly482Arg), deleterious(m_P28360_Arg196Pro), deleterious(m_P11532_Ala168Asp), deleterious(m_O15305_Cys192Gly), deleterious(m_Q9BZ23_Ala509Val), deleterious(m_P43080_Gly159Val), deleterious(m_P40337_Arg167Gln), deleterious(m_O15305_Thr237Arg), deleterious(m_Q99593_Arg237Gln), deleterious(m_P11532_Leu54Arg), deleterious(m_O15305_Asn101Lys), deleterious(m_Q99593_Arg237Trp), deleterious(m_P40337_Arg167Trp), deleterious(m_O14773_Gln278Pro), deleterious(m_O15305_Glu93Ala), deleterious(m_P57082_Gly248Val), deleterious(m_P40337_Leu163Pro), deleterious(m_O15305_Ile153Thr), deleterious(m_Q15465_Ile111Phe), deleterious(m_P60484_Met134Leu)

+ Negative Examples: deleterious(m_P23219_Lys341Arg), deleterious(m_P40763_Phe561Tyr), deleterious(m_O94788_Ala110Val)  
develop  retina001_11   secondary_struc(A, sheet) and lost_contact(A, phob). deleterious(A)
30 (4.55%) 
0 (0.0%) 
49
Covers:
+ Positive Examples: deleterious(m_O15305_Tyr229Ser), deleterious(m_P07949_Phe174Ser), deleterious(m_P10619_Tyr395Cys), deleterious(m_Q16678_Val409Phe), deleterious(m_O14832_Phe257Ser), deleterious(m_P60484_Phe347Leu), deleterious(m_Q9Y4U1_Arg161Gly), deleterious(m_Q9BZ23_Arg264Trp), deleterious(m_P60484_Phe241Ser), deleterious(m_P40337_Trp117Cys), deleterious(m_P40763_Phe384Ser), deleterious(m_P10619_Phe440Val), deleterious(m_P35240_Phe62Ser), deleterious(m_P40337_Pro86Leu), deleterious(m_O15305_Phe172Val), deleterious(m_P07949_Leu40Pro), deleterious(m_P21912_Arg46Gly), deleterious(m_P40337_Leu116Val), deleterious(m_P50897_Trp38Cys), deleterious(m_P40337_Leu118Pro), deleterious(m_P50897_Tyr109Asp), deleterious(m_P40337_Phe119Ser), deleterious(m_P40337_Pro86Ser), deleterious(m_P22748_Arg219Ser), deleterious(m_O15119_Tyr149Ser), deleterious(m_Q9BZ23_Leu282Val), deleterious(m_P07339_Trp383Cys), deleterious(m_O14832_Trp193Arg), deleterious(m_O15305_Phe11Cys), deleterious(m_O15305_Phe206Ser)

+ Negative Examples:  
develop  retina001_43   modif_size(A, size_increase) and modif_charge(A, charge_increase) and modif_hydrophobicity(A, hydrophobicity_decrease) and secondary_struc(A, other). deleterious(A)
33 (5.01%) 
3 (2.05%) 
52
Covers:
+ Positive Examples: deleterious(m_O14773_Gly473Arg), deleterious(m_Q9Y4U1_Gly156Asp), deleterious(m_Q15465_Gly31Arg), deleterious(m_P35240_Cys133Arg), deleterious(m_P40337_Leu101Arg), deleterious(m_P11488_Gly38Asp), deleterious(m_Q14203_Gly71Arg), deleterious(m_Q15465_Gly143Asp), deleterious(m_O14773_Cys365Arg), deleterious(m_P50897_Gly108Arg), deleterious(m_O15305_Gly15Glu), deleterious(m_P06400_Gly310Glu), deleterious(m_O15305_Gly117Arg), deleterious(m_Q14203_Gly71Glu), deleterious(m_P51648_Gly412Arg), deleterious(m_Q9Y4U1_Gly147Asp), deleterious(m_P40337_Gly114Arg), deleterious(m_Q99593_Gly80Arg), deleterious(m_Q16678_Met132Arg), deleterious(m_Q9UMX6_Gly157Arg), deleterious(m_P40337_Gly93Asp), deleterious(m_P21912_Gly53Arg), deleterious(m_Q9NSU2_Val256Asp), deleterious(m_P31040_Gly555Glu), deleterious(m_P06400_Val654Glu), deleterious(m_Q9BZ23_Gly521Arg), deleterious(m_O14773_Gly77Arg), deleterious(m_Q16678_Gly466Asp), deleterious(m_P60484_Cys124Arg), deleterious(m_P60484_Gly165Glu), deleterious(m_O14773_Val385Asp), deleterious(m_P40337_Val170Asp), deleterious(m_P50897_Gly42Glu)

+ Negative Examples: deleterious(m_P19087_Gly183Asp), deleterious(m_P00450_Thr841Arg), deleterious(m_P07339_Gly282Arg)  
develop  retina001_29   modif_hydrophobicity(A, hydrophobicity_decrease) and g_or_p(A, g_or_p_unchanged) and is_in_site(A, yes) and mut_accessibility(A, buried). deleterious(A)
69 (10.47%) 
3 (2.05%) 
54
Covers:
+ Positive Examples: deleterious(m_P60484_Ala34Asp), deleterious(m_P60484_His123Arg), deleterious(m_P40337_Trp88Ser), deleterious(m_P07949_Phe174Ser), deleterious(m_P21912_Cys192Arg), deleterious(m_P60484_Ile67Arg), deleterious(m_P21912_Leu87Ser), deleterious(m_O14832_Phe257Ser), deleterious(m_P40337_Val166Asp), deleterious(m_P51648_Leu106Arg), deleterious(m_P48637_Leu254Arg), deleterious(m_P60484_Val343Glu), deleterious(m_P35240_Cys133Arg), deleterious(m_P40337_Leu101Arg), deleterious(m_Q15465_Thr150Arg), deleterious(m_Q92793_His1470Arg), deleterious(m_O14773_Ala454Glu), deleterious(m_P51648_Thr184Arg), deleterious(m_P60484_Phe241Ser), deleterious(m_O15305_Ile132Asn), deleterious(m_P51648_Tyr279Asn), deleterious(m_P50897_His39Gln), deleterious(m_P40337_Tyr175Asp), deleterious(m_Q15465_Cys183Arg), deleterious(m_P40763_Phe384Ser), deleterious(m_P60484_Cys124Ser), deleterious(m_P21912_Ile127Asn), deleterious(m_P35240_Phe62Ser), deleterious(m_P48637_Ala26Asp), deleterious(m_P35240_Leu234Arg), deleterious(m_O15305_Leu32Arg), deleterious(m_P40337_His115Gln), deleterious(m_O75369_Leu171Arg), deleterious(m_O15305_Phe183Ser), deleterious(m_O15305_Phe157Ser), deleterious(m_P06400_Met457Arg), deleterious(m_O75916_Trp299Arg), deleterious(m_P40337_Phe76Ser), deleterious(m_P11532_Ala168Asp), deleterious(m_Q16678_Met132Arg), deleterious(m_P40337_Leu118Arg), deleterious(m_Q15465_Cys102Arg), deleterious(m_P40337_Phe136Ser), deleterious(m_P50897_Leu219Gln), deleterious(m_P06400_Val654Glu), deleterious(m_Q15465_His140Gln), deleterious(m_O15305_Thr237Arg), deleterious(m_P40337_His115Arg), deleterious(m_P50897_Tyr109Asp), deleterious(m_P11532_Leu54Arg), deleterious(m_P40337_Phe119Ser), deleterious(m_O15305_Thr226Ser), deleterious(m_P60484_Met35Arg), deleterious(m_P11532_Tyr231Asn), deleterious(m_P60484_Cys124Arg), deleterious(m_O15119_Tyr149Ser), deleterious(m_P10619_Tyr249Asn), deleterious(m_Q12948_Phe112Ser), deleterious(m_O14832_Trp193Arg), deleterious(m_P40337_Leu188Gln), deleterious(m_O15305_Phe206Ser), deleterious(m_O15305_Cys241Ser), deleterious(m_P51648_Val64Asp), deleterious(m_O14773_Val385Asp), deleterious(m_Q15465_Ala110Asp), deleterious(m_P06400_Cys712Arg), deleterious(m_P48637_Leu286Gln), deleterious(m_P51648_Phe419Ser), deleterious(m_P10619_Trp65Arg)

+ Negative Examples: deleterious(m_P07686_Lys121Arg), deleterious(m_O00754_Ala250Ser), deleterious(m_P21912_Lys40Glu)  
develop  retina001_36   modif_size(A, size_increase) and secondary_struc(A, other) and gain_contact(A, dc) and stability(A, decrease). deleterious(A)
36 (5.46%) 
3 (2.05%) 
54
Covers:
+ Positive Examples: deleterious(m_O14773_Gly473Arg), deleterious(m_P40337_Asn131Lys), deleterious(m_P35240_Cys133Arg), deleterious(m_P40337_Val155Met), deleterious(m_P11488_Gly38Asp), deleterious(m_Q14203_Gly71Arg), deleterious(m_O14773_Cys365Arg), deleterious(m_P50897_Gly108Arg), deleterious(m_P39905_Ile211Met), deleterious(m_P60484_His93Arg), deleterious(m_O15305_Asp65Tyr), deleterious(m_P40763_Thr622Ile), deleterious(m_O14773_Gly284Val), deleterious(m_O15305_Gly117Arg), deleterious(m_Q14203_Gly71Glu), deleterious(m_P50897_Val181Met), deleterious(m_P51648_Gly412Arg), deleterious(m_O15305_Val231Met), deleterious(m_P40763_Val637Leu), deleterious(m_Q9Y4U1_Gly147Asp), deleterious(m_P10619_Val132Met), deleterious(m_P40337_Gly114Arg), deleterious(m_Q99593_Gly80Arg), deleterious(m_P50897_Val181Leu), deleterious(m_Q9NSU2_Val256Asp), deleterious(m_P40337_Ser80Arg), deleterious(m_Q9BZ23_Gly521Arg), deleterious(m_O14773_Gly77Arg), deleterious(m_P50897_Gly250Val), deleterious(m_P60484_Cys124Arg), deleterious(m_O15305_Gly176Val), deleterious(m_Q15465_Asp171His), deleterious(m_P60484_Gly165Glu), deleterious(m_P60484_Gly165Val), deleterious(m_P40763_Thr389Ile), deleterious(m_O14832_His175Arg)

+ Negative Examples: deleterious(m_Q9H6Z9_Val136Leu), deleterious(m_P23219_Lys359Arg), deleterious(m_O14832_Gly215Ser)  
develop  retina001_12   modif_hydrophobicity(A, hydrophobicity_increase) and secondary_struc(A, helix) and stability(A, decrease). deleterious(A)
56 (8.5%) 
3 (2.05%) 
55
Covers:
+ Positive Examples: deleterious(m_O14773_Pro202Leu), deleterious(m_P48637_Arg283Cys), deleterious(m_P50542_Asn526Lys), deleterious(m_O15305_Gln37His), deleterious(m_P50897_Arg122Trp), deleterious(m_O14832_Asn83Tyr), deleterious(m_Q9BZ23_Glu322Gly), deleterious(m_Q9NRR6_Arg512Trp), deleterious(m_P43080_Pro50Leu), deleterious(m_P32243_Arg89Gly), deleterious(m_O15305_Arg238Gly), deleterious(m_P48637_Asp219Ala), deleterious(m_P40337_Arg200Trp), deleterious(m_P40337_Gln164His), deleterious(m_P40337_Glu186Lys), deleterious(m_P40337_Arg161Gly), deleterious(m_Q15465_Gln100His), deleterious(m_P43080_Glu89Lys), deleterious(m_O14773_Ser475Leu), deleterious(m_O15305_Glu197Ala), deleterious(m_P48637_Asp219Gly), deleterious(m_P40337_Arg167Gly), deleterious(m_O15305_Glu139Lys), deleterious(m_P04198_Arg394His), deleterious(m_P51648_Pro121Leu), deleterious(m_Q15465_Asn115Lys), deleterious(m_P43080_Glu155Gly), deleterious(m_P50897_Asp79Gly), deleterious(m_Q9BZ23_Arg532Trp), deleterious(m_P04198_Arg393His), deleterious(m_O14773_Gln422His), deleterious(m_O14773_Glu343Lys), deleterious(m_P51648_Arg228Cys), deleterious(m_O14521_Pro81Leu), deleterious(m_O14949_Ser45Phe), deleterious(m_O15305_Arg162Trp), deleterious(m_P10071_Arg625Trp), deleterious(m_O14832_Asp177Gly), deleterious(m_P60484_Arg130Leu), deleterious(m_P21912_Arg230Cys), deleterious(m_P07949_Arg77Cys), deleterious(m_O15305_Glu151Gly), deleterious(m_P40337_Arg176Trp), deleterious(m_P60484_Asp107Tyr), deleterious(m_O15305_Arg141Cys), deleterious(m_O14773_Arg206His), deleterious(m_O15305_Asn101Lys), deleterious(m_Q99593_Arg237Trp), deleterious(m_P40337_Arg167Trp), deleterious(m_Q9NRR6_Arg515Trp), deleterious(m_Q9Y4U1_Arg206Trp), deleterious(m_O15305_Glu93Ala), deleterious(m_P48637_Arg330Cys), deleterious(m_O14773_Arg206Cys), deleterious(m_O15305_Arg141His), deleterious(m_Q99714_Arg130Cys)

+ Negative Examples: deleterious(m_P06400_Asn133His), deleterious(m_O15305_Gln37Leu), deleterious(m_O94788_Glu436Lys)  
develop  retina001_32   modif_size(A, size_decrease) and freq_at_pos(A, B) and B>=2. deleterious(A)
75 (11.38%) 
2 (1.37%) 
58
Covers:
+ Positive Examples: deleterious(m_Q16678_Phe445Cys), deleterious(m_P40337_Trp88Ser), deleterious(m_P21912_Arg46Gln), deleterious(m_Q9BZ23_Glu322Gly), deleterious(m_Q9BZ23_Glu322Asp), deleterious(m_P40337_Asn78Thr), deleterious(m_P40337_Arg161Pro), deleterious(m_Q9Y4U1_Arg161Gly), deleterious(m_O15305_Arg238Gly), deleterious(m_P48637_Asp219Ala), deleterious(m_P40763_Arg382Gln), deleterious(m_P40763_Arg382Leu), deleterious(m_P40337_Arg161Gly), deleterious(m_Q16678_Arg368His), deleterious(m_Q16678_Ile399Ser), deleterious(m_Q16678_Gln144Pro), deleterious(m_P40337_Leu101Gly), deleterious(m_P40337_Arg107Gly), deleterious(m_P40337_Tyr156Cys), deleterious(m_P48637_Asp219Gly), deleterious(m_P40337_Arg167Gly), deleterious(m_P40337_Phe119Leu), deleterious(m_O15305_Ile132Thr), deleterious(m_P40337_Leu188Val), deleterious(m_P40763_Phe384Ser), deleterious(m_P40337_Phe76Leu), deleterious(m_Q9BZ23_Arg278Cys), deleterious(m_P40337_Tyr156Asp), deleterious(m_P06400_His673Pro), deleterious(m_O15305_Val44Ala), deleterious(m_P40337_His115Gln), deleterious(m_O15305_Tyr64Cys), deleterious(m_P40337_Arg161Gln), deleterious(m_P40337_Val170Gly), deleterious(m_P04198_Arg393His), deleterious(m_P40337_Phe76Ile), deleterious(m_O14832_Arg275Gln), deleterious(m_P40337_Phe76Ser), deleterious(m_P40337_Asn131Thr), deleterious(m_Q9Y4U1_Arg206Pro), deleterious(m_Q16678_Arg390Ser), deleterious(m_P21912_Arg46Gly), deleterious(m_P40337_Leu158Val), deleterious(m_P40337_Phe136Ser), deleterious(m_P60484_Arg130Leu), deleterious(m_P40337_Tyr156Asn), deleterious(m_P40337_Arg167Gln), deleterious(m_O15305_Asn216Ser), deleterious(m_Q15465_His140Gln), deleterious(m_O15305_Arg141Cys), deleterious(m_P40337_Pro86Ala), deleterious(m_Q99593_Arg237Gln), deleterious(m_O14773_Arg206His), deleterious(m_P40337_Phe119Ser), deleterious(m_P40337_Val155Gly), deleterious(m_P48637_Tyr270Cys), deleterious(m_P40337_Pro86Ser), deleterious(m_P40337_Asn78Ser), deleterious(m_Q15465_Trp117Gly), deleterious(m_Q99593_Ile54Thr), deleterious(m_P11532_Tyr231Asn), deleterious(m_P40337_Arg107Pro), deleterious(m_Q16678_Arg390His), deleterious(m_P40763_Phe384Leu), deleterious(m_P04198_Arg393Ser), deleterious(m_P60484_Arg130Gln), deleterious(m_Q9BZ23_Arg278Leu), deleterious(m_P40337_Phe136Cys), deleterious(m_O14773_Arg206Cys), deleterious(m_Q15465_His140Pro), deleterious(m_P40337_Tyr112Asn), deleterious(m_O15305_Arg238Pro), deleterious(m_O15305_Arg141His), deleterious(m_Q16678_Arg390Cys), deleterious(m_Q9Y4U1_Arg161Gln)

+ Negative Examples: deleterious(m_P23219_Arg149Leu), deleterious(m_P51659_Arg106His)  
develop  retina001_67   modif_charge(A, charge_decrease) and modif_polarity(A, polarity_unchanged) and secondary_struc(A, helix). deleterious(A)
37 (5.61%) 
3 (2.05%) 
60
Covers:
+ Positive Examples: deleterious(m_P48637_Arg283Cys), deleterious(m_P11532_Lys18Asn), deleterious(m_P50897_Arg122Trp), deleterious(m_Q9Y4U1_Arg189Ser), deleterious(m_Q9NRR6_Arg512Trp), deleterious(m_P40337_Arg200Trp), deleterious(m_Q9NZJ4_Lys4508Thr), deleterious(m_Q16678_Arg145Trp), deleterious(m_P25054_Arg414Cys), deleterious(m_P51648_Lys266Asn), deleterious(m_Q9BZ23_Arg532Trp), deleterious(m_O14521_Asp92Tyr), deleterious(m_P51648_Arg228Cys), deleterious(m_O15305_Asp148Asn), deleterious(m_O15305_Arg162Trp), deleterious(m_P10071_Arg625Trp), deleterious(m_Q16678_Arg390Ser), deleterious(m_P21912_Arg230Cys), deleterious(m_P07949_Arg77Cys), deleterious(m_P40337_Arg176Trp), deleterious(m_P60484_Asp107Tyr), deleterious(m_Q15465_His140Gln), deleterious(m_O15305_Arg141Cys), deleterious(m_O14773_Lys428Asn), deleterious(m_Q99593_Arg237Trp), deleterious(m_P40337_Arg167Trp), deleterious(m_P06400_Lys447Gln), deleterious(m_Q9NRR6_Arg515Trp), deleterious(m_Q9Y4U1_Arg206Trp), deleterious(m_P48637_Arg330Cys), deleterious(m_P04198_Arg393Ser), deleterious(m_O14773_Arg206Cys), deleterious(m_Q9Y6K9_Asp311Asn), deleterious(m_P06400_His549Tyr), deleterious(m_Q16678_Arg390Cys), deleterious(m_Q16678_Asp374Asn), deleterious(m_Q99714_Arg130Cys)

+ Negative Examples: deleterious(m_P17655_Lys677Gln), deleterious(m_O43395_Lys12Asn), deleterious(m_O14543_His125Tyr)  
develop  retina001_3   conservation_class(A, global_conservation_rank_1). deleterious(A)
218 (33.08%) 
3 (2.05%) 
61
Covers:
+ Positive Examples: deleterious(m_O14773_Pro202Leu), deleterious(m_P48637_Arg283Cys), deleterious(m_Q16678_Phe445Cys), deleterious(m_P50542_Asn526Lys), deleterious(m_O14773_Gly473Arg), deleterious(m_Q15465_Trp117Arg), deleterious(m_P40337_Arg82Pro), deleterious(m_P60484_His123Arg), deleterious(m_P40337_Trp88Ser), deleterious(m_Q15465_Ile84Phe), deleterious(m_O14521_Leu139Pro), deleterious(m_Q99714_Asn247Ser), deleterious(m_O00754_His72Leu), deleterious(m_Q15465_Asp147Asn), deleterious(m_P10619_Tyr395Cys), deleterious(m_Q9Y4U1_His122Arg), deleterious(m_P50897_Arg122Trp), deleterious(m_P21912_Cys192Arg), deleterious(m_Q14203_Gly71Ala), deleterious(m_P07339_Phe229Ile), deleterious(m_P40337_Leu178Gln), deleterious(m_P40337_Phe136Tyr), deleterious(m_Q16678_Asn203Ser), deleterious(m_O14832_Phe257Ser), deleterious(m_Q14203_Gly59Ser), deleterious(m_P40337_Tyr98His), deleterious(m_Q16678_Pro437Leu), deleterious(m_P40337_Leu188Pro), deleterious(m_P21912_Pro197Arg), deleterious(m_P51648_Pro315Ser), deleterious(m_P40337_Asn78Thr), deleterious(m_Q9Y4U1_Gly156Asp), deleterious(m_Q9H0F7_Leu170Trp), deleterious(m_P48637_Asp469Glu), deleterious(m_Q9Y4U1_Arg161Gly), deleterious(m_P40337_Asn78His), deleterious(m_P35240_Cys133Arg), deleterious(m_P32243_Arg89Gly), deleterious(m_Q15465_Phe170Cys), deleterious(m_Q15465_Thr150Arg), deleterious(m_P48637_Asp219Ala), deleterious(m_P40337_Pro154Leu), deleterious(m_Q14203_Gly71Arg), deleterious(m_Q15465_Thr150Lys), deleterious(m_Q15465_Cys183Phe), deleterious(m_Q15465_Gly143Asp), deleterious(m_O14832_Gly204Ser), deleterious(m_O14773_Arg447His), deleterious(m_O15119_Leu143Pro), deleterious(m_Q16678_Tyr81Asn), deleterious(m_P50897_Gln177Glu), deleterious(m_P51648_Thr184Arg), deleterious(m_O14832_Asn269His), deleterious(m_Q9H0F7_Thr31Met), deleterious(m_P60484_Ser170Arg), deleterious(m_Q9BZ23_Asp447Asn), deleterious(m_P51648_Gly185Ala), deleterious(m_Q12948_Leu130Phe), deleterious(m_P50897_His39Gln), deleterious(m_P56693_Ser135Thr), deleterious(m_Q15465_Asp88Val), deleterious(m_Q15465_Cys183Arg), deleterious(m_P40337_Gly93Ser), deleterious(m_P40337_Leu184Arg), deleterious(m_P51648_Pro114Leu), deleterious(m_P51648_Asn386Ser), deleterious(m_O15305_Phe144Leu), deleterious(m_Q15465_Cys102Tyr), deleterious(m_P40337_Ile180Val), deleterious(m_O14773_Ser475Leu), deleterious(m_P40337_Asp121Gly), deleterious(m_P40337_Trp117Cys), deleterious(m_P51648_Asp245Asn), deleterious(m_P40337_Gly93Cys), deleterious(m_P48637_Asp219Gly), deleterious(m_P40337_Phe119Leu), deleterious(m_P40337_Leu188Val), deleterious(m_P07686_Pro504Ser), deleterious(m_P60484_Cys124Ser), deleterious(m_P60484_Asp252Gly), deleterious(m_Q9NRR6_Arg435Gln), deleterious(m_P40337_Phe76Leu), deleterious(m_P35240_Phe62Ser), deleterious(m_Q15465_Cys183Tyr), deleterious(m_P40337_Ser65Ala), deleterious(m_P51648_Pro121Leu), deleterious(m_Q15465_Asn115Lys), deleterious(m_P35555_Cys2142Tyr), deleterious(m_P43080_Glu155Gly), deleterious(m_Q15465_Glu53Lys), deleterious(m_P40337_His115Gln), deleterious(m_Q9H0F7_Thr31Arg), deleterious(m_O15305_Gly117Arg), deleterious(m_Q14203_Gly71Glu), deleterious(m_P21912_Cys196Tyr), deleterious(m_Q15465_Ala110Thr), deleterious(m_P51648_Gly412Arg), deleterious(m_O14521_Asp92Tyr), deleterious(m_P10619_Val132Met), deleterious(m_P04198_Arg393His), deleterious(m_P40337_Phe76Ile), deleterious(m_O14773_Gln422His), deleterious(m_O14832_Arg275Gln), deleterious(m_Q15465_Val124Met), deleterious(m_O75916_Trp299Arg), deleterious(m_Q16678_Glu387Lys), deleterious(m_P40337_Cys162Phe), deleterious(m_P51648_Arg228Cys), deleterious(m_O14521_Pro81Leu), deleterious(m_P40337_Phe76Ser), deleterious(m_P60484_His123Tyr), deleterious(m_O15305_Asp148Asn), deleterious(m_P06400_Arg661Trp), deleterious(m_P35555_Cys2151Trp), deleterious(m_Q9Y4U1_Leu116Pro), deleterious(m_P40337_Ser65Leu), deleterious(m_Q15465_Ser184Leu), deleterious(m_P40337_Gly93Asp), deleterious(m_P51648_Gly406Arg), deleterious(m_Q9Y4U1_Arg206Pro), deleterious(m_Q13562_Arg111Leu), deleterious(m_P51648_His411Tyr), deleterious(m_P14854_Arg20His), deleterious(m_P43080_Tyr99Cys), deleterious(m_P10071_Arg625Trp), deleterious(m_Q15465_Leu109Phe), deleterious(m_Q16678_Arg390Ser), deleterious(m_P40337_Ser65Trp), deleterious(m_O14832_Arg275Trp), deleterious(m_P51659_Gly16Ser), deleterious(m_P50897_Trp38Cys), deleterious(m_P48637_Gly464Val), deleterious(m_P40337_Leu158Val), deleterious(m_O15305_Phe119Leu), deleterious(m_O14521_Tyr114Cys), deleterious(m_O14832_Asp177Gly), deleterious(m_Q15465_Cys102Arg), deleterious(m_P40337_Phe136Ser), deleterious(m_P60484_Arg130Leu), deleterious(m_P21912_Arg230Cys), deleterious(m_O60333_Gln98Leu), deleterious(m_P60484_Cys105Tyr), deleterious(m_O15305_Gly175Arg), deleterious(m_O15305_Asn216Ser), deleterious(m_P40337_His115Tyr), deleterious(m_O14521_Gly148Val), deleterious(m_P40337_Leu184Pro), deleterious(m_Q15465_His140Gln), deleterious(m_P40337_His115Arg), deleterious(m_O15305_Arg141Cys), deleterious(m_Q9BZ23_Gly521Arg), deleterious(m_P07686_Arg505Gln), deleterious(m_P40337_Cys162Arg), deleterious(m_P40337_Phe119Ser), deleterious(m_P40337_Leu178Pro), deleterious(m_Q9BZ23_Ile501Thr), deleterious(m_P40337_Cys162Trp), deleterious(m_P60484_Met35Arg), deleterious(m_P40337_Cys162Tyr), deleterious(m_O15305_Pro113Leu), deleterious(m_P48637_Tyr270Cys), deleterious(m_O15305_Arg123Gln), deleterious(m_P40337_Asn78Ser), deleterious(m_Q15465_Trp117Gly), deleterious(m_Q16678_Gly466Asp), deleterious(m_P60484_Cys105Phe), deleterious(m_O15305_Asp217Glu), deleterious(m_P11532_Tyr231Asn), deleterious(m_P10071_Cys515Gly), deleterious(m_P60484_Cys124Arg), deleterious(m_P10071_Cys520Tyr), deleterious(m_O15119_Tyr149Ser), deleterious(m_Q9Y4U1_Arg206Trp), deleterious(m_Q15465_Arg144Pro), deleterious(m_P48637_Arg267Trp), deleterious(m_Q92793_Tyr1450His), deleterious(m_P40337_Trp88Arg), deleterious(m_O15305_Pro131Ala), deleterious(m_Q16678_Arg390His), deleterious(m_O14832_Gln176Lys), deleterious(m_Q12948_Phe112Ser), deleterious(m_Q9Y4U1_Trp157Cys), deleterious(m_O14521_His102Leu), deleterious(m_P07339_Trp383Cys), deleterious(m_Q9Y4U1_Leu193Pro), deleterious(m_Q15465_Asp83Val), deleterious(m_O14832_Trp193Arg), deleterious(m_O15305_Phe11Cys), deleterious(m_P40337_Leu188Gln), deleterious(m_P04198_Arg393Ser), deleterious(m_P60484_Arg130Gln), deleterious(m_O14773_Gly389Glu), deleterious(m_Q9Y4U1_Tyr130His), deleterious(m_O15305_Phe206Ser), deleterious(m_O15305_Gly176Val), deleterious(m_P06400_Cys706Tyr), deleterious(m_P40337_Phe136Cys), deleterious(m_Q15465_Asp171His), deleterious(m_P40337_Leu158Pro), deleterious(m_P51648_Thr184Met), deleterious(m_Q15465_His140Pro), deleterious(m_P06400_His549Tyr), deleterious(m_Q15465_Ala110Asp), deleterious(m_O15305_Asp188Gly), deleterious(m_P48637_Tyr270His), deleterious(m_P10619_Gly439Ser), deleterious(m_O15305_Asn216Ile), deleterious(m_P51648_Phe419Ser), deleterious(m_O15305_Arg141His), deleterious(m_Q16678_Arg390Cys), deleterious(m_Q9H0F7_Gly169Ala), deleterious(m_P10619_Trp65Arg), deleterious(m_P43080_Asp100Glu), deleterious(m_O14832_His175Arg), deleterious(m_Q16678_Asp374Asn), deleterious(m_P51648_Met328Ile), deleterious(m_Q99714_Arg130Cys), deleterious(m_Q9Y4U1_Arg161Gln)

+ Negative Examples: deleterious(m_P35555_Cys2170Phe), deleterious(m_P19087_Gly183Asp), deleterious(m_Q15555_Tyr162Cys)  
develop  retina001_25   gain_contact(A, hb) and stability(A, decrease). deleterious(A)
39 (5.92%) 
2 (1.37%) 
61
Covers:
+ Positive Examples: deleterious(m_O15305_Tyr229Ser), deleterious(m_O14773_Gly473Arg), deleterious(m_Q9H0F7_Ala89Val), deleterious(m_P07949_Gly93Ser), deleterious(m_Q9Y4U1_Arg189Ser), deleterious(m_Q15465_Gly31Arg), deleterious(m_P35240_Cys133Arg), deleterious(m_P32243_Arg89Gly), deleterious(m_P40763_Arg382Gln), deleterious(m_P40337_Leu184Arg), deleterious(m_O14832_Glu197Gln), deleterious(m_P60484_Tyr155Cys), deleterious(m_P40763_Thr622Ile), deleterious(m_Q9H0F7_Thr31Arg), deleterious(m_Q14203_Gly71Glu), deleterious(m_Q9NRR6_Lys580Glu), deleterious(m_Q9Y4U1_Gly147Asp), deleterious(m_P10619_Val132Met), deleterious(m_P60484_Gly129Glu), deleterious(m_O14773_Gly482Arg), deleterious(m_Q15465_Leu109Phe), deleterious(m_P40337_Leu198Gln), deleterious(m_P43080_Gly159Val), deleterious(m_Q15465_Cys102Arg), deleterious(m_O14521_Gly148Val), deleterious(m_Q9BZ23_Gly521Arg), deleterious(m_O14773_Gly77Arg), deleterious(m_P60484_Cys124Arg), deleterious(m_P10619_Tyr249Asn), deleterious(m_P40337_Leu198Arg), deleterious(m_P40763_Arg382Trp), deleterious(m_P02462_Gly1580Arg), deleterious(m_O14832_Trp193Arg), deleterious(m_P40337_Leu188Gln), deleterious(m_O15305_Gly228Arg), deleterious(m_O15305_Gly176Val), deleterious(m_Q15465_Asp171His), deleterious(m_P60484_Gly165Glu), deleterious(m_O14832_His175Arg)

+ Negative Examples: deleterious(m_P00352_Gly125Arg), deleterious(m_O15305_Gly42Arg)  
develop  retina001_21   modif_charge(A, charge_unchanged) and modif_hydrophobicity(A, hydrophobicity_increase) and modif_polarity(A, polarity_unchanged) and stability(A, decrease). deleterious(A)
34 (5.16%) 
3 (2.05%) 
61
Covers:
+ Positive Examples: deleterious(m_O14773_Pro202Leu), deleterious(m_O14832_Asn83Tyr), deleterious(m_Q9NSU2_Arg169His), deleterious(m_P40337_Asn78Thr), deleterious(m_P43080_Pro50Leu), deleterious(m_P40337_Pro154Leu), deleterious(m_O14773_Arg447His), deleterious(m_P07949_Arg231His), deleterious(m_P21912_Arg242His), deleterious(m_P51648_Pro114Leu), deleterious(m_P04198_Arg394His), deleterious(m_P51648_Pro121Leu), deleterious(m_P40337_Pro86Leu), deleterious(m_Q9GZT9_Arg371His), deleterious(m_P40337_Ser68Trp), deleterious(m_Q15465_Pro26Leu), deleterious(m_Q9NRR6_Arg563His), deleterious(m_P04198_Arg393His), deleterious(m_O14521_Pro81Leu), deleterious(m_P40337_Asn131Thr), deleterious(m_P14854_Arg20His), deleterious(m_P40337_Ser111Cys), deleterious(m_P40337_Ser65Trp), deleterious(m_P51648_Arg423His), deleterious(m_P35240_Asn220Tyr), deleterious(m_P40337_Pro86Ala), deleterious(m_P07949_Pro64Leu), deleterious(m_O14773_Arg206His), deleterious(m_O15305_Pro113Leu), deleterious(m_O15305_Pro131Ala), deleterious(m_P60484_Pro246Leu), deleterious(m_P07949_Arg114His), deleterious(m_O15305_Arg141His), deleterious(m_P07949_Arg67His)

+ Negative Examples: deleterious(m_P23219_Arg53His), deleterious(m_O14773_Arg175His), deleterious(m_Q12866_Arg466Lys)  
develop  retina001_27   conservation_class(A, global_conservation_rank_2) and secondary_struc(A, other) and stability(A, decrease). deleterious(A)
49 (7.44%) 
3 (2.05%) 
62
Covers:
+ Positive Examples: deleterious(m_P40337_Pro81Ser), deleterious(m_P40337_Asn131Lys), deleterious(m_P40337_Val155Met), deleterious(m_P40337_Leu101Arg), deleterious(m_O15305_His218Leu), deleterious(m_P11488_Gly38Asp), deleterious(m_O14832_Pro173Ser), deleterious(m_P40337_Gly114Ser), deleterious(m_P40337_Leu101Gly), deleterious(m_P40337_Ser80Asn), deleterious(m_O15305_Gly15Glu), deleterious(m_Q9GZT9_Pro317Arg), deleterious(m_O15305_Gln177His), deleterious(m_P40337_Tyr156Cys), deleterious(m_Q15465_Leu39Pro), deleterious(m_O14832_Glu197Gln), deleterious(m_O14773_Pro544Ser), deleterious(m_P60484_Arg47Gly), deleterious(m_P40337_Tyr156Asp), deleterious(m_Q15465_Glu188Gln), deleterious(m_P40337_Ser80Ile), deleterious(m_P35240_Gly197Cys), deleterious(m_P40337_Ser68Trp), deleterious(m_O15305_Val231Met), deleterious(m_Q9Y4U1_Gly147Asp), deleterious(m_Q9GZV9_Ser71Gly), deleterious(m_Q99714_Leu122Val), deleterious(m_P40337_Gly114Arg), deleterious(m_P40337_Asn131Thr), deleterious(m_Q99593_Gly80Arg), deleterious(m_P40337_Gly114Cys), deleterious(m_P40337_Ser80Arg), deleterious(m_P40337_Tyr156Asn), deleterious(m_O14773_Gly77Arg), deleterious(m_P40337_Leu128Phe), deleterious(m_P40337_Val155Gly), deleterious(m_Q9Y4U1_Gly147Ala), deleterious(m_P40763_Ser611Asn), deleterious(m_P21912_Ser100Phe), deleterious(m_P40337_Arg64Pro), deleterious(m_P40337_Thr157Ile), deleterious(m_P40337_Arg79Pro), deleterious(m_P40337_Leu63Pro), deleterious(m_P40337_Asp126Tyr), deleterious(m_P40337_Gln145His), deleterious(m_P60484_Gly165Glu), deleterious(m_O14773_Val385Asp), deleterious(m_P60484_Gly165Val), deleterious(m_P21912_Pro131Arg)

+ Negative Examples: deleterious(m_P23219_Arg149Leu), deleterious(m_Q9H6Z9_Val136Leu), deleterious(m_P63211_Glu50Lys)  
develop  retina001_62   g_or_p(A, g_or_p_unchanged) and secondary_struc(A, helix) and gain_contact(A, dc). deleterious(A)
30 (4.55%) 
3 (2.05%) 
64
Covers:
+ Positive Examples: deleterious(m_P50542_Asn526Lys), deleterious(m_Q9Y4U1_His122Arg), deleterious(m_O15305_Gln37His), deleterious(m_P50897_Arg122Trp), deleterious(m_P21912_Cys192Arg), deleterious(m_Q16678_Asn203Ser), deleterious(m_Q92793_Tyr1175Cys), deleterious(m_P48637_Asp219Ala), deleterious(m_Q9H0F7_Thr31Met), deleterious(m_P40337_Tyr175Asp), deleterious(m_Q16678_Glu229Lys), deleterious(m_O14773_Ser475Leu), deleterious(m_P40337_Leu188Val), deleterious(m_Q9BZ23_Ile497Thr), deleterious(m_P51648_Ser415Asn), deleterious(m_Q9H0F7_Thr31Arg), deleterious(m_P40337_Arg161Gln), deleterious(m_O14773_Glu343Lys), deleterious(m_O15305_His195Arg), deleterious(m_P40337_Leu198Gln), deleterious(m_Q15465_Cys102Arg), deleterious(m_Q16678_Val198Ile), deleterious(m_O15305_Thr237Arg), deleterious(m_P40337_Cys162Arg), deleterious(m_P11532_Leu54Arg), deleterious(m_Q99593_Arg237Trp), deleterious(m_P40337_Leu198Arg), deleterious(m_O14773_Val277Met), deleterious(m_P40337_Leu188Gln), deleterious(m_P51648_Met328Ile)

+ Negative Examples: deleterious(m_P23219_Leu237Met), deleterious(m_P23219_Val481Ile), deleterious(m_P19087_Val124Met)  
develop  retina001_24   modif_size(A, size_unchanged) and modif_polarity(A, polarity_unchanged) and secondary_struc(A, other). deleterious(A)
40 (6.07%) 
3 (2.05%) 
64
Covers:
+ Positive Examples: deleterious(m_Q15465_Trp117Arg), deleterious(m_Q14203_Gly71Ala), deleterious(m_P07686_Pro417Leu), deleterious(m_P40337_Tyr98His), deleterious(m_Q16678_Pro437Leu), deleterious(m_Q12866_Ser661Cys), deleterious(m_P40337_Pro154Leu), deleterious(m_P31040_Arg554Trp), deleterious(m_O15119_Leu143Pro), deleterious(m_Q9BZ23_Asp447Asn), deleterious(m_P51648_Gly185Ala), deleterious(m_P51648_Pro114Leu), deleterious(m_Q15465_Leu39Pro), deleterious(m_P60484_Cys124Ser), deleterious(m_Q16678_Pro193Leu), deleterious(m_Q15465_Pro26Leu), deleterious(m_O14832_His220Tyr), deleterious(m_P39905_Asp150Asn), deleterious(m_Q15465_Gly27Ala), deleterious(m_P06400_Arg661Trp), deleterious(m_Q9Y4U1_Leu116Pro), deleterious(m_P51648_His411Tyr), deleterious(m_Q9BZ23_Leu413Pro), deleterious(m_P40337_His115Tyr), deleterious(m_P40763_His437Tyr), deleterious(m_P06400_Leu662Pro), deleterious(m_P07949_Pro64Leu), deleterious(m_P40337_Leu178Pro), deleterious(m_O15305_Pro113Leu), deleterious(m_Q9NSU2_Asp255Asn), deleterious(m_P06400_Leu657Pro), deleterious(m_Q9Y4U1_Gly147Ala), deleterious(m_P48637_Arg267Trp), deleterious(m_P40763_Arg382Trp), deleterious(m_O15305_Asp223Asn), deleterious(m_P40337_Leu63Pro), deleterious(m_P60484_His93Tyr), deleterious(m_P48637_Tyr270His), deleterious(m_Q16678_Arg469Trp), deleterious(m_Q9H0F7_Gly169Ala)

+ Negative Examples: deleterious(m_P56177_Ser136Cys), deleterious(m_Q9HBH9_Asp73Asn), deleterious(m_P51659_Trp511Arg)  
develop  retina001_35   modif_hydrophobicity(A, hydrophobicity_decrease) and modif_polarity(A, polarity_increase) and g_or_p(A, g_or_p_unchanged) and stability(A, decrease). deleterious(A)
46 (6.98%) 
0 (0.0%) 
66
Covers:
+ Positive Examples: deleterious(m_O14773_Ile287Asn), deleterious(m_P60484_Ala34Asp), deleterious(m_P07949_Phe174Ser), deleterious(m_Q15465_Ile111Asn), deleterious(m_P60484_Ile67Arg), deleterious(m_P40337_Leu178Gln), deleterious(m_P21912_Leu87Ser), deleterious(m_O14832_Phe257Ser), deleterious(m_P40337_Val166Asp), deleterious(m_P51648_Leu106Arg), deleterious(m_P48637_Leu254Arg), deleterious(m_P60484_Val343Glu), deleterious(m_P40337_Leu101Arg), deleterious(m_O14773_Ala454Glu), deleterious(m_P60484_Phe241Ser), deleterious(m_O15305_Ile132Asn), deleterious(m_P42224_Leu706Ser), deleterious(m_P40337_Leu184Arg), deleterious(m_P40763_Phe384Ser), deleterious(m_P21912_Ile127Asn), deleterious(m_P35240_Phe62Ser), deleterious(m_P48637_Ala26Asp), deleterious(m_P35240_Leu234Arg), deleterious(m_O15305_Leu32Arg), deleterious(m_O15305_Phe183Ser), deleterious(m_O15305_Phe157Ser), deleterious(m_P40337_Phe76Ser), deleterious(m_P11532_Ala168Asp), deleterious(m_Q9NSU2_Val256Asp), deleterious(m_P40337_Leu198Gln), deleterious(m_P40337_Leu118Arg), deleterious(m_P40337_Phe136Ser), deleterious(m_P50897_Leu219Gln), deleterious(m_P11532_Leu54Arg), deleterious(m_P40337_Phe119Ser), deleterious(m_P60484_Met35Arg), deleterious(m_P40337_Leu198Arg), deleterious(m_Q12948_Phe112Ser), deleterious(m_P40337_Leu188Gln), deleterious(m_O15305_Phe206Ser), deleterious(m_P51648_Val64Asp), deleterious(m_O14773_Val385Asp), deleterious(m_Q15465_Ala110Asp), deleterious(m_P48637_Leu286Gln), deleterious(m_P40337_Val170Asp), deleterious(m_P51648_Phe419Ser)

+ Negative Examples:  
develop  retina001_65   modif_polarity(A, polarity_increase) and g_or_p(A, g_or_p_unchanged) and is_in_site(A, yes) and stability(A, decrease). deleterious(A)
63 (9.56%) 
3 (2.05%) 
66
Covers:
+ Positive Examples: deleterious(m_P10619_Met406Thr), deleterious(m_P60484_Ala34Asp), deleterious(m_P07949_Phe174Ser), deleterious(m_Q15465_Ile111Asn), deleterious(m_P21912_Leu65His), deleterious(m_P60484_Ile67Arg), deleterious(m_P40337_Leu178Gln), deleterious(m_P21912_Leu87Ser), deleterious(m_P40337_Phe136Tyr), deleterious(m_O14832_Phe257Ser), deleterious(m_P40337_Val166Asp), deleterious(m_P51648_Leu106Arg), deleterious(m_Q9H0F7_Leu170Trp), deleterious(m_P48637_Leu254Arg), deleterious(m_P60484_Val343Glu), deleterious(m_P40337_Leu101Arg), deleterious(m_Q15465_Phe170Cys), deleterious(m_P40337_Ala149Thr), deleterious(m_O14773_Ala454Glu), deleterious(m_P60484_Phe241Ser), deleterious(m_O15305_Ile132Asn), deleterious(m_Q92968_Ile326Thr), deleterious(m_P40337_Leu184Arg), deleterious(m_O15305_Ala233Thr), deleterious(m_O15305_Ile132Thr), deleterious(m_P40763_Phe384Ser), deleterious(m_P21912_Ile127Asn), deleterious(m_P35240_Phe62Ser), deleterious(m_P48637_Ala26Asp), deleterious(m_P35240_Leu234Arg), deleterious(m_Q9BZ23_Ile497Thr), deleterious(m_O15305_Leu32Arg), deleterious(m_Q15465_Ala110Thr), deleterious(m_O15305_Phe183Ser), deleterious(m_O15305_Phe157Ser), deleterious(m_P40337_Phe76Ser), deleterious(m_P11532_Ala168Asp), deleterious(m_P40337_Leu198Gln), deleterious(m_P40337_Leu118Arg), deleterious(m_P40337_Phe136Ser), deleterious(m_P50897_Leu219Gln), deleterious(m_P40337_Ile147Thr), deleterious(m_P11532_Leu54Arg), deleterious(m_P40337_Phe119Ser), deleterious(m_Q9BZ23_Ile501Thr), deleterious(m_P60484_Met35Arg), deleterious(m_Q99593_Ile54Thr), deleterious(m_P06400_Ile185Thr), deleterious(m_P40337_Leu198Arg), deleterious(m_Q12948_Phe112Ser), deleterious(m_O15305_Phe11Cys), deleterious(m_P40337_Leu188Gln), deleterious(m_Q9BZ23_Ala398Thr), deleterious(m_O15305_Phe206Ser), deleterious(m_P40337_Phe136Cys), deleterious(m_P51648_Val64Asp), deleterious(m_O15305_Ile120Thr), deleterious(m_O14773_Val385Asp), deleterious(m_Q15465_Ala110Asp), deleterious(m_O15305_Ile153Thr), deleterious(m_P48637_Leu286Gln), deleterious(m_P40337_Val170Asp), deleterious(m_P51648_Phe419Ser)

+ Negative Examples: deleterious(m_P50897_Ile134Thr), deleterious(m_P42224_Ile30Thr), deleterious(m_P40763_Phe561Tyr)  
develop  retina001_28   modif_size(A, size_decrease) and is_in_site(A, yes) and gain_contact(A, dc). deleterious(A)
30 (4.55%) 
3 (2.05%) 
66
Covers:
+ Positive Examples: deleterious(m_P07339_Phe229Ile), deleterious(m_Q16678_Asn203Ser), deleterious(m_P51648_Pro315Ser), deleterious(m_P40337_Asn78Thr), deleterious(m_Q9Y4U1_Arg161Gly), deleterious(m_O15305_His218Leu), deleterious(m_Q92793_Tyr1175Cys), deleterious(m_P48637_Asp219Ala), deleterious(m_P40763_Arg382Gln), deleterious(m_P40763_Arg382Leu), deleterious(m_P40337_Tyr175Asp), deleterious(m_P51648_Asn386Ser), deleterious(m_O14832_Glu197Gln), deleterious(m_O15305_Ile132Thr), deleterious(m_P40337_Leu188Val), deleterious(m_Q9BZ23_Arg278Cys), deleterious(m_Q9BZ23_Ile497Thr), deleterious(m_P40337_Arg161Gln), deleterious(m_Q9NRR6_Lys580Glu), deleterious(m_O15305_Phe172Val), deleterious(m_P40337_Phe76Ile), deleterious(m_P28360_Arg196Pro), deleterious(m_P60484_Phe341Val), deleterious(m_O15305_Phe119Leu), deleterious(m_P40337_Val155Gly), deleterious(m_O14773_Gln278Pro), deleterious(m_O15305_Phe11Cys), deleterious(m_Q9BZ23_Arg278Leu), deleterious(m_P51648_Met328Ile), deleterious(m_Q9Y4U1_Arg161Gln)

+ Negative Examples: deleterious(m_Q16678_Val422Gly), deleterious(m_O15305_Met212Val), deleterious(m_P17655_Ser68Gly)  
develop  retina001_14   modif_charge(A, charge_decrease) and mut_accessibility(A, buried). deleterious(A)
58 (8.8%) 
2 (1.37%) 
67
Covers:
+ Positive Examples: deleterious(m_P48637_Arg283Cys), deleterious(m_O00754_His72Leu), deleterious(m_Q15465_Asp147Asn), deleterious(m_P50897_Arg122Trp), deleterious(m_Q9Y4U1_Arg189Ser), deleterious(m_Q9BZ23_Glu322Gly), deleterious(m_Q9Y4U1_Arg161Gly), deleterious(m_O15305_His218Leu), deleterious(m_O15305_Arg238Gly), deleterious(m_P48637_Asp219Ala), deleterious(m_P60484_Asp331Gly), deleterious(m_Q9BZ23_Asp447Asn), deleterious(m_P50897_His39Gln), deleterious(m_Q9BZ23_Arg286Cys), deleterious(m_Q16678_Arg145Trp), deleterious(m_P40337_Asp121Gly), deleterious(m_P51648_Asp245Asn), deleterious(m_P48637_Asp219Gly), deleterious(m_P60484_Asp252Gly), deleterious(m_Q9BZ23_Arg278Cys), deleterious(m_P06400_His673Pro), deleterious(m_P43080_Glu155Gly), deleterious(m_P40337_His115Gln), deleterious(m_P50897_Asp79Gly), deleterious(m_O14521_Asp92Tyr), deleterious(m_O14832_His220Tyr), deleterious(m_P51648_Arg228Cys), deleterious(m_P07949_Arg180Pro), deleterious(m_P28360_Arg196Pro), deleterious(m_P60484_His123Tyr), deleterious(m_O15305_Asp148Asn), deleterious(m_P06400_Arg661Trp), deleterious(m_Q9Y4U1_Arg206Pro), deleterious(m_P51648_His411Tyr), deleterious(m_Q16678_Arg390Ser), deleterious(m_P21912_Arg46Gly), deleterious(m_O14832_Arg275Trp), deleterious(m_O14832_Asp177Gly), deleterious(m_P60484_Arg130Leu), deleterious(m_P21912_Arg230Cys), deleterious(m_P40337_His115Tyr), deleterious(m_Q15465_His140Gln), deleterious(m_P40763_His437Tyr), deleterious(m_O15305_Arg141Cys), deleterious(m_P40337_Arg167Trp), deleterious(m_P22748_Arg219Ser), deleterious(m_Q9NRR6_Arg378Cys), deleterious(m_Q9NSU2_Asp73Asn), deleterious(m_Q9Y4U1_Arg206Trp), deleterious(m_Q15465_Arg144Pro), deleterious(m_P48637_Arg267Trp), deleterious(m_O15305_Asp223Asn), deleterious(m_Q9BZ23_Arg278Leu), deleterious(m_P40337_Asp126Tyr), deleterious(m_O14773_Arg206Cys), deleterious(m_Q15465_His140Pro), deleterious(m_O15305_Arg238Pro), deleterious(m_Q16678_Arg390Cys)

+ Negative Examples: deleterious(m_P23219_Arg149Leu), deleterious(m_P06400_Glu746Gly)  
develop  retina001_2   modif_size(A, size_decrease) and g_or_p(A, g_or_p_unchanged) and is_in_site(A, yes) and secondary_struc(A, helix) and wt_accessibility(A, accessible). deleterious(A)
18 (2.73%) 
3 (2.05%) 
68
Covers:
+ Positive Examples: deleterious(m_Q9NZJ4_Arg4331Gln), deleterious(m_Q9Y2V3_Arg192Gln), deleterious(m_P06400_Glu137Asp), deleterious(m_Q9NZJ4_Lys4508Thr), deleterious(m_Q16678_Tyr81Asn), deleterious(m_O15305_Glu197Ala), deleterious(m_P04198_Arg394His), deleterious(m_P40337_Arg161Gln), deleterious(m_P04198_Arg393His), deleterious(m_Q13562_Arg111Leu), deleterious(m_P40337_Leu158Val), deleterious(m_O14521_Tyr114Cys), deleterious(m_Q99593_Arg237Gln), deleterious(m_O14773_Lys428Asn), deleterious(m_O15305_Glu93Ala), deleterious(m_P04198_Arg393Ser), deleterious(m_O14773_Arg127Gln), deleterious(m_Q99714_Arg130Cys)

+ Negative Examples: deleterious(m_P17655_Lys677Gln), deleterious(m_Q16678_Arg266Leu), deleterious(m_O00754_Arg337Gln)  
develop  retina001_13   modif_hydrophobicity(A, hydrophobicity_increase) and secondary_struc(A, sheet). deleterious(A)
26 (3.95%) 
2 (1.37%) 
69
Covers:
+ Positive Examples: deleterious(m_P07686_Ser62Leu), deleterious(m_P40337_Asn78Thr), deleterious(m_Q9Y4U1_Arg161Gly), deleterious(m_Q9BZ23_Arg264Trp), deleterious(m_P40337_Asn78His), deleterious(m_O14773_Arg447His), deleterious(m_P40337_Arg107Gly), deleterious(m_Q9BZ23_Arg286Cys), deleterious(m_P40337_Asp121Gly), deleterious(m_P60484_Asp252Gly), deleterious(m_Q9BZ23_Arg278Cys), deleterious(m_P40337_Pro86Leu), deleterious(m_Q9GZT9_Arg371His), deleterious(m_Q15465_Ser184Leu), deleterious(m_P40337_Ser111Cys), deleterious(m_P21912_Arg46Gly), deleterious(m_O14832_Arg275Trp), deleterious(m_P51648_Arg423His), deleterious(m_P35240_Asn220Tyr), deleterious(m_P40337_Pro86Ala), deleterious(m_P40337_Pro86His), deleterious(m_Q9NRR6_Arg378Cys), deleterious(m_P10619_Ser51Tyr), deleterious(m_P60484_Pro246Leu), deleterious(m_Q9BZ23_Arg278Leu), deleterious(m_P07949_Arg67His)

+ Negative Examples: deleterious(m_P51801_Ser660Leu), deleterious(m_P00450_Pro477Leu)  
develop  retina001_49   conservation_class(A, global_conservation_rank_2) and wt_accessibility(A, intermediate). deleterious(A)
44 (6.68%) 
3 (2.05%) 
71
Covers:
+ Positive Examples: deleterious(m_P11532_Lys18Asn), deleterious(m_P40337_Asn131Lys), deleterious(m_O15305_Leu104Val), deleterious(m_P40337_Tyr112His), deleterious(m_P12644_Ala346Val), deleterious(m_P40337_Val166Asp), deleterious(m_P40337_Val166Phe), deleterious(m_P35555_Asp2127Glu), deleterious(m_P11488_Gly38Asp), deleterious(m_P40337_Arg200Trp), deleterious(m_O14832_Pro173Ser), deleterious(m_P40337_Lys159Glu), deleterious(m_Q9BZ23_Arg286Cys), deleterious(m_O15305_Gln177His), deleterious(m_P40337_Tyr156Cys), deleterious(m_Q15465_Leu39Pro), deleterious(m_O14832_Glu197Gln), deleterious(m_P40337_Arg167Gly), deleterious(m_Q16678_Arg523Thr), deleterious(m_P40337_Tyr156Asp), deleterious(m_Q9BZ23_Asn500Ile), deleterious(m_Q15067_Met278Val), deleterious(m_Q9GZT9_Arg371His), deleterious(m_O15305_Phe183Ser), deleterious(m_Q99714_Leu122Val), deleterious(m_P35555_Asn2144Ser), deleterious(m_P28360_Arg196Pro), deleterious(m_P40337_Asn131Thr), deleterious(m_Q9BZ23_Leu413Pro), deleterious(m_P40337_Tyr156Asn), deleterious(m_Q16678_Gly365Trp), deleterious(m_O75369_Glu227Lys), deleterious(m_Q9BZ23_Ser471Asn), deleterious(m_P40337_Arg167Gln), deleterious(m_O15305_Asn101Lys), deleterious(m_P40337_Arg167Trp), deleterious(m_Q9NRR6_Arg378Cys), deleterious(m_Q92793_Thr1447Ile), deleterious(m_P21912_Ser100Phe), deleterious(m_P40337_Arg64Pro), deleterious(m_P06400_Lys530Arg), deleterious(m_O15305_Ile120Thr), deleterious(m_P40337_Tyr112Asn), deleterious(m_P21912_Pro131Arg)

+ Negative Examples: deleterious(m_P56177_Ser136Cys), deleterious(m_Q15067_Thr153Ile), deleterious(m_Q16678_Pro379Leu)  
develop  retina001_60   modif_hydrophobicity(A, hydrophobicity_decrease) and secondary_struc(A, sheet). deleterious(A)
50 (7.59%) 
3 (2.05%) 
72
Covers:
+ Positive Examples: deleterious(m_O15305_Tyr229Ser), deleterious(m_P60484_Ala34Asp), deleterious(m_P60484_His123Arg), deleterious(m_P40337_Trp88Ser), deleterious(m_P07949_Phe174Ser), deleterious(m_P60484_Ile67Arg), deleterious(m_Q14203_Thr72Pro), deleterious(m_O14832_Phe257Ser), deleterious(m_Q14203_Gly59Ser), deleterious(m_P51648_Leu106Arg), deleterious(m_P48637_Leu254Arg), deleterious(m_P60484_Val343Glu), deleterious(m_P07949_Cys142Ser), deleterious(m_Q15465_Thr150Arg), deleterious(m_Q92793_His1470Arg), deleterious(m_P21912_Ala43Pro), deleterious(m_O14773_Ala454Glu), deleterious(m_P51648_Thr184Arg), deleterious(m_P60484_Phe241Ser), deleterious(m_Q15465_Cys183Arg), deleterious(m_P40763_Phe384Ser), deleterious(m_P21912_Ile127Asn), deleterious(m_P35240_Phe62Ser), deleterious(m_P35240_Leu234Arg), deleterious(m_P60484_Leu70Pro), deleterious(m_O15305_Phe183Ser), deleterious(m_P07949_Leu40Pro), deleterious(m_P40337_Phe76Ser), deleterious(m_P51648_Gly406Arg), deleterious(m_Q6KF10_Lys424Arg), deleterious(m_P60484_Lys342Asn), deleterious(m_P40337_Leu118Arg), deleterious(m_P40337_Leu118Pro), deleterious(m_O15305_Gly175Arg), deleterious(m_P50897_Tyr109Asp), deleterious(m_O14773_Thr353Pro), deleterious(m_P40337_Phe119Ser), deleterious(m_O15305_Thr226Ser), deleterious(m_P60484_Met35Arg), deleterious(m_O15119_Tyr149Ser), deleterious(m_P40337_Trp88Arg), deleterious(m_P40337_Leu89Pro), deleterious(m_P02462_Gly1580Arg), deleterious(m_O14832_Trp193Arg), deleterious(m_O14773_Gly389Glu), deleterious(m_O15305_Phe206Ser), deleterious(m_O15305_Gly228Arg), deleterious(m_P40337_Tyr112Asn), deleterious(m_P10619_Gly439Ser), deleterious(m_P10619_Trp65Arg)

+ Negative Examples: deleterious(m_P21912_Lys40Glu), deleterious(m_O15305_Gly42Arg), deleterious(m_P17655_Lys476Arg)  
develop  retina001_52   modif_size(A, size_increase) and secondary_struc(A, other) and gain_contact(A, phob). deleterious(A)
33 (5.01%) 
3 (2.05%) 
73
Covers:
+ Positive Examples: deleterious(m_P06400_Ala635Pro), deleterious(m_Q15465_Gly143Asp), deleterious(m_O14773_Cys365Arg), deleterious(m_P50897_Gly108Arg), deleterious(m_P60484_His93Arg), deleterious(m_P07949_Cys197Tyr), deleterious(m_P07949_Ser32Leu), deleterious(m_O15305_Asp65Tyr), deleterious(m_P50897_Val181Met), deleterious(m_P21912_Cys196Tyr), deleterious(m_Q16678_Val364Met), deleterious(m_P50542_Ser600Trp), deleterious(m_Q9BZ23_Thr528Met), deleterious(m_Q99593_Gly80Arg), deleterious(m_O14773_Ser153Pro), deleterious(m_Q16678_Gly365Trp), deleterious(m_P40337_His115Arg), deleterious(m_Q9BZ23_Gly521Arg), deleterious(m_P21912_Cys101Tyr), deleterious(m_P07686_Cys309Tyr), deleterious(m_Q16678_Gly466Asp), deleterious(m_P60484_Cys124Arg), deleterious(m_P51648_Ser365Leu), deleterious(m_Q9BZ23_Gly219Val), deleterious(m_O14832_Gln176Lys), deleterious(m_O15305_Gly176Val), deleterious(m_P06400_Cys706Tyr), deleterious(m_Q15465_Asp171His), deleterious(m_P60484_Gly165Glu), deleterious(m_O14773_Val385Asp), deleterious(m_P60484_Gly165Val), deleterious(m_O14832_His175Arg), deleterious(m_P40337_Val170Phe)

+ Negative Examples: deleterious(m_O00206_Leu385Phe), deleterious(m_P36575_Leu44Phe), deleterious(m_P00450_Thr841Arg)  
develop  retina001_26   secondary_struc(A, other) and gain_contact(A, phob) and stability(A, decrease). deleterious(A)
32 (4.86%) 
3 (2.05%) 
74
Covers:
+ Positive Examples: deleterious(m_P40337_Leu178Gln), deleterious(m_P40337_His191Asp), deleterious(m_Q15465_Gly143Asp), deleterious(m_P40763_Arg382Leu), deleterious(m_O14773_Cys365Arg), deleterious(m_P50897_Gly108Arg), deleterious(m_P60484_His93Arg), deleterious(m_P07949_Cys197Tyr), deleterious(m_P07949_Ser32Leu), deleterious(m_O15305_Asp65Tyr), deleterious(m_P50897_Val181Met), deleterious(m_P21912_Cys196Tyr), deleterious(m_Q9BZ23_Thr528Met), deleterious(m_Q99593_Gly80Arg), deleterious(m_O14773_Ser153Pro), deleterious(m_Q9BZ23_Arg357Gln), deleterious(m_P40337_His115Arg), deleterious(m_Q9BZ23_Gly521Arg), deleterious(m_P07949_Pro64Leu), deleterious(m_P21912_Cys101Tyr), deleterious(m_O15305_Pro113Leu), deleterious(m_P60484_Cys124Arg), deleterious(m_P51648_Ser365Leu), deleterious(m_Q15465_Arg144Pro), deleterious(m_P40763_Arg382Trp), deleterious(m_O15305_Gly176Val), deleterious(m_Q15465_Asp171His), deleterious(m_P60484_Gly165Glu), deleterious(m_O14773_Val385Asp), deleterious(m_P60484_Gly165Val), deleterious(m_O14832_His175Arg), deleterious(m_P40337_Val170Phe)

+ Negative Examples: deleterious(m_O00206_Phe443Leu), deleterious(m_O00206_Leu385Phe), deleterious(m_P36575_Leu44Phe)  
develop  retina001_38   modif_size(A, size_decrease) and lost_contact(A, phob) and wt_accessibility(A, buried) and stability(A, decrease). deleterious(A)
46 (6.98%) 
3 (2.05%) 
74
Covers:
+ Positive Examples: deleterious(m_P07949_Phe174Ser), deleterious(m_P10619_Tyr395Cys), deleterious(m_Q9Y4U1_Arg189Ser), deleterious(m_O14832_Phe257Ser), deleterious(m_O15305_Tyr106Cys), deleterious(m_P60484_Phe347Leu), deleterious(m_Q9Y4U1_Arg161Gly), deleterious(m_Q15465_Phe170Cys), deleterious(m_O15305_Arg238Gly), deleterious(m_P60484_Phe241Ser), deleterious(m_P40337_Leu101Gly), deleterious(m_P51648_Tyr279Asn), deleterious(m_P40337_Tyr175Asp), deleterious(m_P40763_Tyr657Cys), deleterious(m_P40337_Trp117Cys), deleterious(m_O15305_Ile132Thr), deleterious(m_P40763_Phe384Ser), deleterious(m_P35240_Phe62Ser), deleterious(m_P43080_Glu155Gly), deleterious(m_O15305_Tyr64Cys), deleterious(m_O15305_Phe172Val), deleterious(m_O15305_Phe157Ser), deleterious(m_P60484_Ile135Val), deleterious(m_P60484_Phe341Val), deleterious(m_P43080_Tyr99Cys), deleterious(m_P21912_Arg46Gly), deleterious(m_P40337_Leu116Val), deleterious(m_P50897_Trp38Cys), deleterious(m_Q15465_His140Gln), deleterious(m_P50897_Tyr109Asp), deleterious(m_P40337_Phe119Ser), deleterious(m_Q9BZ23_Ile501Thr), deleterious(m_P40337_Pro86Ser), deleterious(m_P22748_Arg219Ser), deleterious(m_Q9BZ23_Arg249Pro), deleterious(m_P11532_Tyr231Asn), deleterious(m_O15119_Tyr149Ser), deleterious(m_P10619_Tyr249Asn), deleterious(m_Q9BZ23_Leu282Val), deleterious(m_Q12948_Phe112Ser), deleterious(m_Q9Y4U1_Trp157Cys), deleterious(m_P07339_Trp383Cys), deleterious(m_O15305_Phe11Cys), deleterious(m_O15305_Phe206Ser), deleterious(m_P51648_Phe419Ser), deleterious(m_O15305_Arg238Pro)

+ Negative Examples: deleterious(m_P23219_Arg149Leu), deleterious(m_O00206_Phe443Leu), deleterious(m_O14773_Arg175His)  
develop  retina001_34   modif_hydrophobicity(A, hydrophobicity_increase) and gain_contact(A, dc). deleterious(A)
29 (4.4%) 
2 (1.37%) 
74
Covers:
+ Positive Examples: deleterious(m_P50542_Asn526Lys), deleterious(m_O15305_Gln37His), deleterious(m_P50897_Arg122Trp), deleterious(m_P40337_Asn131Lys), deleterious(m_Q16678_Pro437Leu), deleterious(m_P40337_Asn78Thr), deleterious(m_Q9Y4U1_Arg161Gly), deleterious(m_P40337_Asn78His), deleterious(m_P48637_Asp219Ala), deleterious(m_P40763_Arg382Leu), deleterious(m_Q9NZJ4_Glu4343Lys), deleterious(m_Q16678_Glu229Lys), deleterious(m_O14773_Ser475Leu), deleterious(m_O15305_Asp65Tyr), deleterious(m_Q9BZ23_Arg278Cys), deleterious(m_P40337_Pro86Leu), deleterious(m_P06400_Ser567Leu), deleterious(m_P50542_Ser600Trp), deleterious(m_O14773_Glu343Lys), deleterious(m_O14521_Pro81Leu), deleterious(m_O60333_Gln98Leu), deleterious(m_P07949_Pro64Leu), deleterious(m_Q99593_Arg237Trp), deleterious(m_P40763_Arg382Trp), deleterious(m_Q9BZ23_Arg278Leu), deleterious(m_Q15465_Asp171His), deleterious(m_O15305_Asn216Ile), deleterious(m_Q16678_Ser215Ile), deleterious(m_Q16678_Arg469Trp)

+ Negative Examples: deleterious(m_P00450_Arg367Cys), deleterious(m_P17655_Ser68Gly)  
develop  retina001_19   modif_charge(A, charge_unchanged) and secondary_struc(A, helix) and wt_accessibility(A, intermediate) and stability(A, decrease). deleterious(A)
18 (2.73%) 
2 (1.37%) 
77
Covers:
+ Positive Examples: deleterious(m_P10619_Met406Thr), deleterious(m_O14521_Leu139Pro), deleterious(m_Q99714_Asn247Ser), deleterious(m_Q9Y4U1_His122Arg), deleterious(m_O14832_Asn83Tyr), deleterious(m_O15305_Leu104Val), deleterious(m_Q9BZ23_Glu322Asp), deleterious(m_P07949_Cys157Tyr), deleterious(m_P40337_Val166Phe), deleterious(m_Q9H0F7_Thr31Met), deleterious(m_Q9Y6K9_Ala288Gly), deleterious(m_P40337_Cys162Phe), deleterious(m_O14949_Ser45Phe), deleterious(m_P40337_Arg167Gln), deleterious(m_P40337_Leu184Pro), deleterious(m_P40337_Cys162Trp), deleterious(m_P40337_Cys162Tyr), deleterious(m_O15305_Arg141His)

+ Negative Examples: deleterious(m_P51659_Met728Val), deleterious(m_O14610_Leu11Phe)  
develop  retina001_20   modif_charge(A, charge_unchanged) and conservation_class(A, global_conservation_rank_2) and secondary_struc(A, other). deleterious(A)
45 (6.83%) 
2 (1.37%) 
80
Covers:
+ Positive Examples: deleterious(m_P40337_Pro81Ser), deleterious(m_Q92793_Arg1664His), deleterious(m_P12644_Ala346Val), deleterious(m_P35555_Asp2127Glu), deleterious(m_P40337_Val155Met), deleterious(m_O14832_Pro173Ser), deleterious(m_Q16678_Arg368His), deleterious(m_P40337_Gly114Ser), deleterious(m_P40337_Leu101Gly), deleterious(m_P40337_Ser80Asn), deleterious(m_Q16678_Asn423Tyr), deleterious(m_P40337_Tyr156Cys), deleterious(m_Q15465_Leu39Pro), deleterious(m_O14773_Pro544Ser), deleterious(m_Q16678_Pro193Leu), deleterious(m_P40337_Ser80Ile), deleterious(m_P06400_Ser567Leu), deleterious(m_P35240_Gly197Cys), deleterious(m_Q15067_Met278Val), deleterious(m_P40337_Ser68Trp), deleterious(m_O15305_Val231Met), deleterious(m_Q9GZV9_Ser71Gly), deleterious(m_Q99714_Leu122Val), deleterious(m_P35555_Asn2144Ser), deleterious(m_P40337_Asn131Thr), deleterious(m_P40337_Gly114Cys), deleterious(m_Q9BZ23_Cys428Tyr), deleterious(m_Q9BZ23_Leu413Pro), deleterious(m_P40337_Tyr156Asn), deleterious(m_P10619_Ser90Leu), deleterious(m_Q16678_Gly365Trp), deleterious(m_Q9BZ23_Ser471Asn), deleterious(m_P07686_Cys309Tyr), deleterious(m_P40337_Leu128Phe), deleterious(m_P40337_Val155Gly), deleterious(m_P06400_Leu657Pro), deleterious(m_Q9Y4U1_Gly147Ala), deleterious(m_P40763_Ser611Asn), deleterious(m_P21912_Ser100Phe), deleterious(m_Q9BZ23_Gly219Val), deleterious(m_P40337_Thr157Ile), deleterious(m_P40337_Leu63Pro), deleterious(m_O75369_Gly168Ser), deleterious(m_O75369_Phe161Cys), deleterious(m_P60484_Gly165Val)

+ Negative Examples: deleterious(m_P56177_Ser136Cys), deleterious(m_Q9H6Z9_Val136Leu)  
develop  retina001_57   modif_hydrophobicity(A, hydrophobicity_unchanged) and g_or_p(A, g_or_p_disparition). deleterious(A)
35 (5.31%) 
2 (1.37%) 
82
Covers:
+ Positive Examples: deleterious(m_P40337_Pro81Ser), deleterious(m_O15305_Pro20Ser), deleterious(m_Q14203_Gly71Ala), deleterious(m_P21912_Pro197Arg), deleterious(m_P51648_Pro315Ser), deleterious(m_O15305_Gly228Cys), deleterious(m_O14832_Pro173Ser), deleterious(m_P51648_Gly185Ala), deleterious(m_Q9GZT9_Pro317Arg), deleterious(m_P40337_Gly93Cys), deleterious(m_P07686_Pro504Ser), deleterious(m_O14773_Pro544Ser), deleterious(m_O14773_Gly284Val), deleterious(m_P35240_Gly197Cys), deleterious(m_Q15465_Gly27Ala), deleterious(m_P35555_Pro2154Arg), deleterious(m_P40337_Gly114Cys), deleterious(m_P48637_Gly464Val), deleterious(m_P43080_Gly159Val), deleterious(m_Q16678_Gly365Trp), deleterious(m_O14521_Gly148Val), deleterious(m_P50897_Gly250Val), deleterious(m_P40337_Pro86Ser), deleterious(m_O15305_Pro69Ser), deleterious(m_Q9Y4U1_Gly147Ala), deleterious(m_Q9BZ23_Gly219Val), deleterious(m_O15305_Gly208Ala), deleterious(m_P57082_Gly248Val), deleterious(m_P40337_Pro192Ser), deleterious(m_O15305_Gly176Val), deleterious(m_P40337_Pro86Arg), deleterious(m_P60484_Gly165Val), deleterious(m_P21912_Pro131Arg), deleterious(m_Q9H0F7_Gly169Ala), deleterious(m_Q15067_Gly178Cys)

+ Negative Examples: deleterious(m_P36955_Pro132Arg), deleterious(m_O15034_Pro593Arg)  
develop  retina001_44   modif_hydrophobicity(A, hydrophobicity_unchanged) and modif_polarity(A, polarity_decrease) and stability(A, decrease). deleterious(A)
32 (4.86%) 
3 (2.05%) 
84
Covers:
+ Positive Examples: deleterious(m_P40337_Arg82Pro), deleterious(m_Q14203_Gln74Pro), deleterious(m_O15305_Thr237Met), deleterious(m_P40337_Arg161Pro), deleterious(m_O15305_His218Leu), deleterious(m_Q15465_Cys183Phe), deleterious(m_Q9H0F7_Thr31Met), deleterious(m_Q9BZ23_Thr327Ile), deleterious(m_Q9BZ23_Thr234Ala), deleterious(m_P40763_Thr622Ile), deleterious(m_Q9BZ23_Ser351Pro), deleterious(m_Q9BZ23_Thr528Met), deleterious(m_O15305_Cys103Phe), deleterious(m_P40337_Cys162Phe), deleterious(m_P07949_Arg180Pro), deleterious(m_P28360_Arg196Pro), deleterious(m_O15305_Cys192Gly), deleterious(m_Q9Y4U1_Arg206Pro), deleterious(m_O14773_Ser153Pro), deleterious(m_Q15465_Trp117Gly), deleterious(m_O14773_Gln278Pro), deleterious(m_Q9BZ23_Arg249Pro), deleterious(m_P60484_Cys105Phe), deleterious(m_P10071_Cys515Gly), deleterious(m_Q15465_Arg144Pro), deleterious(m_P40337_Arg64Pro), deleterious(m_P40337_Arg107Pro), deleterious(m_P40337_Thr157Ile), deleterious(m_P40337_Arg79Pro), deleterious(m_P40337_Gln96Pro), deleterious(m_P40763_Thr389Ile), deleterious(m_O15305_Arg238Pro)

+ Negative Examples: deleterious(m_P11532_Gln133Pro), deleterious(m_P36955_Thr72Met), deleterious(m_O00206_Thr175Ala)  
develop  retina001_45   g_or_p(A, g_or_p_unchanged) and gain_contact(A, hb). deleterious(A)
32 (4.86%) 
3 (2.05%) 
87
Covers:
+ Positive Examples: deleterious(m_O15305_Tyr229Ser), deleterious(m_Q9H0F7_Ala89Val), deleterious(m_Q9Y4U1_Arg189Ser), deleterious(m_Q16678_Asn203Ser), deleterious(m_P35240_Cys133Arg), deleterious(m_P40763_Arg382Gln), deleterious(m_P56693_Ser135Thr), deleterious(m_P40337_Leu184Arg), deleterious(m_O14832_Glu197Gln), deleterious(m_Q86UR5_Arg820His), deleterious(m_P60484_Tyr155Cys), deleterious(m_P40763_Thr622Ile), deleterious(m_Q9H0F7_Thr31Arg), deleterious(m_Q9NRR6_Lys580Glu), deleterious(m_P10619_Val132Met), deleterious(m_Q16678_Met132Arg), deleterious(m_Q15465_Leu109Phe), deleterious(m_O00754_Ser453Tyr), deleterious(m_P40337_Leu198Gln), deleterious(m_Q15465_Cys102Arg), deleterious(m_P60484_Cys71Tyr), deleterious(m_P60484_Cys124Arg), deleterious(m_P10619_Tyr249Asn), deleterious(m_P40337_Leu198Arg), deleterious(m_P60484_Lys289Glu), deleterious(m_P40763_Arg382Trp), deleterious(m_O14832_Trp193Arg), deleterious(m_P40337_Leu188Gln), deleterious(m_Q15465_Asp171His), deleterious(m_O14773_Asn286Ser), deleterious(m_P06400_Cys712Arg), deleterious(m_O14832_His175Arg)

+ Negative Examples: deleterious(m_P09874_Val762Ala), deleterious(m_O14773_Gln100Arg), deleterious(m_Q16678_Asp441His)  
develop  retina001_16   modif_hydrophobicity(A, hydrophobicity_increase) and modif_polarity(A, polarity_unchanged) and secondary_struc(A, helix) and mut_accessibility(A, accessible). deleterious(A)
19 (2.88%) 
3 (2.05%) 
87
Covers:
+ Positive Examples: deleterious(m_O15305_Gln37His), deleterious(m_Q9Y6K9_Glu57Lys), deleterious(m_Q9NRR6_Arg512Trp), deleterious(m_P43080_Pro50Leu), deleterious(m_P40337_Arg200Trp), deleterious(m_P40337_Glu186Lys), deleterious(m_Q15465_Gln100His), deleterious(m_P43080_Glu89Lys), deleterious(m_O15305_Glu139Lys), deleterious(m_Q15465_Asn115Lys), deleterious(m_P04198_Arg393His), deleterious(m_O14521_Pro81Leu), deleterious(m_O15305_Arg162Trp), deleterious(m_P10071_Arg625Trp), deleterious(m_P07949_Arg77Cys), deleterious(m_P40337_Arg176Trp), deleterious(m_O15305_Asn101Lys), deleterious(m_Q99593_Arg237Trp), deleterious(m_Q9NRR6_Arg515Trp)

+ Negative Examples: deleterious(m_P06400_Gln436Lys), deleterious(m_P52630_Gln826His), deleterious(m_O94788_Glu436Lys)  
develop  retina001_17   modif_charge(A, charge_unchanged) and g_or_p(A, g_or_p_apparition) and stability(A, decrease). deleterious(A)
41 (6.22%) 
3 (2.05%) 
88
Covers:
+ Positive Examples: deleterious(m_O14521_Leu139Pro), deleterious(m_P10619_Leu236Pro), deleterious(m_P35240_Leu141Pro), deleterious(m_Q14203_Thr72Pro), deleterious(m_Q14203_Gln74Pro), deleterious(m_P40337_Leu188Pro), deleterious(m_P54845_Leu160Pro), deleterious(m_P40337_Val74Gly), deleterious(m_P60484_Leu112Pro), deleterious(m_O15119_Leu143Pro), deleterious(m_P21912_Ala43Pro), deleterious(m_P48637_Leu188Pro), deleterious(m_P40337_Leu101Gly), deleterious(m_Q9Y6K9_Ala288Gly), deleterious(m_Q15465_Leu39Pro), deleterious(m_P11532_Ala171Pro), deleterious(m_P60484_Ala121Gly), deleterious(m_P50897_Thr75Pro), deleterious(m_Q9BZ23_Ser351Pro), deleterious(m_P60484_Leu70Pro), deleterious(m_P40337_Val170Gly), deleterious(m_Q9GZV9_Ser71Gly), deleterious(m_Q9Y4U1_Leu116Pro), deleterious(m_O15305_Cys192Gly), deleterious(m_O14773_Ser153Pro), deleterious(m_P40337_Leu118Pro), deleterious(m_P40337_Thr105Pro), deleterious(m_O94972_Leu76Pro), deleterious(m_P40337_Leu184Pro), deleterious(m_P40337_Leu178Pro), deleterious(m_P40337_Val155Gly), deleterious(m_Q15465_Trp117Gly), deleterious(m_O14773_Gln278Pro), deleterious(m_P10071_Cys515Gly), deleterious(m_P21912_Leu65Pro), deleterious(m_Q9Y4U1_Leu193Pro), deleterious(m_P40337_Leu89Pro), deleterious(m_P40337_Leu63Pro), deleterious(m_P40337_Gln96Pro), deleterious(m_P40337_Leu163Pro), deleterious(m_P40337_Leu158Pro)

+ Negative Examples: deleterious(m_P11532_Gln133Pro), deleterious(m_O00206_Val310Gly), deleterious(m_P17655_Ser68Gly)  
develop  retina001_37   modif_size(A, size_decrease) and secondary_struc(A, helix) and mut_accessibility(A, intermediate). deleterious(A)
29 (4.4%) 
3 (2.05%) 
88
Covers:
+ Positive Examples: deleterious(m_Q16678_Phe445Cys), deleterious(m_Q99714_Asn247Ser), deleterious(m_P11532_Lys18Asn), deleterious(m_O15305_Leu104Val), deleterious(m_Q9BZ23_Glu322Asp), deleterious(m_P40337_Arg161Pro), deleterious(m_P32243_Arg89Gly), deleterious(m_Q9NZJ4_Lys4508Thr), deleterious(m_P06400_Arg500Gly), deleterious(m_Q16678_Tyr81Asn), deleterious(m_P40337_Arg161Gly), deleterious(m_Q16678_Gln144Pro), deleterious(m_Q9Y6K9_Arg319Gln), deleterious(m_O15305_Glu197Ala), deleterious(m_P40337_Arg167Gly), deleterious(m_P25054_Arg414Cys), deleterious(m_P04198_Arg394His), deleterious(m_P51648_Lys266Asn), deleterious(m_O15305_Glu151Gly), deleterious(m_P40337_Arg167Gln), deleterious(m_Q9Y6K9_Glu315Ala), deleterious(m_Q9BZ23_Arg249Pro), deleterious(m_P06400_Lys447Gln), deleterious(m_O14521_His102Leu), deleterious(m_P48637_Arg330Cys), deleterious(m_P35240_Glu106Gly), deleterious(m_P04198_Arg393Ser), deleterious(m_O15305_Arg141His), deleterious(m_Q99714_Arg130Cys)

+ Negative Examples: deleterious(m_P40763_Met143Ile), deleterious(m_O43395_Lys12Asn), deleterious(m_P51659_Met728Val)  
develop  retina001_23   conservation_class(A, global_conservation_rank_2) and secondary_struc(A, helix) and mut_accessibility(A, buried). deleterious(A)
37 (5.61%) 
3 (2.05%) 
90
Covers:
+ Positive Examples: deleterious(m_P35240_Leu141Pro), deleterious(m_O15305_Thr237Met), deleterious(m_P60484_Cys136Tyr), deleterious(m_O15305_Tyr106Cys), deleterious(m_P40337_Val166Asp), deleterious(m_Q16678_Ala330Phe), deleterious(m_P54845_Leu160Pro), deleterious(m_P40337_Gln164His), deleterious(m_Q16678_Arg444Gln), deleterious(m_P40337_Tyr175Asp), deleterious(m_P25054_Ser722Gly), deleterious(m_Q16678_Arg145Trp), deleterious(m_O75369_Met202Val), deleterious(m_P11532_Ala171Pro), deleterious(m_P60484_Tyr155Cys), deleterious(m_P40337_Gln164Arg), deleterious(m_Q9BZ23_Ile497Thr), deleterious(m_O75369_Ala173Val), deleterious(m_P60484_Gly129Glu), deleterious(m_O15305_Phe157Ser), deleterious(m_P60484_Ile135Val), deleterious(m_P56589_Gly138Glu), deleterious(m_O14773_Gly482Arg), deleterious(m_P28360_Arg196Pro), deleterious(m_P11532_Ala168Asp), deleterious(m_O15305_Cys192Gly), deleterious(m_Q9BZ23_Ala509Val), deleterious(m_P43080_Gly159Val), deleterious(m_O15305_Thr237Arg), deleterious(m_P11532_Leu54Arg), deleterious(m_P40337_Arg167Trp), deleterious(m_O14773_Gln278Pro), deleterious(m_P57082_Gly248Val), deleterious(m_P40337_Leu163Pro), deleterious(m_O15305_Ile153Thr), deleterious(m_P06400_Cys712Arg), deleterious(m_P60484_Met134Leu)

+ Negative Examples: deleterious(m_P23219_Val481Ile), deleterious(m_P40763_Phe561Tyr), deleterious(m_O94788_Ala110Val)  
develop  retina001_31   modif_hydrophobicity(A, hydrophobicity_decrease) and gain_contact(A, phob). deleterious(A)
28 (4.25%) 
3 (2.05%) 
91
Covers:
+ Positive Examples: deleterious(m_P60484_His123Arg), deleterious(m_P21912_Cys192Arg), deleterious(m_P40337_Leu178Gln), deleterious(m_P40337_His191Asp), deleterious(m_P06400_Ala635Pro), deleterious(m_Q15465_Gly143Asp), deleterious(m_P06400_Lys616Glu), deleterious(m_O14773_Cys365Arg), deleterious(m_P51648_Thr184Arg), deleterious(m_P50897_Gly108Arg), deleterious(m_P60484_His93Arg), deleterious(m_P06400_His673Pro), deleterious(m_P60484_Gly129Glu), deleterious(m_Q99593_Gly80Arg), deleterious(m_P51648_Gly406Arg), deleterious(m_O94972_Leu76Pro), deleterious(m_O15305_Gly175Arg), deleterious(m_O15305_Thr237Arg), deleterious(m_P40337_His115Arg), deleterious(m_Q9BZ23_Gly521Arg), deleterious(m_Q16678_Gly466Asp), deleterious(m_P60484_Cys124Arg), deleterious(m_P40337_Leu198Arg), deleterious(m_Q9Y4U1_Leu193Pro), deleterious(m_P40337_Leu188Gln), deleterious(m_P60484_Gly165Glu), deleterious(m_O14773_Val385Asp), deleterious(m_O14832_His175Arg)

+ Negative Examples: deleterious(m_P00352_Gly125Arg), deleterious(m_P00450_Thr841Arg), deleterious(m_O15305_Gly42Arg)  
develop  retina001_22   modif_polarity(A, polarity_decrease) and g_or_p(A, g_or_p_unchanged) and is_in_site(A, yes) and secondary_struc(A, other). deleterious(A)
24 (3.64%) 
3 (2.05%) 
96
Covers:
+ Positive Examples: deleterious(m_O00754_His72Leu), deleterious(m_Q16678_Ser515Leu), deleterious(m_O15305_His218Leu), deleterious(m_P40763_Arg382Leu), deleterious(m_Q15465_Asp88Val), deleterious(m_Q9BZ23_Thr234Ala), deleterious(m_Q9BZ23_Asn404Ile), deleterious(m_P40337_Ser65Ala), deleterious(m_P40763_Thr622Ile), deleterious(m_P40337_Ser80Ile), deleterious(m_P06400_Ser567Leu), deleterious(m_Q9BZ23_Thr528Met), deleterious(m_P40337_Ser65Leu), deleterious(m_O60333_Gln98Leu), deleterious(m_P10619_Ser90Leu), deleterious(m_O00754_His200Leu), deleterious(m_P21912_Ser100Phe), deleterious(m_P51648_Ser365Leu), deleterious(m_Q15465_Asp83Val), deleterious(m_P40337_Thr157Ile), deleterious(m_Q16678_Asp192Val), deleterious(m_P40763_Thr389Ile), deleterious(m_O15305_Asn216Ile), deleterious(m_Q16678_Ser215Ile)

+ Negative Examples: deleterious(m_P23219_Arg149Leu), deleterious(m_O00206_Thr399Ile), deleterious(m_O00206_Thr175Ala)  
develop  retina001_68   modif_hydrophobicity(A, hydrophobicity_increase) and modif_polarity(A, polarity_unchanged) and conservation_class(A, no_conservation_typification) and wt_accessibility(A, accessible) and stability(A, decrease). deleterious(A)
14 (2.12%) 
3 (2.05%) 
97
Covers:
+ Positive Examples: deleterious(m_O15305_Gln37His), deleterious(m_Q9NRR6_Arg512Trp), deleterious(m_Q9NSU2_Arg169His), deleterious(m_P43080_Pro50Leu), deleterious(m_P43080_Glu89Lys), deleterious(m_O15305_Glu139Lys), deleterious(m_Q15465_Pro26Leu), deleterious(m_O15305_Arg162Trp), deleterious(m_P51648_Arg423His), deleterious(m_P07949_Arg77Cys), deleterious(m_P40337_Arg176Trp), deleterious(m_Q9NRR6_Arg515Trp), deleterious(m_P07949_Arg114His), deleterious(m_P07949_Glu251Lys)

+ Negative Examples: deleterious(m_P23219_Arg53His), deleterious(m_Q12866_Arg466Lys), deleterious(m_O94788_Glu436Lys)  
develop  retina001_58   modif_hydrophobicity(A, hydrophobicity_unchanged) and conservation_mut(A, B) and B>=12.96 and mut_accessibility(A, buried). deleterious(A)
9 (1.37%) 
3 (2.05%) 
103
Covers:
+ Positive Examples: deleterious(m_P10619_Met406Thr), deleterious(m_P40337_Phe136Tyr), deleterious(m_Q16678_Ala388Thr), deleterious(m_P40763_Val637Leu), deleterious(m_P60484_Ile135Val), deleterious(m_Q16678_Leu345Phe), deleterious(m_O15305_Pro69Ser), deleterious(m_Q16678_Gln144Arg), deleterious(m_O75369_Leu234Val)

+ Negative Examples: deleterious(m_O00206_Phe443Leu), deleterious(m_P51659_Ile559Val), deleterious(m_O00754_Thr312Ile)  
develop  retina001_53   modif_hydrophobicity(A, hydrophobicity_increase) and conservation_class(A, sub_family_conservation). deleterious(A)
12 (1.82%) 
1 (0.68%) 
104
Covers:
+ Positive Examples: deleterious(m_Q9BZ23_Glu322Gly), deleterious(m_P60484_Asp331Gly), deleterious(m_P21912_Arg242His), deleterious(m_Q9BZ23_Arg278Cys), deleterious(m_Q9BZ23_Asn404Ile), deleterious(m_P40337_Pro86Leu), deleterious(m_P50897_Asp79Gly), deleterious(m_Q15465_Glu136Lys), deleterious(m_O14949_Ser45Phe), deleterious(m_P40337_Pro86Ala), deleterious(m_P40337_Pro86His), deleterious(m_Q9BZ23_Arg278Leu)

+ Negative Examples: deleterious(m_P27540_Glu435Lys)  
develop  retina001_46   modif_size(A, size_increase) and modif_hydrophobicity(A, hydrophobicity_unchanged) and wt_accessibility(A, intermediate) and stability(A, decrease). deleterious(A)
18 (2.73%) 
3 (2.05%) 
104
Covers:
+ Positive Examples: deleterious(m_P07949_Cys157Tyr), deleterious(m_P21912_Pro197Arg), deleterious(m_P40337_Val166Phe), deleterious(m_Q9H0F7_Thr31Met), deleterious(m_O15305_Ala233Thr), deleterious(m_O14773_Cys365Tyr), deleterious(m_P31040_Ala524Val), deleterious(m_P40763_Val637Leu), deleterious(m_Q9BZ23_Thr528Met), deleterious(m_P40337_Cys162Phe), deleterious(m_P48637_Gly464Val), deleterious(m_P40337_Ala122Ile), deleterious(m_P50897_Gly250Val), deleterious(m_P40337_Cys162Trp), deleterious(m_P40337_Cys162Tyr), deleterious(m_O15305_Asp217Glu), deleterious(m_P40763_Val637Met), deleterious(m_P21912_Pro131Arg)

+ Negative Examples: deleterious(m_O94788_Val348Ile), deleterious(m_P51160_Asp157Glu), deleterious(m_O14610_Leu11Phe)  
develop  retina001_48   modif_hydrophobicity(A, hydrophobicity_decrease) and g_or_p(A, g_or_p_unchanged) and secondary_struc(A, other) and stability(A, decrease). deleterious(A)
30 (4.55%) 
3 (2.05%) 
110
Covers:
+ Positive Examples: deleterious(m_Q15465_Trp117Arg), deleterious(m_O14773_Ile287Asn), deleterious(m_P40337_Leu178Gln), deleterious(m_P21912_Leu87Ser), deleterious(m_P40337_His191Asp), deleterious(m_P35240_Cys133Arg), deleterious(m_P40337_Leu101Arg), deleterious(m_O14773_Cys365Arg), deleterious(m_O15305_Ile132Asn), deleterious(m_P51648_Tyr279Asn), deleterious(m_P50897_His39Gln), deleterious(m_P42224_Leu706Ser), deleterious(m_P60484_His93Arg), deleterious(m_P60484_Cys124Ser), deleterious(m_P40337_Tyr156Asp), deleterious(m_P10619_Lys453Glu), deleterious(m_P40337_His115Gln), deleterious(m_Q9NRR6_Lys580Glu), deleterious(m_Q9NSU2_Val256Asp), deleterious(m_P40337_Phe136Ser), deleterious(m_P40337_Tyr156Asn), deleterious(m_P40337_His115Arg), deleterious(m_P60484_Cys124Arg), deleterious(m_P10619_Tyr249Asn), deleterious(m_Q12948_Phe112Ser), deleterious(m_O14773_Val385Asp), deleterious(m_P40337_Val170Asp), deleterious(m_P51648_Phe419Ser), deleterious(m_P39905_Thr154Ser), deleterious(m_O14832_His175Arg)

+ Negative Examples: deleterious(m_P17655_Lys568Gln), deleterious(m_Q96SF7_His156Asn), deleterious(m_P23219_Lys359Arg)  
develop  retina001_54   modif_size(A, size_decrease) and modif_charge(A, charge_unchanged) and modif_hydrophobicity(A, hydrophobicity_decrease). deleterious(A)
28 (4.25%) 
1 (0.68%) 
111
Covers:
+ Positive Examples: deleterious(m_O15305_Tyr229Ser), deleterious(m_P40337_Trp88Ser), deleterious(m_P07949_Phe174Ser), deleterious(m_P21912_Leu87Ser), deleterious(m_O14832_Phe257Ser), deleterious(m_Q16678_Tyr81Asn), deleterious(m_P60484_Phe241Ser), deleterious(m_Q16678_Ile399Ser), deleterious(m_P51648_Tyr279Asn), deleterious(m_P42224_Leu706Ser), deleterious(m_P40763_Phe384Ser), deleterious(m_P35240_Phe62Ser), deleterious(m_P07686_Tyr456Ser), deleterious(m_O15305_Phe183Ser), deleterious(m_O15305_Phe157Ser), deleterious(m_P40337_Phe76Ser), deleterious(m_P40337_Phe136Ser), deleterious(m_P40337_Tyr156Asn), deleterious(m_P40337_Phe119Ser), deleterious(m_O15305_Thr226Ser), deleterious(m_P11532_Tyr231Asn), deleterious(m_O15119_Tyr149Ser), deleterious(m_P10619_Tyr249Asn), deleterious(m_Q12948_Phe112Ser), deleterious(m_O15305_Phe206Ser), deleterious(m_P40337_Tyr112Asn), deleterious(m_P51648_Phe419Ser), deleterious(m_P39905_Thr154Ser)

+ Negative Examples: deleterious(m_P51659_Thr292Ser)  
develop  retina001_56   is_in_site(A, yes) and lost_contact(A, dc) and wt_accessibility(A, intermediate). deleterious(A)
31 (4.7%) 
3 (2.05%) 
112
Covers:
+ Positive Examples: deleterious(m_P40337_Arg82Pro), deleterious(m_Q99714_Asn247Ser), deleterious(m_P11532_Lys18Asn), deleterious(m_O15305_Leu104Val), deleterious(m_P40337_Arg200Trp), deleterious(m_P07949_Arg231His), deleterious(m_P40337_Lys159Glu), deleterious(m_Q16678_Ile399Ser), deleterious(m_P40337_Arg107Gly), deleterious(m_Q9BZ23_Arg286Cys), deleterious(m_P40337_Ile180Val), deleterious(m_O15305_Ala233Thr), deleterious(m_P40337_Arg167Gly), deleterious(m_Q9NRR6_Lys580Glu), deleterious(m_O14832_Arg245Gln), deleterious(m_P51648_Arg228Cys), deleterious(m_P07949_Arg180Pro), deleterious(m_P60484_Lys342Asn), deleterious(m_Q9NZJ4_Asn4549Asp), deleterious(m_P40337_Arg167Gln), deleterious(m_P40337_Leu184Pro), deleterious(m_P40337_Leu178Pro), deleterious(m_P40337_Arg167Trp), deleterious(m_Q15465_Trp117Gly), deleterious(m_Q9NRR6_Arg378Cys), deleterious(m_Q92793_Thr1447Ile), deleterious(m_P40337_Arg64Pro), deleterious(m_P40337_Arg107Pro), deleterious(m_P06400_Lys530Arg), deleterious(m_P06400_His549Tyr), deleterious(m_Q16678_Arg469Trp)

+ Negative Examples: deleterious(m_P51659_Arg106His), deleterious(m_P42229_Arg389His), deleterious(m_P47895_Met386Val)  
develop  retina001_63   modif_size(A, size_decrease) and is_in_site(A, yes) and stability(A, increase). deleterious(A)
13 (1.97%) 
3 (2.05%) 
113
Covers:
+ Positive Examples: deleterious(m_Q9Y2V3_Arg192Gln), deleterious(m_Q15465_Asp88Val), deleterious(m_O14773_Phe481Cys), deleterious(m_Q13562_Arg111Leu), deleterious(m_P21912_His132Pro), deleterious(m_O15305_Asn216Ser), deleterious(m_O14773_Lys428Asn), deleterious(m_P40763_Arg423Gln), deleterious(m_O14521_His102Leu), deleterious(m_P60484_Lys289Glu), deleterious(m_P35240_Glu106Gly), deleterious(m_Q15465_His140Pro), deleterious(m_O14773_Asn286Ser)

+ Negative Examples: deleterious(m_P40763_Met143Ile), deleterious(m_P23219_Lys185Thr), deleterious(m_P48637_Lys437Glu)  
develop  retina001_55   modif_size(A, size_decrease) and conservation_mut(A, B) and B>=4.55 and mut_accessibility(A, intermediate). deleterious(A)
11 (1.67%) 
3 (2.05%) 
114
Covers:
+ Positive Examples: deleterious(m_Q16678_Glu499Gly), deleterious(m_Q99714_Asn247Ser), deleterious(m_O15305_Pro20Ser), deleterious(m_O15305_Glu197Ala), deleterious(m_P51648_Lys266Asn), deleterious(m_Q9BZ23_Asn355Ser), deleterious(m_Q99714_Leu122Val), deleterious(m_P40337_Ile147Thr), deleterious(m_P06400_Lys447Gln), deleterious(m_O14773_Asn286Ser), deleterious(m_P39905_Thr154Ser)

+ Negative Examples: deleterious(m_P09622_Leu331Val), deleterious(m_P47895_Met386Val), deleterious(m_Q15555_Tyr162Cys)  
develop  retina001_64   modif_charge(A, charge_increase) and modif_hydrophobicity(A, hydrophobicity_unchanged) and is_in_site(A, yes). deleterious(A)
23 (3.49%) 
2 (1.37%) 
121
Covers:
+ Positive Examples: deleterious(m_P21912_Leu65His), deleterious(m_P40337_Tyr112His), deleterious(m_P40337_Tyr98His), deleterious(m_P21912_Pro197Arg), deleterious(m_Q15465_Thr150Lys), deleterious(m_P50897_Gln177Glu), deleterious(m_P60484_Ser170Arg), deleterious(m_Q15465_Ser156Arg), deleterious(m_P60484_Tyr68His), deleterious(m_Q9GZT9_Pro317Arg), deleterious(m_Q16678_Ser239Arg), deleterious(m_P07686_Ser255Arg), deleterious(m_P50897_Tyr247His), deleterious(m_P35555_Pro2154Arg), deleterious(m_Q9NZJ4_Asn4549Asp), deleterious(m_P40337_Ser80Arg), deleterious(m_Q9BZ23_Asn511Asp), deleterious(m_Q92793_Tyr1450His), deleterious(m_Q9Y4U1_Tyr130His), deleterious(m_P40337_Pro86Arg), deleterious(m_P48637_Tyr270His), deleterious(m_P21912_Pro131Arg), deleterious(m_P40337_Ser111Arg)

+ Negative Examples: deleterious(m_Q12866_Gln662Glu), deleterious(m_P36955_Pro132Arg)  
develop  retina001_59   modif_hydrophobicity(A, hydrophobicity_increase) and g_or_p(A, g_or_p_unchanged) and is_in_site(A, yes) and wt_accessibility(A, intermediate) and stability(A, decrease). deleterious(A)
27 (4.1%) 
3 (2.05%) 
121
Covers:
+ Positive Examples: deleterious(m_O14832_Asn83Tyr), deleterious(m_P40337_Asn131Lys), deleterious(m_P31040_Arg554Trp), deleterious(m_P40337_Arg200Trp), deleterious(m_P40763_Arg382Leu), deleterious(m_P40337_Glu186Lys), deleterious(m_P07949_Arg231His), deleterious(m_Q9BZ23_Arg286Cys), deleterious(m_P21912_Arg242His), deleterious(m_O15305_Gln177His), deleterious(m_Q9GZT9_Arg371His), deleterious(m_Q9BZ23_Arg532Trp), deleterious(m_P51648_Arg228Cys), deleterious(m_P40337_Asn131Thr), deleterious(m_O14949_Ser45Phe), deleterious(m_P40337_Glu70Lys), deleterious(m_P60484_Asp107Tyr), deleterious(m_P35240_Asn220Tyr), deleterious(m_O15305_Arg141Cys), deleterious(m_O15305_Asn101Lys), deleterious(m_P40337_Arg167Trp), deleterious(m_Q9NRR6_Arg378Cys), deleterious(m_P21912_Ser100Phe), deleterious(m_P48637_Arg330Cys), deleterious(m_Q15465_Asp83Val), deleterious(m_P40763_Arg382Trp), deleterious(m_O15305_Arg141His)

+ Negative Examples: deleterious(m_O00206_Gln510His), deleterious(m_P06400_Asn133His), deleterious(m_O00206_Glu474Lys)  
develop  retina001_47   modif_size(A, size_increase) and modif_polarity(A, polarity_unchanged) and secondary_struc(A, helix) and wt_accessibility(A, intermediate). deleterious(A)
17 (2.58%) 
3 (2.05%) 
123
Covers:
+ Positive Examples: deleterious(m_Q9Y4U1_His122Arg), deleterious(m_O14832_Asn83Tyr), deleterious(m_P07949_Cys157Tyr), deleterious(m_P40337_Val166Phe), deleterious(m_Q9Y6K9_Ala323Pro), deleterious(m_P40337_Glu186Lys), deleterious(m_P56693_Ser135Thr), deleterious(m_Q16678_Glu229Lys), deleterious(m_Q16678_Val320Leu), deleterious(m_Q9H0F7_Thr31Arg), deleterious(m_O75369_Glu227Lys), deleterious(m_P60484_Asp107Tyr), deleterious(m_P40337_Cys162Arg), deleterious(m_P40337_Cys162Trp), deleterious(m_O15305_Asn101Lys), deleterious(m_P40337_Cys162Tyr), deleterious(m_P06400_Lys530Arg)

+ Negative Examples: deleterious(m_O14773_Gln100Arg), deleterious(m_P06400_Asn133His), deleterious(m_O14610_Leu11Phe)  
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help How to interpret the rules



Statistic

  Descriptor Description and comments Frequence in
set of rules
 secondary_struc  In a secondary structure element? (helix, sheet, no)
28 (13.27%) 
 stability  The change in protein relative stability upon mutation.
26 (12.32%) 
 modif_hydrophobicity  Hydrophobicity modification. Value: hydrophobicity_increase (+) / hydrophobicity_decrease (-) / hydrophobicity_unchanged (=)
21 (9.95%) 
 g_or_p  Glycine or Proline loss or apparition. Value: g_or_p_apparition (+) / g_or_p_disparition (-) / g_or_p_unchanged(=)
21 (9.95%) 
 modif_size  Size modification. Value: size_increase (+) / size_decrease (-) / size_unchanged (=)
19 (9.00%) 
 mut_accessibility  Accessibility of the mutant residue.
14 (6.64%) 
 modif_polarity  Polarity modification. Value: polarity_increase (+) / polarity_decrease (-) / polarity_unchanged (=)
14 (6.64%) 
 wt_accessibility  Accessibility of the wild type residue.
13 (6.16%) 
 modif_charge  Charge modification. Value: charge_increase (+) / charge_decrease (-) / charge_unchanged (=) / charge_opposite (!=)
13 (6.16%) 
10 
 is_in_site  In an annoted site?
12 (5.69%) 
11 
 gain_contact  Contacts between:
- the wild type residue and its direct 3D neighbors, based on the wild type 3D model
- the mutant residue and its direct 3D neighbors, based on the mutant 3D model
are computed and compared.
10 (4.74%) 
12 
 conservation_class  Conservation in the alignment
10 (4.74%) 
13 
 lost_contact  Contacts between:
- the wild type residue and its direct 3D neighbors, based on the wild type 3D model
- the mutant residue and its direct 3D neighbors, based on the mutant 3D model
are computed and compared.
5 (2.37%) 
14 
 freq_at_pos  Number of known mutations at this position.
2 (0.95%) 
15 
 conservation_mut  Conservation in the mutant residue representation in alignment.
2 (0.95%) 
16 
 fold  Identification of related proteins at the fold level using SCOP classification
1 (0.47%)