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There are total 111 rules.

help How to interpret the rules

Id     
    
If Statement Then
Coverage
Positive     
    
Negative     
    
Rank     
    
        Enter a key word:  
develop  humvar398_8   conservation_class(A, global_conservation_rank_1) and freq_at_pos(A, B) and B>=2. deleterious(A)
475 (7.92%) 
2 (0.1%) 
1
Covers:
+ Positive Examples: deleterious(m_Q01968_Arg500Gly), deleterious(m_P19438_Cys62Tyr), deleterious(m_P12271_Arg234Trp), deleterious(m_Q9UGJ0_Arg531Gly), deleterious(m_P04049_Asp486Asn), deleterious(m_P13569_Arg560Thr), deleterious(m_P08397_Arg173Trp), deleterious(m_P00480_Pro220Ala), deleterious(m_Q06187_Met509Val), deleterious(m_P00740_Gln241His), deleterious(m_Q05066_Met64Ile), deleterious(m_O43186_Glu80Ala), deleterious(m_Q16678_Arg368His), deleterious(m_Q01968_Arg500Gln), deleterious(m_P43246_His639Arg), deleterious(m_P01185_Cys116Arg), deleterious(m_P08100_Pro171Ser), deleterious(m_P10275_Glu772Ala), deleterious(m_Q06124_Gln510Arg), deleterious(m_P60484_Arg173Cys), deleterious(m_Q13950_Arg190Trp), deleterious(m_Q13950_Gln209Arg), deleterious(m_P13569_Gly551Asp), deleterious(m_Q06187_Lys430Arg), deleterious(m_P51843_Arg425Thr), deleterious(m_P08100_Pro171Gln), deleterious(m_P43246_Pro622Leu), deleterious(m_P01185_Cys92Ser), deleterious(m_P23760_Ile59Asn), deleterious(m_P06280_Cys142Tyr), deleterious(m_P11511_Arg375Cys), deleterious(m_Q9UM73_Phe1174Cys), deleterious(m_P06280_Trp236Leu), deleterious(m_P48436_Met113Val), deleterious(m_Q03426_His20Pro), deleterious(m_Q06187_Met509Ile), deleterious(m_P07902_Tyr209Ser), deleterious(m_P00492_Asp177Tyr), deleterious(m_Q03426_Gly211Glu), deleterious(m_Q15465_Trp117Gly), deleterious(m_O75695_Arg118Leu), deleterious(m_P35680_Arg295Pro), deleterious(m_Q9UGJ0_Arg531Gln), deleterious(m_P51857_Arg261Cys), deleterious(m_O95409_His286Gln), deleterious(m_P10828_Gly345Arg), deleterious(m_P00480_Asp196Tyr), deleterious(m_Q06187_Leu512Pro), deleterious(m_P00480_His302Gln), deleterious(m_P30566_Arg396Cys), deleterious(m_Q06187_Arg641His), deleterious(m_P00480_Asp263Gly), deleterious(m_P23760_Asn47Lys), deleterious(m_P31785_Cys115Arg), deleterious(m_Q9Y4U1_Arg206Trp), deleterious(m_P98172_Gly151Val), deleterious(m_P40692_Ile68Asn), deleterious(m_Q06124_Asn308Ser), deleterious(m_Q06187_Asp521His), deleterious(m_P39019_Arg62Trp), deleterious(m_P08397_Gln217His), deleterious(m_P13569_Arg560Lys), deleterious(m_P00740_Cys252Ser), deleterious(m_O15305_Asn216Ile), deleterious(m_O43602_Arg140His), deleterious(m_P06280_Asp264Val), deleterious(m_P35680_Ser148Trp), deleterious(m_Q92838_His252Tyr), deleterious(m_Q7LG56_Glu194Gly), deleterious(m_P00492_Asp194Asn), deleterious(m_P51843_Ala300Pro), deleterious(m_P29400_Cys1564Ser), deleterious(m_P05186_Asp378Val), deleterious(m_P98172_Cys153Tyr), deleterious(m_P00480_Cys303Tyr), deleterious(m_Q15465_His140Pro), deleterious(m_P48436_Pro170Leu), deleterious(m_P01008_Asn219Asp), deleterious(m_P00480_Arg141Pro), deleterious(m_Q13501_Met404Val), deleterious(m_P20823_Arg203Cys), deleterious(m_P98172_Gly151Ser), deleterious(m_P25445_Arg250Pro), deleterious(m_Q13496_Gly402Ala), deleterious(m_P98172_Pro119Ser), deleterious(m_Q06124_Arg502Trp), deleterious(m_P00441_His49Arg), deleterious(m_P06280_Trp162Cys), deleterious(m_P39019_Arg62Gln), deleterious(m_Q06187_Met630Lys), deleterious(m_O43602_Arg159Leu), deleterious(m_P35520_Arg121Leu), deleterious(m_Q13950_Met175Arg), deleterious(m_Q06187_Glu589Gly), deleterious(m_P00451_Trp2248Cys), deleterious(m_Q14203_Gly71Ala), deleterious(m_P38117_Arg164Gln), deleterious(m_P35520_Ala155Val), deleterious(m_P45381_Asp114Tyr), deleterious(m_P00441_His49Gln), deleterious(m_Q01968_His524Arg), deleterious(m_Q06187_Met630Thr), deleterious(m_P43246_Asp603Asn), deleterious(m_P08100_Pro267Leu), deleterious(m_Q06187_Glu589Asp), deleterious(m_Q15465_His140Gln), deleterious(m_P10275_Met807Arg), deleterious(m_P06280_Asp264Tyr), deleterious(m_O15305_Arg141His), deleterious(m_Q06187_Pro619Ala), deleterious(m_P00441_Ile113Met), deleterious(m_P00441_Asp125Val), deleterious(m_P00492_His204Asp), deleterious(m_P06280_Asp92Tyr), deleterious(m_P41181_Gly180Ser), deleterious(m_Q06187_Pro619Ser), deleterious(m_P08100_Arg135Gly), deleterious(m_P49748_Arg469Gln), deleterious(m_P01185_Cys59Arg), deleterious(m_P08709_Cys254Tyr), deleterious(m_Q16678_Arg390Ser), deleterious(m_P00480_Asp196Val), deleterious(m_P19438_Cys62Gly), deleterious(m_P07902_Arg231His), deleterious(m_P11532_Tyr231Asn), deleterious(m_P02489_Arg116Cys), deleterious(m_P10275_Arg855His), deleterious(m_P15056_Gly596Val), deleterious(m_P06280_Cys142Arg), deleterious(m_Q13950_Ser118Arg), deleterious(m_P22033_Gly215Ser), deleterious(m_P04198_Arg393His), deleterious(m_O75792_Gly37Ser), deleterious(m_P02545_Arg377Leu), deleterious(m_P13569_Gly551Ser), deleterious(m_P10828_Gly345Val), deleterious(m_O43918_Pro326Gln), deleterious(m_P25445_Glu272Gly), deleterious(m_P00740_Cys407Arg), deleterious(m_P01185_Cys116Gly), deleterious(m_O15553_Phe743Leu), deleterious(m_P35680_Ser148Leu), deleterious(m_Q13496_Gly378Arg), deleterious(m_P13569_Ser549Ile), deleterious(m_Q06187_Arg544Gly), deleterious(m_P00451_Asn1941Asp), deleterious(m_P98172_Pro119His), deleterious(m_P04839_Trp516Cys), deleterious(m_P01241_Cys79Ser), deleterious(m_P35520_Arg121His), deleterious(m_P01008_Met283Val), deleterious(m_P23760_Ile59Phe), deleterious(m_P15056_Asn581Asp), deleterious(m_Q92947_Gly390Arg), deleterious(m_P16930_Asp233Val), deleterious(m_P06280_Asp266Asn), deleterious(m_P01008_Met283Ile), deleterious(m_P45381_Asp114Glu), deleterious(m_Q01968_Glu468Gly), deleterious(m_P98172_Cys153Ser), deleterious(m_Q12840_Arg280His), deleterious(m_Q13950_Arg169Pro), deleterious(m_Q05066_Tyr127Cys), deleterious(m_P25189_Arg98Pro), deleterious(m_Q06187_Glu589Lys), deleterious(m_P00451_Trp2248Ser), deleterious(m_Q15465_Trp117Arg), deleterious(m_Q06187_Arg544Lys), deleterious(m_P10275_Met807Thr), deleterious(m_P11161_Arg381Cys), deleterious(m_P00451_Trp412Arg), deleterious(m_P25189_Arg98Cys), deleterious(m_Q06124_Tyr279Cys), deleterious(m_P10828_Arg320Cys), deleterious(m_P00480_His302Leu), deleterious(m_P39019_Trp52Cys), deleterious(m_P01185_Cys105Arg), deleterious(m_Q8WVQ1_Arg300His), deleterious(m_Q15833_Arg405Trp), deleterious(m_O75695_Arg118His), deleterious(m_P40692_Pro648Ser), deleterious(m_Q14203_Gly71Glu), deleterious(m_P04839_Trp516Arg), deleterious(m_Q01968_Asp451Asn), deleterious(m_P49748_Lys247Thr), deleterious(m_Q13950_Arg131Ser), deleterious(m_P51843_Arg425Gly), deleterious(m_P10275_Glu772Gly), deleterious(m_Q06187_Phe644Leu), deleterious(m_P02545_Asn456Asp), deleterious(m_P48436_Phe112Ser), deleterious(m_P32322_Arg119His), deleterious(m_P19438_Cys117Tyr), deleterious(m_Q13950_Lys218Gln), deleterious(m_P04198_Arg393Ser), deleterious(m_P04839_Gly389Ala), deleterious(m_P10275_Arg855Cys), deleterious(m_P10275_Met742Val), deleterious(m_P00441_Asp102Gly), deleterious(m_P02545_Arg377His), deleterious(m_P05186_Gly162Ser), deleterious(m_O15305_Arg141Cys), deleterious(m_P00492_His204Arg), deleterious(m_Q7LG56_Glu194Lys), deleterious(m_P19438_Cys59Ser), deleterious(m_P06280_Cys172Tyr), deleterious(m_P35557_Glu300Gln), deleterious(m_O95409_Arg325Ser), deleterious(m_Q13501_Met404Thr), deleterious(m_P00451_Asn1941Ser), deleterious(m_Q03692_Tyr597His), deleterious(m_P53634_His405Asn), deleterious(m_P08100_Tyr178Asn), deleterious(m_O75695_Arg118Cys), deleterious(m_P13569_Ser549Arg), deleterious(m_P35520_Ala155Thr), deleterious(m_P00480_His168Arg), deleterious(m_Q92947_Gly390Ala), deleterious(m_P30566_Arg396His), deleterious(m_Q06187_Gly594Glu), deleterious(m_P51649_Pro382Gln), deleterious(m_P00480_Gly162Arg), deleterious(m_Q13950_Thr200Ala), deleterious(m_P08397_Gln217Leu), deleterious(m_P25445_Arg250Gln), deleterious(m_P00740_Cys407Ser), deleterious(m_P05186_Tyr297Asp), deleterious(m_Q06187_Lys430Glu), deleterious(m_P00740_Trp431Arg), deleterious(m_P19438_Cys99Ser), deleterious(m_P40692_Asp63Glu), deleterious(m_Q15465_Cys102Arg), deleterious(m_Q05066_Gly95Glu), deleterious(m_P02545_Asn456Ile), deleterious(m_Q13950_Arg190Gln), deleterious(m_P51648_Thr184Arg), deleterious(m_P35914_Asp42Gly), deleterious(m_P08100_Cys110Phe), deleterious(m_P01185_Cys98Ser), deleterious(m_P48436_Met113Thr), deleterious(m_P06280_Trp287Gly), deleterious(m_P35914_Asp42His), deleterious(m_Q13950_Val156Asp), deleterious(m_O95409_Arg325Leu), deleterious(m_P13569_Ser549Asn), deleterious(m_P00441_Asp102Asn), deleterious(m_Q9Y4U1_Arg161Gln), deleterious(m_P35520_Asn228Lys), deleterious(m_Q15833_Arg405Gln), deleterious(m_P49748_Arg366Cys), deleterious(m_P49748_Lys247Glu), deleterious(m_P39019_Leu131Pro), deleterious(m_O43602_Tyr206His), deleterious(m_P00451_Cys2345Ser), deleterious(m_P10275_Pro904His), deleterious(m_P25189_Arg98His), deleterious(m_O15305_Asn216Ser), deleterious(m_P01185_Cys92Tyr), deleterious(m_P00480_Arg141Gln), deleterious(m_P00480_Asn198Lys), deleterious(m_Q13496_Gly402Arg), deleterious(m_P48436_Pro170Arg), deleterious(m_P01185_Cys104Phe), deleterious(m_P10275_Ala765Thr), deleterious(m_P78330_Asp32Asn), deleterious(m_P40692_Gly67Trp), deleterious(m_Q13950_Gln209His), deleterious(m_Q16678_Phe445Cys), deleterious(m_P48637_Tyr270His), deleterious(m_Q01968_His524Gln), deleterious(m_P08100_Pro171Leu), deleterious(m_P22033_Gly215Cys), deleterious(m_O95409_His286Tyr), deleterious(m_P08397_Arg167Gln), deleterious(m_Q06187_Arg641Cys), deleterious(m_P29965_Gly257Asp), deleterious(m_P11161_Arg381His), deleterious(m_Q13950_Lys218Asn), deleterious(m_P15056_Glu501Gly), deleterious(m_O14832_Arg275Gln), deleterious(m_P05155_Pro498Arg), deleterious(m_P98172_Met158Ile), deleterious(m_Q13950_Thr200Ile), deleterious(m_P00451_Cys2345Tyr), deleterious(m_P98172_Pro119Thr), deleterious(m_P10275_Ala765Val), deleterious(m_P08100_Pro267Arg), deleterious(m_Q76LX8_Arg398His), deleterious(m_P10275_Asp864Asn), deleterious(m_P04181_Arg154Leu), deleterious(m_P06280_Phe113Ser), deleterious(m_Q13950_Met175Val), deleterious(m_Q9Y4U1_Arg161Gly), deleterious(m_Q13496_Arg241Leu), deleterious(m_P04839_Gly389Glu), deleterious(m_P52701_Arg772Trp), deleterious(m_P08397_Arg26Cys), deleterious(m_O43602_Arg140Leu), deleterious(m_P00480_Asp263Asn), deleterious(m_P41181_Arg187Cys), deleterious(m_P40337_Ser65Ala), deleterious(m_P39019_Trp52Arg), deleterious(m_P05186_Arg71Cys), deleterious(m_O43186_Arg41Gln), deleterious(m_Q03692_Gly595Arg), deleterious(m_P10828_Arg320His), deleterious(m_P01008_Ala416Ser), deleterious(m_P08397_Arg116Gln), deleterious(m_P29965_Trp140Gly), deleterious(m_P05106_Cys586Arg), deleterious(m_P10275_Pro904Ser), deleterious(m_Q16595_Leu182Phe), deleterious(m_P08397_Gln34Pro), deleterious(m_Q13950_Ser118Asn), deleterious(m_P00451_Trp412Gly), deleterious(m_Q01968_Asp451Gly), deleterious(m_P08100_Cys110Tyr), deleterious(m_P06280_Asp92His), deleterious(m_P02489_Arg116His), deleterious(m_P40692_Thr117Arg), deleterious(m_P48637_Asp219Gly), deleterious(m_P19438_Cys81Phe), deleterious(m_P06280_Trp236Cys), deleterious(m_Q06187_Phe644Ser), deleterious(m_P10275_Asp732Tyr), deleterious(m_P05186_Arg71Pro), deleterious(m_Q03426_His20Asn), deleterious(m_Q15582_His626Arg), deleterious(m_P13569_Tyr569Asp), deleterious(m_P05186_Gly162Val), deleterious(m_Q06124_Gln510Pro), deleterious(m_P29965_Trp140Arg), deleterious(m_P08100_Tyr178Cys), deleterious(m_Q92838_His252Leu), deleterious(m_P06280_Phe113Leu), deleterious(m_P00740_Cys396Ser), deleterious(m_Q05066_Gly95Arg), deleterious(m_P36551_Pro249Arg), deleterious(m_Q13496_Gly402Val), deleterious(m_Q06187_Pro619Thr), deleterious(m_P01009_Ser77Phe), deleterious(m_P69892_His64Leu), deleterious(m_O43602_Arg159His), deleterious(m_O43918_Pro326Leu), deleterious(m_P08559_Arg302His), deleterious(m_P01185_Cys105Tyr), deleterious(m_P11802_Arg24His), deleterious(m_Q13950_Arg131Gly), deleterious(m_P07902_Tyr209Cys), deleterious(m_P00480_Trp265Leu), deleterious(m_Q14376_Gly302Asp), deleterious(m_P69892_Trp16Arg), deleterious(m_P35557_Gly80Ala), deleterious(m_P25189_Gly123Cys), deleterious(m_P40692_Asn38His), deleterious(m_P48436_Phe112Leu), deleterious(m_P00480_Gly197Arg), deleterious(m_P08397_Arg149Leu), deleterious(m_P05166_Arg165Gln), deleterious(m_P05107_Asp128Asn), deleterious(m_P01185_Cys59Tyr), deleterious(m_Q8WVQ1_Arg300Cys), deleterious(m_P10828_Gly345Ser), deleterious(m_Q03692_Tyr597Cys), deleterious(m_P35557_Glu300Lys), deleterious(m_Q06187_Leu512Gln), deleterious(m_P40692_Gly67Arg), deleterious(m_P00740_Gln241Lys), deleterious(m_O43602_Tyr206Asp), deleterious(m_Q12840_Arg280Cys), deleterious(m_P00441_Ile113Thr), deleterious(m_P49748_Arg366His), deleterious(m_Q00266_Arg264His), deleterious(m_P08397_Arg116Trp), deleterious(m_P08397_Arg26His), deleterious(m_P48436_His165Tyr), deleterious(m_P98172_Met158Val), deleterious(m_P15056_Gly466Val), deleterious(m_P00492_Asp177Val), deleterious(m_Q9H0F7_Thr31Arg), deleterious(m_P08397_Gln34Lys), deleterious(m_Q05066_Met64Arg), deleterious(m_Q13496_Gly378Glu), deleterious(m_P13569_Tyr569Cys), deleterious(m_P43246_His639Tyr), deleterious(m_P07954_Arg233His), deleterious(m_P48637_Tyr270Cys), deleterious(m_P00740_Cys382Tyr), deleterious(m_Q06124_Arg502Leu), deleterious(m_Q04656_Gly876Glu), deleterious(m_P35520_Arg121Cys), deleterious(m_P48637_Asp219Ala), deleterious(m_P00480_His302Tyr), deleterious(m_P00480_Cys303Arg), deleterious(m_Q92838_Trp274Arg), deleterious(m_P06280_Asp266Val), deleterious(m_P51843_Ala300Val), deleterious(m_P19438_Cys59Arg), deleterious(m_P01008_Pro439Leu), deleterious(m_P15056_Glu501Lys), deleterious(m_P40692_Glu102Lys), deleterious(m_Q06187_Asp521Gly), deleterious(m_Q16678_Arg390Cys), deleterious(m_Q00266_Arg264Cys), deleterious(m_P01008_Pro439Thr), deleterious(m_Q13496_Arg241Cys), deleterious(m_P41181_Arg187His), deleterious(m_P01008_Ala416Pro), deleterious(m_P35680_Arg295Cys), deleterious(m_P39019_Leu131Arg), deleterious(m_P08397_Arg173Gln), deleterious(m_Q92947_Arg257Gln), deleterious(m_Q13950_Lys218Glu), deleterious(m_P10275_Arg831Leu), deleterious(m_O43186_Arg41Trp), deleterious(m_P32322_Arg119Gly), deleterious(m_Q13950_Arg131Cys), deleterious(m_P40692_Pro648Leu), deleterious(m_P60484_Cys105Phe), deleterious(m_P35914_Asp42Glu), deleterious(m_P00740_Trp431Gly), deleterious(m_P29965_Gly257Ser), deleterious(m_P13569_Tyr569His), deleterious(m_P05155_Pro498Ser), deleterious(m_P19438_Cys117Arg), deleterious(m_P05186_Arg71His), deleterious(m_Q12840_Arg280Leu), deleterious(m_P13569_Val520Phe), deleterious(m_P06280_Asp266His), deleterious(m_P00492_Asp194Glu), deleterious(m_P20823_Arg203His), deleterious(m_P02545_Asn456Lys), deleterious(m_P04049_Asp486Gly), deleterious(m_Q06187_Arg562Trp), deleterious(m_P60484_Cys105Tyr), deleterious(m_P01008_Asn219Lys), deleterious(m_P51649_Pro382Leu), deleterious(m_Q15582_His626Pro), deleterious(m_Q06187_Gly594Arg), deleterious(m_P23760_Asn47His), deleterious(m_P49675_Arg182Leu), deleterious(m_O14832_Arg275Trp), deleterious(m_Q16595_Arg165Cys), deleterious(m_P00740_Met394Lys), deleterious(m_P00441_His81Ala), deleterious(m_P35680_Arg295His), deleterious(m_Q92838_Trp274Gly), deleterious(m_Q06187_Arg562Pro), deleterious(m_P05186_Ala116Thr), deleterious(m_P08397_Gln34Arg), deleterious(m_P35520_Asn228Ser), deleterious(m_Q06187_Asp521Asn), deleterious(m_P40692_Thr117Met), deleterious(m_P00740_Cys252Tyr), deleterious(m_P53634_His405Arg), deleterious(m_P51648_Thr184Met), deleterious(m_Q16518_Gly528Val), deleterious(m_Q03692_Gly595Glu), deleterious(m_P69892_His64Tyr), deleterious(m_Q01968_Glu468Lys), deleterious(m_Q13950_Arg193Gln), deleterious(m_P05106_Cys586Phe), deleterious(m_O14836_Cys104Arg), deleterious(m_P01008_Tyr198His), deleterious(m_O95409_His286Leu), deleterious(m_P04839_Pro415Leu), deleterious(m_P08100_Arg135Trp), deleterious(m_P01185_Cys98Gly), deleterious(m_P35670_Leu795Arg), deleterious(m_Q13950_Met175Lys), deleterious(m_P35557_Gly80Ser), deleterious(m_P22033_Arg369His), deleterious(m_P00740_Cys396Phe), deleterious(m_P43246_Gly692Arg), deleterious(m_Q03426_His20Gln)

+ Negative Examples: deleterious(m_P16442_Phe216Ile), deleterious(m_P34913_Arg287Gln)  
develop  humvar398_42   freq_at_pos(A, B) and B>=2 and secondary_struc(A, other) and wt_accessibility(A, buried). deleterious(A)
397 (6.62%) 
2 (0.1%) 
2
Covers:
+ Positive Examples: deleterious(m_P19438_Cys62Tyr), deleterious(m_P00451_Gly1779Arg), deleterious(m_Q04771_Gly328Trp), deleterious(m_P00740_Ser411Gly), deleterious(m_P43246_Cys697Arg), deleterious(m_P00480_Pro220Ala), deleterious(m_P01112_Ala146Val), deleterious(m_P07902_Met142Val), deleterious(m_P54803_Pro318Arg), deleterious(m_P08100_Asp190Tyr), deleterious(m_P00451_Gly2045Glu), deleterious(m_P43246_His639Arg), deleterious(m_P08514_Pro176Ala), deleterious(m_P01185_Cys116Arg), deleterious(m_P00966_Gly324Ser), deleterious(m_Q06124_Gln510Arg), deleterious(m_P06396_Asp214Asn), deleterious(m_P00451_Cys329Phe), deleterious(m_P30613_Arg163Leu), deleterious(m_P46100_Gly249Asp), deleterious(m_P07902_Arg333Gln), deleterious(m_P30613_Ala468Val), deleterious(m_P00451_Gly164Val), deleterious(m_P08100_Pro23His), deleterious(m_P43246_Pro622Leu), deleterious(m_Q04771_Gly328Glu), deleterious(m_P40692_Ser44Phe), deleterious(m_P40692_Asp485Glu), deleterious(m_Q9UM73_Phe1174Cys), deleterious(m_P00451_Leu117Phe), deleterious(m_P06280_Cys94Tyr), deleterious(m_P00740_Val228Leu), deleterious(m_Q03426_Gly211Glu), deleterious(m_P00480_Thr264Ile), deleterious(m_P35680_Arg276Gly), deleterious(m_P30613_Gly263Trp), deleterious(m_O15118_Cys177Gly), deleterious(m_Q13496_Arg69Ser), deleterious(m_O15118_Cys177Tyr), deleterious(m_P01185_Gly88Arg), deleterious(m_P10828_Gly345Arg), deleterious(m_P00480_Asp196Tyr), deleterious(m_P00441_Gly94Val), deleterious(m_Q06187_Arg641His), deleterious(m_P00480_Asp263Gly), deleterious(m_P00451_Ser554Gly), deleterious(m_O15305_Tyr64Cys), deleterious(m_P00451_Ala1939Thr), deleterious(m_P00439_Val245Glu), deleterious(m_P00439_Tyr343Cys), deleterious(m_P08100_Pro23Leu), deleterious(m_P51608_Leu100Arg), deleterious(m_Q06187_Asp521His), deleterious(m_P08397_Gln217His), deleterious(m_P04049_Thr491Ile), deleterious(m_P05186_Gly63Val), deleterious(m_P00451_Tyr605Ser), deleterious(m_P43246_Ser323Tyr), deleterious(m_P00451_His1980Pro), deleterious(m_P06280_Asn298His), deleterious(m_P05155_Val473Met), deleterious(m_P00451_Ala303Pro), deleterious(m_P00451_Gly2045Val), deleterious(m_P00441_Val15Gly), deleterious(m_P06280_Gly328Ala), deleterious(m_P00439_Val245Leu), deleterious(m_P05186_Asp378Val), deleterious(m_P98172_Cys153Tyr), deleterious(m_P00966_Gly117Ser), deleterious(m_P00480_Cys303Tyr), deleterious(m_P00439_Arg270Ser), deleterious(m_Q9Y4U1_Gly147Asp), deleterious(m_P05186_Met62Val), deleterious(m_P07902_Tyr251Ser), deleterious(m_P01116_Gly60Arg), deleterious(m_P11413_Gly410Cys), deleterious(m_P49747_Asp361Val), deleterious(m_P06280_Gly328Arg), deleterious(m_P11413_Arg198Cys), deleterious(m_Q14203_Gly71Ala), deleterious(m_Q01968_His524Arg), deleterious(m_P06280_Asn224Asp), deleterious(m_P00451_Gly164Asp), deleterious(m_P05186_Gly63Arg), deleterious(m_O15118_Asp242Asn), deleterious(m_P00451_Arg550His), deleterious(m_P11362_Pro722His), deleterious(m_Q06187_Pro619Ala), deleterious(m_P00441_Ile113Met), deleterious(m_P00451_Gly474Arg), deleterious(m_P00441_Asp125Val), deleterious(m_P00492_His204Asp), deleterious(m_P05186_Asp294Tyr), deleterious(m_P00441_Leu39Arg), deleterious(m_P06280_Asp92Tyr), deleterious(m_P00439_Ile224Met), deleterious(m_Q06187_Pro619Ser), deleterious(m_P06280_Pro409Ala), deleterious(m_P04156_Phe198Ser), deleterious(m_P00740_Val227Asp), deleterious(m_P00451_Leu26Pro), deleterious(m_P00451_Gly1869Val), deleterious(m_P05106_Arg119Trp), deleterious(m_P00480_Asp196Val), deleterious(m_P19438_Cys62Gly), deleterious(m_P07902_Arg231His), deleterious(m_P00451_Arg2228Gln), deleterious(m_P00439_Asp282Asn), deleterious(m_P00740_Gly442Glu), deleterious(m_P15056_Gly596Val), deleterious(m_Q13950_Ser118Arg), deleterious(m_P22033_Gly215Ser), deleterious(m_P00451_Asn631Lys), deleterious(m_P00451_Asn637Ser), deleterious(m_P00451_Glu1904Asp), deleterious(m_P00451_Leu117Arg), deleterious(m_O75792_Gly37Ser), deleterious(m_P00740_Ile390Phe), deleterious(m_P10828_Gly345Val), deleterious(m_P00451_Ser202Arg), deleterious(m_P00451_Tyr492His), deleterious(m_P00740_Cys407Arg), deleterious(m_P40692_Ile25Phe), deleterious(m_P01185_Cys116Gly), deleterious(m_Q13496_Gly378Arg), deleterious(m_P01112_Ala146Thr), deleterious(m_P00451_Gly439Asp), deleterious(m_P22033_Gly94Arg), deleterious(m_P00451_Ser1907Arg), deleterious(m_P25189_Ile62Phe), deleterious(m_P00441_Gly94Cys), deleterious(m_P00451_Asn1941Asp), deleterious(m_P29033_Trp44Ser), deleterious(m_P00480_Pro225Arg), deleterious(m_P00480_Met213Lys), deleterious(m_P01241_Cys79Ser), deleterious(m_P06280_Pro409Thr), deleterious(m_P00451_Leu2185Ser), deleterious(m_P07902_Gln317His), deleterious(m_P15056_Asn581Asp), deleterious(m_P35670_Gly875Val), deleterious(m_P43246_Ser323Cys), deleterious(m_P16930_Asp233Val), deleterious(m_P06280_Asp266Asn), deleterious(m_P00439_Phe331Leu), deleterious(m_P00439_Arg408Gln), deleterious(m_Q01968_Glu468Gly), deleterious(m_P00451_Ser603Arg), deleterious(m_P35557_Gly261Arg), deleterious(m_P98172_Cys153Ser), deleterious(m_Q92838_Thr378Pro), deleterious(m_P53634_Gly300Ser), deleterious(m_P25189_Arg98Pro), deleterious(m_O75197_Ala214Val), deleterious(m_P25189_Arg98Cys), deleterious(m_Q06124_Tyr279Cys), deleterious(m_P10828_Arg320Cys), deleterious(m_P39019_Trp52Cys), deleterious(m_Q8WVQ1_Arg300His), deleterious(m_P00451_Ala111Thr), deleterious(m_P40692_Pro648Ser), deleterious(m_P35520_Ala288Thr), deleterious(m_Q14203_Gly71Glu), deleterious(m_P53634_Gly301Val), deleterious(m_Q01968_Asp451Asn), deleterious(m_P00441_Gly94Asp), deleterious(m_P05155_Leu481Pro), deleterious(m_P00451_Met2183Arg), deleterious(m_P05186_Ala51Ser), deleterious(m_P00492_Gly16Asp), deleterious(m_P06280_His46Tyr), deleterious(m_P06280_Asp93Asn), deleterious(m_P04839_Gly389Ala), deleterious(m_P00451_Ala303Glu), deleterious(m_P05186_Met295Thr), deleterious(m_P00451_Arg550Gly), deleterious(m_O15305_Asp223Glu), deleterious(m_P06280_His46Pro), deleterious(m_P04275_Arg1374Cys), deleterious(m_P00492_His204Arg), deleterious(m_P06213_Arg1158Gln), deleterious(m_P00451_Ser202Asn), deleterious(m_P00439_Gly247Val), deleterious(m_P00451_Gly1869Asp), deleterious(m_P00451_Glu1904Lys), deleterious(m_P06280_Cys172Tyr), deleterious(m_P04275_Arg1374His), deleterious(m_O15305_Ile132Thr), deleterious(m_P00451_Asn1941Ser), deleterious(m_P00451_Arg2182Pro), deleterious(m_O15305_Ile132Phe), deleterious(m_P00451_Tyr492Cys), deleterious(m_P35557_Gly261Glu), deleterious(m_P22033_Gly94Val), deleterious(m_P00480_His168Arg), deleterious(m_Q06187_Gly594Glu), deleterious(m_P51649_Pro382Gln), deleterious(m_P06280_Asn272Lys), deleterious(m_P49747_Asp361Tyr), deleterious(m_P08397_Gln217Leu), deleterious(m_P06280_Ser148Arg), deleterious(m_P00451_Leu26Arg), deleterious(m_P00740_Cys407Ser), deleterious(m_P05186_Tyr297Asp), deleterious(m_P00439_Ile174Thr), deleterious(m_P05186_Thr134Asn), deleterious(m_P19438_Cys99Ser), deleterious(m_P43246_Cys697Phe), deleterious(m_P00451_Arg2228Gly), deleterious(m_P53634_Gly301Ser), deleterious(m_P06280_Arg356Trp), deleterious(m_P06280_Asn298Ser), deleterious(m_Q13496_Arg69Cys), deleterious(m_P00441_Gly94Arg), deleterious(m_P06280_Pro40Leu), deleterious(m_P11413_Gly410Asp), deleterious(m_P00439_Arg408Trp), deleterious(m_Q06124_Asp61Asn), deleterious(m_P00451_Val181Glu), deleterious(m_P06396_Asp214Tyr), deleterious(m_P10721_Phe584Cys), deleterious(m_P00451_Ile2117Phe), deleterious(m_P05155_Leu481Arg), deleterious(m_P25189_Arg98His), deleterious(m_O15118_Asp242His), deleterious(m_P00740_Gly357Glu), deleterious(m_P00480_Asn198Lys), deleterious(m_P00451_Arg550Cys), deleterious(m_P07902_Tyr251Cys), deleterious(m_P00439_Phe240Ser), deleterious(m_P08100_Asp190Asn), deleterious(m_P08100_Asp190Gly), deleterious(m_P54803_Gly111Asp), deleterious(m_Q01968_His524Gln), deleterious(m_P04275_Ala1461Val), deleterious(m_P22033_Gly215Cys), deleterious(m_Q92838_Gly291Arg), deleterious(m_Q13496_Arg69Pro), deleterious(m_P46100_Cys220Arg), deleterious(m_Q06187_Arg641Cys), deleterious(m_Q9Y4U1_Gly147Ala), deleterious(m_P46100_Gly249Cys), deleterious(m_P35680_Arg276Gln), deleterious(m_P09417_Gly17Arg), deleterious(m_P06132_Ala80Ser), deleterious(m_P40337_Asp126Tyr), deleterious(m_P06280_Cys94Ser), deleterious(m_Q76LX8_Arg398His), deleterious(m_P21817_Leu13Arg), deleterious(m_P06280_Phe113Ser), deleterious(m_P00451_Arg2182Cys), deleterious(m_P04275_Cys1272Arg), deleterious(m_P04839_Gly389Glu), deleterious(m_P10721_Phe584Leu), deleterious(m_O15305_Asp223Asn), deleterious(m_P00439_Gly344Val), deleterious(m_P05186_Asp294Ala), deleterious(m_P00966_Gly324Val), deleterious(m_P00480_Asp263Asn), deleterious(m_P08709_Asp302Asn), deleterious(m_P00451_Lys67Glu), deleterious(m_P40337_Ser65Ala), deleterious(m_P39019_Trp52Arg), deleterious(m_P06280_Asp93Gly), deleterious(m_P00740_Ala436Val), deleterious(m_P10828_Arg320His), deleterious(m_P54803_Pro318Ala), deleterious(m_P08397_Arg116Gln), deleterious(m_P00439_Pro225Thr), deleterious(m_P05186_Arg223Gln), deleterious(m_P05186_Gly334Asp), deleterious(m_P00813_Arg156Cys), deleterious(m_P00451_Arg2182His), deleterious(m_P00451_Tyr605His), deleterious(m_P00451_Asp135Tyr), deleterious(m_Q06124_Asp61Gly), deleterious(m_P07902_Gln317Arg), deleterious(m_Q13950_Ser118Asn), deleterious(m_P11413_Arg387His), deleterious(m_P06280_Ser148Asn), deleterious(m_P19438_Thr79Met), deleterious(m_P07902_Met142Lys), deleterious(m_Q01968_Asp451Gly), deleterious(m_P06280_Asp92His), deleterious(m_P07902_Ser135Leu), deleterious(m_Q06124_Gln510Pro), deleterious(m_P11362_Arg622Gln), deleterious(m_P05186_Ala399Ser), deleterious(m_P06280_Phe113Leu), deleterious(m_P00439_Gly344Arg), deleterious(m_Q04771_Gly328Arg), deleterious(m_P00451_Gly89Val), deleterious(m_O75197_Gly171Arg), deleterious(m_Q92838_Thr378Met), deleterious(m_P00813_Arg156His), deleterious(m_P00439_Leu249Phe), deleterious(m_Q06187_Pro619Thr), deleterious(m_P01009_Ser77Phe), deleterious(m_P00740_Gly357Arg), deleterious(m_P22607_Lys650Met), deleterious(m_P08559_Arg302His), deleterious(m_O15305_Ile132Asn), deleterious(m_P00480_Trp265Leu), deleterious(m_P35557_Gly80Ala), deleterious(m_Q9UBC3_Gly663Ser), deleterious(m_P00451_Gly439Ser), deleterious(m_Q96QS3_Pro353Leu), deleterious(m_P00480_Gly197Arg), deleterious(m_P05166_Arg165Gln), deleterious(m_Q8WVQ1_Arg300Cys), deleterious(m_P10828_Gly345Ser), deleterious(m_P00451_Asp135Gly), deleterious(m_Q06124_Ala72Ser), deleterious(m_P40692_Asp485His), deleterious(m_P00441_Ile113Thr), deleterious(m_P00740_Val228Phe), deleterious(m_P00451_Leu2185Trp), deleterious(m_P08397_Arg116Trp), deleterious(m_P08709_Gly391Ser), deleterious(m_P35520_Ala288Pro), deleterious(m_Q06124_Glu69Gln), deleterious(m_P00451_Val181Met), deleterious(m_P49768_Ala431Glu), deleterious(m_Q13496_Gly378Glu), deleterious(m_P43246_His639Tyr), deleterious(m_P00451_Gly439Val), deleterious(m_P04275_Arg1306Trp), deleterious(m_P05186_Ala51Val), deleterious(m_P00480_Pro225Leu), deleterious(m_Q92838_Gly291Trp), deleterious(m_P00441_Val15Met), deleterious(m_P00439_Pro225Arg), deleterious(m_P00480_Cys303Arg), deleterious(m_P00451_Tyr35His), deleterious(m_P06280_Asp266Val), deleterious(m_P11362_Arg622Gly), deleterious(m_P05186_Glu291Lys), deleterious(m_P01008_Pro439Leu), deleterious(m_Q06187_Asp521Gly), deleterious(m_P21817_Leu13Val), deleterious(m_P01008_Pro439Thr), deleterious(m_P06132_Ala80Gly), deleterious(m_P29033_Trp44Cys), deleterious(m_P40692_Pro648Leu), deleterious(m_P05186_Thr134His), deleterious(m_P00439_Arg270Lys), deleterious(m_Q06124_Ala72Gly), deleterious(m_P00451_Gly89Asp), deleterious(m_P00451_Arg2228Leu), deleterious(m_P06280_Arg112Cys), deleterious(m_P05186_His171Arg), deleterious(m_P06280_Asp266His), deleterious(m_Q92838_Leu266Arg), deleterious(m_P00451_Ser603Ile), deleterious(m_P00451_Lys67Asn), deleterious(m_P30613_Ala468Gly), deleterious(m_P08709_Asp302His), deleterious(m_Q06187_Arg562Trp), deleterious(m_P00966_Gly117Asp), deleterious(m_P51649_Pro382Leu), deleterious(m_P00451_Asn631Ser), deleterious(m_Q06187_Gly594Arg), deleterious(m_P07902_Arg333Gly), deleterious(m_P00439_Ile174Val), deleterious(m_P00451_Arg2228Pro), deleterious(m_P54803_Met117Leu), deleterious(m_P11413_Arg387Cys), deleterious(m_P00441_His81Ala), deleterious(m_P00439_Val245Ala), deleterious(m_P46100_Cys220Tyr), deleterious(m_P51608_Leu100Val), deleterious(m_Q06187_Arg562Pro), deleterious(m_P05186_Gly326Arg), deleterious(m_P30613_Arg163Cys), deleterious(m_Q06187_Asp521Asn), deleterious(m_P06280_Arg112Ser), deleterious(m_P35520_Lys384Glu), deleterious(m_P00451_Gln2106Arg), deleterious(m_P35520_Lys384Asn), deleterious(m_P11413_Arg198Pro), deleterious(m_P00441_Leu39Val), deleterious(m_P00492_Gly16Ser), deleterious(m_P10828_Arg243Trp), deleterious(m_P07902_Arg333Trp), deleterious(m_P11362_Pro722Ser), deleterious(m_P00451_Gln2106Glu), deleterious(m_Q01968_Glu468Lys), deleterious(m_O14836_Cys104Arg), deleterious(m_P01008_Tyr198His), deleterious(m_P47989_Arg149Cys), deleterious(m_P08514_Pro176Leu), deleterious(m_P35557_Gly80Ser), deleterious(m_P43246_Gly692Arg), deleterious(m_P06280_Gly328Val), deleterious(m_P53634_Gly300Asp), deleterious(m_P00451_Ala111Val), deleterious(m_P00480_Pro225Thr)

+ Negative Examples: deleterious(m_Q9Y2C9_Val427Ala), deleterious(m_Q7Z434_Cys79Phe)  
develop  humvar398_35   freq_at_pos(A, B) and B>=3 and secondary_struc(A, other). deleterious(A)
249 (4.15%) 
5 (0.25%) 
3
Covers:
+ Positive Examples: deleterious(m_P00439_Met276Ile), deleterious(m_Q04771_Gly328Trp), deleterious(m_P00480_Tyr345Asp), deleterious(m_P07902_Met142Val), deleterious(m_P08100_Asp190Tyr), deleterious(m_P01308_Arg89Cys), deleterious(m_P01112_Gly13Asp), deleterious(m_P43246_His639Arg), deleterious(m_P00451_Arg391His), deleterious(m_P08514_Pro176Ala), deleterious(m_P51608_Pro101Ser), deleterious(m_P01185_Cys116Arg), deleterious(m_P05155_Arg466Ser), deleterious(m_P00451_Cys329Phe), deleterious(m_P15918_Arg396Leu), deleterious(m_P07902_Arg333Gln), deleterious(m_P08100_Pro347Ala), deleterious(m_P08100_Pro23His), deleterious(m_Q04771_Gly328Glu), deleterious(m_P00451_Asp101Val), deleterious(m_Q9UM73_Phe1174Cys), deleterious(m_Q03426_His20Pro), deleterious(m_P00451_Gln584His), deleterious(m_P19429_Pro82Ser), deleterious(m_P01112_Gly12Glu), deleterious(m_P00480_Thr264Ile), deleterious(m_P00451_Arg2178Leu), deleterious(m_P10275_Asp695His), deleterious(m_Q13496_Arg69Ser), deleterious(m_P00451_Arg2323Leu), deleterious(m_P10828_Gly345Arg), deleterious(m_P00480_Asp196Tyr), deleterious(m_P00441_Gly94Val), deleterious(m_P00740_Pro333Thr), deleterious(m_P00439_Val245Glu), deleterious(m_P00439_Tyr343Cys), deleterious(m_P08100_Pro23Leu), deleterious(m_Q06187_Asp521His), deleterious(m_P06280_Asn298His), deleterious(m_P06280_Gly328Ala), deleterious(m_P00439_Val245Leu), deleterious(m_Q9H3D4_Arg319Ser), deleterious(m_P00439_Glu280Lys), deleterious(m_P05186_Met62Val), deleterious(m_P29033_Arg184Gln), deleterious(m_P98172_Pro119Ser), deleterious(m_P01111_Gln61Lys), deleterious(m_P15918_Arg396His), deleterious(m_P51608_Arg133His), deleterious(m_P06280_Gly328Arg), deleterious(m_P11413_Arg198Cys), deleterious(m_Q14203_Gly71Ala), deleterious(m_P04156_Pro105Leu), deleterious(m_P10275_Asp695Asn), deleterious(m_P00451_Pro470Leu), deleterious(m_P00451_Arg550His), deleterious(m_Q06187_Pro619Ala), deleterious(m_P00451_Gly474Arg), deleterious(m_P42336_His1047Arg), deleterious(m_Q06187_Pro619Ser), deleterious(m_P22607_Asn540Ser), deleterious(m_P40763_Arg382Leu), deleterious(m_P22033_Arg108Cys), deleterious(m_P00480_Asp196Val), deleterious(m_P00451_Arg2228Gln), deleterious(m_P00451_Pro470Arg), deleterious(m_P00451_Asn637Ser), deleterious(m_P02649_Pro102Arg), deleterious(m_P10828_Gly345Val), deleterious(m_P00451_Ser202Arg), deleterious(m_P00451_Asp101His), deleterious(m_P01185_Cys116Gly), deleterious(m_P00451_Asp75Glu), deleterious(m_P13569_Ser549Ile), deleterious(m_P00451_Gly439Asp), deleterious(m_P51608_Arg133Cys), deleterious(m_P00441_Gly94Cys), deleterious(m_P00480_Ser90Arg), deleterious(m_P98172_Pro119His), deleterious(m_P00480_Pro225Arg), deleterious(m_P01116_Pro34Leu), deleterious(m_P01112_Gly13Cys), deleterious(m_P06280_Asp266Asn), deleterious(m_P01308_Arg89His), deleterious(m_P01008_Arg425Pro), deleterious(m_P00451_Cys348Ser), deleterious(m_P00966_Arg363Gly), deleterious(m_P25189_Arg98Pro), deleterious(m_P22607_Asn540Lys), deleterious(m_P00451_Arg2178His), deleterious(m_P25189_Arg98Cys), deleterious(m_P10828_Arg320Cys), deleterious(m_P00451_Cys348Tyr), deleterious(m_P06280_Cys56Tyr), deleterious(m_P35520_Ala288Thr), deleterious(m_Q14203_Gly71Glu), deleterious(m_P00451_Arg1800Cys), deleterious(m_P00441_Gly94Asp), deleterious(m_Q13950_Arg131Ser), deleterious(m_P01008_Arg425His), deleterious(m_P25189_Asp134Gly), deleterious(m_Q13950_Arg225Leu), deleterious(m_P00451_Gln584Arg), deleterious(m_P06280_His46Tyr), deleterious(m_Q13950_Lys218Gln), deleterious(m_P05186_Met295Thr), deleterious(m_P00451_Arg550Gly), deleterious(m_P06280_His46Pro), deleterious(m_P04275_Arg1374Cys), deleterious(m_Q8NBP7_Asp374His), deleterious(m_P51608_Pro101Thr), deleterious(m_P00451_Ser202Asn), deleterious(m_P00439_Met276Val), deleterious(m_P00439_Gly247Val), deleterious(m_P00451_Asp75Tyr), deleterious(m_P05155_Arg466His), deleterious(m_P04275_Arg1374His), deleterious(m_O15305_Ile132Thr), deleterious(m_P00451_Arg2182Pro), deleterious(m_O15305_Ile132Phe), deleterious(m_P40337_Tyr156Asn), deleterious(m_P06280_Cys56Phe), deleterious(m_P13569_Ser549Arg), deleterious(m_P00439_Arg176Leu), deleterious(m_P01008_Phe434Ser), deleterious(m_Q9H3D4_Arg318Gln), deleterious(m_P01008_Phe434Cys), deleterious(m_P51608_Pro101Arg), deleterious(m_P22033_Arg108Gly), deleterious(m_P01008_Arg425Cys), deleterious(m_P00439_Ile174Thr), deleterious(m_P19438_Cys99Ser), deleterious(m_P46100_Pro190Ser), deleterious(m_P00451_Arg2228Gly), deleterious(m_P06280_Asn298Ser), deleterious(m_Q13496_Arg69Cys), deleterious(m_P00441_Gly94Arg), deleterious(m_P00480_Tyr345Cys), deleterious(m_P13569_Ser549Asn), deleterious(m_P00451_Arg1800Gly), deleterious(m_Q06124_Asp61Asn), deleterious(m_P49748_Arg366Cys), deleterious(m_Q9H3D4_Arg319His), deleterious(m_P06280_Cys56Gly), deleterious(m_P00451_Asp101Gly), deleterious(m_P05186_Gly426Asp), deleterious(m_P40763_Arg382Gln), deleterious(m_P25189_Arg98His), deleterious(m_P00451_Arg550Cys), deleterious(m_Q13950_Arg225Gln), deleterious(m_P00492_Asp201Asn), deleterious(m_P00451_Arg2323Cys), deleterious(m_P40692_Gly67Trp), deleterious(m_P08100_Asp190Asn), deleterious(m_P08100_Asp190Gly), deleterious(m_P08397_Arg167Gln), deleterious(m_Q13496_Arg69Pro), deleterious(m_Q13950_Lys218Asn), deleterious(m_P22033_Arg108His), deleterious(m_P98172_Pro119Thr), deleterious(m_P51608_Phe155Ile), deleterious(m_P51608_Pro101Leu), deleterious(m_P00451_Arg2182Cys), deleterious(m_P08100_Pro347Gln), deleterious(m_P04275_Cys1272Arg), deleterious(m_P29033_Arg184Pro), deleterious(m_P00966_Arg363Trp), deleterious(m_P00439_Gly344Val), deleterious(m_P40337_Ser65Ala), deleterious(m_P10828_Arg320His), deleterious(m_P00439_Pro225Thr), deleterious(m_P10275_Asp695Val), deleterious(m_P00439_Arg176Pro), deleterious(m_P01112_Gly12Cys), deleterious(m_Q9H3D4_Arg318His), deleterious(m_P00966_Arg363Leu), deleterious(m_P00451_Arg2182His), deleterious(m_P00451_Arg2323His), deleterious(m_Q06124_Asp61Gly), deleterious(m_P07902_Met142Lys), deleterious(m_Q03426_His20Asn), deleterious(m_P01116_Pro34Gln), deleterious(m_P08100_Pro347Arg), deleterious(m_P01111_Gly13Asp), deleterious(m_P00439_Gly344Arg), deleterious(m_P00439_Pro314His), deleterious(m_P00451_Arg2178Cys), deleterious(m_Q04771_Gly328Arg), deleterious(m_Q06187_Pro619Thr), deleterious(m_P01009_Ser77Phe), deleterious(m_P22607_Lys650Met), deleterious(m_O15305_Ile132Asn), deleterious(m_Q13950_Arg131Gly), deleterious(m_P01308_Arg89Leu), deleterious(m_P00966_Arg363Gln), deleterious(m_P40763_Arg382Trp), deleterious(m_P00451_Arg391Pro), deleterious(m_P00451_Gly439Ser), deleterious(m_P29033_Arg184Trp), deleterious(m_P00740_Pro333His), deleterious(m_P10828_Gly345Ser), deleterious(m_P00492_Asp201Tyr), deleterious(m_P40692_Gly67Arg), deleterious(m_Q06124_Ala72Ser), deleterious(m_P49748_Arg366His), deleterious(m_P15056_Gly466Val), deleterious(m_P35520_Ala288Pro), deleterious(m_Q8NBP7_Asp374Tyr), deleterious(m_P43246_His639Tyr), deleterious(m_P00451_Gly439Val), deleterious(m_P15918_Arg396Cys), deleterious(m_P00451_Gln584Lys), deleterious(m_P00480_Pro225Leu), deleterious(m_P00439_Pro225Arg), deleterious(m_P08100_Pro347Ser), deleterious(m_P46100_Pro190Ala), deleterious(m_P06280_Asp266Val), deleterious(m_P08100_Pro347Leu), deleterious(m_Q06187_Asp521Gly), deleterious(m_Q15848_Arg112Cys), deleterious(m_Q13950_Lys218Glu), deleterious(m_Q13950_Arg131Cys), deleterious(m_Q06124_Ala72Gly), deleterious(m_P05155_Arg466Leu), deleterious(m_P00451_Arg2228Leu), deleterious(m_P06280_Arg112Cys), deleterious(m_P51608_Phe155Ser), deleterious(m_P06280_Asp266His), deleterious(m_P00451_Arg2323Gly), deleterious(m_P07902_Arg333Gly), deleterious(m_P00439_Ile174Val), deleterious(m_P00451_Arg2228Pro), deleterious(m_P00439_Val245Ala), deleterious(m_Q06187_Asp521Asn), deleterious(m_P06280_Arg112Ser), deleterious(m_P00451_Gln2106Arg), deleterious(m_P11413_Arg198Pro), deleterious(m_Q13950_Arg225Trp), deleterious(m_P07902_Arg333Trp), deleterious(m_P01116_Pro34Arg), deleterious(m_P00451_Gln2106Glu), deleterious(m_P00451_Arg391Cys), deleterious(m_P00451_Pro470Thr), deleterious(m_P25189_Asp134Glu), deleterious(m_P08514_Pro176Leu), deleterious(m_Q9H3D4_Arg318Cys), deleterious(m_P06280_Gly328Val), deleterious(m_Q03426_His20Gln), deleterious(m_P00480_Pro225Thr)

+ Negative Examples: deleterious(m_P24394_Ile75Leu), deleterious(m_Q8TDZ2_Ala758Glu), deleterious(m_P24394_Ile75Phe), deleterious(m_Q8TDZ2_Ala758Thr), deleterious(m_P01909_Cys70Tyr)  
develop  humvar398_12   g_or_p(A, g_or_p_unchanged) and conservation_class(A, global_conservation_rank_1) and secondary_struc(A, other) and wt_accessibility(A, buried). deleterious(A)
214 (3.57%) 
3 (0.15%) 
4
Covers:
+ Positive Examples: deleterious(m_P49747_Asp290Asn), deleterious(m_P19438_Cys62Tyr), deleterious(m_P10275_Met780Ile), deleterious(m_P28329_Arg420Cys), deleterious(m_P43246_His639Arg), deleterious(m_P01185_Cys116Arg), deleterious(m_Q06124_Gln510Arg), deleterious(m_Q03426_Ala334Thr), deleterious(m_P11498_Tyr304Cys), deleterious(m_P10275_Leu821Val), deleterious(m_O14832_His175Arg), deleterious(m_P23786_Arg503Cys), deleterious(m_P60484_His61Asp), deleterious(m_O00294_Lys489Arg), deleterious(m_Q16518_Glu417Gln), deleterious(m_P07954_Gln185Arg), deleterious(m_Q01968_Trp503Arg), deleterious(m_Q9UM73_Phe1174Cys), deleterious(m_P04424_Arg111Trp), deleterious(m_P55316_Phe215Leu), deleterious(m_P02545_Trp520Ser), deleterious(m_P43034_Asp317His), deleterious(m_P00480_Asp196Tyr), deleterious(m_Q01968_Cys498Tyr), deleterious(m_Q06187_Arg641His), deleterious(m_P11511_Arg435Cys), deleterious(m_Q15582_Asn622Lys), deleterious(m_P01008_Thr243Ile), deleterious(m_P00441_Ile150Thr), deleterious(m_Q13496_His232Arg), deleterious(m_P05166_Met442Thr), deleterious(m_Q06187_Asp521His), deleterious(m_P40692_Leu155Arg), deleterious(m_P08397_Gln217His), deleterious(m_P43026_Cys400Tyr), deleterious(m_P16435_Tyr575Cys), deleterious(m_P01008_Trp257Arg), deleterious(m_P00451_His1973Leu), deleterious(m_Q14623_Val190Ala), deleterious(m_P15259_Glu89Ala), deleterious(m_P05186_Asp378Val), deleterious(m_P98172_Cys153Tyr), deleterious(m_P15259_Arg90Trp), deleterious(m_P00480_Cys303Tyr), deleterious(m_P35914_Cys174Tyr), deleterious(m_Q13950_Thr205Arg), deleterious(m_P07225_Cys267Ser), deleterious(m_P50897_His39Gln), deleterious(m_Q01968_His524Arg), deleterious(m_P41181_Asn68Ser), deleterious(m_P35557_Glu256Lys), deleterious(m_P54803_Tyr314Cys), deleterious(m_P31785_Cys182Arg), deleterious(m_Q13496_Asn189Ser), deleterious(m_Q93099_His371Arg), deleterious(m_P00441_Ile113Met), deleterious(m_P05156_His418Leu), deleterious(m_P00441_Asp125Val), deleterious(m_P00492_His204Asp), deleterious(m_Q06187_Trp563Leu), deleterious(m_P06280_Asp92Tyr), deleterious(m_P00480_Asp196Val), deleterious(m_P49748_Glu218Lys), deleterious(m_P07902_Arg231His), deleterious(m_Q06187_Tyr598Cys), deleterious(m_Q13950_Ser118Arg), deleterious(m_P02753_Ile59Asn), deleterious(m_P00740_Cys407Arg), deleterious(m_Q15582_Phe540Ser), deleterious(m_P12694_Arg159Trp), deleterious(m_O43602_Leu178Arg), deleterious(m_P01009_Glu366Lys), deleterious(m_P00451_Asn1941Asp), deleterious(m_P00451_Trp1908Leu), deleterious(m_P01241_Cys79Ser), deleterious(m_P15056_Asn581Asp), deleterious(m_P16930_Asp233Val), deleterious(m_P06280_Asp266Asn), deleterious(m_P06280_Trp95Ser), deleterious(m_P00480_Leu304Phe), deleterious(m_P45381_Asp68Ala), deleterious(m_P98172_Cys153Ser), deleterious(m_P25189_Arg98Cys), deleterious(m_Q06124_Tyr279Cys), deleterious(m_P10828_Arg320Cys), deleterious(m_O95409_Cys335Phe), deleterious(m_P05186_Arg246Ser), deleterious(m_P39019_Trp52Cys), deleterious(m_Q8WVQ1_Arg300His), deleterious(m_P54840_Asn39Ser), deleterious(m_Q01968_Asp451Asn), deleterious(m_P51843_Ile439Ser), deleterious(m_P00492_His204Arg), deleterious(m_P10746_Val99Ala), deleterious(m_P43246_Thr335Ile), deleterious(m_Q8NI22_Ile136Thr), deleterious(m_P06280_Cys172Tyr), deleterious(m_Q8WXF7_Arg217Gln), deleterious(m_Q9BZ23_Asp447Asn), deleterious(m_P00740_Cys435Tyr), deleterious(m_P00451_Asn1941Ser), deleterious(m_Q92947_Glu414Lys), deleterious(m_Q8NI22_Asp129Glu), deleterious(m_P00813_His15Asp), deleterious(m_P08559_Asp315Asn), deleterious(m_Q14749_Asn141Ser), deleterious(m_P00480_His168Arg), deleterious(m_Q03692_Cys591Arg), deleterious(m_Q02127_Thr284Ile), deleterious(m_P03950_Cys63Trp), deleterious(m_Q9Y4U1_Trp157Cys), deleterious(m_P08397_Gln217Leu), deleterious(m_Q16678_Asn423Tyr), deleterious(m_P00740_Cys407Ser), deleterious(m_P05186_Tyr297Asp), deleterious(m_P19438_Cys99Ser), deleterious(m_P40763_Ser611Asn), deleterious(m_P06280_Asp165Val), deleterious(m_P15056_Phe468Ser), deleterious(m_P51649_Cys223Tyr), deleterious(m_P10071_Cys520Tyr), deleterious(m_O14832_Asn269His), deleterious(m_P07101_Thr314Met), deleterious(m_P25189_Arg98His), deleterious(m_P10275_Asp767Glu), deleterious(m_P00480_Asn198Lys), deleterious(m_Q04446_His545Arg), deleterious(m_P50993_Met731Thr), deleterious(m_Q9NUW8_His493Arg), deleterious(m_Q01968_His524Gln), deleterious(m_Q12840_Asn256Ser), deleterious(m_Q06187_Arg641Cys), deleterious(m_P08559_His292Leu), deleterious(m_P43080_Asp100Glu), deleterious(m_P98172_Thr137Ala), deleterious(m_Q16518_Tyr431Cys), deleterious(m_P05166_Ser106Arg), deleterious(m_P00451_Cys2040Tyr), deleterious(m_P43034_His149Arg), deleterious(m_Q76LX8_Arg398His), deleterious(m_P06280_Phe113Ser), deleterious(m_Q76LX8_Cys508Tyr), deleterious(m_P35520_Asp376Asn), deleterious(m_Q06124_Met508Val), deleterious(m_P00480_Asp263Asn), deleterious(m_P40337_Ser65Ala), deleterious(m_Q92947_Met191Thr), deleterious(m_P39019_Trp52Arg), deleterious(m_O43918_Cys311Tyr), deleterious(m_P10828_Arg320His), deleterious(m_P08397_Arg116Gln), deleterious(m_P49747_Asp349Val), deleterious(m_P07902_Asn97Ser), deleterious(m_Q7LG56_Trp64Arg), deleterious(m_P15529_Cys35Tyr), deleterious(m_P21912_Cys196Tyr), deleterious(m_Q13950_Ser118Asn), deleterious(m_P06280_Asp92His), deleterious(m_Q13285_Met78Ile), deleterious(m_P29965_Thr254Met), deleterious(m_P06280_Phe113Leu), deleterious(m_P00451_Trp2065Arg), deleterious(m_P04424_Arg236Trp), deleterious(m_Q01968_Ser522Arg), deleterious(m_P37231_Arg425Cys), deleterious(m_P01009_Ser77Phe), deleterious(m_P08559_Arg302His), deleterious(m_P00480_Trp265Leu), deleterious(m_Q01968_Asn424Asp), deleterious(m_P36894_Arg443Cys), deleterious(m_Q06187_Met477Arg), deleterious(m_P05166_Arg165Gln), deleterious(m_Q8WVQ1_Arg300Cys), deleterious(m_P03951_Trp587Ser), deleterious(m_P08559_Asp258Ala), deleterious(m_O60481_Cys253Ser), deleterious(m_P00441_Ile113Thr), deleterious(m_O60333_Gln98Leu), deleterious(m_P06280_Tyr86Cys), deleterious(m_Q06187_Leu518Arg), deleterious(m_P08397_Arg116Trp), deleterious(m_P61457_Thr79Ile), deleterious(m_P43246_His639Tyr), deleterious(m_P00480_Cys303Arg), deleterious(m_P06280_Asp266Val), deleterious(m_O00754_His72Leu), deleterious(m_P35916_His1035Arg), deleterious(m_P00451_Cys267Tyr), deleterious(m_P22033_Trp105Arg), deleterious(m_P10644_Ala213Asp), deleterious(m_P08559_Arg288His), deleterious(m_P15918_Cys328Tyr), deleterious(m_O43602_Asp143Asn), deleterious(m_Q06124_Ala465Thr), deleterious(m_O14958_Asp307His), deleterious(m_P06280_Asp266His), deleterious(m_P04181_Arg271Lys), deleterious(m_P49747_Asp342Tyr), deleterious(m_Q06187_Arg562Trp), deleterious(m_P08100_Lys296Glu), deleterious(m_Q01968_Tyr479Cys), deleterious(m_Q01968_Phe463Ser), deleterious(m_P08236_His351Tyr), deleterious(m_P00441_His81Ala), deleterious(m_P00740_Trp356Cys), deleterious(m_Q06187_Asp521Asn), deleterious(m_O75695_Cys67Tyr), deleterious(m_O14832_Gln176Lys), deleterious(m_Q16678_Arg444Gln), deleterious(m_P51648_His411Tyr), deleterious(m_Q01968_Glu468Lys), deleterious(m_P04839_Cys537Arg), deleterious(m_O14836_Cys104Arg), deleterious(m_P01008_Tyr198His)

+ Negative Examples: deleterious(m_A6NHL2_Arg250Trp), deleterious(m_Q9UN36_Thr45Ser), deleterious(m_P00338_Ser161Arg)  
develop  humvar398_37   modif_charge(A, charge_unchanged) and modif_polarity(A, polarity_increase) and conservation_class(A, global_conservation_rank_1). deleterious(A)
211 (3.52%) 
3 (0.15%) 
5
Covers:
+ Positive Examples: deleterious(m_P19438_Cys62Tyr), deleterious(m_P55771_Gly51Ser), deleterious(m_Q06187_Phe583Ser), deleterious(m_P35557_Gly227Cys), deleterious(m_P12694_Ala253Thr), deleterious(m_P29400_Trp1538Ser), deleterious(m_P08100_Pro171Ser), deleterious(m_O14832_Phe257Ser), deleterious(m_P35520_Gly307Ser), deleterious(m_Q03426_Ala334Thr), deleterious(m_P16435_Cys566Tyr), deleterious(m_O15305_Phe206Ser), deleterious(m_P10275_Phe794Ser), deleterious(m_P08100_Pro171Gln), deleterious(m_P01185_Cys92Ser), deleterious(m_P23760_Ile59Asn), deleterious(m_P06280_Cys142Tyr), deleterious(m_O43602_Ile185Thr), deleterious(m_Q9UM73_Phe1174Cys), deleterious(m_P35916_Pro1137Ser), deleterious(m_Q13496_Pro199Ser), deleterious(m_P02545_Trp520Ser), deleterious(m_O15305_Phe11Cys), deleterious(m_P02545_Leu380Ser), deleterious(m_Q01968_Cys498Tyr), deleterious(m_P07686_Pro504Ser), deleterious(m_P40692_Ile68Asn), deleterious(m_P00441_Ile150Thr), deleterious(m_P05166_Met442Thr), deleterious(m_P28069_Pro239Ser), deleterious(m_Q16595_Leu106Ser), deleterious(m_Q14203_Gly59Ser), deleterious(m_P00740_Cys252Ser), deleterious(m_P43026_Cys400Tyr), deleterious(m_P29400_Cys1564Ser), deleterious(m_P99999_Gly42Ser), deleterious(m_P98172_Cys153Tyr), deleterious(m_P00480_Cys303Tyr), deleterious(m_P98172_Gly151Ser), deleterious(m_P98172_Pro119Ser), deleterious(m_P35914_Cys174Tyr), deleterious(m_P10275_Pro723Ser), deleterious(m_P54803_Phe514Ser), deleterious(m_P07225_Cys267Ser), deleterious(m_Q06187_Met630Thr), deleterious(m_P05155_Phe477Ser), deleterious(m_O14832_Gly204Ser), deleterious(m_Q92838_Cys332Tyr), deleterious(m_P25189_Cys127Tyr), deleterious(m_P10275_Pro766Ser), deleterious(m_Q92947_Cys308Ser), deleterious(m_P41181_Gly180Ser), deleterious(m_Q06187_Pro619Ser), deleterious(m_P08709_Cys254Tyr), deleterious(m_Q92915_Phe145Ser), deleterious(m_P36894_Met470Thr), deleterious(m_P13569_Leu558Ser), deleterious(m_P22033_Gly215Ser), deleterious(m_P13569_Leu619Ser), deleterious(m_O75792_Gly37Ser), deleterious(m_P13569_Gly551Ser), deleterious(m_P11511_Cys437Tyr), deleterious(m_O43918_Pro326Gln), deleterious(m_P02753_Ile59Asn), deleterious(m_O95292_Pro56Ser), deleterious(m_P48165_Pro88Ser), deleterious(m_Q15582_Phe540Ser), deleterious(m_P13569_Leu610Ser), deleterious(m_P22033_Gly145Ser), deleterious(m_P01241_Cys79Ser), deleterious(m_P35557_Phe150Ser), deleterious(m_Q03426_Gly309Ser), deleterious(m_P00441_Phe46Cys), deleterious(m_P06280_Trp95Ser), deleterious(m_P36894_Cys376Tyr), deleterious(m_P98172_Cys153Ser), deleterious(m_P00451_Trp2248Ser), deleterious(m_P10275_Cys806Tyr), deleterious(m_P10275_Met807Thr), deleterious(m_P10275_Cys784Tyr), deleterious(m_P05106_Cys532Tyr), deleterious(m_P35520_Gly347Ser), deleterious(m_P40692_Pro648Ser), deleterious(m_P39019_Ala135Thr), deleterious(m_P40259_Gly137Ser), deleterious(m_Q9BZ23_Ile501Thr), deleterious(m_P51843_Ile439Ser), deleterious(m_P54840_Pro479Gln), deleterious(m_P48436_Phe112Ser), deleterious(m_P19438_Cys117Tyr), deleterious(m_P05186_Gly162Ser), deleterious(m_Q8NI22_Ile136Thr), deleterious(m_P19438_Cys59Ser), deleterious(m_Q13950_Phe187Ser), deleterious(m_P06280_Cys172Tyr), deleterious(m_Q13950_Phe197Ser), deleterious(m_P00740_Cys435Tyr), deleterious(m_Q13501_Met404Thr), deleterious(m_P10912_Cys56Ser), deleterious(m_P10746_Ile129Thr), deleterious(m_P35520_Ala155Thr), deleterious(m_P61916_Pro120Ser), deleterious(m_P16930_Pro249Thr), deleterious(m_P51649_Pro382Gln), deleterious(m_Q30201_Cys282Tyr), deleterious(m_O95409_Phe314Cys), deleterious(m_P00740_Cys407Ser), deleterious(m_P35520_Pro88Ser), deleterious(m_P19438_Cys99Ser), deleterious(m_P01732_Gly111Ser), deleterious(m_P19971_Gly153Ser), deleterious(m_P01185_Cys98Ser), deleterious(m_P48436_Met113Thr), deleterious(m_P40692_Pro640Ser), deleterious(m_P05106_Cys400Tyr), deleterious(m_P36551_Gly197Trp), deleterious(m_P15056_Phe468Ser), deleterious(m_P35520_Leu154Gln), deleterious(m_P51649_Cys223Tyr), deleterious(m_P08100_Cys140Ser), deleterious(m_P32322_Ala179Thr), deleterious(m_P10071_Cys520Tyr), deleterious(m_P00451_Cys2345Ser), deleterious(m_P01185_Cys92Tyr), deleterious(m_Q13496_Pro226Thr), deleterious(m_P08709_Cys238Tyr), deleterious(m_P50993_Met731Thr), deleterious(m_P10275_Ala765Thr), deleterious(m_P40692_Gly67Trp), deleterious(m_P31785_Cys231Tyr), deleterious(m_P00441_Phe21Cys), deleterious(m_Q16678_Phe445Cys), deleterious(m_P22033_Gly215Cys), deleterious(m_Q13950_Phe121Cys), deleterious(m_P49768_Cys410Tyr), deleterious(m_P00451_Cys2345Tyr), deleterious(m_P53634_Cys291Tyr), deleterious(m_P98172_Pro119Thr), deleterious(m_P13569_Ala559Thr), deleterious(m_P00451_Cys2040Tyr), deleterious(m_P15260_Cys77Tyr), deleterious(m_P06280_Phe113Ser), deleterious(m_Q76LX8_Cys508Tyr), deleterious(m_P41181_Ala190Thr), deleterious(m_Q92947_Met191Thr), deleterious(m_O43918_Cys311Tyr), deleterious(m_P01008_Ala416Ser), deleterious(m_P10275_Pro904Ser), deleterious(m_P13051_Phe251Ser), deleterious(m_P15529_Cys35Tyr), deleterious(m_P29965_Leu231Ser), deleterious(m_P04150_Gly679Ser), deleterious(m_P02792_Ala96Thr), deleterious(m_P21912_Cys196Tyr), deleterious(m_P14222_Cys279Tyr), deleterious(m_Q12840_Met198Thr), deleterious(m_Q92838_Cys346Tyr), deleterious(m_P08100_Cys110Tyr), deleterious(m_Q7Z406_Gly376Cys), deleterious(m_P00480_Ala336Ser), deleterious(m_Q06187_Phe644Ser), deleterious(m_P00740_Cys396Ser), deleterious(m_Q06187_Pro619Thr), deleterious(m_Q92743_Ala252Thr), deleterious(m_P10912_Phe114Ser), deleterious(m_P01185_Cys105Tyr), deleterious(m_P36551_Gly189Ser), deleterious(m_P25189_Gly123Cys), deleterious(m_P10275_Pro682Thr), deleterious(m_P01185_Cys59Tyr), deleterious(m_Q9UIF7_Pro402Ser), deleterious(m_P01008_Ala414Thr), deleterious(m_P19429_Leu144Gln), deleterious(m_P10828_Gly345Ser), deleterious(m_P03951_Trp587Ser), deleterious(m_Q06187_Leu512Gln), deleterious(m_O60481_Cys253Ser), deleterious(m_P21439_Pro1168Ser), deleterious(m_P00441_Ile113Thr), deleterious(m_P03952_Cys548Tyr), deleterious(m_Q7LG56_Ile224Ser), deleterious(m_P00740_Cys382Tyr), deleterious(m_P48436_Ala158Thr), deleterious(m_P13569_Leu571Ser), deleterious(m_P10619_Gly439Ser), deleterious(m_P01008_Pro439Thr), deleterious(m_P58335_Ile189Thr), deleterious(m_P00451_Cys267Tyr), deleterious(m_P29965_Gly257Ser), deleterious(m_P05155_Pro498Ser), deleterious(m_P15918_Cys328Tyr), deleterious(m_Q06124_Ala465Thr), deleterious(m_P28069_Phe135Cys), deleterious(m_P60484_Cys105Tyr), deleterious(m_Q01968_Phe463Ser), deleterious(m_Q71U36_Pro263Thr), deleterious(m_P10275_Ile898Thr), deleterious(m_P05186_Ala116Thr), deleterious(m_P07902_Phe171Ser), deleterious(m_P00740_Cys252Tyr), deleterious(m_P10912_Pro149Gln), deleterious(m_Q06187_Phe559Ser), deleterious(m_P78330_Met52Thr), deleterious(m_O75695_Cys67Tyr), deleterious(m_P01008_Pro112Thr), deleterious(m_P09467_Phe194Ser), deleterious(m_P13569_Gly480Cys), deleterious(m_Q16518_Gly40Ser), deleterious(m_P29400_Pro1517Thr), deleterious(m_P49747_Cys371Ser), deleterious(m_P35557_Gly80Ser)

+ Negative Examples: deleterious(m_O60218_Met286Thr), deleterious(m_Q8NI77_Pro334Ser), deleterious(m_Q7Z3Z3_Pro375Ser)  
develop  humvar398_78   modif_hydrophobicity(A, hydrophobicity_decrease) and is_in_site(A, yes) and freq_at_pos(A, B) and B>=2 and secondary_struc(A, other). deleterious(A)
211 (3.52%) 
4 (0.2%) 
6
Covers:
+ Positive Examples: deleterious(m_P00451_Gly1779Arg), deleterious(m_P43246_Cys697Arg), deleterious(m_P00480_Tyr345Asp), deleterious(m_P10912_Val162Asp), deleterious(m_P00451_His113Arg), deleterious(m_P01112_Gly13Asp), deleterious(m_P00451_Gly2045Glu), deleterious(m_P43246_His639Arg), deleterious(m_P01185_Cys116Arg), deleterious(m_Q06124_Gln510Arg), deleterious(m_P00451_Tyr450Asp), deleterious(m_O14773_Cys365Arg), deleterious(m_P46100_Gly249Asp), deleterious(m_P06280_Ala143Pro), deleterious(m_Q16678_Ile399Ser), deleterious(m_Q04771_Gly328Glu), deleterious(m_Q03426_His20Pro), deleterious(m_P00451_Ile585Thr), deleterious(m_P01112_Gly12Glu), deleterious(m_P22830_Cys406Ser), deleterious(m_Q03426_Gly211Glu), deleterious(m_Q15465_Trp117Gly), deleterious(m_P01185_Gly88Arg), deleterious(m_P10828_Gly345Arg), deleterious(m_P00451_Ala1939Thr), deleterious(m_P00439_Val245Glu), deleterious(m_P40692_Ile68Asn), deleterious(m_P06280_Cys52Arg), deleterious(m_P00441_Leu68Arg), deleterious(m_P00451_Tyr683Asn), deleterious(m_P51608_Leu100Arg), deleterious(m_P00451_Tyr605Ser), deleterious(m_P00451_His1980Pro), deleterious(m_P00451_Ala303Pro), deleterious(m_P00441_Val15Gly), deleterious(m_Q92838_Ala356Asp), deleterious(m_Q9Y4U1_Gly147Asp), deleterious(m_P60484_His93Arg), deleterious(m_P01241_Ser134Arg), deleterious(m_P01111_Gln61Lys), deleterious(m_P07902_Tyr251Ser), deleterious(m_P01116_Gly60Arg), deleterious(m_Q01968_His524Arg), deleterious(m_P00451_Gly164Asp), deleterious(m_P00439_His170Arg), deleterious(m_P05186_Gly63Arg), deleterious(m_O60260_Ala46Pro), deleterious(m_P00451_Gly474Arg), deleterious(m_P00492_His204Asp), deleterious(m_P00480_Gly188Arg), deleterious(m_P00441_Leu39Arg), deleterious(m_P00439_Tyr277Asp), deleterious(m_P42336_His1047Arg), deleterious(m_P04156_Phe198Ser), deleterious(m_P00740_Val227Asp), deleterious(m_P00451_Leu26Pro), deleterious(m_P19438_Cys62Gly), deleterious(m_P49747_Gly440Arg), deleterious(m_P11362_Gly237Asp), deleterious(m_P00740_Gly442Glu), deleterious(m_P06280_Cys142Arg), deleterious(m_Q13950_Ser118Arg), deleterious(m_P10746_Gly188Arg), deleterious(m_P00451_Leu117Arg), deleterious(m_P00451_Ser202Arg), deleterious(m_P00451_Tyr492His), deleterious(m_P00740_Cys407Arg), deleterious(m_P01185_Cys116Gly), deleterious(m_Q13496_Gly378Arg), deleterious(m_P01112_Ala146Thr), deleterious(m_P00451_Gly439Asp), deleterious(m_P22033_Gly94Arg), deleterious(m_P49747_Gly440Glu), deleterious(m_P00451_Ser1907Arg), deleterious(m_P00480_Ser90Arg), deleterious(m_P29033_Trp44Ser), deleterious(m_P00480_Met213Lys), deleterious(m_P01241_Cys79Ser), deleterious(m_P63316_Gly159Arg), deleterious(m_P00439_His170Asp), deleterious(m_P00451_Leu2185Ser), deleterious(m_Q06187_Cys155Gly), deleterious(m_P00451_Ser603Arg), deleterious(m_P35557_Gly261Arg), deleterious(m_P98172_Cys153Ser), deleterious(m_Q92838_Thr378Pro), deleterious(m_P00480_His117Arg), deleterious(m_P00451_Cys348Ser), deleterious(m_P00451_Trp2248Ser), deleterious(m_Q15465_Trp117Arg), deleterious(m_P00451_Ala111Thr), deleterious(m_P00451_Ile585Arg), deleterious(m_P35520_Ala288Thr), deleterious(m_Q14203_Gly71Glu), deleterious(m_P08709_Gly402Glu), deleterious(m_P04839_Trp516Arg), deleterious(m_P00441_Gly94Asp), deleterious(m_P05155_Leu481Pro), deleterious(m_P00451_Met2183Arg), deleterious(m_P05186_Ala51Ser), deleterious(m_P00492_Gly16Asp), deleterious(m_P00451_Gln584Arg), deleterious(m_P00451_Ala303Glu), deleterious(m_P05186_Met295Thr), deleterious(m_P06280_His46Pro), deleterious(m_P00492_His204Arg), deleterious(m_P00451_Ser202Asn), deleterious(m_P00451_Gly1869Asp), deleterious(m_O15305_Ile132Thr), deleterious(m_P40337_Tyr156Asn), deleterious(m_P53634_His405Asn), deleterious(m_P13569_Ser549Arg), deleterious(m_P06280_Ala143Thr), deleterious(m_P01308_Cys96Ser), deleterious(m_P35557_Gly261Glu), deleterious(m_P01008_Phe434Ser), deleterious(m_P00480_His168Arg), deleterious(m_P49768_Gly378Glu), deleterious(m_Q06187_Gly594Glu), deleterious(m_P06280_Ser148Arg), deleterious(m_P25445_Thr241Lys), deleterious(m_P00451_Leu26Arg), deleterious(m_P00740_Cys407Ser), deleterious(m_P05186_Tyr297Asp), deleterious(m_P00439_Ile174Thr), deleterious(m_P05186_Thr134Asn), deleterious(m_P19438_Cys99Ser), deleterious(m_P00441_Gly94Arg), deleterious(m_P11413_Gly410Asp), deleterious(m_P13569_Ser549Asn), deleterious(m_P00451_Tyr450Asn), deleterious(m_P00451_Val181Glu), deleterious(m_P06280_Cys56Gly), deleterious(m_P05155_Leu481Arg), deleterious(m_P05186_Gly426Asp), deleterious(m_P21912_Gly53Arg), deleterious(m_P25445_Thr241Pro), deleterious(m_P25189_Ile135Thr), deleterious(m_P00740_Gly357Glu), deleterious(m_P00439_Phe240Ser), deleterious(m_P54803_Gly111Asp), deleterious(m_P48637_Tyr270His), deleterious(m_Q92838_Gly291Arg), deleterious(m_P46100_Cys220Arg), deleterious(m_P00451_Ser392Pro), deleterious(m_P35670_Gly869Arg), deleterious(m_P06280_Cys52Ser), deleterious(m_P09417_Gly17Arg), deleterious(m_P06132_Ala80Ser), deleterious(m_P06280_Cys94Ser), deleterious(m_P21817_Leu13Arg), deleterious(m_P06280_Phe113Ser), deleterious(m_P04275_Cys1272Arg), deleterious(m_P04839_Gly389Glu), deleterious(m_P39019_Trp52Arg), deleterious(m_P05186_Gly334Asp), deleterious(m_Q06187_Cys155Arg), deleterious(m_P00451_Tyr605His), deleterious(m_P07902_Gln317Arg), deleterious(m_Q13950_Ser118Asn), deleterious(m_P06280_Ser148Asn), deleterious(m_P07902_Met142Lys), deleterious(m_O75712_Gly12Asp), deleterious(m_Q03426_His20Asn), deleterious(m_Q06124_Gln510Pro), deleterious(m_P05186_Ala399Ser), deleterious(m_P01111_Gly13Asp), deleterious(m_P00439_Gly344Arg), deleterious(m_Q04771_Gly328Arg), deleterious(m_O75197_Gly171Arg), deleterious(m_P00740_Gly357Arg), deleterious(m_O15305_Ile132Asn), deleterious(m_P25189_Ser54Pro), deleterious(m_P11362_Gly703Arg), deleterious(m_Q14376_Gly302Asp), deleterious(m_P00480_Gly197Arg), deleterious(m_P40692_Gly67Arg), deleterious(m_Q06124_Ala72Ser), deleterious(m_P00441_Ile113Thr), deleterious(m_P29033_Gly12Arg), deleterious(m_P35520_Ala288Pro), deleterious(m_P21953_His206Arg), deleterious(m_Q05066_Met64Arg), deleterious(m_P49768_Ala431Glu), deleterious(m_Q13496_Gly378Glu), deleterious(m_P00451_Gln584Lys), deleterious(m_Q04656_Gly876Glu), deleterious(m_P00480_Cys303Arg), deleterious(m_P00451_Tyr35His), deleterious(m_P06132_Ala80Gly), deleterious(m_Q06124_Ala72Gly), deleterious(m_P19438_Cys117Arg), deleterious(m_P00451_Gly89Asp), deleterious(m_P05186_His171Arg), deleterious(m_P51608_Phe155Ser), deleterious(m_Q92838_Leu266Arg), deleterious(m_P30613_Ala468Gly), deleterious(m_P00966_Gly117Asp), deleterious(m_Q06187_Gly594Arg), deleterious(m_P05186_Gly326Arg), deleterious(m_P00439_Gly171Arg), deleterious(m_P00451_Gln2106Arg), deleterious(m_P53634_His405Arg), deleterious(m_P00451_Gln2106Glu), deleterious(m_O75712_Gly12Arg), deleterious(m_P05186_Gly456Arg), deleterious(m_O14836_Cys104Arg), deleterious(m_P01008_Tyr198His), deleterious(m_P69892_His78Arg), deleterious(m_P43246_Gly692Arg), deleterious(m_P53634_Gly300Asp)

+ Negative Examples: deleterious(m_O75151_Thr56Pro), deleterious(m_P23368_Gly450Glu), deleterious(m_Q6PEY2_Ser101Asn), deleterious(m_Q16690_Ala220Thr)  
develop  humvar398_50   g_or_p(A, g_or_p_disparition) and freq_at_pos(A, B) and B>=2 and secondary_struc(A, other). deleterious(A)
208 (3.47%) 
5 (0.25%) 
7
Covers:
+ Positive Examples: deleterious(m_P00451_Gly1779Arg), deleterious(m_Q04771_Gly328Trp), deleterious(m_P07225_Gly95Glu), deleterious(m_P00480_Pro220Ala), deleterious(m_P54803_Pro318Arg), deleterious(m_P29033_Gly59Ala), deleterious(m_P01112_Gly13Asp), deleterious(m_P07225_Gly95Arg), deleterious(m_P00451_Gly2045Glu), deleterious(m_P08514_Pro176Ala), deleterious(m_P51608_Pro101Ser), deleterious(m_P00966_Gly324Ser), deleterious(m_P46100_Gly249Asp), deleterious(m_P08100_Pro347Ala), deleterious(m_P00451_Gly164Val), deleterious(m_P08100_Pro23His), deleterious(m_P43246_Pro622Leu), deleterious(m_Q04771_Gly328Glu), deleterious(m_P19429_Pro82Ser), deleterious(m_P01112_Gly12Glu), deleterious(m_Q03426_Gly211Glu), deleterious(m_P30613_Gly263Trp), deleterious(m_P01185_Gly88Arg), deleterious(m_P10828_Gly345Arg), deleterious(m_P00441_Gly94Val), deleterious(m_P00740_Pro333Thr), deleterious(m_P98172_Gly151Val), deleterious(m_P08100_Pro23Leu), deleterious(m_P22033_Pro615Arg), deleterious(m_P05186_Gly63Val), deleterious(m_P00451_Gly2045Val), deleterious(m_P06280_Gly328Ala), deleterious(m_P29033_Gly59Ser), deleterious(m_P00966_Gly117Ser), deleterious(m_Q9Y4U1_Gly147Asp), deleterious(m_P98172_Gly151Ser), deleterious(m_P98172_Pro119Ser), deleterious(m_P04275_Pro1266Leu), deleterious(m_P01116_Gly60Arg), deleterious(m_P11413_Gly410Cys), deleterious(m_P06280_Gly328Arg), deleterious(m_Q14203_Gly71Ala), deleterious(m_P49768_Pro436Gln), deleterious(m_P04156_Pro105Leu), deleterious(m_P00451_Gly164Asp), deleterious(m_P00439_Pro281Leu), deleterious(m_P51608_Pro152Arg), deleterious(m_P05186_Gly63Arg), deleterious(m_P00451_Pro470Leu), deleterious(m_P11362_Pro722His), deleterious(m_Q06187_Pro619Ala), deleterious(m_P00451_Gly474Arg), deleterious(m_P00480_Gly188Arg), deleterious(m_P04792_Pro182Leu), deleterious(m_P06280_Pro259Leu), deleterious(m_P41181_Gly180Ser), deleterious(m_Q06187_Pro619Ser), deleterious(m_P06280_Pro409Ala), deleterious(m_P00451_Gly1869Val), deleterious(m_P49747_Gly440Arg), deleterious(m_P11362_Gly237Asp), deleterious(m_P00451_Pro470Arg), deleterious(m_P00740_Gly442Glu), deleterious(m_P15056_Gly596Val), deleterious(m_P22033_Gly215Ser), deleterious(m_P10746_Gly188Arg), deleterious(m_O75792_Gly37Ser), deleterious(m_P02649_Pro102Arg), deleterious(m_P10828_Gly345Val), deleterious(m_O43918_Pro326Gln), deleterious(m_Q13496_Gly378Arg), deleterious(m_P00451_Gly439Asp), deleterious(m_P22033_Gly94Arg), deleterious(m_P49747_Gly440Glu), deleterious(m_P00441_Gly94Cys), deleterious(m_P98172_Pro119His), deleterious(m_P00480_Pro225Arg), deleterious(m_P63316_Gly159Arg), deleterious(m_P01116_Pro34Leu), deleterious(m_P06280_Pro409Thr), deleterious(m_Q9NZR4_Gly160Asp), deleterious(m_P01112_Gly13Cys), deleterious(m_P35670_Gly875Val), deleterious(m_P35557_Gly261Arg), deleterious(m_P53634_Gly300Ser), deleterious(m_P00451_Gly513Ser), deleterious(m_P40692_Pro648Ser), deleterious(m_Q14203_Gly71Glu), deleterious(m_P08709_Gly402Glu), deleterious(m_P53634_Gly301Val), deleterious(m_P00441_Gly94Asp), deleterious(m_P35670_Gly869Val), deleterious(m_P00492_Gly16Asp), deleterious(m_P04839_Gly389Ala), deleterious(m_P51608_Pro101Thr), deleterious(m_P00439_Gly247Val), deleterious(m_P00451_Gly1869Asp), deleterious(m_P02647_Pro27His), deleterious(m_P35557_Gly261Glu), deleterious(m_P22033_Gly94Val), deleterious(m_P49768_Gly378Glu), deleterious(m_P00367_Gly499Asp), deleterious(m_Q06187_Gly594Glu), deleterious(m_P51649_Pro382Gln), deleterious(m_P01009_Pro386Thr), deleterious(m_P51608_Pro101Arg), deleterious(m_P46100_Pro190Ser), deleterious(m_P29965_Gly116Ser), deleterious(m_P00367_Gly499Ser), deleterious(m_P53634_Gly301Ser), deleterious(m_P00441_Gly94Arg), deleterious(m_P06280_Pro40Leu), deleterious(m_P11413_Gly410Asp), deleterious(m_P10746_Gly188Trp), deleterious(m_P05186_Gly426Asp), deleterious(m_P21912_Gly53Arg), deleterious(m_P00740_Gly357Glu), deleterious(m_P40692_Gly67Trp), deleterious(m_P54803_Gly111Asp), deleterious(m_P22033_Gly215Cys), deleterious(m_Q92838_Gly291Arg), deleterious(m_P00740_Gly432Val), deleterious(m_P05155_Pro498Arg), deleterious(m_P00439_Gly239Ser), deleterious(m_Q9Y4U1_Gly147Ala), deleterious(m_P98172_Pro119Thr), deleterious(m_P35670_Gly869Arg), deleterious(m_P46100_Gly249Cys), deleterious(m_P00451_Pro2319Ser), deleterious(m_P29965_Gly116Arg), deleterious(m_P11362_Gly703Ser), deleterious(m_P09417_Gly17Arg), deleterious(m_P51608_Pro101Leu), deleterious(m_P08100_Pro347Gln), deleterious(m_P04839_Gly389Glu), deleterious(m_P00439_Gly344Val), deleterious(m_P00966_Gly324Val), deleterious(m_P54803_Pro318Ala), deleterious(m_P00439_Pro225Thr), deleterious(m_P01112_Gly12Cys), deleterious(m_P05186_Gly334Asp), deleterious(m_P00439_Pro407Ser), deleterious(m_O75712_Gly12Asp), deleterious(m_P11362_Gly237Ser), deleterious(m_P11362_Pro252Arg), deleterious(m_P01116_Pro34Gln), deleterious(m_P08100_Pro347Arg), deleterious(m_P01111_Gly13Asp), deleterious(m_P00439_Gly344Arg), deleterious(m_P00439_Pro314His), deleterious(m_Q04771_Gly328Arg), deleterious(m_P00451_Gly89Val), deleterious(m_O75197_Gly171Arg), deleterious(m_Q06187_Pro619Thr), deleterious(m_P00740_Gly357Arg), deleterious(m_O43918_Pro326Leu), deleterious(m_P11362_Gly703Arg), deleterious(m_Q14376_Gly302Asp), deleterious(m_P35557_Gly80Ala), deleterious(m_Q9UBC3_Gly663Ser), deleterious(m_P00451_Gly439Ser), deleterious(m_Q96QS3_Pro353Leu), deleterious(m_P00480_Gly197Arg), deleterious(m_P00740_Pro333His), deleterious(m_P06280_Pro259Arg), deleterious(m_P10828_Gly345Ser), deleterious(m_P00451_Pro2319Leu), deleterious(m_P00439_Gly171Ala), deleterious(m_P40692_Gly67Arg), deleterious(m_P08709_Gly391Ser), deleterious(m_P15056_Gly466Val), deleterious(m_P29033_Gly12Arg), deleterious(m_Q13496_Gly378Glu), deleterious(m_P00451_Gly439Val), deleterious(m_Q04656_Gly876Glu), deleterious(m_P00480_Pro225Leu), deleterious(m_Q92838_Gly291Trp), deleterious(m_P00740_Gly432Ser), deleterious(m_P00439_Pro225Arg), deleterious(m_P08100_Pro347Ser), deleterious(m_P46100_Pro190Ala), deleterious(m_P01008_Pro439Leu), deleterious(m_P08100_Pro347Leu), deleterious(m_P22033_Pro615Thr), deleterious(m_P01008_Pro439Thr), deleterious(m_P40692_Pro648Leu), deleterious(m_P49768_Pro436Ser), deleterious(m_P05155_Pro498Ser), deleterious(m_P00451_Gly89Asp), deleterious(m_P00966_Gly117Asp), deleterious(m_P51649_Pro382Leu), deleterious(m_Q06187_Gly594Arg), deleterious(m_P04275_Gly1324Ser), deleterious(m_P05186_Gly326Arg), deleterious(m_P00439_Gly171Arg), deleterious(m_P00480_Gly188Val), deleterious(m_P00492_Gly16Ser), deleterious(m_P01116_Pro34Arg), deleterious(m_P11362_Pro722Ser), deleterious(m_O75712_Gly12Arg), deleterious(m_P05186_Gly456Arg), deleterious(m_P00451_Pro470Thr), deleterious(m_P08514_Pro176Leu), deleterious(m_P35557_Gly80Ser), deleterious(m_P43246_Gly692Arg), deleterious(m_P06280_Gly328Val), deleterious(m_P53634_Gly300Asp), deleterious(m_P00480_Pro225Thr)

+ Negative Examples: deleterious(m_O95817_Pro407Leu), deleterious(m_P23368_Gly450Glu), deleterious(m_Q7L576_Gly820Ser), deleterious(m_P07357_Pro575Leu), deleterious(m_P36955_Pro132Arg)  
develop  humvar398_11   modif_polarity(A, polarity_increase) and conservation_class(A, global_conservation_rank_2) and mut_accessibility(A, buried) and stability(A, decrease). deleterious(A)
200 (3.33%) 
5 (0.25%) 
8
Covers:
+ Positive Examples: deleterious(m_Q13501_Gly411Ser), deleterious(m_P58012_Ile80Thr), deleterious(m_P03951_Ile618Ser), deleterious(m_P01185_Gly96Cys), deleterious(m_P58012_Ile84Ser), deleterious(m_P35557_Ile110Thr), deleterious(m_P45381_Met195Arg), deleterious(m_P40692_Met35Arg), deleterious(m_P06280_Trp340Arg), deleterious(m_P00441_Ala146Thr), deleterious(m_P09467_Gly164Ser), deleterious(m_P30613_Ile357Thr), deleterious(m_P10746_Ala69Thr), deleterious(m_P08100_Pro23His), deleterious(m_P06280_Ala156Thr), deleterious(m_P06280_Cys94Tyr), deleterious(m_P02753_Gly93Asp), deleterious(m_Q13496_Leu202Ser), deleterious(m_P06276_Pro65Ser), deleterious(m_P20711_Ala275Thr), deleterious(m_O15305_Phe183Ser), deleterious(m_P00451_Phe2145Cys), deleterious(m_Q13496_Ile264Ser), deleterious(m_P21333_Ala200Ser), deleterious(m_P08100_Gly182Ser), deleterious(m_P40692_Met35Asn), deleterious(m_P10912_Ile171Thr), deleterious(m_P35520_Gly116Arg), deleterious(m_Q15465_Cys183Arg), deleterious(m_P43034_Gly162Ser), deleterious(m_P11532_Leu54Arg), deleterious(m_P00492_Val130Asp), deleterious(m_P06280_Gly138Arg), deleterious(m_Q00266_Ala55Asp), deleterious(m_P30613_Ile314Thr), deleterious(m_Q9Y4U1_Gly147Asp), deleterious(m_P00740_Gly412Glu), deleterious(m_P08236_Pro148Ser), deleterious(m_Q06187_Ala523Glu), deleterious(m_P00740_Gly253Arg), deleterious(m_P30613_Gly332Ser), deleterious(m_P30613_Gly111Arg), deleterious(m_P45381_Gly27Arg), deleterious(m_P00492_Ile42Thr), deleterious(m_Q15465_Phe170Cys), deleterious(m_O43602_Ala152Ser), deleterious(m_Q96EY8_Ile96Thr), deleterious(m_Q06187_Ile429Asn), deleterious(m_P01009_Ile116Asn), deleterious(m_P10275_Ala748Asp), deleterious(m_P05062_Ala175Asp), deleterious(m_P00740_Gly413Arg), deleterious(m_P68032_Ala297Ser), deleterious(m_P11532_Ala168Asp), deleterious(m_P31785_Gly114Asp), deleterious(m_P08397_Ala31Thr), deleterious(m_P54803_Gly284Ser), deleterious(m_P58012_Ile84Asn), deleterious(m_P25189_Gly103Glu), deleterious(m_P00740_Gly442Glu), deleterious(m_P06276_Gly143Asp), deleterious(m_P29965_Ala208Asp), deleterious(m_Q05066_Phe109Ser), deleterious(m_P29965_Leu258Ser), deleterious(m_P29033_Trp44Ser), deleterious(m_P00740_Ile454Thr), deleterious(m_O00294_Phe382Ser), deleterious(m_P45381_Pro280Ser), deleterious(m_Q9UQ90_Gly349Ser), deleterious(m_Q93099_Phe227Ser), deleterious(m_P00740_Gly253Glu), deleterious(m_P00740_Ala265Thr), deleterious(m_P00740_Leu321Gln), deleterious(m_P26367_Val53Asp), deleterious(m_Q13496_Ala389Asp), deleterious(m_P04150_Ile559Asn), deleterious(m_P07902_Pro324Ser), deleterious(m_P19878_Gly78Glu), deleterious(m_P05107_Gly273Arg), deleterious(m_P35914_Gly203Glu), deleterious(m_P54803_Gly553Arg), deleterious(m_P29965_Ala173Asp), deleterious(m_P00480_Ile160Ser), deleterious(m_Q92838_Ile360Asn), deleterious(m_P00451_Gly1967Asp), deleterious(m_P58012_Ile63Thr), deleterious(m_P06280_Cys202Tyr), deleterious(m_P08100_Gly114Asp), deleterious(m_Q92838_Gly255Cys), deleterious(m_Q92838_Gly299Asp), deleterious(m_P07902_Cys130Tyr), deleterious(m_P35557_Cys213Arg), deleterious(m_P00451_Pro2172Arg), deleterious(m_P35557_Ala188Thr), deleterious(m_P00813_Ala215Thr), deleterious(m_P19429_Ala171Thr), deleterious(m_Q02094_Gly280Arg), deleterious(m_P30613_Ala336Ser), deleterious(m_P14222_Ile224Asn), deleterious(m_P02679_Met336Thr), deleterious(m_P10275_Met745Thr), deleterious(m_P00740_Gly357Glu), deleterious(m_Q6PHW0_Ile116Thr), deleterious(m_P06280_Ile91Thr), deleterious(m_O14773_Pro544Ser), deleterious(m_P49748_Gly185Ser), deleterious(m_P01009_Ala84Thr), deleterious(m_P29400_Gly1596Asp), deleterious(m_P16435_Val489Glu), deleterious(m_P54803_Gly111Asp), deleterious(m_Q92838_Gly291Arg), deleterious(m_O00255_Pro282His), deleterious(m_P35557_Met210Lys), deleterious(m_P00439_Ala345Ser), deleterious(m_Q06187_Gly462Asp), deleterious(m_P00451_Gly1872Glu), deleterious(m_P22830_Pro192Thr), deleterious(m_Q8IWL1_Phe198Ser), deleterious(m_Q93099_Gly161Arg), deleterious(m_P06280_Cys94Ser), deleterious(m_P00813_Gly20Arg), deleterious(m_P21953_Gly278Ser), deleterious(m_P98172_Leu98Ser), deleterious(m_P30613_Gly511Arg), deleterious(m_P10275_Ile737Thr), deleterious(m_P08100_Met44Thr), deleterious(m_P11217_Ala660Asp), deleterious(m_Q92947_Leu179Arg), deleterious(m_P00439_Pro225Thr), deleterious(m_P13569_Ala455Glu), deleterious(m_Q13496_Met317Arg), deleterious(m_P35557_Met210Thr), deleterious(m_P19971_Gly145Arg), deleterious(m_P29965_Val237Glu), deleterious(m_P10275_Met895Thr), deleterious(m_P05166_Ala468Thr), deleterious(m_Q05066_Ala113Thr), deleterious(m_P05107_Gly169Arg), deleterious(m_Q06187_Cys506Tyr), deleterious(m_P00439_Gly344Arg), deleterious(m_P08246_Gly214Arg), deleterious(m_P00451_Pro2172Gln), deleterious(m_P58335_Gly105Asp), deleterious(m_P00740_Gly357Arg), deleterious(m_Q92968_Ile326Thr), deleterious(m_P12235_Ala123Asp), deleterious(m_P10746_Gly225Ser), deleterious(m_P00740_Pro414Thr), deleterious(m_Q15465_Ala110Asp), deleterious(m_P05062_Ile74Thr), deleterious(m_O14773_Val385Asp), deleterious(m_P49748_Ala281Asp), deleterious(m_P30613_Ala394Asp), deleterious(m_P48165_Val44Glu), deleterious(m_P00439_Ala300Ser), deleterious(m_P10275_Gly750Asp), deleterious(m_P51648_Pro315Ser), deleterious(m_P08514_Gly273Asp), deleterious(m_Q15465_Cys183Tyr), deleterious(m_P20823_Val259Asp), deleterious(m_Q92838_Gly291Trp), deleterious(m_P54803_Gly59Arg), deleterious(m_P00439_Pro225Arg), deleterious(m_P43235_Gly146Arg), deleterious(m_P56589_Gly138Glu), deleterious(m_P19367_Leu529Ser), deleterious(m_Q15465_Gly143Asp), deleterious(m_P35520_Cys370Tyr), deleterious(m_Q13496_Cys444Tyr), deleterious(m_Q92947_Gly178Arg), deleterious(m_P00441_Gly17Ser), deleterious(m_Q16518_Val473Asp), deleterious(m_O14773_Ala454Glu), deleterious(m_P40692_Gly244Asp), deleterious(m_P51648_Phe419Ser), deleterious(m_P35557_Ala384Thr), deleterious(m_Q92838_Gly255Asp), deleterious(m_Q15465_Ala110Thr), deleterious(m_P00966_Gly117Asp), deleterious(m_P13569_Ile618Thr), deleterious(m_P11217_Gly686Arg), deleterious(m_P23786_Pro604Ser), deleterious(m_Q06187_Ala508Asp), deleterious(m_P26367_Ile42Ser), deleterious(m_P00492_Leu131Ser), deleterious(m_P06276_Pro128Ser), deleterious(m_P40692_Met35Lys), deleterious(m_Q00266_Gly378Ser), deleterious(m_P07602_Cys241Ser), deleterious(m_Q9BZ23_Ile497Thr), deleterious(m_P10275_Ile842Thr), deleterious(m_Q15582_Ala546Thr), deleterious(m_P25189_Ile112Thr), deleterious(m_P09417_Gly23Asp), deleterious(m_P25189_Gly137Ser), deleterious(m_P23786_Met214Thr), deleterious(m_Q13642_Trp122Ser), deleterious(m_P60484_Ala34Asp), deleterious(m_P00492_Ile132Thr), deleterious(m_P00451_Pro1873Arg)

+ Negative Examples: deleterious(m_Q6IMI6_Gly179Arg), deleterious(m_P08218_Gly235Ser), deleterious(m_P48200_Ile580Thr), deleterious(m_O14793_Ile348Thr), deleterious(m_Q8N9L9_Ala187Asp)  
develop  humvar398_55   modif_charge(A, charge_increase) and modif_polarity(A, polarity_increase) and conservation_class(A, global_conservation_rank_1). deleterious(A)
196 (3.27%) 
5 (0.25%) 
9
Covers:
+ Positive Examples: deleterious(m_O75914_Ala380Glu), deleterious(m_P40692_Gly101Asp), deleterious(m_P10275_Leu707Arg), deleterious(m_Q9BZ23_Gly521Arg), deleterious(m_Q06187_Trp581Arg), deleterious(m_P01185_Cys116Arg), deleterious(m_P50336_Gly232Arg), deleterious(m_P05062_Trp148Arg), deleterious(m_Q9UJ71_Trp264Arg), deleterious(m_P07902_Gly179Asp), deleterious(m_P13569_Gly551Asp), deleterious(m_P01009_Gly91Glu), deleterious(m_O75916_Trp299Arg), deleterious(m_Q01968_Trp503Arg), deleterious(m_P00441_Cys147Arg), deleterious(m_Q03426_Gly211Glu), deleterious(m_P10828_Gly345Arg), deleterious(m_Q01968_Gly421Glu), deleterious(m_P08514_Gly380Asp), deleterious(m_P31785_Cys115Arg), deleterious(m_P01008_Leu178His), deleterious(m_Q9Y4U1_Gly156Asp), deleterious(m_P40692_Leu155Arg), deleterious(m_P11217_Trp798Arg), deleterious(m_P51843_Leu381His), deleterious(m_P01008_Trp257Arg), deleterious(m_P10619_Trp65Arg), deleterious(m_P15259_Gly97Asp), deleterious(m_P12955_Gly448Arg), deleterious(m_P05166_Gly112Asp), deleterious(m_P05062_Cys135Arg), deleterious(m_P11172_Gly429Arg), deleterious(m_Q06187_Met630Lys), deleterious(m_P04080_Gly4Arg), deleterious(m_Q13950_Met175Arg), deleterious(m_P49747_Cys348Arg), deleterious(m_P40692_Ile107Arg), deleterious(m_Q13950_Leu113Arg), deleterious(m_Q03692_Trp651Arg), deleterious(m_P05186_Gly120Arg), deleterious(m_P31785_Cys182Arg), deleterious(m_P10275_Met807Arg), deleterious(m_O15305_Gly117Arg), deleterious(m_Q04771_Gly356Asp), deleterious(m_P08559_Gly162Arg), deleterious(m_P01185_Cys59Arg), deleterious(m_P07320_Trp43Arg), deleterious(m_P05106_Cys568Arg), deleterious(m_Q13950_Ile201Lys), deleterious(m_P06280_Cys142Arg), deleterious(m_P05062_Cys178Arg), deleterious(m_P04839_Trp453Arg), deleterious(m_P13569_Gly622Asp), deleterious(m_P45381_Gly123Glu), deleterious(m_P00740_Cys407Arg), deleterious(m_Q13496_Gly378Arg), deleterious(m_O43602_Leu178Arg), deleterious(m_P00480_Gly195Arg), deleterious(m_Q05066_Pro131Arg), deleterious(m_P36551_Trp427Arg), deleterious(m_P98172_Pro119His), deleterious(m_Q03426_Gly202Arg), deleterious(m_Q14117_Trp360Arg), deleterious(m_P13569_Gly628Arg), deleterious(m_Q16595_Trp155Arg), deleterious(m_Q92947_Gly390Arg), deleterious(m_P35520_Gly305Arg), deleterious(m_P35520_Gly151Arg), deleterious(m_Q15465_Trp117Arg), deleterious(m_P00451_Trp412Arg), deleterious(m_P01185_Cys105Arg), deleterious(m_P01008_Met121Lys), deleterious(m_Q14203_Gly71Glu), deleterious(m_P04839_Trp516Arg), deleterious(m_P08514_Gly449Asp), deleterious(m_P35557_Gly299Arg), deleterious(m_P54868_Gly212Arg), deleterious(m_P01008_Gly456Arg), deleterious(m_Q02127_Gly152Arg), deleterious(m_P20711_Pro47His), deleterious(m_Q9Y5X4_Gly56Arg), deleterious(m_Q02094_Gly279Glu), deleterious(m_P08246_Cys71Arg), deleterious(m_P23786_Gly549Asp), deleterious(m_P05166_Gly131Arg), deleterious(m_Q9H9Q4_Cys123Arg), deleterious(m_P09467_Pro284Arg), deleterious(m_Q15583_Pro192Arg), deleterious(m_P10721_Gly601Arg), deleterious(m_O14788_Met199Lys), deleterious(m_Q03692_Cys591Arg), deleterious(m_Q06187_Gly594Glu), deleterious(m_P07902_Trp249Arg), deleterious(m_P13569_Pro574His), deleterious(m_Q9H0P0_Gly280Arg), deleterious(m_P00480_Gly162Arg), deleterious(m_P58335_Cys218Arg), deleterious(m_Q9UIF7_Trp128Arg), deleterious(m_P49748_Gly441Asp), deleterious(m_O14832_Trp193Arg), deleterious(m_P35520_Gly85Arg), deleterious(m_P00480_Pro305His), deleterious(m_P00740_Trp431Arg), deleterious(m_Q15465_Cys102Arg), deleterious(m_Q05066_Gly95Glu), deleterious(m_P39019_Gly127Glu), deleterious(m_P00451_Trp2332Arg), deleterious(m_Q13950_Val156Asp), deleterious(m_O14773_Gly473Arg), deleterious(m_Q13950_Cys123Arg), deleterious(m_P35557_Trp257Arg), deleterious(m_P48436_Trp143Arg), deleterious(m_P10275_Pro904His), deleterious(m_P41181_Ala70Asp), deleterious(m_Q13496_Gly402Arg), deleterious(m_P28358_Met319Lys), deleterious(m_P48436_Pro170Arg), deleterious(m_P29965_Gly257Asp), deleterious(m_P08514_Cys705Arg), deleterious(m_P36551_Gly279Arg), deleterious(m_Q16678_Gly466Asp), deleterious(m_P35520_Gly139Arg), deleterious(m_P05155_Pro498Arg), deleterious(m_P32189_Trp509Arg), deleterious(m_P10275_Trp751Arg), deleterious(m_P29400_Cys1567Arg), deleterious(m_P15382_Trp87Arg), deleterious(m_Q9Y5Y6_Gly827Arg), deleterious(m_Q06187_Gly613Asp), deleterious(m_P08100_Pro267Arg), deleterious(m_P04839_Gly389Glu), deleterious(m_P05166_Gly198Asp), deleterious(m_P39019_Trp52Arg), deleterious(m_Q03692_Gly595Arg), deleterious(m_P05106_Cys586Arg), deleterious(m_Q7LG56_Trp64Arg), deleterious(m_Q13285_Gly35Glu), deleterious(m_Q14117_Gly435Arg), deleterious(m_P02647_Pro167Arg), deleterious(m_Q04656_Gly853Arg), deleterious(m_Q06710_Leu62Arg), deleterious(m_P05155_Gly493Glu), deleterious(m_P29965_Trp140Arg), deleterious(m_P00451_Trp2065Arg), deleterious(m_Q05066_Gly95Arg), deleterious(m_Q05066_Pro108Arg), deleterious(m_P36551_Pro249Arg), deleterious(m_P10828_Gly347Glu), deleterious(m_Q14376_Gly302Asp), deleterious(m_P69892_Trp16Arg), deleterious(m_P02462_Gly1580Arg), deleterious(m_Q06187_Met477Arg), deleterious(m_P00480_Gly197Arg), deleterious(m_P10912_Trp68Arg), deleterious(m_P49748_Gly463Glu), deleterious(m_P21817_Cys35Arg), deleterious(m_P40692_Gly67Arg), deleterious(m_Q06187_Leu518Arg), deleterious(m_Q15582_Gly623Asp), deleterious(m_P05106_Cys601Arg), deleterious(m_Q05066_Met64Arg), deleterious(m_Q13496_Gly378Glu), deleterious(m_Q04656_Gly876Glu), deleterious(m_P10746_Cys73Arg), deleterious(m_P00480_Cys303Arg), deleterious(m_Q92838_Trp274Arg), deleterious(m_Q03692_Leu644Arg), deleterious(m_P19438_Cys59Arg), deleterious(m_P39019_Leu131Arg), deleterious(m_Q9BQB4_Cys167Arg), deleterious(m_P22033_Trp105Arg), deleterious(m_P00740_Trp453Arg), deleterious(m_P19438_Cys117Arg), deleterious(m_P10644_Ala213Asp), deleterious(m_P01185_Cys52Arg), deleterious(m_P36551_Gly280Arg), deleterious(m_P12955_Gly278Asp), deleterious(m_Q06187_Gly594Arg), deleterious(m_P02655_Trp48Arg), deleterious(m_P61916_Cys99Arg), deleterious(m_P00740_Met394Lys), deleterious(m_P39019_Gly120Arg), deleterious(m_P41181_Gly64Arg), deleterious(m_P35520_Gly148Arg), deleterious(m_P04181_Gly353Asp), deleterious(m_P35713_Trp95Arg), deleterious(m_O14773_Gly389Glu), deleterious(m_Q03692_Gly595Glu), deleterious(m_P04839_Cys537Arg), deleterious(m_O14836_Cys104Arg), deleterious(m_P26367_Cys52Arg), deleterious(m_P35670_Leu795Arg), deleterious(m_P06276_Trp499Arg), deleterious(m_Q13950_Met175Lys), deleterious(m_P43246_Gly692Arg), deleterious(m_P49748_Gly290Asp)

+ Negative Examples: deleterious(m_P16870_Trp235Arg), deleterious(m_Q6ZWJ1_Gly92Arg), deleterious(m_Q9NZA1_Pro257His), deleterious(m_Q9Y4X1_Gly308Arg), deleterious(m_O60909_Gly338Arg)  
develop  humvar398_9   conservation_class(A, global_conservation_rank_1) and gain_contact(A, dc) and wt_accessibility(A, buried). deleterious(A)
194 (3.23%) 
4 (0.2%) 
10
Covers:
+ Positive Examples: deleterious(m_P30566_Met26Leu), deleterious(m_P19438_Cys62Tyr), deleterious(m_Q9UGJ0_Arg531Gly), deleterious(m_P00480_Pro220Ala), deleterious(m_P10275_Leu707Arg), deleterious(m_P35557_Gly227Cys), deleterious(m_P10721_Gly812Val), deleterious(m_Q9BZ23_Gly521Arg), deleterious(m_P08235_Asn770Lys), deleterious(m_P35520_Glu144Lys), deleterious(m_Q06187_Trp581Arg), deleterious(m_P50336_Gly232Arg), deleterious(m_Q03426_Ala334Thr), deleterious(m_P14222_Pro345Leu), deleterious(m_P01008_Phe90Leu), deleterious(m_Q06187_Lys430Arg), deleterious(m_P01009_Gly91Glu), deleterious(m_O14832_His175Arg), deleterious(m_P43246_Pro622Leu), deleterious(m_P43699_Trp208Leu), deleterious(m_O75695_Pro95Leu), deleterious(m_P00480_Asp175Val), deleterious(m_O15305_Phe11Cys), deleterious(m_P36897_Lys232Glu), deleterious(m_P10828_Gly345Arg), deleterious(m_Q01968_Gly421Glu), deleterious(m_P51149_Val162Met), deleterious(m_Q14203_Gly59Ser), deleterious(m_P40692_Leu155Arg), deleterious(m_P10619_Trp65Arg), deleterious(m_P51843_Ala300Pro), deleterious(m_P05186_Asp378Val), deleterious(m_P12955_Gly448Arg), deleterious(m_P05062_Cys135Arg), deleterious(m_P11172_Gly429Arg), deleterious(m_P51648_Met328Ile), deleterious(m_Q03692_Trp651Arg), deleterious(m_Q01968_His524Arg), deleterious(m_Q16518_Arg44Gln), deleterious(m_P35557_Glu256Lys), deleterious(m_P31785_Cys182Arg), deleterious(m_Q13496_Asn189Ser), deleterious(m_Q93099_His371Arg), deleterious(m_P10275_Met807Arg), deleterious(m_O15305_Gly117Arg), deleterious(m_Q06187_Pro619Ser), deleterious(m_P49748_Arg469Gln), deleterious(m_P01185_Cys59Arg), deleterious(m_P00491_Tyr192Cys), deleterious(m_P19438_Cys62Gly), deleterious(m_P49748_Glu218Lys), deleterious(m_P07902_Arg231His), deleterious(m_P05106_Cys568Arg), deleterious(m_P15056_Gly596Val), deleterious(m_P05062_Cys178Arg), deleterious(m_P10828_Gly345Val), deleterious(m_P45381_Gly123Glu), deleterious(m_P35914_Asp204Asn), deleterious(m_O43602_Leu178Arg), deleterious(m_P00480_Gly195Arg), deleterious(m_P49748_Asp454Asn), deleterious(m_P06737_Asn377Lys), deleterious(m_P00451_Asn1941Asp), deleterious(m_P22033_Gly145Ser), deleterious(m_P00451_Trp1908Leu), deleterious(m_P06280_Trp95Ser), deleterious(m_P45381_Asp114Glu), deleterious(m_P35520_Gly151Arg), deleterious(m_Q12794_Glu268Lys), deleterious(m_P01185_Cys105Arg), deleterious(m_P39019_Ala135Thr), deleterious(m_Q14203_Gly71Glu), deleterious(m_P03950_Pro136Leu), deleterious(m_Q01968_Asp451Asn), deleterious(m_P05166_Pro228Leu), deleterious(m_P35557_Gly299Arg), deleterious(m_P32322_Arg119His), deleterious(m_Q13496_Arg421Gln), deleterious(m_P54868_Gly212Arg), deleterious(m_P01008_Gly456Arg), deleterious(m_P00492_His204Arg), deleterious(m_P43246_Thr335Ile), deleterious(m_P10275_Leu768Pro), deleterious(m_Q02094_Gly279Glu), deleterious(m_P05166_Gly131Arg), deleterious(m_Q9H9Q4_Cys123Arg), deleterious(m_Q15583_Pro192Arg), deleterious(m_P10721_Gly601Arg), deleterious(m_Q14749_Asn141Ser), deleterious(m_P00480_His168Arg), deleterious(m_Q03692_Cys591Arg), deleterious(m_Q02127_Thr284Ile), deleterious(m_Q9H0P0_Gly280Arg), deleterious(m_P00480_Gly162Arg), deleterious(m_P08397_Gln217Leu), deleterious(m_P35520_Gly85Arg), deleterious(m_P00740_Cys407Ser), deleterious(m_Q15465_Cys102Arg), deleterious(m_P01732_Gly111Ser), deleterious(m_P51648_Thr184Arg), deleterious(m_P13569_Gly458Val), deleterious(m_O14773_Gly473Arg), deleterious(m_Q9Y4U1_Arg161Gln), deleterious(m_P35520_Asn228Lys), deleterious(m_Q13950_Cys123Arg), deleterious(m_Q15833_Arg405Gln), deleterious(m_P39019_Leu131Pro), deleterious(m_O00358_Ala65Val), deleterious(m_P07101_Thr314Met), deleterious(m_Q15582_Thr538Arg), deleterious(m_P01185_Cys92Tyr), deleterious(m_Q04446_His545Arg), deleterious(m_Q13496_Gly402Arg), deleterious(m_P22033_Gly215Cys), deleterious(m_P50897_Arg122Trp), deleterious(m_P29965_Gly257Asp), deleterious(m_P08514_Cys705Arg), deleterious(m_P36551_Gly279Arg), deleterious(m_Q16678_Gly466Asp), deleterious(m_Q13950_Phe121Cys), deleterious(m_P28069_Arg143Gln), deleterious(m_P20933_Thr257Ile), deleterious(m_O14773_Ser475Leu), deleterious(m_Q9Y4U1_Arg161Gly), deleterious(m_Q13496_Arg241Leu), deleterious(m_P06132_Asn304Lys), deleterious(m_P40692_Pro28Leu), deleterious(m_P04839_Gly389Glu), deleterious(m_Q06124_Met508Val), deleterious(m_P05166_Gly198Asp), deleterious(m_P39019_Trp52Arg), deleterious(m_Q03692_Gly595Arg), deleterious(m_P49747_Asp349Val), deleterious(m_Q7LG56_Trp64Arg), deleterious(m_Q9ULV0_Arg656Cys), deleterious(m_Q14117_Gly435Arg), deleterious(m_P10721_Leu656Pro), deleterious(m_P13569_Tyr563Asn), deleterious(m_Q13950_Ser118Asn), deleterious(m_P05155_Gly493Glu), deleterious(m_P40692_Thr117Arg), deleterious(m_Q15582_His626Arg), deleterious(m_P31939_Lys426Arg), deleterious(m_P05186_Gly162Val), deleterious(m_P29965_Thr254Met), deleterious(m_P08100_Tyr178Cys), deleterious(m_P06280_Phe113Leu), deleterious(m_P19971_Lys222Arg), deleterious(m_P00740_Cys396Ser), deleterious(m_Q9BXW9_Arg302Trp), deleterious(m_Q01968_Ser522Arg), deleterious(m_Q06187_Pro619Thr), deleterious(m_P01185_Cys105Tyr), deleterious(m_P00492_Phe74Leu), deleterious(m_P36894_Arg443Cys), deleterious(m_P48165_Glu48Lys), deleterious(m_P69892_Trp16Arg), deleterious(m_P35557_Gly80Ala), deleterious(m_P02462_Gly1580Arg), deleterious(m_P25189_Gly123Cys), deleterious(m_P00480_Gly197Arg), deleterious(m_P10828_Gly345Ser), deleterious(m_P21817_Cys35Arg), deleterious(m_P00740_Gln241Lys), deleterious(m_O60333_Gln98Leu), deleterious(m_Q15582_Gly623Asp), deleterious(m_P18858_Glu566Lys), deleterious(m_P05106_Cys601Arg), deleterious(m_P48637_Asp219Ala), deleterious(m_P10746_Cys73Arg), deleterious(m_P00480_Cys303Arg), deleterious(m_P19438_Cys59Arg), deleterious(m_Q13496_Arg241Cys), deleterious(m_P36551_Gly280Arg), deleterious(m_P01008_Pro461Leu), deleterious(m_P08709_Cys389Gly), deleterious(m_Q15582_His626Pro), deleterious(m_P36551_Ser208Phe), deleterious(m_P49748_Arg453Gln), deleterious(m_Q92838_Trp274Gly), deleterious(m_P50542_Asn526Lys), deleterious(m_P39019_Gly120Arg), deleterious(m_P40692_Thr117Met), deleterious(m_Q04656_Gly860Val), deleterious(m_P35520_Gly148Arg), deleterious(m_O14773_Gly389Glu), deleterious(m_Q16518_Gly40Ser), deleterious(m_Q16518_Gly528Val), deleterious(m_Q01968_Glu468Lys), deleterious(m_O14836_Cys104Arg), deleterious(m_O95409_His286Leu), deleterious(m_P07954_Gly282Val), deleterious(m_P35557_Gly80Ser), deleterious(m_P43246_Gly692Arg)

+ Negative Examples: deleterious(m_P16442_Phe216Ile), deleterious(m_P00338_Ser161Arg), deleterious(m_O60909_Gly338Arg), deleterious(m_Q7Z3Z3_Pro375Ser)  
develop  humvar398_44   modif_charge(A, charge_increase) and modif_hydrophobicity(A, hydrophobicity_decrease) and secondary_struc(A, helix) and wt_accessibility(A, buried) and mut_accessibility(A, buried). deleterious(A)
191 (3.18%) 
5 (0.25%) 
11
Covers:
+ Positive Examples: deleterious(m_Q16678_Gln144Arg), deleterious(m_O75914_Ala380Glu), deleterious(m_P10275_Leu707Arg), deleterious(m_P39019_Leu18Arg), deleterious(m_P05186_Tyr436His), deleterious(m_P45381_Met195Arg), deleterious(m_P51648_Val64Asp), deleterious(m_P06213_Ala1162Glu), deleterious(m_Q01968_Leu891Arg), deleterious(m_P60891_Gly306Arg), deleterious(m_Q06187_Trp581Arg), deleterious(m_P08100_Cys167Arg), deleterious(m_P07686_Ser255Arg), deleterious(m_P40692_Met35Arg), deleterious(m_Q13144_Trp628Arg), deleterious(m_Q92947_Gly354Arg), deleterious(m_P21439_Ala546Asp), deleterious(m_P13569_Gly551Asp), deleterious(m_P00439_Gln304Arg), deleterious(m_P21912_Leu65His), deleterious(m_O75916_Trp299Arg), deleterious(m_P00492_Met143Lys), deleterious(m_P35680_Gln136Glu), deleterious(m_P06132_Met165Arg), deleterious(m_P08236_Tyr626His), deleterious(m_P51649_Gly268Glu), deleterious(m_P08235_Gln776Arg), deleterious(m_P11217_Trp798Arg), deleterious(m_P08236_Gly572Asp), deleterious(m_P51843_Leu381His), deleterious(m_P16615_Cys318Arg), deleterious(m_P11532_Leu54Arg), deleterious(m_P05186_Gly339Arg), deleterious(m_P06280_Val316Glu), deleterious(m_Q8WWY3_Ala194Glu), deleterious(m_P00480_Gly100Asp), deleterious(m_P69892_Gly26Glu), deleterious(m_Q06187_Met630Lys), deleterious(m_P08100_Met216Lys), deleterious(m_P06276_Ala356Asp), deleterious(m_P51843_Tyr380Asp), deleterious(m_P08397_Leu177Arg), deleterious(m_P45381_Gly27Arg), deleterious(m_P22033_Gly203Arg), deleterious(m_P06280_Ala288Asp), deleterious(m_P08100_Ala164Glu), deleterious(m_P10275_Met807Arg), deleterious(m_P10275_Ala748Asp), deleterious(m_P22033_Gly642Arg), deleterious(m_P05062_Ala175Asp), deleterious(m_P29033_Gln80Lys), deleterious(m_P11532_Ala168Asp), deleterious(m_P60484_Ser170Arg), deleterious(m_P06280_Tyr216Asp), deleterious(m_P35557_Ala119Asp), deleterious(m_P05062_Cys178Arg), deleterious(m_P40692_Leu622His), deleterious(m_P01116_Gln22Arg), deleterious(m_Q15582_Val505Asp), deleterious(m_P08100_Gly109Arg), deleterious(m_P16615_Gly769Arg), deleterious(m_Q14117_Trp360Arg), deleterious(m_P00480_Met206Arg), deleterious(m_Q92947_Cys375Arg), deleterious(m_Q13093_Gln281Arg), deleterious(m_P30613_Val134Asp), deleterious(m_P35520_Gly151Arg), deleterious(m_P30613_Ala352Asp), deleterious(m_P26367_Ile87Arg), deleterious(m_O00255_Gly310Asp), deleterious(m_Q16678_Gly232Arg), deleterious(m_O75695_Leu253Arg), deleterious(m_P26367_Val53Asp), deleterious(m_Q13496_Ala389Asp), deleterious(m_P01008_Met121Lys), deleterious(m_P08100_Thr58Arg), deleterious(m_P53634_Gln286Arg), deleterious(m_P00740_Thr342Lys), deleterious(m_P08397_Cys247Arg), deleterious(m_P19878_Gly78Glu), deleterious(m_P00813_Ala83Asp), deleterious(m_P41181_Gly100Arg), deleterious(m_P13804_Gly116Arg), deleterious(m_P08397_Leu85Arg), deleterious(m_P05107_Gly273Arg), deleterious(m_P06280_Gln279Glu), deleterious(m_P11362_Gly687Arg), deleterious(m_Q02094_Gly279Glu), deleterious(m_P08246_Cys71Arg), deleterious(m_P05166_Gly131Arg), deleterious(m_P08100_Gly114Asp), deleterious(m_P54803_Gly286Asp), deleterious(m_P02649_Cys130Arg), deleterious(m_Q92793_Tyr1450His), deleterious(m_Q9H0P0_Gly280Arg), deleterious(m_P50897_Gln177Glu), deleterious(m_Q02127_Gly202Asp), deleterious(m_Q9UIF7_Trp128Arg), deleterious(m_P49748_Gly441Asp), deleterious(m_P35557_Cys213Arg), deleterious(m_P08100_Val87Asp), deleterious(m_P22033_Ala197Glu), deleterious(m_Q15465_Cys102Arg), deleterious(m_P00813_Leu304Arg), deleterious(m_P08397_Gly335Asp), deleterious(m_P39019_Gly127Glu), deleterious(m_Q12809_Leu86Arg), deleterious(m_Q15582_Leu569Arg), deleterious(m_Q02094_Gly280Arg), deleterious(m_P35557_Trp257Arg), deleterious(m_P22033_Gly291Glu), deleterious(m_P22033_Gly637Glu), deleterious(m_P08100_Met207Arg), deleterious(m_P41181_Ala70Asp), deleterious(m_P06280_Gly183Asp), deleterious(m_P16435_Val489Glu), deleterious(m_P00439_Ser87Arg), deleterious(m_P35557_Met210Lys), deleterious(m_P32189_Trp509Arg), deleterious(m_P49748_Gln159Arg), deleterious(m_Q9UIF7_Tyr125His), deleterious(m_P00813_Gly20Arg), deleterious(m_P00813_Gly140Glu), deleterious(m_P05166_Val205Asp), deleterious(m_P11217_Ala660Asp), deleterious(m_Q92947_Tyr295His), deleterious(m_Q13496_Met317Arg), deleterious(m_P32929_Gln240Glu), deleterious(m_P30613_Gln421Lys), deleterious(m_P40692_Thr117Arg), deleterious(m_P00480_Ser207Arg), deleterious(m_P10275_Val866Glu), deleterious(m_P22033_Ala377Glu), deleterious(m_P11362_Trp666Arg), deleterious(m_Q15582_Leu518Arg), deleterious(m_P30613_Gly275Arg), deleterious(m_P02649_Leu270Glu), deleterious(m_P58335_Gly105Asp), deleterious(m_P40692_Ala589Asp), deleterious(m_P12235_Ala123Asp), deleterious(m_O15118_Cys113Arg), deleterious(m_P16615_Gly749Arg), deleterious(m_Q15465_Ala110Asp), deleterious(m_P08100_Gly51Arg), deleterious(m_O15305_Thr237Arg), deleterious(m_P30613_Ala394Asp), deleterious(m_P08235_Ser815Arg), deleterious(m_P48165_Val44Glu), deleterious(m_P08100_Leu125Arg), deleterious(m_Q15046_Leu105His), deleterious(m_P10275_Gly750Asp), deleterious(m_P06276_Gly393Arg), deleterious(m_P08397_Gln34Lys), deleterious(m_P35520_Thr262Arg), deleterious(m_P22830_Met288Lys), deleterious(m_P10746_Cys73Arg), deleterious(m_P22033_Gly637Arg), deleterious(m_P61764_Val84Asp), deleterious(m_P43235_Gly146Arg), deleterious(m_P01112_Gln22Lys), deleterious(m_P56589_Gly138Glu), deleterious(m_P39019_Leu131Arg), deleterious(m_P08397_Leu245Arg), deleterious(m_P48637_Ala26Asp), deleterious(m_P00439_Ala309Asp), deleterious(m_P22033_Thr566Arg), deleterious(m_P00740_Trp453Arg), deleterious(m_Q13873_Cys123Arg), deleterious(m_P08100_Ala292Glu), deleterious(m_P26367_Ile87Lys), deleterious(m_Q15582_Leu509Arg), deleterious(m_P00966_Cys19Arg), deleterious(m_P61764_Met443Arg), deleterious(m_P16615_Ala745Asp), deleterious(m_P06213_Ala1075Asp), deleterious(m_Q06187_Ala508Asp), deleterious(m_P01116_Gln22Glu), deleterious(m_P22033_Leu685Arg), deleterious(m_O15305_Leu32Arg), deleterious(m_P40692_Met35Lys), deleterious(m_P08397_Gln34Arg), deleterious(m_P12271_Met226Lys), deleterious(m_P41181_Gly175Arg), deleterious(m_P10275_Gly743Glu), deleterious(m_P04181_Gly353Asp), deleterious(m_P02730_Ala285Asp), deleterious(m_P39019_Ala61Glu), deleterious(m_P09417_Gly23Asp), deleterious(m_P06276_Trp499Arg), deleterious(m_P00480_Tyr55Asp), deleterious(m_P10275_Gln711Glu)

+ Negative Examples: deleterious(m_P30486_Tyr195His), deleterious(m_P01889_Tyr195His), deleterious(m_Q08043_Cys628Arg), deleterious(m_P04440_Ala84Asp), deleterious(m_Q31610_Tyr195His)  
develop  humvar398_80   modif_size(A, size_increase) and modif_polarity(A, polarity_unchanged) and conservation_class(A, global_conservation_rank_1) and wt_accessibility(A, buried). deleterious(A)
180 (3.0%) 
4 (0.2%) 
12
Covers:
+ Positive Examples: deleterious(m_P22033_Pro86Leu), deleterious(m_P00480_Leu301Phe), deleterious(m_P10721_Gly812Val), deleterious(m_P08235_Asn770Lys), deleterious(m_P00740_Gln241His), deleterious(m_Q13950_Leu199Phe), deleterious(m_P35520_Glu176Lys), deleterious(m_P35520_Ser349Asn), deleterious(m_P43246_His639Arg), deleterious(m_P35520_Glu144Lys), deleterious(m_Q06124_Gln510Arg), deleterious(m_P14222_Pro345Leu), deleterious(m_Q13950_Gln209Arg), deleterious(m_P29965_Gly227Val), deleterious(m_Q06187_Lys430Arg), deleterious(m_O14832_His175Arg), deleterious(m_P43246_Pro622Leu), deleterious(m_P35680_Gln136Glu), deleterious(m_O00294_Lys489Arg), deleterious(m_P07954_Gln185Arg), deleterious(m_O75695_Pro95Leu), deleterious(m_Q01968_Pro495Leu), deleterious(m_P43034_Asp317His), deleterious(m_P00480_Asp196Tyr), deleterious(m_P23786_Pro227Leu), deleterious(m_Q06187_Ser578Tyr), deleterious(m_P51149_Val162Met), deleterious(m_P08235_Gln776Arg), deleterious(m_Q15582_Asn622Lys), deleterious(m_Q13496_His232Arg), deleterious(m_Q06187_Asp521His), deleterious(m_P08397_Gln217His), deleterious(m_Q15582_His572Arg), deleterious(m_P51843_Ala300Pro), deleterious(m_P36551_Glu201Lys), deleterious(m_P48728_His42Arg), deleterious(m_P00441_His49Arg), deleterious(m_Q13950_Thr205Arg), deleterious(m_O14521_Asp92Tyr), deleterious(m_P35520_Ala155Val), deleterious(m_P45381_Asp114Tyr), deleterious(m_Q01968_His524Arg), deleterious(m_P35557_Glu256Lys), deleterious(m_Q93099_His371Arg), deleterious(m_P06280_Asp264Tyr), deleterious(m_P00441_Ile113Met), deleterious(m_P06280_Asp92Tyr), deleterious(m_P51159_Ala152Pro), deleterious(m_P41181_Val168Met), deleterious(m_P49748_Glu218Lys), deleterious(m_Q13950_Ala211Pro), deleterious(m_O14773_Pro202Leu), deleterious(m_Q8WVQ1_Pro299Leu), deleterious(m_P15056_Gly596Val), deleterious(m_Q13950_Ser118Arg), deleterious(m_P10828_Gly345Val), deleterious(m_P05166_Gly246Val), deleterious(m_Q92947_His403Arg), deleterious(m_P32754_Ala268Val), deleterious(m_P06737_Asn377Lys), deleterious(m_P01009_Glu366Lys), deleterious(m_P23760_Ile59Phe), deleterious(m_Q06187_Asn526Lys), deleterious(m_P45381_Asp114Glu), deleterious(m_P00480_Leu304Phe), deleterious(m_Q9BZ23_Gly219Val), deleterious(m_Q06187_Glu589Lys), deleterious(m_Q12794_Glu268Lys), deleterious(m_P03950_Pro136Leu), deleterious(m_P63261_Pro264Leu), deleterious(m_P05166_Pro228Leu), deleterious(m_P51648_Pro121Leu), deleterious(m_P00492_His204Arg), deleterious(m_Q7LG56_Glu194Lys), deleterious(m_O14773_Gln422His), deleterious(m_Q92947_Glu414Lys), deleterious(m_Q8NI22_Asp129Glu), deleterious(m_P10275_Leu762Phe), deleterious(m_P00480_His168Arg), deleterious(m_P03950_Cys63Trp), deleterious(m_P50897_Gln177Glu), deleterious(m_P05166_Val107Met), deleterious(m_P51843_Glu377Lys), deleterious(m_Q16678_Asn423Tyr), deleterious(m_Q16678_Ala330Phe), deleterious(m_Q12948_Ile126Met), deleterious(m_P40692_Asp63Glu), deleterious(m_P51648_Thr184Arg), deleterious(m_P13569_Gly458Val), deleterious(m_P35520_Val371Met), deleterious(m_P40763_Ser611Asn), deleterious(m_P35914_Asp42His), deleterious(m_P31271_Asn372His), deleterious(m_P35520_Asn228Lys), deleterious(m_O00358_Ala65Val), deleterious(m_O14832_Asn269His), deleterious(m_P10275_Asp767Glu), deleterious(m_Q15582_Thr538Arg), deleterious(m_P00480_Asn198Lys), deleterious(m_Q04446_His545Arg), deleterious(m_P51648_Pro114Leu), deleterious(m_P10275_Leu812Phe), deleterious(m_Q9NUW8_His493Arg), deleterious(m_P43699_Val205Phe), deleterious(m_Q13950_Gln209His), deleterious(m_P08100_Pro171Leu), deleterious(m_Q12948_Ile87Met), deleterious(m_P43080_Asp100Glu), deleterious(m_Q16595_Ile154Phe), deleterious(m_P05166_Ser106Arg), deleterious(m_P10275_Ala765Val), deleterious(m_Q8WWY3_Ala216Pro), deleterious(m_P35914_His233Arg), deleterious(m_P43034_His149Arg), deleterious(m_P06132_Asn304Lys), deleterious(m_Q01968_Asp499His), deleterious(m_P40692_Pro28Leu), deleterious(m_Q9NZR4_Gln175His), deleterious(m_P00441_His47Arg), deleterious(m_P35914_Glu37Lys), deleterious(m_P35520_Ile143Met), deleterious(m_Q16595_Leu182Phe), deleterious(m_Q96EY8_Glu193Lys), deleterious(m_P15056_Asp638Glu), deleterious(m_P10275_Gln733His), deleterious(m_Q13950_Ser118Asn), deleterious(m_P06280_Asp92His), deleterious(m_P40692_Thr117Arg), deleterious(m_P10275_Asp732Tyr), deleterious(m_Q15582_His626Arg), deleterious(m_P31939_Lys426Arg), deleterious(m_P35914_Glu279Lys), deleterious(m_P00480_Ala174Pro), deleterious(m_P05186_Gly162Val), deleterious(m_P08514_Cys161Trp), deleterious(m_P19971_Lys222Arg), deleterious(m_Q03426_Gly376Val), deleterious(m_P00740_Cys268Trp), deleterious(m_Q01968_Ser522Arg), deleterious(m_Q13496_Gly402Val), deleterious(m_P43246_Pro349Leu), deleterious(m_Q12948_Leu130Phe), deleterious(m_P48165_Glu48Lys), deleterious(m_P35557_Glu300Lys), deleterious(m_P00740_Gln241Lys), deleterious(m_P18858_Glu566Lys), deleterious(m_P08397_Gln34Lys), deleterious(m_Q92838_Gln306His), deleterious(m_P51843_Ala300Val), deleterious(m_P01008_Pro439Leu), deleterious(m_P15056_Glu501Lys), deleterious(m_P35916_His1035Arg), deleterious(m_P01008_Ala416Pro), deleterious(m_Q14623_Glu131Lys), deleterious(m_P40692_Pro648Leu), deleterious(m_P35914_Asp42Glu), deleterious(m_Q14232_Asn208Tyr), deleterious(m_P00441_His44Arg), deleterious(m_P13569_Val520Phe), deleterious(m_O14958_Asp307His), deleterious(m_P06280_Asp266His), deleterious(m_P02545_Asn456Lys), deleterious(m_P35916_Pro1114Leu), deleterious(m_P01008_Pro461Leu), deleterious(m_P49747_Asp342Tyr), deleterious(m_P01008_Asn219Lys), deleterious(m_P51649_Pro382Leu), deleterious(m_P50542_Asn526Lys), deleterious(m_P08397_Gln34Arg), deleterious(m_Q01968_Gln277Arg), deleterious(m_Q04656_Gly860Val), deleterious(m_O14832_Gln176Lys), deleterious(m_Q06187_Glu567Lys), deleterious(m_P01008_Gln133Lys), deleterious(m_Q16518_Gly528Val), deleterious(m_Q9H0F7_Ala89Val), deleterious(m_Q01968_Glu468Lys), deleterious(m_P08559_Pro217Leu), deleterious(m_P07954_Gly282Val), deleterious(m_P10275_Gln711Glu)

+ Negative Examples: deleterious(m_P42025_Ala143Val), deleterious(m_Q9UQ84_Val76Ile), deleterious(m_P00338_Ser161Arg), deleterious(m_Q8WW01_Gln59His)  
develop  humvar398_14   g_or_p(A, g_or_p_disparition) and gain_contact(A, phob) and wt_accessibility(A, buried). deleterious(A)
173 (2.88%) 
5 (0.25%) 
13
Covers:
+ Positive Examples: deleterious(m_P22033_Pro86Leu), deleterious(m_P00451_Gly1779Arg), deleterious(m_P51857_Pro198Leu), deleterious(m_P04839_Gly408Glu), deleterious(m_P10721_Gly812Val), deleterious(m_Q9BZ23_Gly521Arg), deleterious(m_P00451_Gly2045Glu), deleterious(m_P16930_Gly369Val), deleterious(m_P29965_Gly227Val), deleterious(m_P05155_Gly345Arg), deleterious(m_P01009_Gly91Glu), deleterious(m_P00451_Gly164Val), deleterious(m_P43246_Pro622Leu), deleterious(m_Q04771_Gly328Glu), deleterious(m_P20933_Gly252Arg), deleterious(m_P08514_Gly412Arg), deleterious(m_P00451_Gly193Arg), deleterious(m_P00558_Gly158Val), deleterious(m_P35557_Gly385Val), deleterious(m_Q03426_Gly211Glu), deleterious(m_P50053_Gly40Arg), deleterious(m_P30613_Gly263Trp), deleterious(m_Q01968_Pro495Leu), deleterious(m_P51649_Gly268Glu), deleterious(m_P10828_Gly345Arg), deleterious(m_P00451_Gly266Glu), deleterious(m_P00441_Gly86Arg), deleterious(m_P08514_Gly380Asp), deleterious(m_P00480_Gly83Arg), deleterious(m_P05186_Gly63Val), deleterious(m_P35520_Gly116Arg), deleterious(m_P05186_Gly339Arg), deleterious(m_P00451_Pro1780Leu), deleterious(m_P10644_Gly289Trp), deleterious(m_P00740_Gly412Glu), deleterious(m_P05166_Gly112Asp), deleterious(m_P08100_Gly51Val), deleterious(m_P03951_Gly263Glu), deleterious(m_P16930_Pro261Leu), deleterious(m_P00451_Gly466Glu), deleterious(m_P05186_Gly120Arg), deleterious(m_P00451_Gly164Asp), deleterious(m_P54803_Gly323Arg), deleterious(m_P51857_Pro133Arg), deleterious(m_P11413_Gly131Val), deleterious(m_P00451_Gly474Arg), deleterious(m_P04839_Gly408Arg), deleterious(m_P08559_Gly162Arg), deleterious(m_P25189_Gly103Glu), deleterious(m_O14773_Pro202Leu), deleterious(m_P15056_Gly596Val), deleterious(m_P06276_Gly143Asp), deleterious(m_P10828_Gly345Val), deleterious(m_P05166_Gly246Val), deleterious(m_P45381_Gly123Glu), deleterious(m_P00451_Gly2304Val), deleterious(m_P45381_Pro280Leu), deleterious(m_P00480_Gly195Arg), deleterious(m_P00451_Gly439Asp), deleterious(m_Q13651_Gly141Arg), deleterious(m_P16615_Gly769Arg), deleterious(m_P30613_Gly364Asp), deleterious(m_P35670_Gly875Val), deleterious(m_P05156_Gly287Arg), deleterious(m_P10275_Gly708Val), deleterious(m_P35520_Gly151Arg), deleterious(m_P35557_Gly261Arg), deleterious(m_Q9BZ23_Gly219Val), deleterious(m_P00740_Gly351Asp), deleterious(m_O75369_Gly1834Arg), deleterious(m_P30613_Gly165Val), deleterious(m_P63261_Pro264Leu), deleterious(m_P53634_Gly301Val), deleterious(m_P08100_Gly188Arg), deleterious(m_P05166_Pro228Leu), deleterious(m_P20933_Gly252Glu), deleterious(m_P19878_Gly78Glu), deleterious(m_P54868_Gly212Arg), deleterious(m_P13804_Gly116Arg), deleterious(m_P05107_Gly273Arg), deleterious(m_P35914_Gly203Glu), deleterious(m_Q02094_Gly279Glu), deleterious(m_P00813_Gly216Arg), deleterious(m_P54803_Gly553Arg), deleterious(m_P31785_Gly232Arg), deleterious(m_P16615_Gly211Asp), deleterious(m_P00480_Gly50Arg), deleterious(m_P05186_Gly220Val), deleterious(m_P24752_Gly379Val), deleterious(m_P35557_Gly261Glu), deleterious(m_P54803_Gly286Asp), deleterious(m_P22033_Gly94Val), deleterious(m_P08100_Gly106Trp), deleterious(m_Q92838_Gly299Asp), deleterious(m_P00480_Gly162Arg), deleterious(m_P00451_Pro2172Arg), deleterious(m_P00451_Gly92Ala), deleterious(m_P35520_Gly85Arg), deleterious(m_P00451_Gly710Trp), deleterious(m_P39019_Gly127Glu), deleterious(m_Q02094_Gly280Arg), deleterious(m_P36551_Gly197Trp), deleterious(m_P25189_Gly110Asp), deleterious(m_P22033_Gly637Glu), deleterious(m_P22830_Pro334Leu), deleterious(m_Q13485_Gly352Arg), deleterious(m_P08246_Pro139Leu), deleterious(m_P35680_Gly285Asp), deleterious(m_P54803_Gly111Asp), deleterious(m_Q92838_Gly291Arg), deleterious(m_O00255_Pro282His), deleterious(m_Q16678_Gly466Asp), deleterious(m_P03951_Pro538Leu), deleterious(m_P00451_Gly1872Glu), deleterious(m_P24752_Gly183Arg), deleterious(m_P09417_Gly17Arg), deleterious(m_P00813_Gly140Glu), deleterious(m_P04839_Gly389Glu), deleterious(m_P30613_Gly511Arg), deleterious(m_P30613_Gly159Val), deleterious(m_P05166_Gly198Asp), deleterious(m_Q03426_Gly326Arg), deleterious(m_Q14117_Gly435Arg), deleterious(m_P05155_Gly493Glu), deleterious(m_P14222_Gly429Glu), deleterious(m_P49747_Gly299Arg), deleterious(m_P13716_Gly133Arg), deleterious(m_P00439_Gly344Arg), deleterious(m_O75197_Gly171Arg), deleterious(m_P30613_Gly275Arg), deleterious(m_Q03426_Gly376Val), deleterious(m_Q01968_Gly357Glu), deleterious(m_P22033_Gly623Arg), deleterious(m_P08100_Gly51Arg), deleterious(m_Q96QS3_Pro353Leu), deleterious(m_P06132_Gly281Val), deleterious(m_P01308_Gly84Arg), deleterious(m_Q99593_Gly80Arg), deleterious(m_P10275_Gly750Asp), deleterious(m_P06276_Gly393Arg), deleterious(m_P08100_Gly188Glu), deleterious(m_Q13501_Pro387Leu), deleterious(m_P08514_Gly273Asp), deleterious(m_P07949_Pro64Leu), deleterious(m_P51648_Gly406Arg), deleterious(m_P50897_Gly108Arg), deleterious(m_P00451_Gly439Val), deleterious(m_Q92838_Gly291Trp), deleterious(m_P05156_Gly243Asp), deleterious(m_Q03426_Pro167Leu), deleterious(m_P22033_Gly637Arg), deleterious(m_P01008_Pro439Leu), deleterious(m_P69892_Gly73Arg), deleterious(m_Q15465_Gly143Asp), deleterious(m_P53634_Gly139Arg), deleterious(m_P41181_Gly100Val), deleterious(m_P23786_Gly600Arg), deleterious(m_P22033_Gly703Arg), deleterious(m_P40692_Gly244Asp), deleterious(m_P08397_Gly260Asp), deleterious(m_P40692_Pro654Leu), deleterious(m_P06132_Gly281Glu), deleterious(m_P36551_Gly280Arg), deleterious(m_P32322_Gly206Arg), deleterious(m_P22033_Pro95Arg), deleterious(m_Q92838_Gly381Arg), deleterious(m_P41181_Gly175Arg), deleterious(m_P10275_Gly743Val), deleterious(m_Q16518_Pro363Thr), deleterious(m_P06213_Gly1035Val), deleterious(m_P08514_Pro176Leu), deleterious(m_P43246_Gly692Arg), deleterious(m_P06280_Gly328Val)

+ Negative Examples: deleterious(m_Q460N3_Gly606Arg), deleterious(m_Q6IMI6_Gly179Arg), deleterious(m_P20813_Gly99Glu), deleterious(m_O60909_Gly338Arg), deleterious(m_P00450_Pro477Leu)  
develop  humvar398_69   modif_polarity(A, polarity_decrease) and g_or_p(A, g_or_p_unchanged) and conservation_class(A, global_conservation_rank_1) and stability(A, decrease). deleterious(A)
173 (2.88%) 
5 (0.25%) 
13
Covers:
+ Positive Examples: deleterious(m_P12271_Arg234Trp), deleterious(m_P08397_Arg173Trp), deleterious(m_O43819_Arg171Trp), deleterious(m_P28329_Arg420Cys), deleterious(m_O43186_Glu80Ala), deleterious(m_P52952_Thr178Met), deleterious(m_Q12840_Tyr276Cys), deleterious(m_P10275_Glu772Ala), deleterious(m_P08709_Cys370Phe), deleterious(m_P60484_Arg173Cys), deleterious(m_Q13950_Arg190Trp), deleterious(m_P11498_Tyr304Cys), deleterious(m_Q16518_Tyr435Cys), deleterious(m_P54868_Tyr167Cys), deleterious(m_P00451_Trp2290Leu), deleterious(m_P23786_Arg503Cys), deleterious(m_P11511_Arg375Cys), deleterious(m_P06280_Trp236Leu), deleterious(m_P04424_Arg111Trp), deleterious(m_P43699_Trp208Leu), deleterious(m_P15313_Arg157Cys), deleterious(m_O75695_Arg118Leu), deleterious(m_P51857_Arg261Cys), deleterious(m_P30566_Arg396Cys), deleterious(m_P11511_Arg435Cys), deleterious(m_P48637_Arg283Cys), deleterious(m_Q9Y4U1_Arg206Trp), deleterious(m_P39019_Arg62Trp), deleterious(m_P16435_Tyr575Cys), deleterious(m_P06280_Asp264Val), deleterious(m_P15259_Glu89Ala), deleterious(m_P15259_Arg90Trp), deleterious(m_P61916_Cys47Phe), deleterious(m_P20823_Arg203Cys), deleterious(m_Q06124_Arg502Trp), deleterious(m_O43602_Arg159Leu), deleterious(m_P35520_Arg121Leu), deleterious(m_P23760_Ser84Phe), deleterious(m_Q13642_Cys132Phe), deleterious(m_P05166_Tyr439Cys), deleterious(m_P54803_Tyr314Cys), deleterious(m_O00358_Arg102Cys), deleterious(m_Q92947_Arg294Trp), deleterious(m_Q06187_Trp563Leu), deleterious(m_P52952_Arg142Cys), deleterious(m_P11161_Arg359Trp), deleterious(m_P00491_Tyr192Cys), deleterious(m_P28069_Arg271Trp), deleterious(m_P02489_Arg116Cys), deleterious(m_Q06187_Tyr598Cys), deleterious(m_P02545_Arg377Leu), deleterious(m_P11161_Arg409Trp), deleterious(m_O14521_Tyr114Cys), deleterious(m_P12694_Arg159Trp), deleterious(m_P04181_Tyr245Cys), deleterious(m_P00451_Trp1908Leu), deleterious(m_Q14376_Arg239Trp), deleterious(m_P16930_Asp233Val), deleterious(m_P29965_Tyr170Cys), deleterious(m_P45381_Asp68Ala), deleterious(m_P15313_Arg124Trp), deleterious(m_Q05066_Tyr127Cys), deleterious(m_Q93099_Tyr62Cys), deleterious(m_P05166_Arg512Cys), deleterious(m_P11161_Arg381Cys), deleterious(m_P25189_Arg98Cys), deleterious(m_Q06124_Tyr279Cys), deleterious(m_P10828_Arg320Cys), deleterious(m_P55316_Arg244Cys), deleterious(m_P10275_Arg855Cys), deleterious(m_O15305_Arg141Cys), deleterious(m_P43246_Thr335Ile), deleterious(m_Q9NRR6_Arg378Cys), deleterious(m_O75695_Arg118Cys), deleterious(m_P54803_Tyr335Cys), deleterious(m_P01185_Cys58Phe), deleterious(m_P10746_Thr62Ala), deleterious(m_P09417_Tyr150Cys), deleterious(m_P08559_Thr231Ala), deleterious(m_Q02127_Thr284Ile), deleterious(m_P54819_Arg103Trp), deleterious(m_Q9UIF7_Arg238Trp), deleterious(m_Q13950_Thr200Ala), deleterious(m_P08397_Gln217Leu), deleterious(m_P10275_Tyr834Cys), deleterious(m_P36551_Arg328Cys), deleterious(m_P08100_Cys110Phe), deleterious(m_O43186_Arg90Trp), deleterious(m_P06280_Asp165Val), deleterious(m_P50336_Arg152Cys), deleterious(m_O95409_Arg325Leu), deleterious(m_P23760_Ser73Leu), deleterious(m_P49748_Arg366Cys), deleterious(m_O95954_Arg135Cys), deleterious(m_P07101_Thr314Met), deleterious(m_P10912_Tyr226Cys), deleterious(m_P01185_Cys104Phe), deleterious(m_Q06187_Arg641Cys), deleterious(m_P50897_Arg122Trp), deleterious(m_Q13950_Thr200Ile), deleterious(m_P98172_Thr137Ala), deleterious(m_Q16518_Tyr431Cys), deleterious(m_O14773_Ser475Leu), deleterious(m_P35557_Thr209Met), deleterious(m_P04181_Arg154Leu), deleterious(m_Q13496_Arg241Leu), deleterious(m_Q96EY8_Arg191Trp), deleterious(m_P52701_Arg772Trp), deleterious(m_P08397_Arg26Cys), deleterious(m_O43602_Arg140Leu), deleterious(m_Q9Y5X4_Arg104Trp), deleterious(m_P10746_Tyr19Cys), deleterious(m_P41181_Arg187Cys), deleterious(m_P40337_Ser65Ala), deleterious(m_P05186_Arg71Cys), deleterious(m_P11161_Asp355Val), deleterious(m_Q9ULV0_Arg656Cys), deleterious(m_P23760_Arg56Leu), deleterious(m_P29965_Thr254Met), deleterious(m_O15553_Glu656Ala), deleterious(m_P08100_Tyr178Cys), deleterious(m_Q6NVY1_Tyr122Cys), deleterious(m_P04424_Arg236Trp), deleterious(m_Q9BXW9_Arg302Trp), deleterious(m_P37231_Arg425Cys), deleterious(m_Q9ULV5_Arg119Cys), deleterious(m_P07902_Tyr209Cys), deleterious(m_P00480_Trp265Leu), deleterious(m_P11498_Arg270Trp), deleterious(m_P36894_Arg443Cys), deleterious(m_P08397_Arg149Leu), deleterious(m_P68032_Tyr168Cys), deleterious(m_Q8WVQ1_Arg300Cys), deleterious(m_Q03692_Tyr597Cys), deleterious(m_P08559_Asp258Ala), deleterious(m_Q12840_Arg280Cys), deleterious(m_P06280_Tyr86Cys), deleterious(m_P08397_Arg116Trp), deleterious(m_P00492_Asp177Val), deleterious(m_P61457_Thr79Ile), deleterious(m_P13569_Tyr569Cys), deleterious(m_P48637_Tyr270Cys), deleterious(m_Q06124_Arg502Leu), deleterious(m_P40692_Asp304Val), deleterious(m_P35520_Arg121Cys), deleterious(m_P48637_Asp219Ala), deleterious(m_P06280_Asp266Val), deleterious(m_Q00266_Arg264Cys), deleterious(m_Q13496_Arg241Cys), deleterious(m_P98172_Thr111Ile), deleterious(m_P35680_Arg295Cys), deleterious(m_P10619_Tyr395Cys), deleterious(m_P10275_Arg831Leu), deleterious(m_Q13950_Arg131Cys), deleterious(m_P60484_Cys105Phe), deleterious(m_P10828_Arg338Trp), deleterious(m_Q12840_Arg280Leu), deleterious(m_Q06187_Arg562Trp), deleterious(m_P36551_Ser208Phe), deleterious(m_P04792_Arg136Trp), deleterious(m_O14832_Arg275Trp), deleterious(m_Q99714_Arg130Cys), deleterious(m_Q16595_Arg165Cys), deleterious(m_P00441_His81Ala), deleterious(m_P08559_Arg72Cys), deleterious(m_Q13496_Tyr397Cys), deleterious(m_P40692_Thr117Met), deleterious(m_Q02127_Arg135Cys), deleterious(m_P07315_Arg169Trp), deleterious(m_P08100_Arg135Trp), deleterious(m_P00740_Cys396Phe), deleterious(m_Q02750_Tyr130Cys), deleterious(m_P08397_Arg195Cys)

+ Negative Examples: deleterious(m_P78417_Ser86Cys), deleterious(m_A6NHL2_Arg250Trp), deleterious(m_Q9NQX4_Arg172Cys), deleterious(m_P47874_Arg26Trp), deleterious(m_Q9BPX1_Arg130Trp)  
develop  humvar398_4   modif_size(A, size_decrease) and modif_charge(A, charge_decrease) and g_or_p(A, g_or_p_unchanged) and wt_accessibility(A, buried) and mut_accessibility(A, buried) and stability(A, decrease). deleterious(A)
166 (2.77%) 
5 (0.25%) 
15
Covers:
+ Positive Examples: deleterious(m_Q9Y4U1_Arg189Ser), deleterious(m_P30613_Arg337Gln), deleterious(m_P45381_Arg168Cys), deleterious(m_P08236_Arg382Cys), deleterious(m_P28329_Arg420Cys), deleterious(m_O14773_Arg206Cys), deleterious(m_Q8IVH4_Arg145Gln), deleterious(m_P00480_Lys88Asn), deleterious(m_P30613_Arg163Leu), deleterious(m_P21817_Arg177Cys), deleterious(m_P07902_Arg333Gln), deleterious(m_P51843_Arg425Thr), deleterious(m_P23786_Arg503Cys), deleterious(m_P11511_Arg375Cys), deleterious(m_Q04446_Arg524Gln), deleterious(m_Q16518_Glu417Gln), deleterious(m_Q9UGJ0_Arg531Gln), deleterious(m_Q13496_Arg69Ser), deleterious(m_P51857_Arg261Cys), deleterious(m_P08709_Arg307Cys), deleterious(m_P00480_His302Gln), deleterious(m_P11511_Arg435Cys), deleterious(m_P48637_Arg283Cys), deleterious(m_P00451_Lys1751Gln), deleterious(m_P30613_Arg510Gln), deleterious(m_P06280_Asp264Val), deleterious(m_P00966_Arg127Gln), deleterious(m_P00367_Arg274Cys), deleterious(m_Q9Y617_Asp100Ala), deleterious(m_P62736_Arg118Gln), deleterious(m_P15259_Glu89Ala), deleterious(m_P02649_Arg160Cys), deleterious(m_P07902_His319Gln), deleterious(m_P45381_Glu285Ala), deleterious(m_P00439_Arg270Ser), deleterious(m_P35914_Arg41Gln), deleterious(m_P35520_Arg121Leu), deleterious(m_P23945_Asp224Val), deleterious(m_P06280_Arg342Gln), deleterious(m_P11413_Arg198Cys), deleterious(m_P38117_Arg164Gln), deleterious(m_P50897_His39Gln), deleterious(m_P00441_His49Gln), deleterious(m_Q16518_Arg44Gln), deleterious(m_P23786_Arg151Gln), deleterious(m_P39019_Arg56Gln), deleterious(m_P06276_Arg414Cys), deleterious(m_Q15465_His140Gln), deleterious(m_P21912_Arg46Gln), deleterious(m_P11473_Arg73Gln), deleterious(m_Q9BZ23_Arg278Leu), deleterious(m_P49748_Arg469Gln), deleterious(m_P06280_Asp170Val), deleterious(m_P00451_Arg2228Gln), deleterious(m_P06280_Arg227Gln), deleterious(m_P19878_Arg77Gln), deleterious(m_Q92947_Arg402Gln), deleterious(m_Q14749_His177Asn), deleterious(m_P15104_Arg324Cys), deleterious(m_P16930_Asp233Val), deleterious(m_P45381_Asp68Ala), deleterious(m_Q9C0B1_Arg316Gln), deleterious(m_P00966_Glu270Gln), deleterious(m_P00439_Glu183Gln), deleterious(m_P05166_Arg512Cys), deleterious(m_P25189_Arg98Cys), deleterious(m_P10828_Arg320Cys), deleterious(m_P05186_Arg246Ser), deleterious(m_P43246_His46Gln), deleterious(m_P08397_Glu250Ala), deleterious(m_P49748_Lys247Thr), deleterious(m_Q13496_Arg421Gln), deleterious(m_P04275_Arg1374Cys), deleterious(m_P06213_Arg1158Gln), deleterious(m_P11511_Arg365Gln), deleterious(m_P06280_Glu66Gln), deleterious(m_P35557_Glu300Gln), deleterious(m_P15104_Arg341Cys), deleterious(m_P12955_Arg184Gln), deleterious(m_P00439_His264Leu), deleterious(m_Q16518_Lys294Thr), deleterious(m_P11217_Lys543Thr), deleterious(m_Q16518_His182Asn), deleterious(m_P00966_Arg95Ser), deleterious(m_P06280_Asp165Val), deleterious(m_P00439_Arg252Gln), deleterious(m_Q9Y4U1_Arg161Gln), deleterious(m_P20823_Arg263Cys), deleterious(m_Q15833_Arg405Gln), deleterious(m_P00480_Arg277Gln), deleterious(m_P52701_Glu1163Val), deleterious(m_P00480_Arg141Gln), deleterious(m_P17050_Arg329Gln), deleterious(m_P35680_His153Asn), deleterious(m_Q06187_Arg641Cys), deleterious(m_Q9UM73_Arg1275Gln), deleterious(m_O14832_Arg275Gln), deleterious(m_P02649_Arg152Gln), deleterious(m_P07902_Lys285Asn), deleterious(m_P35680_Arg276Gln), deleterious(m_P28069_Arg143Gln), deleterious(m_Q9NRR6_Arg435Gln), deleterious(m_P00451_Arg2182Cys), deleterious(m_Q13496_Arg241Leu), deleterious(m_Q13509_Arg62Gln), deleterious(m_O43602_Arg140Leu), deleterious(m_P41181_Arg187Cys), deleterious(m_P02649_Arg154Cys), deleterious(m_P08397_Arg116Gln), deleterious(m_P05186_Arg223Gln), deleterious(m_P30613_Arg488Gln), deleterious(m_P00813_Arg156Cys), deleterious(m_Q9ULV0_Arg656Cys), deleterious(m_P12271_Arg151Gln), deleterious(m_P08397_Glu250Gln), deleterious(m_P00813_Arg101Gln), deleterious(m_P00439_Arg243Gln), deleterious(m_P19971_Glu289Ala), deleterious(m_O15553_Glu656Ala), deleterious(m_P00451_Arg2169Cys), deleterious(m_P37231_Arg425Cys), deleterious(m_P08559_Arg263Gln), deleterious(m_Q9BZ23_Arg278Cys), deleterious(m_P36894_Arg443Cys), deleterious(m_P02649_Arg154Ser), deleterious(m_P08397_Arg149Leu), deleterious(m_P04424_Arg95Cys), deleterious(m_P05166_Arg165Gln), deleterious(m_P30613_Arg532Gln), deleterious(m_Q8WVQ1_Arg300Cys), deleterious(m_O15305_His218Leu), deleterious(m_P08559_Asp258Ala), deleterious(m_P23786_Arg296Gln), deleterious(m_P00813_Arg101Leu), deleterious(m_Q06124_Glu69Gln), deleterious(m_P41235_Glu285Gln), deleterious(m_Q06124_Arg502Leu), deleterious(m_P29033_Arg143Gln), deleterious(m_P08236_Lys606Asn), deleterious(m_P35520_Arg121Cys), deleterious(m_P48637_Asp219Ala), deleterious(m_Q9Y4Z2_Arg107Ser), deleterious(m_P06280_Asp266Val), deleterious(m_P00451_Arg1960Gln), deleterious(m_Q13496_Arg241Cys), deleterious(m_P11473_Arg80Gln), deleterious(m_P22748_Arg219Ser), deleterious(m_P08397_Arg173Gln), deleterious(m_P10275_Arg831Leu), deleterious(m_O75197_Arg154Met), deleterious(m_P21912_Arg230Cys), deleterious(m_P00813_Arg211Cys), deleterious(m_P00451_Arg2228Leu), deleterious(m_P06280_Arg112Cys), deleterious(m_P02649_Lys164Gln), deleterious(m_P13569_His620Gln), deleterious(m_P11413_Arg387Cys), deleterious(m_P00441_His81Ala), deleterious(m_P49748_Arg453Gln), deleterious(m_P08559_Arg72Cys), deleterious(m_P30613_Arg163Cys), deleterious(m_P06280_Arg112Ser), deleterious(m_P35520_Lys384Asn), deleterious(m_P10275_Arg774Cys), deleterious(m_P02649_Arg176Cys), deleterious(m_P00387_Arg58Gln)

+ Negative Examples: deleterious(m_Q03518_Arg708Gln), deleterious(m_Q08043_Glu635Ala), deleterious(m_P50995_Arg230Cys), deleterious(m_P11712_Arg144Cys), deleterious(m_P20073_Arg441Gln)  
develop  humvar398_13   modif_size(A, size_decrease) and modif_hydrophobicity(A, hydrophobicity_decrease) and secondary_struc(A, sheet) and wt_accessibility(A, buried). deleterious(A)
163 (2.72%) 
5 (0.25%) 
16
Covers:
+ Positive Examples: deleterious(m_Q92838_Leu293Pro), deleterious(m_P02545_Ile469Thr), deleterious(m_P50897_Tyr109Asp), deleterious(m_P00451_Ile405Ser), deleterious(m_Q9UBV7_Leu206Pro), deleterious(m_P29400_Trp1538Ser), deleterious(m_P35520_Ile278Thr), deleterious(m_Q01968_Phe242Ser), deleterious(m_P00439_Leu41Pro), deleterious(m_O14832_Phe257Ser), deleterious(m_P04181_Leu402Pro), deleterious(m_P01008_Leu302Pro), deleterious(m_P28329_Ile305Thr), deleterious(m_O15305_Phe206Ser), deleterious(m_Q06187_Tyr40Asn), deleterious(m_Q03426_Leu39Pro), deleterious(m_O15119_Tyr149Ser), deleterious(m_O43602_Ile185Thr), deleterious(m_P13569_His620Pro), deleterious(m_Q06187_Tyr39Ser), deleterious(m_P35916_Leu1044Pro), deleterious(m_P08514_Leu847Pro), deleterious(m_P54803_Ile384Thr), deleterious(m_Q92838_Val307Gly), deleterious(m_P22830_Ile186Thr), deleterious(m_Q13496_Leu202Ser), deleterious(m_P53634_Trp39Ser), deleterious(m_P15313_Leu81Pro), deleterious(m_P54803_Ile599Ser), deleterious(m_P40692_Gln542Pro), deleterious(m_P06744_Leu339Pro), deleterious(m_P00492_Ile183Thr), deleterious(m_P07949_Phe174Ser), deleterious(m_P00451_Met699Thr), deleterious(m_P31785_Leu172Pro), deleterious(m_P10912_Ile171Thr), deleterious(m_Q16518_Tyr144Asp), deleterious(m_P42224_Leu600Pro), deleterious(m_P40763_Phe384Ser), deleterious(m_Q93099_Val300Gly), deleterious(m_P30613_Ile314Thr), deleterious(m_P08236_Tyr320Ser), deleterious(m_P00387_Leu149Pro), deleterious(m_P54803_Phe514Ser), deleterious(m_P05186_Phe327Gly), deleterious(m_P02545_Leu530Pro), deleterious(m_Q01968_Ile274Thr), deleterious(m_P35557_Leu164Pro), deleterious(m_P16615_Phe675Ser), deleterious(m_P06280_Leu414Ser), deleterious(m_Q01968_Ile533Ser), deleterious(m_P00746_Val213Gly), deleterious(m_P45381_Phe295Ser), deleterious(m_P38571_His129Pro), deleterious(m_P16615_Ile348Thr), deleterious(m_Q92915_Phe145Ser), deleterious(m_P11362_Leu245Pro), deleterious(m_P13569_Leu619Ser), deleterious(m_Q92838_Val323Gly), deleterious(m_Q14749_His177Asn), deleterious(m_P00480_Ile159Thr), deleterious(m_P29965_Leu258Ser), deleterious(m_P35557_Phe150Ser), deleterious(m_O00294_Phe382Ser), deleterious(m_P05062_Leu229Pro), deleterious(m_P01024_His1464Asp), deleterious(m_P45381_Ile16Thr), deleterious(m_P60484_Phe241Ser), deleterious(m_P00451_Trp532Gly), deleterious(m_Q13496_Leu228Pro), deleterious(m_P05089_Ile11Thr), deleterious(m_Q14376_Leu183Pro), deleterious(m_P10275_Leu768Pro), deleterious(m_P04629_Leu213Pro), deleterious(m_Q13950_Phe197Ser), deleterious(m_P00480_Ile160Ser), deleterious(m_P08100_Tyr178Asn), deleterious(m_Q9UBC3_Val699Gly), deleterious(m_P08397_Ile113Thr), deleterious(m_P30613_Ile153Thr), deleterious(m_P11413_Ile48Thr), deleterious(m_P43246_Val163Gly), deleterious(m_P16930_Val166Gly), deleterious(m_Q16518_His182Asn), deleterious(m_P00734_Met380Thr), deleterious(m_P06280_Leu131Pro), deleterious(m_P07949_Leu40Pro), deleterious(m_P43235_Leu309Pro), deleterious(m_P05106_Leu222Pro), deleterious(m_P54803_Val566Gly), deleterious(m_P00451_Leu326Pro), deleterious(m_P01008_Ile453Thr), deleterious(m_P00439_Phe410Ser), deleterious(m_P06132_Ile334Thr), deleterious(m_P23945_Ile160Thr), deleterious(m_P51159_Leu130Pro), deleterious(m_P30613_Leu155Pro), deleterious(m_P06132_Ile260Thr), deleterious(m_Q8IWL1_Phe198Ser), deleterious(m_Q06187_Leu11Pro), deleterious(m_P08514_Leu214Pro), deleterious(m_P54803_Trp426Gly), deleterious(m_P08397_Leu92Pro), deleterious(m_P30613_Ile219Thr), deleterious(m_P29965_Trp140Gly), deleterious(m_P00451_Leu659Pro), deleterious(m_P13051_Phe251Ser), deleterious(m_P40692_Leu574Pro), deleterious(m_P29965_Leu231Ser), deleterious(m_Q01968_Val372Gly), deleterious(m_P10721_Leu656Pro), deleterious(m_P00451_Trp412Gly), deleterious(m_P09417_Leu14Pro), deleterious(m_P13569_Tyr569Asp), deleterious(m_P38571_Leu200Pro), deleterious(m_P00966_Tyr190Asp), deleterious(m_P53673_Phe94Ser), deleterious(m_P22033_His386Asn), deleterious(m_P14222_Val183Gly), deleterious(m_P24752_Ile312Thr), deleterious(m_P43246_Leu173Pro), deleterious(m_Q92968_Ile326Thr), deleterious(m_P10912_Phe114Ser), deleterious(m_P10912_Val173Gly), deleterious(m_P05062_Ile74Thr), deleterious(m_P54803_Ile250Thr), deleterious(m_P00451_Leu327Pro), deleterious(m_P40692_Leu550Pro), deleterious(m_P06276_Phe446Ser), deleterious(m_O43602_Tyr206Asp), deleterious(m_P06280_Tyr134Ser), deleterious(m_Q03692_Leu614Pro), deleterious(m_Q03692_Tyr582Asp), deleterious(m_P29965_Leu195Pro), deleterious(m_P08397_Leu278Pro), deleterious(m_P00480_Leu139Ser), deleterious(m_P00439_Ile65Thr), deleterious(m_P00451_Ile2281Thr), deleterious(m_P00451_Trp33Gly), deleterious(m_P54840_His446Asp), deleterious(m_P13569_Leu571Ser), deleterious(m_P58335_Leu45Pro), deleterious(m_P19367_Leu529Ser), deleterious(m_P11172_Val109Gly), deleterious(m_Q9ULV0_Val108Gly), deleterious(m_P06280_Leu89Pro), deleterious(m_P00740_Trp431Gly), deleterious(m_P40692_Leu292Pro), deleterious(m_P31785_Leu183Ser), deleterious(m_P13569_Ile618Thr), deleterious(m_Q15582_His626Pro), deleterious(m_P07902_Met129Thr), deleterious(m_Q92838_Trp274Gly), deleterious(m_P00492_Leu131Ser), deleterious(m_P07902_Phe171Ser), deleterious(m_Q13496_His374Asp), deleterious(m_P09467_Phe194Ser), deleterious(m_Q93099_Trp97Gly), deleterious(m_P25189_Ile112Thr), deleterious(m_P51159_Trp73Gly), deleterious(m_P08559_His113Asp), deleterious(m_P08514_Ile405Thr), deleterious(m_P00492_Ile132Thr)

+ Negative Examples: deleterious(m_Q9BZP6_Val324Gly), deleterious(m_P04798_Ile78Thr), deleterious(m_Q08AH1_Ile515Thr), deleterious(m_O14793_Ile348Thr), deleterious(m_Q12913_Ile1235Thr)  
develop  humvar398_107   modif_size(A, size_increase) and modif_charge(A, charge_increase) and conservation_class(A, global_conservation_rank_2) and wt_accessibility(A, buried). deleterious(A)
160 (2.67%) 
5 (0.25%) 
17
Covers:
+ Positive Examples: deleterious(m_P07902_Gln252His), deleterious(m_P45381_Met195Arg), deleterious(m_P00451_Gly2045Glu), deleterious(m_P49747_Pro276Arg), deleterious(m_P40692_Met35Arg), deleterious(m_P10828_Gln340His), deleterious(m_P08100_Pro23His), deleterious(m_P20933_Gly252Arg), deleterious(m_P50053_Gly40Arg), deleterious(m_P02753_Gly93Asp), deleterious(m_P51649_Gly409Asp), deleterious(m_Q01968_Asn591Lys), deleterious(m_Q15582_Leu527Arg), deleterious(m_Q92947_Asn406Lys), deleterious(m_P35520_Gly116Arg), deleterious(m_Q15465_Cys183Arg), deleterious(m_P01185_Gly54Arg), deleterious(m_P11532_Leu54Arg), deleterious(m_P00492_Val130Asp), deleterious(m_P06280_Gly138Arg), deleterious(m_Q00266_Ala55Asp), deleterious(m_Q9Y4U1_Gly147Asp), deleterious(m_P00740_Gly412Glu), deleterious(m_Q06187_Ala523Glu), deleterious(m_P05155_Ala456Glu), deleterious(m_Q9Y6Q6_Cys175Arg), deleterious(m_P00740_Gly253Arg), deleterious(m_P30613_Gly111Arg), deleterious(m_P45381_Gly27Arg), deleterious(m_P35916_Gly857Arg), deleterious(m_P51857_Pro133Arg), deleterious(m_P10275_Ala748Asp), deleterious(m_P05062_Ala175Asp), deleterious(m_P29033_Gln80Lys), deleterious(m_P00740_Gly413Arg), deleterious(m_P11532_Ala168Asp), deleterious(m_P60484_Ser170Arg), deleterious(m_P31785_Gly114Asp), deleterious(m_Q15465_Thr150Arg), deleterious(m_P25189_Gly103Glu), deleterious(m_P00740_Gly442Glu), deleterious(m_P06276_Gly143Asp), deleterious(m_P29965_Ala208Asp), deleterious(m_Q93099_Gly270Arg), deleterious(m_P40692_Leu622His), deleterious(m_P22033_Gly94Arg), deleterious(m_Q15465_Thr150Lys), deleterious(m_P00451_Ser1907Arg), deleterious(m_P05156_Gly287Arg), deleterious(m_P00740_Gly253Glu), deleterious(m_P10828_Gly332Arg), deleterious(m_P26367_Val53Asp), deleterious(m_P49638_Gly246Arg), deleterious(m_Q13496_Ala389Asp), deleterious(m_P53634_Gln286Arg), deleterious(m_P48728_Gly269Asp), deleterious(m_P00451_Gln2265Arg), deleterious(m_P20933_Gly252Glu), deleterious(m_Q14117_Thr68Arg), deleterious(m_P19878_Gly78Glu), deleterious(m_P05107_Gly273Arg), deleterious(m_P35914_Gly203Glu), deleterious(m_P00813_Gly216Arg), deleterious(m_P54803_Gly553Arg), deleterious(m_P07225_Ala68Asp), deleterious(m_P29965_Ala173Asp), deleterious(m_P00451_Gly1967Asp), deleterious(m_P08100_Gly114Asp), deleterious(m_P07225_Cys265Arg), deleterious(m_P49747_Gly719Asp), deleterious(m_Q92838_Gly299Asp), deleterious(m_P35557_Cys213Arg), deleterious(m_P00451_Pro2172Arg), deleterious(m_P35914_Ser75Arg), deleterious(m_Q02094_Gly280Arg), deleterious(m_P51843_Leu466Arg), deleterious(m_P05062_Asn335Lys), deleterious(m_Q13485_Gly352Arg), deleterious(m_P51648_Gly412Arg), deleterious(m_P00740_Gly357Glu), deleterious(m_P29400_Gly1596Asp), deleterious(m_P16435_Val489Glu), deleterious(m_P54803_Gly111Asp), deleterious(m_Q92838_Gly291Arg), deleterious(m_O00255_Pro282His), deleterious(m_P35557_Met210Lys), deleterious(m_P02545_Gly465Asp), deleterious(m_Q06187_Gly462Asp), deleterious(m_P00451_Gly1872Glu), deleterious(m_P49747_Thr585Arg), deleterious(m_P09417_Gly17Arg), deleterious(m_Q93099_Gly161Arg), deleterious(m_P00813_Gly20Arg), deleterious(m_P30613_Gly511Arg), deleterious(m_P08709_Pro363Arg), deleterious(m_P11217_Ala660Asp), deleterious(m_Q92947_Leu179Arg), deleterious(m_P22033_Gln218His), deleterious(m_P13569_Ala455Glu), deleterious(m_Q13496_Met317Arg), deleterious(m_P19971_Gly145Arg), deleterious(m_P29965_Val237Glu), deleterious(m_P14222_Gly429Glu), deleterious(m_P49747_Gly299Arg), deleterious(m_P05107_Gly169Arg), deleterious(m_P00439_Gly344Arg), deleterious(m_P08246_Gly214Arg), deleterious(m_Q01968_Gly357Glu), deleterious(m_P58335_Gly105Asp), deleterious(m_P00740_Gly357Arg), deleterious(m_P12235_Ala123Asp), deleterious(m_Q15465_Ala110Asp), deleterious(m_O14773_Val385Asp), deleterious(m_P49748_Ala281Asp), deleterious(m_O15305_Thr237Arg), deleterious(m_P29965_Ala123Glu), deleterious(m_P30613_Ala394Asp), deleterious(m_P08235_Ser815Arg), deleterious(m_P48165_Val44Glu), deleterious(m_Q99593_Gly80Arg), deleterious(m_P10275_Gly750Asp), deleterious(m_P08514_Gly273Asp), deleterious(m_P49768_Ala431Glu), deleterious(m_P51648_Gly406Arg), deleterious(m_P22033_Gly427Asp), deleterious(m_Q03393_Asn36Lys), deleterious(m_P50897_Gly108Arg), deleterious(m_P35520_Thr262Arg), deleterious(m_P20823_Val259Asp), deleterious(m_P54803_Gly59Arg), deleterious(m_P00439_Pro225Arg), deleterious(m_P43235_Gly146Arg), deleterious(m_P56589_Gly138Glu), deleterious(m_Q15465_Gly143Asp), deleterious(m_P20933_Gly302Arg), deleterious(m_Q92947_Gly178Arg), deleterious(m_Q16518_Val473Asp), deleterious(m_O14773_Ala454Glu), deleterious(m_P08100_Gly106Arg), deleterious(m_P40692_Gly244Asp), deleterious(m_P00480_Thr262Lys), deleterious(m_P15924_Ser299Arg), deleterious(m_Q92838_Gly255Asp), deleterious(m_P00966_Gly117Asp), deleterious(m_P11217_Gly686Arg), deleterious(m_O14773_Gly77Arg), deleterious(m_Q06187_Ala508Asp), deleterious(m_P40692_Met35Lys), deleterious(m_Q92838_Gly381Arg), deleterious(m_P11217_Gln666Glu), deleterious(m_P00451_Gln2106Arg), deleterious(m_P09417_Gly23Asp), deleterious(m_P00451_Gln2106Glu), deleterious(m_P25189_Thr124Lys), deleterious(m_P07195_Ser129Arg), deleterious(m_P60484_Ala34Asp), deleterious(m_P00441_Gly148Arg), deleterious(m_Q14896_Asn754Lys), deleterious(m_P00451_Pro1873Arg), deleterious(m_P53634_Gly300Asp)

+ Negative Examples: deleterious(m_Q9UNI1_Gln243Arg), deleterious(m_Q6IMI6_Gly179Arg), deleterious(m_Q9UK55_Gln384Arg), deleterious(m_Q8N9L9_Ala187Asp), deleterious(m_Q9BZP6_Gly102Arg)  
develop  humvar398_10   modif_size(A, size_decrease) and freq_at_pos(A, B) and B>=2 and secondary_struc(A, sheet) and mut_accessibility(A, buried). deleterious(A)
148 (2.47%) 
3 (0.15%) 
18
Covers:
+ Positive Examples: deleterious(m_Q01968_Arg500Gly), deleterious(m_P29965_Val126Ala), deleterious(m_Q06187_Arg28His), deleterious(m_Q9UGJ0_Arg531Gly), deleterious(m_P00451_Val2251Ala), deleterious(m_P00439_Arg241Cys), deleterious(m_P08236_Arg382Cys), deleterious(m_P00451_Ile405Ser), deleterious(m_Q01968_Arg500Gln), deleterious(m_O15305_Val44Ala), deleterious(m_Q06187_Arg28Pro), deleterious(m_P21912_Arg46Gly), deleterious(m_P00439_Leu41Pro), deleterious(m_P28329_Ile305Thr), deleterious(m_Q06187_Tyr40Asn), deleterious(m_P11511_Arg375Cys), deleterious(m_P31785_Arg226His), deleterious(m_P13569_His620Pro), deleterious(m_P08709_Arg307His), deleterious(m_P00451_Arg2326Leu), deleterious(m_P00740_Phe395Ile), deleterious(m_Q9UGJ0_Arg531Gln), deleterious(m_P00451_Leu327Val), deleterious(m_P08709_Arg307Cys), deleterious(m_P40692_Gln542Pro), deleterious(m_P00480_His302Gln), deleterious(m_P00451_Phe2279Cys), deleterious(m_P35520_Val168Ala), deleterious(m_P00451_Phe2279Ile), deleterious(m_P00451_Met699Thr), deleterious(m_P31785_Leu172Pro), deleterious(m_O43602_Arg140His), deleterious(m_P06280_Asp264Val), deleterious(m_P08236_Arg382His), deleterious(m_P40763_Phe384Ser), deleterious(m_Q00266_Arg199Cys), deleterious(m_P00480_Arg141Pro), deleterious(m_P08236_Tyr320Ser), deleterious(m_P05186_Phe327Gly), deleterious(m_P02545_Arg541Ser), deleterious(m_P08236_Tyr320Cys), deleterious(m_P38117_Arg164Gln), deleterious(m_P00441_His49Gln), deleterious(m_P10912_Arg229Gly), deleterious(m_Q13496_Arg184Gly), deleterious(m_P00439_Arg241His), deleterious(m_P21912_Arg46Gln), deleterious(m_P29400_Arg1677Pro), deleterious(m_Q9BZ23_Arg278Leu), deleterious(m_P40763_Phe384Leu), deleterious(m_P38571_His129Pro), deleterious(m_Q06187_Arg28Cys), deleterious(m_P06280_Met42Val), deleterious(m_P00734_Arg425Cys), deleterious(m_P00480_Asn161Ser), deleterious(m_P45381_Pro280Ser), deleterious(m_P01008_Met283Val), deleterious(m_P00451_Arg301Cys), deleterious(m_Q06187_Tyr40Cys), deleterious(m_P00480_His302Leu), deleterious(m_P54803_Arg531His), deleterious(m_P49748_Lys247Thr), deleterious(m_P01137_Arg218Cys), deleterious(m_P32322_Arg119His), deleterious(m_P00451_Arg2326Pro), deleterious(m_P00441_Asp102Gly), deleterious(m_P00480_Ile160Ser), deleterious(m_P08100_Tyr178Asn), deleterious(m_O75695_Arg118Cys), deleterious(m_P02545_Arg527Pro), deleterious(m_P11413_Ile48Thr), deleterious(m_P43246_Val163Gly), deleterious(m_P06280_Met42Leu), deleterious(m_P01185_Arg97Cys), deleterious(m_P00451_Phe2120Cys), deleterious(m_Q16518_His182Asn), deleterious(m_Q06187_Lys430Glu), deleterious(m_P25189_Thr65Ala), deleterious(m_P31785_Arg226Cys), deleterious(m_P08397_Arg225Gly), deleterious(m_Q9Y4U1_Arg161Gln), deleterious(m_P02545_Arg453Pro), deleterious(m_P49748_Lys247Glu), deleterious(m_P06280_Met296Val), deleterious(m_P01137_Arg218His), deleterious(m_P00480_Arg141Gln), deleterious(m_P17050_Arg329Gln), deleterious(m_O14832_Arg275Gln), deleterious(m_P05186_Phe327Leu), deleterious(m_P00451_Arg2326Gly), deleterious(m_Q13950_Met175Val), deleterious(m_P21439_Thr424Ala), deleterious(m_Q9Y4U1_Arg161Gly), deleterious(m_Q13496_Arg241Leu), deleterious(m_O43602_Arg140Leu), deleterious(m_P00439_Glu76Ala), deleterious(m_P35520_Arg369Cys), deleterious(m_P29965_Trp140Gly), deleterious(m_P08709_Met358Val), deleterious(m_P06280_Met296Ile), deleterious(m_P00813_Arg101Gln), deleterious(m_P00439_Arg243Gln), deleterious(m_P00451_Arg2169His), deleterious(m_P13569_Tyr569Asp), deleterious(m_P21802_Glu565Gly), deleterious(m_P08100_Tyr178Cys), deleterious(m_P00451_Arg2169Cys), deleterious(m_P43246_Leu173Pro), deleterious(m_P51608_Arg106Gln), deleterious(m_Q9BZ23_Arg278Cys), deleterious(m_P00441_Leu9Val), deleterious(m_P00451_Leu327Pro), deleterious(m_Q03692_Tyr597Cys), deleterious(m_O43602_Tyr206Asp), deleterious(m_P54803_Arg531Cys), deleterious(m_P00813_Arg101Leu), deleterious(m_P00813_Arg211His), deleterious(m_P13569_Tyr569Cys), deleterious(m_P00439_Ile65Thr), deleterious(m_P00451_Arg1960Gln), deleterious(m_Q13496_Arg241Cys), deleterious(m_P02545_Arg541His), deleterious(m_P02545_Arg527Cys), deleterious(m_P32322_Arg119Gly), deleterious(m_P06280_Leu89Pro), deleterious(m_P00740_Trp431Gly), deleterious(m_P49675_Glu169Gly), deleterious(m_P10912_Arg229His), deleterious(m_P00813_Arg211Cys), deleterious(m_P00451_Asp2093Gly), deleterious(m_P13569_His620Gln), deleterious(m_P00441_Leu85Val), deleterious(m_P00740_Arg294Gln), deleterious(m_P00439_Lys341Thr), deleterious(m_P00740_Arg294Gly), deleterious(m_Q15582_His626Pro), deleterious(m_P00740_Phe395Leu), deleterious(m_P00441_Glu22Gly), deleterious(m_P00451_Met699Val), deleterious(m_P00451_Arg301Leu), deleterious(m_P01185_Arg97Pro), deleterious(m_P08559_His113Asp), deleterious(m_P00451_Val345Ala), deleterious(m_P00451_Phe2120Leu), deleterious(m_P00451_Arg2326Gln), deleterious(m_Q30201_Arg224Gly), deleterious(m_P00492_Ile132Thr), deleterious(m_P19438_Ser115Gly)

+ Negative Examples: deleterious(m_P20036_Met62Leu), deleterious(m_P16442_Phe216Ile), deleterious(m_O95050_Phe254Cys)  
develop  humvar398_23   fold(A, 'Aromatic aminoacid monoxygenases, catalytic and oligomerization domains'). deleterious(A)
144 (2.4%) 
0 (0.0%) 
19
Covers:
+ Positive Examples: deleterious(m_P00439_Tyr386Cys), deleterious(m_P00439_Arg155Pro), deleterious(m_P00439_Met276Ile), deleterious(m_P00439_Pro173Thr), deleterious(m_P00439_Arg241Cys), deleterious(m_P00439_Gly218Val), deleterious(m_P00439_His201Tyr), deleterious(m_P00439_Gln304Arg), deleterious(m_P00439_Ala395Pro), deleterious(m_P00439_Tyr387His), deleterious(m_P00439_Arg261Pro), deleterious(m_P00439_Leu242Phe), deleterious(m_P00439_Ile306Val), deleterious(m_P00439_Leu194Pro), deleterious(m_P00439_Val245Glu), deleterious(m_P00439_Tyr343Cys), deleterious(m_P00439_Pro362Thr), deleterious(m_P00439_Val388Met), deleterious(m_P00439_Arg297Cys), deleterious(m_P00439_Leu248Pro), deleterious(m_P00439_Asp222Val), deleterious(m_P00439_Val245Leu), deleterious(m_P00439_Arg169His), deleterious(m_P00439_Arg270Ser), deleterious(m_P00439_Cys357Gly), deleterious(m_P00439_Glu280Lys), deleterious(m_P00439_Tyr377Cys), deleterious(m_P00439_Gly257Cys), deleterious(m_P00439_Glu330Asp), deleterious(m_P00439_His170Arg), deleterious(m_P00439_Pro281Leu), deleterious(m_P00439_Asp415Asn), deleterious(m_P00439_Arg241His), deleterious(m_P00439_Leu255Ser), deleterious(m_P00439_Ser303Pro), deleterious(m_P00439_Asn167Ile), deleterious(m_P00439_Tyr277Asp), deleterious(m_P00439_Ile224Met), deleterious(m_P00439_Thr278Ala), deleterious(m_P00439_Ile283Asn), deleterious(m_P00439_Asp338Tyr), deleterious(m_P00439_Asp282Asn), deleterious(m_P00439_Ala322Gly), deleterious(m_P00439_Arg297His), deleterious(m_P00439_Cys334Ser), deleterious(m_P00439_His170Asp), deleterious(m_P00439_Val177Leu), deleterious(m_P00439_Leu333Phe), deleterious(m_P00439_Phe331Leu), deleterious(m_P00439_Arg408Gln), deleterious(m_P00439_Asp143Gly), deleterious(m_P00439_Glu183Gln), deleterious(m_P00439_Phe233Leu), deleterious(m_P00439_Leu311Pro), deleterious(m_P00439_Ser350Thr), deleterious(m_P00439_Arg413Pro), deleterious(m_P00439_Met276Val), deleterious(m_P00439_Gly247Val), deleterious(m_P00439_Tyr154Asn), deleterious(m_P00439_Ala309Val), deleterious(m_P00439_Gly337Val), deleterious(m_P00439_Asp394His), deleterious(m_P00439_Arg176Leu), deleterious(m_P00439_Ala342Thr), deleterious(m_P00439_His264Leu), deleterious(m_P00439_Asn207Ser), deleterious(m_P00439_Arg261Gln), deleterious(m_P00439_Ala259Val), deleterious(m_P00439_Ile174Thr), deleterious(m_P00439_Asp151His), deleterious(m_P00439_Tyr277Cys), deleterious(m_P00439_Asn207Asp), deleterious(m_P00439_Arg408Trp), deleterious(m_P00439_Glu178Gly), deleterious(m_P00439_Glu390Gly), deleterious(m_P00439_Arg252Gln), deleterious(m_P00439_Asp145Val), deleterious(m_P00439_Phe410Ser), deleterious(m_P00439_Arg413Ser), deleterious(m_P00439_Ala246Asp), deleterious(m_P00439_Phe240Ser), deleterious(m_P00439_Leu348Val), deleterious(m_P00439_Gly148Ser), deleterious(m_P00439_Pro211Thr), deleterious(m_P00439_Ala345Ser), deleterious(m_P00439_Gly239Ser), deleterious(m_P00439_Ala259Thr), deleterious(m_P00439_His146Tyr), deleterious(m_P00439_His271Tyr), deleterious(m_P00439_Cys265Gly), deleterious(m_P00439_Ile318Thr), deleterious(m_P00439_Thr418Pro), deleterious(m_P00439_Arg157Asn), deleterious(m_P00439_Val230Ile), deleterious(m_P00439_Glu205Ala), deleterious(m_P00439_Gly344Val), deleterious(m_P00439_Arg158Trp), deleterious(m_P00439_Thr372Ser), deleterious(m_P00439_Pro225Thr), deleterious(m_P00439_Glu221Gly), deleterious(m_P00439_Arg176Pro), deleterious(m_P00439_Ile164Thr), deleterious(m_P00439_Phe161Ser), deleterious(m_P00439_Arg252Gly), deleterious(m_P00439_Ala403Val), deleterious(m_P00439_Pro407Ser), deleterious(m_P00439_His201Arg), deleterious(m_P00439_Arg243Gln), deleterious(m_P00439_Gly344Arg), deleterious(m_P00439_Pro314His), deleterious(m_P00439_Leu347Phe), deleterious(m_P00439_Leu249Phe), deleterious(m_P00439_Ile283Phe), deleterious(m_P00439_Ala345Thr), deleterious(m_P00439_Gly171Ala), deleterious(m_P00439_Ala300Ser), deleterious(m_P00439_Gln160Pro), deleterious(m_P00439_Tyr325Cys), deleterious(m_P00439_Ser310Phe), deleterious(m_P00439_Tyr414Cys), deleterious(m_P00439_Ala322Thr), deleterious(m_P00439_Ala300Val), deleterious(m_P00439_Pro225Arg), deleterious(m_P00439_Asn167Ser), deleterious(m_P00439_Pro366His), deleterious(m_P00439_Leu212Pro), deleterious(m_P00439_Ala309Asp), deleterious(m_P00439_Arg270Lys), deleterious(m_P00439_Tyr204Cys), deleterious(m_P00439_Leu213Pro), deleterious(m_P00439_Ser231Pro), deleterious(m_P00439_Lys341Thr), deleterious(m_P00439_Ile174Val), deleterious(m_P00439_Arg158Gln), deleterious(m_P00439_Asp394Ala), deleterious(m_P00439_Val245Ala), deleterious(m_P00439_Val388Leu), deleterious(m_P00439_Ser273Phe), deleterious(m_P00439_Gly171Arg), deleterious(m_P00439_Phe299Cys), deleterious(m_P00439_Pro175Ala), deleterious(m_P00439_Lys341Arg), deleterious(m_P00439_Leu255Val), deleterious(m_P00439_Thr238Pro)

+ Negative Examples:  
develop  humvar398_1   freq_at_pos(A, B) and B>=2 and secondary_struc(A, other) and lost_contact(A, dc) and stability(A, decrease). deleterious(A)
140 (2.33%) 
5 (0.25%) 
20
Covers:
+ Positive Examples: deleterious(m_Q14524_Arg1826His), deleterious(m_P12271_Arg234Trp), deleterious(m_P06280_Arg100Lys), deleterious(m_P01112_Ala146Val), deleterious(m_P07902_Met142Val), deleterious(m_Q05066_Met64Ile), deleterious(m_P01308_Arg89Cys), deleterious(m_P01112_Gly13Asp), deleterious(m_P00451_Gly2045Glu), deleterious(m_P01185_Cys116Arg), deleterious(m_P00966_Gly324Ser), deleterious(m_Q13509_Arg262Cys), deleterious(m_Q13950_Arg190Trp), deleterious(m_Q14524_Arg1826Cys), deleterious(m_P08236_Asp152Gly), deleterious(m_P22830_Cys406Ser), deleterious(m_P00492_Asp177Tyr), deleterious(m_P00439_Arg261Pro), deleterious(m_Q15465_Trp117Gly), deleterious(m_P35680_Arg276Gly), deleterious(m_Q13496_Arg69Ser), deleterious(m_Q06124_Asn308Ser), deleterious(m_P00441_Leu68Arg), deleterious(m_P51608_Leu100Arg), deleterious(m_P04049_Thr491Ile), deleterious(m_P62736_Arg39His), deleterious(m_P00451_Gly2045Val), deleterious(m_P00492_Asp194Asn), deleterious(m_Q9H3D4_Arg319Ser), deleterious(m_P00439_Arg270Ser), deleterious(m_P05186_Met62Val), deleterious(m_P60484_His93Arg), deleterious(m_P29033_Arg184Gln), deleterious(m_P01111_Gln61Lys), deleterious(m_P51608_Arg133His), deleterious(m_P11413_Arg198Cys), deleterious(m_P04156_Pro105Leu), deleterious(m_P00966_Glu191Lys), deleterious(m_P05186_Arg391Cys), deleterious(m_O15118_Asp242Asn), deleterious(m_P35520_Lys102Gln), deleterious(m_P00441_Ile113Met), deleterious(m_P00740_Glu433Lys), deleterious(m_P00441_Leu39Arg), deleterious(m_P00439_Tyr277Asp), deleterious(m_P00439_Thr278Ala), deleterious(m_P22607_Asn540Ser), deleterious(m_P00480_Arg40His), deleterious(m_P02649_Pro102Arg), deleterious(m_P01185_Cys116Gly), deleterious(m_P01112_Ala146Thr), deleterious(m_P51608_Arg133Cys), deleterious(m_P01241_Cys79Ser), deleterious(m_P01112_Gly13Cys), deleterious(m_P00439_Arg408Gln), deleterious(m_P11413_Asp58Asn), deleterious(m_P35557_Gly261Arg), deleterious(m_P98172_Cys153Ser), deleterious(m_Q05066_Tyr127Cys), deleterious(m_P00966_Arg363Gly), deleterious(m_P25189_Arg98Pro), deleterious(m_P11161_Arg381Cys), deleterious(m_P25189_Arg98Cys), deleterious(m_P10828_Arg320Cys), deleterious(m_Q8WVQ1_Arg300His), deleterious(m_P55072_Arg159His), deleterious(m_Q14203_Gly71Glu), deleterious(m_P00451_Arg1800Cys), deleterious(m_P07902_Arg51Gln), deleterious(m_P00451_Met2183Arg), deleterious(m_P06280_Asp93Asn), deleterious(m_P06280_His46Pro), deleterious(m_P04275_Arg1374Cys), deleterious(m_P51608_Asp156Gly), deleterious(m_P04275_Arg1374His), deleterious(m_P07902_Glu291Lys), deleterious(m_P00451_Arg2182Pro), deleterious(m_P01308_Phe48Cys), deleterious(m_P02647_Pro27His), deleterious(m_P35557_Gly261Glu), deleterious(m_P00451_Arg2016Pro), deleterious(m_P00439_Arg261Gln), deleterious(m_P00439_Ile174Thr), deleterious(m_Q13950_Arg190Gln), deleterious(m_P00451_Arg2228Gly), deleterious(m_P06280_Arg356Trp), deleterious(m_Q13496_Arg69Cys), deleterious(m_Q03393_Arg25Gly), deleterious(m_P00451_Arg1800Gly), deleterious(m_P49748_Arg366Cys), deleterious(m_Q9H3D4_Arg319His), deleterious(m_P06280_Cys56Gly), deleterious(m_P07902_Arg51Leu), deleterious(m_P25189_Arg98His), deleterious(m_O15118_Asp242His), deleterious(m_P00439_Phe240Ser), deleterious(m_P08100_Asp190Asn), deleterious(m_P31785_Glu68Gly), deleterious(m_Q92838_Gly291Arg), deleterious(m_Q76LX8_Arg398His), deleterious(m_P00451_Arg2182Cys), deleterious(m_P04275_Cys1272Arg), deleterious(m_P00966_Arg363Trp), deleterious(m_P05186_Asp294Ala), deleterious(m_P06280_Asp93Gly), deleterious(m_P10828_Arg320His), deleterious(m_P54803_Pro318Ala), deleterious(m_P00966_Arg363Leu), deleterious(m_P00813_Arg156Cys), deleterious(m_P00451_Arg2182His), deleterious(m_Q06124_Asp61Gly), deleterious(m_Q13509_Arg262His), deleterious(m_P01308_Arg89Leu), deleterious(m_P00966_Arg363Gln), deleterious(m_P02679_Arg301His), deleterious(m_P05166_Arg165Gln), deleterious(m_Q8WVQ1_Arg300Cys), deleterious(m_P00441_Ile113Thr), deleterious(m_P49748_Arg366His), deleterious(m_P00740_Val228Phe), deleterious(m_P98172_Met158Val), deleterious(m_P00492_Asp177Val), deleterious(m_P00740_Gly432Ser), deleterious(m_P07902_Arg123Gln), deleterious(m_Q15848_Arg112Cys), deleterious(m_P00439_Arg270Lys), deleterious(m_P00451_Arg2228Leu), deleterious(m_P06280_Arg112Cys), deleterious(m_P00439_Ile174Val), deleterious(m_P00451_Arg2228Pro), deleterious(m_P00740_Glu433Ala), deleterious(m_P51608_Leu100Val), deleterious(m_P08100_Val345Met), deleterious(m_P06280_Arg112Ser), deleterious(m_P35520_Lys384Glu), deleterious(m_P35520_Lys384Asn), deleterious(m_Q05066_Val60Ala), deleterious(m_P00441_Leu39Val), deleterious(m_P16442_Arg176Gly), deleterious(m_Q9H3D4_Arg318Cys)

+ Negative Examples: deleterious(m_Q9Y2C9_Val427Ala), deleterious(m_Q7Z434_Cys79Phe), deleterious(m_Q08493_Arg344Gln), deleterious(m_P14780_Arg668Gln), deleterious(m_O00241_Arg53His)  
develop  humvar398_17   modif_size(A, size_increase) and modif_hydrophobicity(A, hydrophobicity_decrease) and g_or_p(A, g_or_p_unchanged) and conservation_class(A, global_conservation_rank_1). deleterious(A)
138 (2.3%) 
5 (0.25%) 
21
Covers:
+ Positive Examples: deleterious(m_P06744_His389Arg), deleterious(m_O75914_Ala380Glu), deleterious(m_P10275_Leu707Arg), deleterious(m_P00480_Ser267Arg), deleterious(m_P12694_Ala253Thr), deleterious(m_P35520_Ser349Asn), deleterious(m_P43246_His639Arg), deleterious(m_P01185_Cys116Arg), deleterious(m_Q06124_Gln510Arg), deleterious(m_Q03426_Ala334Thr), deleterious(m_Q13950_Gln209Arg), deleterious(m_O14832_His175Arg), deleterious(m_P35680_Gln136Glu), deleterious(m_P07954_Gln185Arg), deleterious(m_P00441_Cys147Arg), deleterious(m_P29965_Gln174Arg), deleterious(m_P31785_Cys115Arg), deleterious(m_P08235_Gln776Arg), deleterious(m_P01008_Leu178His), deleterious(m_Q13496_His232Arg), deleterious(m_P40692_Leu155Arg), deleterious(m_Q15582_His572Arg), deleterious(m_P51843_Leu381His), deleterious(m_P48728_His42Arg), deleterious(m_P00441_His49Arg), deleterious(m_P05062_Cys135Arg), deleterious(m_Q06187_Met630Lys), deleterious(m_Q13950_Thr205Arg), deleterious(m_Q13950_Met175Arg), deleterious(m_P49747_Cys348Arg), deleterious(m_P28069_Ser179Arg), deleterious(m_P40692_Ile107Arg), deleterious(m_Q13950_Leu113Arg), deleterious(m_Q01968_His524Arg), deleterious(m_P31785_Cys182Arg), deleterious(m_Q93099_His371Arg), deleterious(m_P10275_Met807Arg), deleterious(m_P01185_Cys59Arg), deleterious(m_P05106_Cys568Arg), deleterious(m_Q13950_Ile201Lys), deleterious(m_P06280_Cys142Arg), deleterious(m_Q13950_Ser118Arg), deleterious(m_P05062_Cys178Arg), deleterious(m_P00740_Cys407Arg), deleterious(m_O43602_Leu178Arg), deleterious(m_Q92947_His403Arg), deleterious(m_P29965_His125Arg), deleterious(m_Q99453_Gln143Arg), deleterious(m_P01185_Cys105Arg), deleterious(m_P01008_Met121Lys), deleterious(m_P39019_Ala135Thr), deleterious(m_P00492_His204Arg), deleterious(m_P08246_Cys71Arg), deleterious(m_Q9H9Q4_Cys123Arg), deleterious(m_P13569_Ser549Arg), deleterious(m_P35520_Ala155Thr), deleterious(m_P00480_His168Arg), deleterious(m_O14788_Met199Lys), deleterious(m_Q03692_Cys591Arg), deleterious(m_P58335_Cys218Arg), deleterious(m_P50897_Gln177Glu), deleterious(m_Q15465_Cys102Arg), deleterious(m_P51648_Thr184Arg), deleterious(m_P40763_Ser611Asn), deleterious(m_Q13950_Val156Asp), deleterious(m_P13569_Ser549Asn), deleterious(m_Q13950_Cys123Arg), deleterious(m_P32322_Ala179Thr), deleterious(m_P41181_Ala70Asp), deleterious(m_Q15582_Thr538Arg), deleterious(m_Q04446_His545Arg), deleterious(m_P28358_Met319Lys), deleterious(m_P45381_His244Arg), deleterious(m_P10275_Ala765Thr), deleterious(m_Q9NUW8_His493Arg), deleterious(m_O43364_Gln186Lys), deleterious(m_P03950_His138Arg), deleterious(m_P08514_Cys705Arg), deleterious(m_P29400_Cys1567Arg), deleterious(m_Q9Y4U1_His122Arg), deleterious(m_P13569_Ala559Thr), deleterious(m_P05166_Ser106Arg), deleterious(m_P35914_His233Arg), deleterious(m_Q9UGJ0_His383Arg), deleterious(m_P43034_His149Arg), deleterious(m_P41181_Ala190Thr), deleterious(m_P00441_His47Arg), deleterious(m_P05106_Cys586Arg), deleterious(m_P02792_Ala96Thr), deleterious(m_Q13950_Ser118Asn), deleterious(m_Q06710_Leu62Arg), deleterious(m_Q92947_Gln333Glu), deleterious(m_P40692_Thr117Arg), deleterious(m_Q15582_His626Arg), deleterious(m_Q01968_Ser522Arg), deleterious(m_O60481_His286Arg), deleterious(m_Q92743_Ala252Thr), deleterious(m_Q06187_Met477Arg), deleterious(m_P01008_Ala414Thr), deleterious(m_O00358_Ser57Asn), deleterious(m_P21817_Cys35Arg), deleterious(m_P00740_Gln241Lys), deleterious(m_Q06187_Leu518Arg), deleterious(m_Q9H0F7_Thr31Arg), deleterious(m_P05106_Cys601Arg), deleterious(m_P08397_Gln34Lys), deleterious(m_Q05066_Met64Arg), deleterious(m_Q13950_Ser191Asn), deleterious(m_P48436_Ala158Thr), deleterious(m_P10746_Cys73Arg), deleterious(m_P00480_Cys303Arg), deleterious(m_Q03692_Leu644Arg), deleterious(m_P19438_Cys59Arg), deleterious(m_P35916_His1035Arg), deleterious(m_P39019_Leu131Arg), deleterious(m_Q9BQB4_Cys167Arg), deleterious(m_Q04656_Gln924Arg), deleterious(m_P19438_Cys117Arg), deleterious(m_P10644_Ala213Asp), deleterious(m_P01185_Cys52Arg), deleterious(m_P00441_His44Arg), deleterious(m_Q06124_Ala465Thr), deleterious(m_P35453_Gln325Arg), deleterious(m_P61916_Cys99Arg), deleterious(m_P00740_Met394Lys), deleterious(m_P04424_Gln286Arg), deleterious(m_P05186_Ala116Thr), deleterious(m_P08397_Gln34Arg), deleterious(m_Q01968_Gln277Arg), deleterious(m_O14832_Gln176Lys), deleterious(m_P53634_His405Arg), deleterious(m_P01008_Gln133Lys), deleterious(m_P04839_Cys537Arg), deleterious(m_O14836_Cys104Arg), deleterious(m_P26367_Cys52Arg), deleterious(m_P35670_Leu795Arg), deleterious(m_Q13950_Met175Lys), deleterious(m_P10275_Gln711Glu)

+ Negative Examples: deleterious(m_Q9NP86_Thr65Arg), deleterious(m_P23946_His66Arg), deleterious(m_Q7Z4J2_His195Arg), deleterious(m_P00338_Ser161Arg), deleterious(m_P05154_Ser64Asn)  
develop  humvar398_40   modif_size(A, size_increase) and modif_charge(A, charge_unchanged) and modif_hydrophobicity(A, hydrophobicity_increase) and is_in_site(A, yes) and wt_accessibility(A, buried) and mut_accessibility(A, buried) and stability(A, decrease). deleterious(A)
136 (2.27%) 
5 (0.25%) 
22
Covers:
+ Positive Examples: deleterious(m_P51857_Pro198Leu), deleterious(m_P08235_Ser818Leu), deleterious(m_P30613_Ser485Phe), deleterious(m_Q13496_Thr197Ile), deleterious(m_P14222_Pro345Leu), deleterious(m_P63261_Thr89Ile), deleterious(m_P11217_Asn685Tyr), deleterious(m_P08100_Pro171Gln), deleterious(m_P43246_Pro622Leu), deleterious(m_P00558_Gly158Val), deleterious(m_O75695_Pro95Leu), deleterious(m_P35557_Gly385Val), deleterious(m_P00480_Thr264Ile), deleterious(m_P08183_Gly185Val), deleterious(m_P30613_Gly263Trp), deleterious(m_P25189_Thr65Ile), deleterious(m_P51649_Thr233Met), deleterious(m_P23786_Pro227Leu), deleterious(m_P43246_Thr44Met), deleterious(m_Q06187_Ser578Tyr), deleterious(m_P51648_Ser365Leu), deleterious(m_P08100_Pro23Leu), deleterious(m_P04049_Thr491Ile), deleterious(m_P05186_Gly63Val), deleterious(m_P00492_Pro176Leu), deleterious(m_P00451_Pro1780Leu), deleterious(m_P30613_Thr408Ile), deleterious(m_P08397_Thr35Met), deleterious(m_P01185_Gly54Val), deleterious(m_P00740_Thr342Met), deleterious(m_P16930_Pro261Leu), deleterious(m_O15305_Thr237Met), deleterious(m_P11413_Gly131Val), deleterious(m_P16615_Ser765Leu), deleterious(m_Q06124_Thr472Met), deleterious(m_P07902_Pro325Leu), deleterious(m_O14773_Pro202Leu), deleterious(m_Q8WVQ1_Pro299Leu), deleterious(m_P57082_Gly248Val), deleterious(m_P01185_Gly96Val), deleterious(m_P00451_Gly2304Val), deleterious(m_P45381_Pro280Leu), deleterious(m_P06744_Thr195Ile), deleterious(m_Q00266_Pro357Leu), deleterious(m_P08709_Thr419Met), deleterious(m_Q06124_Thr73Ile), deleterious(m_P01112_Thr58Ile), deleterious(m_P29400_Ser1488Phe), deleterious(m_P01241_Thr53Ile), deleterious(m_P30613_Gly165Val), deleterious(m_P03950_Pro136Leu), deleterious(m_P25189_Ser63Phe), deleterious(m_P54840_Pro479Gln), deleterious(m_Q12809_Gly47Val), deleterious(m_P50570_Ser619Leu), deleterious(m_P51648_Pro121Leu), deleterious(m_P10275_Asn705Tyr), deleterious(m_P04181_Pro241Leu), deleterious(m_P43246_Thr335Ile), deleterious(m_P00439_Gly247Val), deleterious(m_P00813_Thr233Ile), deleterious(m_P05186_Gly220Val), deleterious(m_P24752_Gly379Val), deleterious(m_Q93099_Ser189Ile), deleterious(m_Q02127_Thr284Ile), deleterious(m_P51649_Pro382Gln), deleterious(m_P10746_Pro53Leu), deleterious(m_P06280_Pro40Leu), deleterious(m_P05166_Thr428Ile), deleterious(m_P36551_Gly197Trp), deleterious(m_P22830_Pro334Leu), deleterious(m_P08246_Pro139Leu), deleterious(m_P07101_Thr314Met), deleterious(m_P51648_Pro114Leu), deleterious(m_P00480_Thr44Ile), deleterious(m_P08100_Pro171Leu), deleterious(m_Q06187_Gly462Val), deleterious(m_P35557_Thr209Met), deleterious(m_P08397_Ser96Phe), deleterious(m_O14983_Pro789Leu), deleterious(m_P40692_Pro28Leu), deleterious(m_P00966_Gly324Val), deleterious(m_P30613_Gly159Val), deleterious(m_P00451_Ser1803Tyr), deleterious(m_Q13496_Thr186Ile), deleterious(m_P29965_Thr176Ile), deleterious(m_P63261_Thr278Ile), deleterious(m_P00451_Pro2162Leu), deleterious(m_P07902_Ser135Leu), deleterious(m_P05186_Gly162Val), deleterious(m_P29965_Thr254Met), deleterious(m_P13637_Thr613Met), deleterious(m_Q92838_Thr378Met), deleterious(m_P32929_Thr67Ile), deleterious(m_Q92838_Gly269Val), deleterious(m_P00451_Pro2172Gln), deleterious(m_Q13496_Gly402Val), deleterious(m_P43246_Pro349Leu), deleterious(m_Q96QS3_Pro353Leu), deleterious(m_P06276_Asn124Tyr), deleterious(m_P06132_Gly281Val), deleterious(m_P00492_Thr168Ile), deleterious(m_P01116_Thr58Ile), deleterious(m_P40763_Thr622Ile), deleterious(m_P08514_Thr207Ile), deleterious(m_P00439_Ser310Phe), deleterious(m_P61457_Thr79Ile), deleterious(m_Q92838_Gly291Trp), deleterious(m_P06213_Pro1205Leu), deleterious(m_Q01968_Pro801Leu), deleterious(m_P54803_Ser303Phe), deleterious(m_Q14232_Asn208Tyr), deleterious(m_P00439_Thr124Ile), deleterious(m_P24752_Thr297Met), deleterious(m_P00813_Ser291Leu), deleterious(m_P35916_Pro1114Leu), deleterious(m_P03951_Gly418Val), deleterious(m_Q15465_Ser184Leu), deleterious(m_P36551_Ser208Phe), deleterious(m_P22830_Thr283Ile), deleterious(m_P00451_Pro2224Leu), deleterious(m_P40692_Thr117Met), deleterious(m_P10912_Pro149Gln), deleterious(m_P25189_Thr34Ile), deleterious(m_P06280_Ser201Phe), deleterious(m_P10275_Gly743Val), deleterious(m_P00813_Pro297Gln), deleterious(m_B7U540_Thr354Met), deleterious(m_P08559_Pro217Leu), deleterious(m_Q02094_Gly380Val), deleterious(m_P35520_Thr353Met), deleterious(m_P08514_Pro176Leu), deleterious(m_P35520_Thr262Met), deleterious(m_P49748_Thr260Met), deleterious(m_P00480_Thr178Met), deleterious(m_P25067_Pro575Leu)

+ Negative Examples: deleterious(m_Q9H4B7_Thr274Met), deleterious(m_P05154_Gly94Val), deleterious(m_Q92901_Pro291Leu), deleterious(m_O00754_Thr312Ile), deleterious(m_P16050_Thr560Met)  
develop  humvar398_108   modif_charge(A, charge_decrease) and conservation_class(A, global_conservation_rank_2) and mut_accessibility(A, buried). deleterious(A)
131 (2.18%) 
5 (0.25%) 
23
Covers:
+ Positive Examples: deleterious(m_P30613_Arg337Gln), deleterious(m_P08236_Arg382Cys), deleterious(m_P08100_Asp190Tyr), deleterious(m_P21912_Arg46Gly), deleterious(m_P00451_Glu2018Gly), deleterious(m_P06396_Asp214Asn), deleterious(m_Q8IVH4_Arg145Gln), deleterious(m_P00480_Lys88Asn), deleterious(m_P30613_Arg163Leu), deleterious(m_P21817_Arg177Cys), deleterious(m_O75197_Asp203Asn), deleterious(m_Q04446_Arg524Gln), deleterious(m_P00451_Arg2326Leu), deleterious(m_P35680_Arg276Gly), deleterious(m_P30301_Glu134Gly), deleterious(m_P30613_Glu387Gly), deleterious(m_P60484_Asp252Gly), deleterious(m_P11473_Arg274Leu), deleterious(m_P49747_Asp473Gly), deleterious(m_Q16518_His68Tyr), deleterious(m_P51648_Arg228Cys), deleterious(m_P54819_Asp165Gly), deleterious(m_P00966_Arg127Gln), deleterious(m_P00797_Asp104Asn), deleterious(m_P22033_His265Tyr), deleterious(m_P02649_Arg160Cys), deleterious(m_P10721_Arg791Gly), deleterious(m_P45381_Glu285Ala), deleterious(m_P00439_Arg270Ser), deleterious(m_P35914_Arg41Gln), deleterious(m_P23945_Asp224Val), deleterious(m_P07225_Glu204Gly), deleterious(m_P23786_Arg151Gln), deleterious(m_Q8N335_Arg273Cys), deleterious(m_P10912_Arg229Gly), deleterious(m_O75096_Asp529Asn), deleterious(m_P06276_Arg414Cys), deleterious(m_Q13496_Arg184Gly), deleterious(m_P21912_Arg46Gln), deleterious(m_P01185_Glu78Gly), deleterious(m_P29400_Arg1677Pro), deleterious(m_P00480_Arg92Gln), deleterious(m_P06280_Asp170Val), deleterious(m_P22033_Arg108Cys), deleterious(m_P05106_Arg119Trp), deleterious(m_P50336_Arg59Trp), deleterious(m_P00439_Asp282Asn), deleterious(m_Q8IVH4_Arg359Gly), deleterious(m_P19878_Arg77Gln), deleterious(m_P22033_His350Tyr), deleterious(m_P15104_Arg324Cys), deleterious(m_P00966_Glu270Gln), deleterious(m_P00439_Glu183Gln), deleterious(m_P01008_Arg438Gly), deleterious(m_O00187_Asp120Gly), deleterious(m_P40692_Arg18Cys), deleterious(m_P49747_Asp408Tyr), deleterious(m_P00451_Arg2326Pro), deleterious(m_P01008_Arg457Thr), deleterious(m_P06280_Asp93Asn), deleterious(m_P06280_Glu66Gln), deleterious(m_P15104_Arg341Cys), deleterious(m_P49747_Asp361Tyr), deleterious(m_P11217_Lys543Thr), deleterious(m_P22033_Arg108Gly), deleterious(m_Q13485_Glu330Gly), deleterious(m_P00966_Arg95Ser), deleterious(m_Q03393_Arg25Gly), deleterious(m_P00480_Arg277Gln), deleterious(m_Q13285_Asp293Asn), deleterious(m_P01009_Glu288Val), deleterious(m_P00451_Arg2323Cys), deleterious(m_P08100_Asp190Asn), deleterious(m_P69892_Asp8Asn), deleterious(m_P08100_Asp190Gly), deleterious(m_P02649_Arg152Gln), deleterious(m_P35520_Arg266Gly), deleterious(m_P00480_Arg94Thr), deleterious(m_P35680_Arg276Gln), deleterious(m_P40337_Asp126Tyr), deleterious(m_P00451_Arg2326Gly), deleterious(m_P28069_Glu174Gly), deleterious(m_P05106_Asp145Asn), deleterious(m_Q13509_Arg62Gln), deleterious(m_P10721_Asp820Gly), deleterious(m_P01241_Arg42Cys), deleterious(m_P02649_Arg154Cys), deleterious(m_P08709_Asp302Asn), deleterious(m_P08236_Arg216Trp), deleterious(m_P00451_Asp1865Asn), deleterious(m_P06280_Asp93Gly), deleterious(m_P30613_Arg488Gln), deleterious(m_P00813_Arg156Cys), deleterious(m_P49747_Asp518Asn), deleterious(m_P00813_Arg101Gln), deleterious(m_P19971_Glu289Ala), deleterious(m_P22033_His386Asn), deleterious(m_P00451_Arg2169Cys), deleterious(m_P00966_Arg127Trp), deleterious(m_P00966_Arg272Cys), deleterious(m_Q14623_Asp100Asn), deleterious(m_P02649_Arg154Ser), deleterious(m_P04424_Arg95Cys), deleterious(m_P30613_Asp390Asn), deleterious(m_Q13485_Arg361Cys), deleterious(m_P00813_Arg101Leu), deleterious(m_Q9H4B7_Arg318Trp), deleterious(m_P05106_Asp145Tyr), deleterious(m_Q15465_Asp147Asn), deleterious(m_P08236_Lys606Asn), deleterious(m_P40692_Arg659Pro), deleterious(m_Q8IWU9_Arg303Trp), deleterious(m_Q01968_Arg361Ile), deleterious(m_P22748_Arg219Ser), deleterious(m_P30613_Arg337Pro), deleterious(m_P21912_Arg230Cys), deleterious(m_Q92947_Arg161Gln), deleterious(m_P06280_Arg112Cys), deleterious(m_P02649_Lys164Gln), deleterious(m_P00451_Arg2323Gly), deleterious(m_P40692_Arg182Gly), deleterious(m_P60891_Asp65Asn), deleterious(m_P30613_Arg163Cys), deleterious(m_P06280_Arg112Ser), deleterious(m_P35520_Lys384Asn), deleterious(m_P10275_Arg774Cys), deleterious(m_P00451_Asp1865Tyr), deleterious(m_Q15465_Arg144Pro), deleterious(m_P01008_Arg438Met), deleterious(m_P00451_Arg2326Gln), deleterious(m_Q30201_Arg224Gly)

+ Negative Examples: deleterious(m_Q03518_Arg708Gln), deleterious(m_Q08752_Arg49Cys), deleterious(m_Q8IVF5_Arg1101Cys), deleterious(m_P41567_Arg90Gly), deleterious(m_P17035_Lys465Gln)  
develop  humvar398_33   modif_hydrophobicity(A, hydrophobicity_increase) and is_in_site(A, yes) and freq_at_pos(A, B) and B>=2 and gain_contact(A, dc). deleterious(A)
125 (2.08%) 
5 (0.25%) 
24
Covers:
+ Positive Examples: deleterious(m_Q06187_Arg28His), deleterious(m_P12271_Arg234Trp), deleterious(m_Q9UGJ0_Arg531Gly), deleterious(m_P00451_Thr314Ala), deleterious(m_P01185_Gly96Cys), deleterious(m_P00480_Pro220Ala), deleterious(m_P69891_Asp74His), deleterious(m_P51608_Gly161Val), deleterious(m_P10912_Arg179Cys), deleterious(m_P05155_Arg466Ser), deleterious(m_P00451_Gly164Val), deleterious(m_P43246_Pro622Leu), deleterious(m_P00480_Thr264Ile), deleterious(m_P30613_Gly263Trp), deleterious(m_P30613_Glu387Gly), deleterious(m_P04049_Thr491Ile), deleterious(m_P05186_Gly63Val), deleterious(m_O15305_Asn216Ile), deleterious(m_P00451_Gly2045Val), deleterious(m_P05186_Asp378Val), deleterious(m_P01241_Gln117Leu), deleterious(m_P01185_Gly54Val), deleterious(m_P08100_Gly51Val), deleterious(m_P00740_Arg379Gln), deleterious(m_P11413_Gly410Cys), deleterious(m_P00451_Asp579Ala), deleterious(m_P08100_Pro267Leu), deleterious(m_P54803_Arg396Leu), deleterious(m_P21912_Arg46Gln), deleterious(m_P00439_Asn167Ile), deleterious(m_Q9BZ23_Arg278Leu), deleterious(m_P00966_Arg265His), deleterious(m_P00439_Thr278Ala), deleterious(m_Q06187_Pro619Ser), deleterious(m_P49748_Arg469Gln), deleterious(m_P69891_Asp81Tyr), deleterious(m_P00480_Arg92Gln), deleterious(m_P40763_Arg382Leu), deleterious(m_P07902_Arg231His), deleterious(m_P15056_Gly596Val), deleterious(m_P10828_Gly345Val), deleterious(m_P45381_Pro280Leu), deleterious(m_P06276_Asp98His), deleterious(m_P13569_Ser549Ile), deleterious(m_P35670_Gly875Val), deleterious(m_O15553_Lys695Met), deleterious(m_P10275_Gly708Val), deleterious(m_P55072_Arg159His), deleterious(m_P05106_Arg240Trp), deleterious(m_Q03393_Pro87Leu), deleterious(m_P53634_Gly301Val), deleterious(m_P32322_Arg119His), deleterious(m_Q15582_Arg555Gln), deleterious(m_P00439_Gly247Val), deleterious(m_P05186_Gly220Val), deleterious(m_P02647_Pro27His), deleterious(m_P00439_Arg176Leu), deleterious(m_Q92838_Gly255Cys), deleterious(m_P08100_Gly106Trp), deleterious(m_P08397_Gln217Leu), deleterious(m_P08397_Glu250Val), deleterious(m_P00439_Arg261Gln), deleterious(m_P11413_Arg227Gln), deleterious(m_P00439_Arg408Trp), deleterious(m_O95409_Arg325Leu), deleterious(m_Q9Y4U1_Arg161Gln), deleterious(m_P00451_Arg1800Gly), deleterious(m_Q15833_Arg405Gln), deleterious(m_Q9H3D4_Arg319His), deleterious(m_P40763_Arg382Gln), deleterious(m_Q16518_His182Tyr), deleterious(m_Q13950_Arg225Gln), deleterious(m_P21817_Arg44Cys), deleterious(m_P40692_Gly67Trp), deleterious(m_P22033_Gly215Cys), deleterious(m_P00740_Gly432Val), deleterious(m_Q15582_Arg555Trp), deleterious(m_P05062_Arg304Gln), deleterious(m_P51608_Pro101Leu), deleterious(m_P00439_Glu205Ala), deleterious(m_Q9Y4U1_Arg161Gly), deleterious(m_Q13496_Arg241Leu), deleterious(m_P00439_Gly344Val), deleterious(m_P00966_Gly324Val), deleterious(m_P01112_Gly12Cys), deleterious(m_Q99593_Arg237Trp), deleterious(m_P08397_Glu250Gln), deleterious(m_P19438_Thr79Met), deleterious(m_P00451_Ser392Leu), deleterious(m_P01116_Pro34Gln), deleterious(m_P05186_Gly162Val), deleterious(m_P00451_Gly89Val), deleterious(m_P00451_Pro2172Gln), deleterious(m_Q06187_Pro619Thr), deleterious(m_P40692_Gln542Leu), deleterious(m_P11802_Arg24His), deleterious(m_P46100_Arg246Cys), deleterious(m_P01308_Arg89Leu), deleterious(m_Q9BZ23_Arg278Cys), deleterious(m_P00966_Arg363Gln), deleterious(m_P40763_Arg382Trp), deleterious(m_P35557_Gly80Ala), deleterious(m_P25189_Gly123Cys), deleterious(m_P15056_Gly466Val), deleterious(m_Q06124_Glu69Gln), deleterious(m_Q92838_Gly291Trp), deleterious(m_P48637_Asp219Ala), deleterious(m_P25189_Thr124Met), deleterious(m_Q13496_Arg241Cys), deleterious(m_P51608_Thr158Met), deleterious(m_P41181_Gly100Val), deleterious(m_P10912_Arg229His), deleterious(m_P00451_Gly2344Cys), deleterious(m_P08709_Asp302His), deleterious(m_P00451_Thr2173Ile), deleterious(m_P49675_Arg182Leu), deleterious(m_P00439_Arg158Gln), deleterious(m_P40692_Thr117Met), deleterious(m_P10275_Gly743Val), deleterious(m_Q16518_Gly528Val), deleterious(m_P35520_Arg369His), deleterious(m_O95409_His286Leu), deleterious(m_P04839_Pro415Leu), deleterious(m_P47989_Arg149Cys), deleterious(m_P08514_Pro176Leu)

+ Negative Examples: deleterious(m_P14780_Arg668Gln), deleterious(m_Q9BWS9_Arg331Gln), deleterious(m_P07357_Pro575Leu), deleterious(m_P56945_Arg491Leu), deleterious(m_P01889_Ser48Ala)  
develop  humvar398_24   modif_charge(A, charge_decrease) and modif_hydrophobicity(A, hydrophobicity_increase) and secondary_struc(A, sheet) and mut_accessibility(A, buried). deleterious(A)
121 (2.02%) 
4 (0.2%) 
25
Covers:
+ Positive Examples: deleterious(m_Q01968_Arg500Gly), deleterious(m_Q9UGJ0_Arg531Gly), deleterious(m_P31785_Arg222Cys), deleterious(m_P00439_Arg241Cys), deleterious(m_P08236_Arg382Cys), deleterious(m_Q93099_Asp153Gly), deleterious(m_Q01968_Arg500Gln), deleterious(m_P02511_Arg120Gly), deleterious(m_P21912_Arg46Gly), deleterious(m_P00451_Glu2018Gly), deleterious(m_Q8IVH4_Arg145Gln), deleterious(m_P11511_Arg375Cys), deleterious(m_P00439_Arg68Ser), deleterious(m_P05155_Asp408Val), deleterious(m_P00451_Arg2326Leu), deleterious(m_P11217_Arg602Trp), deleterious(m_P60484_Asp252Gly), deleterious(m_Q9UGJ0_Arg531Gln), deleterious(m_P08709_Arg307Cys), deleterious(m_Q15437_Arg497Cys), deleterious(m_Q16518_His68Tyr), deleterious(m_P06280_Asp264Val), deleterious(m_Q9Y617_Asp100Ala), deleterious(m_Q00266_Arg199Cys), deleterious(m_P02545_Arg541Ser), deleterious(m_P23945_Asp224Val), deleterious(m_P06280_Arg342Gln), deleterious(m_P38117_Arg164Gln), deleterious(m_P45381_Asp114Tyr), deleterious(m_Q16518_Arg44Gln), deleterious(m_P10912_Arg229Gly), deleterious(m_Q13496_Arg184Gly), deleterious(m_P06280_Asp264Tyr), deleterious(m_P00451_Arg1715Gly), deleterious(m_P21912_Arg46Gln), deleterious(m_Q9BZ23_Arg278Leu), deleterious(m_Q76LX8_Arg528Gly), deleterious(m_P06280_Asp170Val), deleterious(m_Q06187_Arg28Cys), deleterious(m_P06280_Arg227Gln), deleterious(m_P15104_Arg324Cys), deleterious(m_P00734_Arg425Cys), deleterious(m_P00813_Arg149Trp), deleterious(m_Q9C0B1_Arg316Gln), deleterious(m_P00966_Glu270Gln), deleterious(m_P00451_Arg301Cys), deleterious(m_P07320_Arg37Ser), deleterious(m_P00480_His302Leu), deleterious(m_P49748_Lys247Thr), deleterious(m_P01137_Arg218Cys), deleterious(m_P01008_Arg457Thr), deleterious(m_Q9Y6Q6_Arg170Gly), deleterious(m_P00441_Asp102Gly), deleterious(m_Q9NRR6_Arg378Cys), deleterious(m_P28329_Arg482Gly), deleterious(m_O75695_Arg118Cys), deleterious(m_P00439_His264Leu), deleterious(m_P01185_Arg97Cys), deleterious(m_P00451_His275Leu), deleterious(m_Q13485_Glu330Gly), deleterious(m_P31785_Arg226Cys), deleterious(m_P11172_Arg96Gly), deleterious(m_P08397_Arg225Gly), deleterious(m_Q9Y4U1_Arg161Gln), deleterious(m_P23526_Arg49Cys), deleterious(m_Q16518_His182Tyr), deleterious(m_P00480_Arg141Gln), deleterious(m_O75695_Glu138Gly), deleterious(m_P21439_Glu395Gly), deleterious(m_P17050_Arg329Gln), deleterious(m_O14832_Arg275Gln), deleterious(m_P00451_Arg2326Gly), deleterious(m_Q9Y4U1_Arg161Gly), deleterious(m_Q13496_Arg241Leu), deleterious(m_O43602_Arg140Leu), deleterious(m_P00439_Glu76Ala), deleterious(m_P35520_Arg369Cys), deleterious(m_Q9ULV0_Arg656Cys), deleterious(m_P00558_Asp285Val), deleterious(m_P12271_Arg151Gln), deleterious(m_P00451_Glu1894Gly), deleterious(m_P00813_Arg101Gln), deleterious(m_P00439_Arg243Gln), deleterious(m_P21802_Glu565Gly), deleterious(m_O15553_Glu656Ala), deleterious(m_P00451_Arg2169Cys), deleterious(m_P51608_Arg106Gln), deleterious(m_P17050_Arg329Trp), deleterious(m_Q9BZ23_Arg278Cys), deleterious(m_Q13485_Arg361Cys), deleterious(m_P54803_Arg531Cys), deleterious(m_P35270_Arg150Gly), deleterious(m_P00813_Arg101Leu), deleterious(m_Q9H4B7_Arg318Trp), deleterious(m_P05106_Asp145Tyr), deleterious(m_P00480_His302Tyr), deleterious(m_P55075_Arg116Gly), deleterious(m_Q01968_Arg361Ile), deleterious(m_P00451_Arg1960Gln), deleterious(m_Q13496_Arg241Cys), deleterious(m_P22748_Arg219Ser), deleterious(m_P02545_Arg527Cys), deleterious(m_P32322_Arg119Gly), deleterious(m_O75197_Arg154Met), deleterious(m_P49675_Glu169Gly), deleterious(m_P00813_Arg211Cys), deleterious(m_P00451_Asp2093Gly), deleterious(m_P00740_Arg294Gln), deleterious(m_P00439_Lys341Thr), deleterious(m_P00740_Arg294Gly), deleterious(m_P08397_Arg22Cys), deleterious(m_O14832_Arg275Trp), deleterious(m_P16930_Arg381Gly), deleterious(m_Q01968_His375Tyr), deleterious(m_P00441_Glu22Gly), deleterious(m_Q02127_Arg135Cys), deleterious(m_P00451_Arg301Leu), deleterious(m_Q14896_Arg732Cys), deleterious(m_P00387_Arg58Gln), deleterious(m_P00451_Arg2326Gln), deleterious(m_Q30201_Arg224Gly)

+ Negative Examples: deleterious(m_P47989_Arg607Gln), deleterious(m_P78324_Arg107Ser), deleterious(m_Q9UDX4_Arg364Cys), deleterious(m_P36871_Arg221Cys)  
develop  humvar398_5   modif_size(A, size_decrease) and modif_hydrophobicity(A, hydrophobicity_decrease) and modif_polarity(A, polarity_unchanged) and lost_contact(A, phob) and stability(A, decrease). deleterious(A)
122 (2.03%) 
5 (0.25%) 
25
Covers:
+ Positive Examples: deleterious(m_Q06124_Tyr62Asp), deleterious(m_P04839_Leu420Pro), deleterious(m_Q15833_Leu209Pro), deleterious(m_P11413_Leu323Pro), deleterious(m_P05166_Leu519Pro), deleterious(m_P38398_Leu1786Pro), deleterious(m_P00480_Tyr345Asp), deleterious(m_P02768_Leu90Pro), deleterious(m_P50897_Tyr109Asp), deleterious(m_Q9UBV7_Leu206Pro), deleterious(m_P00439_Leu41Pro), deleterious(m_P10619_Tyr249Asn), deleterious(m_P04181_Leu402Pro), deleterious(m_P43026_Leu441Pro), deleterious(m_P35520_Leu338Pro), deleterious(m_P60484_His61Asp), deleterious(m_O15119_Tyr149Ser), deleterious(m_P07902_Tyr209Ser), deleterious(m_P35916_Leu1044Pro), deleterious(m_O95409_Tyr402Asn), deleterious(m_P08514_Leu847Pro), deleterious(m_Q92838_Val307Gly), deleterious(m_Q06187_Leu512Pro), deleterious(m_P06744_Leu339Pro), deleterious(m_P08397_Leu81Pro), deleterious(m_Q15582_Leu518Pro), deleterious(m_P05062_Leu257Pro), deleterious(m_Q16518_Tyr144Asp), deleterious(m_P42224_Leu600Pro), deleterious(m_P39019_Leu64Pro), deleterious(m_P23786_Tyr210Asp), deleterious(m_Q93099_Val300Gly), deleterious(m_P12694_Tyr438Asn), deleterious(m_Q06187_Leu542Pro), deleterious(m_P10619_Leu236Pro), deleterious(m_P08236_Tyr320Ser), deleterious(m_P00387_Leu149Pro), deleterious(m_P07902_Tyr251Ser), deleterious(m_P05186_Phe327Gly), deleterious(m_P51843_Tyr380Asp), deleterious(m_P10275_Leu677Pro), deleterious(m_Q14353_Leu197Pro), deleterious(m_P31785_Tyr125Asn), deleterious(m_P00439_Tyr277Asp), deleterious(m_P42768_Leu270Pro), deleterious(m_P11532_Tyr231Asn), deleterious(m_P06280_Leu32Pro), deleterious(m_Q92838_Val323Gly), deleterious(m_P08397_Leu343Pro), deleterious(m_P51843_Val287Gly), deleterious(m_P00439_His170Asp), deleterious(m_P05062_Leu229Pro), deleterious(m_Q6VVX0_Leu99Pro), deleterious(m_P00966_Tyr291Ser), deleterious(m_Q9H0P0_Leu181Pro), deleterious(m_P08235_Leu979Pro), deleterious(m_P00439_Leu311Pro), deleterious(m_P16435_Tyr178Asp), deleterious(m_P25189_Tyr145Ser), deleterious(m_Q06187_Tyr476Asp), deleterious(m_P14410_Leu341Pro), deleterious(m_P54803_Tyr490Asn), deleterious(m_P09417_Leu74Pro), deleterious(m_P00439_Tyr154Asn), deleterious(m_P51843_Val385Gly), deleterious(m_P40337_Tyr156Asn), deleterious(m_Q13950_Leu136Pro), deleterious(m_P00451_Leu1963Pro), deleterious(m_P11217_Leu292Pro), deleterious(m_P05107_Leu149Pro), deleterious(m_P16930_Val166Gly), deleterious(m_Q16518_His182Asn), deleterious(m_P51843_Leu295Pro), deleterious(m_P06280_Leu131Pro), deleterious(m_P00451_Leu1771Pro), deleterious(m_P00480_Leu63Pro), deleterious(m_P51843_Leu278Pro), deleterious(m_P54803_Val566Gly), deleterious(m_P39019_Leu131Pro), deleterious(m_Q16518_Val452Gly), deleterious(m_P00480_Leu341Pro), deleterious(m_P51159_Leu130Pro), deleterious(m_P00813_Leu107Pro), deleterious(m_P43246_Leu187Pro), deleterious(m_P00966_Val345Gly), deleterious(m_P08397_Leu92Pro), deleterious(m_P31785_Leu230Pro), deleterious(m_P35914_Leu263Pro), deleterious(m_P00966_Leu206Pro), deleterious(m_P09417_Leu14Pro), deleterious(m_P51648_Tyr279Asn), deleterious(m_O14521_Leu139Pro), deleterious(m_P00966_Tyr190Asp), deleterious(m_P14222_Val183Gly), deleterious(m_P43246_Leu173Pro), deleterious(m_P10912_Val173Gly), deleterious(m_Q00266_Leu305Pro), deleterious(m_P23786_Tyr628Ser), deleterious(m_Q03692_Tyr582Asp), deleterious(m_P29965_Leu195Pro), deleterious(m_O15305_Tyr229Ser), deleterious(m_P13569_Leu633Pro), deleterious(m_P07902_Leu226Pro), deleterious(m_P30613_Leu374Pro), deleterious(m_P07902_Leu217Pro), deleterious(m_Q9ULV0_Val108Gly), deleterious(m_P07902_Leu74Pro), deleterious(m_P06280_Leu89Pro), deleterious(m_P03951_Leu320Pro), deleterious(m_P01308_Leu35Pro), deleterious(m_P40692_Leu292Pro), deleterious(m_Q14524_Leu1825Pro), deleterious(m_P40692_Val185Gly), deleterious(m_P00480_Leu45Pro), deleterious(m_P10828_Leu341Pro), deleterious(m_Q13496_His374Asp), deleterious(m_Q13496_Val364Gly), deleterious(m_P00966_Leu160Pro), deleterious(m_Q8IVH4_Leu89Pro), deleterious(m_P11217_Leu116Pro), deleterious(m_P48637_Leu188Pro), deleterious(m_P00492_Leu41Pro)

+ Negative Examples: deleterious(m_P41567_Leu59Pro), deleterious(m_O75715_Leu85Pro), deleterious(m_P06737_Val698Gly), deleterious(m_Q96PP9_Tyr541Asn), deleterious(m_P53621_Val1040Gly)  
develop  humvar398_54   conservation_class(A, global_conservation_rank_2) and freq_at_pos(A, B) and B>=2 and secondary_struc(A, helix). deleterious(A)
117 (1.95%) 
3 (0.15%) 
27
Covers:
+ Positive Examples: deleterious(m_P30613_Arg337Gln), deleterious(m_P30613_Ala394Val), deleterious(m_P58012_Ile84Ser), deleterious(m_P58012_Trp98Arg), deleterious(m_P40692_Met35Arg), deleterious(m_P26367_Ile29Ser), deleterious(m_P58012_Trp98Gly), deleterious(m_P58012_Leu106Phe), deleterious(m_P13569_Val562Leu), deleterious(m_P19429_Arg162Gln), deleterious(m_P06280_Ala156Thr), deleterious(m_P30613_Gly341Asp), deleterious(m_P30613_Glu387Gly), deleterious(m_P19429_Arg162Pro), deleterious(m_P40692_Met35Asn), deleterious(m_P49768_Leu392Val), deleterious(m_P30613_Asn393Lys), deleterious(m_P00966_Arg127Gln), deleterious(m_P00966_Arg157His), deleterious(m_P40692_Arg182Lys), deleterious(m_P29033_Val84Met), deleterious(m_O15305_Thr237Met), deleterious(m_P00492_Ile42Thr), deleterious(m_P08397_Ala31Thr), deleterious(m_P58012_Ile84Asn), deleterious(m_P00480_Arg92Gln), deleterious(m_P10275_Asn705Ser), deleterious(m_Q8IVH4_Arg359Gly), deleterious(m_P35520_Arg336His), deleterious(m_Q14623_Asp100Glu), deleterious(m_P10275_Leu701Phe), deleterious(m_P29033_Arg75Gln), deleterious(m_P10275_Gly708Val), deleterious(m_P00439_Glu183Gln), deleterious(m_P26367_Val53Asp), deleterious(m_Q06187_Arg525Pro), deleterious(m_P43246_Met688Ile), deleterious(m_P30613_Asn393Ser), deleterious(m_P10275_Asn705Tyr), deleterious(m_P69892_Lys67Gln), deleterious(m_Q8IVH4_Arg359Gln), deleterious(m_P15056_Lys499Asn), deleterious(m_P07951_Glu117Ala), deleterious(m_P08100_Gly106Trp), deleterious(m_Q99593_Arg237Gln), deleterious(m_P35520_Arg266Lys), deleterious(m_P35520_Ala331Val), deleterious(m_P08397_Asp99Asn), deleterious(m_Q15465_Ile111Asn), deleterious(m_P10828_Pro453His), deleterious(m_Q15465_Ile111Phe), deleterious(m_P00480_Arg277Gln), deleterious(m_P69892_Lys67Arg), deleterious(m_Q9Y5X4_Arg76Gln), deleterious(m_P39019_Ala17Pro), deleterious(m_P00492_Ile42Phe), deleterious(m_P35557_Met210Lys), deleterious(m_P00439_Ala345Ser), deleterious(m_P35520_Arg266Gly), deleterious(m_Q06187_Arg525Gly), deleterious(m_P05062_Arg304Gln), deleterious(m_Q9Y5X4_Arg76Trp), deleterious(m_P06280_Ala156Val), deleterious(m_P10275_Phe754Val), deleterious(m_P35520_Arg336Cys), deleterious(m_P02649_Arg154Cys), deleterious(m_P00451_Asp1865Asn), deleterious(m_Q03393_Ile114Val), deleterious(m_P35557_Met210Thr), deleterious(m_Q99593_Arg237Trp), deleterious(m_Q06187_Arg525Gln), deleterious(m_Q06187_Cys506Tyr), deleterious(m_P00966_Arg127Trp), deleterious(m_Q04446_Arg515His), deleterious(m_Q14623_Asp100Asn), deleterious(m_P26367_Ile29Val), deleterious(m_Q15465_Ala110Asp), deleterious(m_P29033_Arg32His), deleterious(m_O15305_Thr237Arg), deleterious(m_P02649_Arg154Ser), deleterious(m_P04424_Arg95Cys), deleterious(m_P30613_Ala394Asp), deleterious(m_P00439_Ala345Thr), deleterious(m_P00492_Ala50Val), deleterious(m_P10828_Pro453Leu), deleterious(m_P00439_Ala300Ser), deleterious(m_P30613_Gly341Ala), deleterious(m_P26367_Val53Leu), deleterious(m_P00492_Ala50Pro), deleterious(m_P35520_Thr262Arg), deleterious(m_P40692_Arg659Pro), deleterious(m_P01008_Tyr95Cys), deleterious(m_P08397_Ala31Pro), deleterious(m_P00439_Ala300Val), deleterious(m_P05062_Arg304Trp), deleterious(m_P15056_Lys499Glu), deleterious(m_P30613_Arg337Pro), deleterious(m_P01008_Tyr95Ser), deleterious(m_P29033_Arg75Trp), deleterious(m_P08100_Gly106Arg), deleterious(m_P02649_Lys164Gln), deleterious(m_P10828_Pro453Thr), deleterious(m_P40692_Arg182Gly), deleterious(m_P69892_Lys9Glu), deleterious(m_P40692_Arg659Leu), deleterious(m_Q15465_Ala110Thr), deleterious(m_P08397_Asp99His), deleterious(m_P10275_Arg774His), deleterious(m_P02649_Lys164Glu), deleterious(m_P00966_Arg157Cys), deleterious(m_P40692_Met35Lys), deleterious(m_P35520_Arg379Trp), deleterious(m_P10275_Arg774Cys), deleterious(m_P00451_Asp1865Tyr), deleterious(m_Q15582_Ala546Thr), deleterious(m_P35520_Thr262Met), deleterious(m_P08397_Asp99Gly)

+ Negative Examples: deleterious(m_Q05655_Asn348Ser), deleterious(m_Q9UDX3_Glu211Lys), deleterious(m_O15492_His137Arg)  
develop  humvar398_70   modif_size(A, size_decrease) and modif_polarity(A, polarity_decrease) and is_in_site(A, yes) and secondary_struc(A, other) and wt_accessibility(A, buried). deleterious(A)
119 (1.98%) 
5 (0.25%) 
27
Covers:
+ Positive Examples: deleterious(m_P00740_Ser411Gly), deleterious(m_Q16678_Asp192Val), deleterious(m_P28329_Arg420Cys), deleterious(m_P40763_Tyr657Cys), deleterious(m_P11498_Tyr304Cys), deleterious(m_Q8WXF7_His247Pro), deleterious(m_P30613_Arg163Leu), deleterious(m_P21817_Arg177Cys), deleterious(m_P23786_Arg503Cys), deleterious(m_P35680_Arg276Gly), deleterious(m_P00480_Asp263Gly), deleterious(m_Q9H2C0_Ser52Gly), deleterious(m_P11511_Arg435Cys), deleterious(m_P00451_Ser554Gly), deleterious(m_P49747_Asp473Gly), deleterious(m_O15305_Tyr64Cys), deleterious(m_P00439_Tyr343Cys), deleterious(m_Q15465_Asp88Val), deleterious(m_P54819_Asp165Gly), deleterious(m_P00451_His1980Pro), deleterious(m_P16435_Tyr575Cys), deleterious(m_P00451_His1973Leu), deleterious(m_P15259_Glu89Ala), deleterious(m_P05186_Asp378Val), deleterious(m_P45381_Glu285Ala), deleterious(m_P49747_Asp361Val), deleterious(m_P11413_Arg198Cys), deleterious(m_P49747_Asp420Ala), deleterious(m_P00439_Tyr377Cys), deleterious(m_P54803_Tyr314Cys), deleterious(m_P05156_His418Leu), deleterious(m_P00441_Asp125Val), deleterious(m_Q06187_Trp563Leu), deleterious(m_P54803_Thr112Ala), deleterious(m_P00480_Asp196Val), deleterious(m_Q06187_Tyr598Cys), deleterious(m_P06276_Tyr61Cys), deleterious(m_P05186_Asp306Val), deleterious(m_P00451_Trp1908Leu), deleterious(m_P16930_Asp233Val), deleterious(m_P45381_Asp68Ala), deleterious(m_Q01968_Glu468Gly), deleterious(m_P07902_Thr350Ala), deleterious(m_P25189_Arg98Pro), deleterious(m_P06132_His220Pro), deleterious(m_O00187_Asp120Gly), deleterious(m_P25189_Arg98Cys), deleterious(m_Q06124_Tyr279Cys), deleterious(m_P10828_Arg320Cys), deleterious(m_P00492_Tyr195Cys), deleterious(m_P00451_Arg550Gly), deleterious(m_P06280_His46Pro), deleterious(m_P04275_Arg1374Cys), deleterious(m_Q03692_Asp648Gly), deleterious(m_P00451_Arg2182Pro), deleterious(m_P00451_Tyr492Cys), deleterious(m_P15104_Arg341Cys), deleterious(m_P49747_Asp482Gly), deleterious(m_P00451_Tyr639Cys), deleterious(m_P00451_Arg2228Gly), deleterious(m_P36871_Thr115Ala), deleterious(m_Q13496_Arg69Cys), deleterious(m_P06276_Ser226Gly), deleterious(m_P06280_Asp165Val), deleterious(m_P13569_Asp579Gly), deleterious(m_Q9HBA0_Thr295Ala), deleterious(m_P23786_Asp213Gly), deleterious(m_P00451_Arg550Cys), deleterious(m_P07902_Tyr251Cys), deleterious(m_P30613_Arg86Pro), deleterious(m_P45381_His21Pro), deleterious(m_P08100_Asp190Gly), deleterious(m_Q13496_Arg69Pro), deleterious(m_Q06187_Arg641Cys), deleterious(m_P08559_His292Leu), deleterious(m_P00491_Asp128Gly), deleterious(m_P98172_Thr137Ala), deleterious(m_Q16518_Tyr431Cys), deleterious(m_P00451_Arg2182Cys), deleterious(m_P05186_Asp294Ala), deleterious(m_P00451_Tyr2036Cys), deleterious(m_P06280_Asp93Gly), deleterious(m_P49747_Asp349Val), deleterious(m_P00813_Arg156Cys), deleterious(m_Q06124_Asp61Gly), deleterious(m_Q01968_Asp451Gly), deleterious(m_Q06124_Gln510Pro), deleterious(m_P37231_Arg425Cys), deleterious(m_P22607_Lys650Met), deleterious(m_P45381_Glu24Gly), deleterious(m_P00480_Trp265Leu), deleterious(m_P36894_Arg443Cys), deleterious(m_Q8WVQ1_Arg300Cys), deleterious(m_O15305_His218Leu), deleterious(m_P00451_Asp135Gly), deleterious(m_P08559_Asp258Ala), deleterious(m_P06280_Tyr86Cys), deleterious(m_P45381_Tyr231Cys), deleterious(m_P06280_Asp266Val), deleterious(m_P11362_Arg622Gly), deleterious(m_O00754_His72Leu), deleterious(m_Q06187_Asp521Gly), deleterious(m_P16930_Trp234Gly), deleterious(m_P00451_Arg2228Leu), deleterious(m_P06280_Arg112Cys), deleterious(m_P02649_Thr60Ala), deleterious(m_Q01968_Tyr479Cys), deleterious(m_P07902_Arg333Gly), deleterious(m_P00451_Arg2228Pro), deleterious(m_P11413_Arg387Cys), deleterious(m_P00441_His81Ala), deleterious(m_Q06187_Arg562Pro), deleterious(m_P30613_Arg163Cys), deleterious(m_P46100_Gln219Pro), deleterious(m_P05186_Thr411Ala), deleterious(m_P11413_Arg198Pro), deleterious(m_Q15465_Arg144Pro), deleterious(m_P47989_Arg149Cys), deleterious(m_O60481_Trp255Gly)

+ Negative Examples: deleterious(m_Q86YB8_Asp129Val), deleterious(m_P50995_Arg230Cys), deleterious(m_P40227_Tyr229Cys), deleterious(m_Q8WXQ8_Ser378Gly), deleterious(m_P47944_Tyr30Cys)  
develop  humvar398_61   modif_charge(A, charge_increase) and modif_polarity(A, polarity_increase) and g_or_p(A, g_or_p_unchanged) and conservation_class(A, no_conservation_typification) and wt_accessibility(A, buried) and mut_accessibility(A, buried). deleterious(A)
114 (1.9%) 
5 (0.25%) 
29
Covers:
+ Positive Examples: deleterious(m_P43246_Cys697Arg), deleterious(m_P54840_Met491Arg), deleterious(m_P00813_Ala179Asp), deleterious(m_P39019_Leu18Arg), deleterious(m_P51648_Val64Asp), deleterious(m_P06213_Ala1162Glu), deleterious(m_P00451_Ala219Asp), deleterious(m_Q01968_Leu891Arg), deleterious(m_Q13144_Trp628Arg), deleterious(m_P21439_Ala546Asp), deleterious(m_P36551_Leu214Arg), deleterious(m_P21439_Leu556Arg), deleterious(m_P00966_Ala202Glu), deleterious(m_P55809_Val133Glu), deleterious(m_P00439_Val245Glu), deleterious(m_P16615_Cys318Arg), deleterious(m_O14958_Leu167His), deleterious(m_P06280_Val316Glu), deleterious(m_Q8WWY3_Ala194Glu), deleterious(m_P08100_Met216Lys), deleterious(m_P06276_Ala356Asp), deleterious(m_P16615_Cys560Arg), deleterious(m_P08397_Leu177Arg), deleterious(m_P06280_Ala288Asp), deleterious(m_P08397_Ala219Asp), deleterious(m_P00451_Val556Asp), deleterious(m_P22033_Leu617Arg), deleterious(m_O15118_Cys63Arg), deleterious(m_P00441_Leu39Arg), deleterious(m_P35557_Ala119Asp), deleterious(m_P00451_Ile1782Arg), deleterious(m_P00740_Val227Asp), deleterious(m_P00451_Leu217His), deleterious(m_Q7Z699_Val44Asp), deleterious(m_P00451_Leu117Arg), deleterious(m_P48637_Leu254Arg), deleterious(m_Q16678_Met132Arg), deleterious(m_Q15582_Val505Asp), deleterious(m_P00480_Met206Arg), deleterious(m_P30613_Val134Asp), deleterious(m_P30613_Ala352Asp), deleterious(m_P26367_Ile87Arg), deleterious(m_P50570_Leu570His), deleterious(m_O75695_Leu253Arg), deleterious(m_P43246_Cys199Arg), deleterious(m_P00451_Met2183Arg), deleterious(m_P08397_Cys247Arg), deleterious(m_P08397_Val124Asp), deleterious(m_P00813_Ala83Asp), deleterious(m_P08397_Leu85Arg), deleterious(m_P00451_Ala303Glu), deleterious(m_P43246_Val161Asp), deleterious(m_P05155_Val454Glu), deleterious(m_Q06187_Val64Asp), deleterious(m_P02649_Cys130Arg), deleterious(m_P00451_Leu26Arg), deleterious(m_P08100_Val87Asp), deleterious(m_P22033_Ala197Glu), deleterious(m_P29965_Val126Asp), deleterious(m_P00813_Leu304Arg), deleterious(m_Q12809_Leu86Arg), deleterious(m_P00451_Val181Glu), deleterious(m_P05155_Leu481Arg), deleterious(m_P00387_Cys204Arg), deleterious(m_P08514_Ala581Asp), deleterious(m_P06280_Ala377Asp), deleterious(m_P05166_Val205Asp), deleterious(m_P07902_Met142Lys), deleterious(m_Q01968_Val508Asp), deleterious(m_P22033_Ala377Glu), deleterious(m_P11362_Trp666Arg), deleterious(m_Q15582_Leu518Arg), deleterious(m_P03951_Cys56Arg), deleterious(m_P22033_Val669Glu), deleterious(m_P02649_Leu270Glu), deleterious(m_P51648_Leu106Arg), deleterious(m_P40692_Ala589Asp), deleterious(m_O15118_Cys113Arg), deleterious(m_Q06187_Val113Asp), deleterious(m_P00451_Val99Asp), deleterious(m_P49748_Leu243Arg), deleterious(m_P16930_Phe405His), deleterious(m_Q5TBB1_Leu60Arg), deleterious(m_P06132_Leu282Arg), deleterious(m_Q15046_Leu105His), deleterious(m_Q16518_Ala393Glu), deleterious(m_P35520_Val534Asp), deleterious(m_P00740_Leu318Arg), deleterious(m_P61764_Val84Asp), deleterious(m_P11362_Met719Arg), deleterious(m_P06280_Leu89Arg), deleterious(m_P08397_Leu245Arg), deleterious(m_P48637_Ala26Asp), deleterious(m_P00439_Ala309Asp), deleterious(m_P09467_Ala177Asp), deleterious(m_P16930_Cys193Arg), deleterious(m_P35240_Leu234Arg), deleterious(m_P22033_Leu347Arg), deleterious(m_Q13873_Cys123Arg), deleterious(m_P08100_Ala292Glu), deleterious(m_P26367_Ile87Lys), deleterious(m_Q15582_Leu509Arg), deleterious(m_P61764_Met443Arg), deleterious(m_P08397_Leu238Arg), deleterious(m_P06213_Ala1075Asp), deleterious(m_P51649_Val487Glu), deleterious(m_P22033_Leu685Arg), deleterious(m_O15305_Leu32Arg), deleterious(m_P22033_Ala191Glu), deleterious(m_P02730_Ala285Asp), deleterious(m_P39019_Ala61Glu), deleterious(m_Q9UBV7_Ala186Asp), deleterious(m_P43246_Val163Asp), deleterious(m_P02675_Leu383Arg)

+ Negative Examples: deleterious(m_Q15166_Ala179Asp), deleterious(m_P50895_Met204Lys), deleterious(m_Q08043_Cys628Arg), deleterious(m_P04440_Ala84Asp), deleterious(m_Q9UBR1_Ala340Asp)  
develop  humvar398_53   modif_size(A, size_decrease) and modif_hydrophobicity(A, hydrophobicity_decrease) and g_or_p(A, g_or_p_apparition) and secondary_struc(A, helix) and stability(A, decrease). deleterious(A)
109 (1.82%) 
4 (0.2%) 
30
Covers:
+ Positive Examples: deleterious(m_P04839_Leu420Pro), deleterious(m_Q15833_Leu209Pro), deleterious(m_P05166_Leu519Pro), deleterious(m_P08397_Leu254Pro), deleterious(m_Q13496_Leu391Pro), deleterious(m_P38398_Leu1786Pro), deleterious(m_P02768_Leu90Pro), deleterious(m_P29033_Leu79Pro), deleterious(m_Q06187_Leu647Pro), deleterious(m_O00255_Gln265Pro), deleterious(m_P43026_Leu441Pro), deleterious(m_P08235_Leu924Pro), deleterious(m_P58012_Trp98Gly), deleterious(m_P29033_Leu90Pro), deleterious(m_P35520_Leu338Pro), deleterious(m_P07101_Leu236Pro), deleterious(m_P35680_Val110Gly), deleterious(m_P21333_Gln170Pro), deleterious(m_P00480_Leu201Pro), deleterious(m_Q13496_Leu470Pro), deleterious(m_Q06187_Leu512Pro), deleterious(m_P08397_Leu81Pro), deleterious(m_Q15582_Leu518Pro), deleterious(m_P05062_Leu257Pro), deleterious(m_O00255_Leu272Pro), deleterious(m_P04839_Leu546Pro), deleterious(m_P39019_Leu64Pro), deleterious(m_P10619_Leu236Pro), deleterious(m_P05062_Leu284Pro), deleterious(m_Q14749_Leu50Pro), deleterious(m_P01009_Leu65Pro), deleterious(m_P10275_Leu677Pro), deleterious(m_Q14353_Leu197Pro), deleterious(m_Q9Y4U1_Leu193Pro), deleterious(m_P14410_Leu620Pro), deleterious(m_Q92947_Leu407Pro), deleterious(m_O14773_Gln278Pro), deleterious(m_P42768_Leu270Pro), deleterious(m_P29033_Leu214Pro), deleterious(m_P07196_Leu336Pro), deleterious(m_P08397_Leu343Pro), deleterious(m_P08100_His211Pro), deleterious(m_P51843_Val287Gly), deleterious(m_P35557_Leu309Pro), deleterious(m_P04156_Gln212Pro), deleterious(m_P08397_Leu244Pro), deleterious(m_Q6VVX0_Leu99Pro), deleterious(m_P06276_Leu335Pro), deleterious(m_P14410_Leu341Pro), deleterious(m_P09417_Leu74Pro), deleterious(m_P51843_Val385Gly), deleterious(m_P41181_Gln57Pro), deleterious(m_P11217_Leu292Pro), deleterious(m_P48165_Val64Gly), deleterious(m_P51843_Leu295Pro), deleterious(m_P00451_Leu1771Pro), deleterious(m_Q13496_Leu406Pro), deleterious(m_P06280_Trp287Gly), deleterious(m_P00480_Leu63Pro), deleterious(m_P39019_Leu18Pro), deleterious(m_P08100_Leu131Pro), deleterious(m_P39019_Leu131Pro), deleterious(m_P35498_Trp1812Gly), deleterious(m_P00480_Leu341Pro), deleterious(m_Q9ULV5_Leu114Pro), deleterious(m_P00813_Leu107Pro), deleterious(m_P08235_Leu769Pro), deleterious(m_P43246_Leu187Pro), deleterious(m_P00966_Val345Gly), deleterious(m_P51843_Leu297Pro), deleterious(m_P08397_Gln34Pro), deleterious(m_P69891_Trp38Gly), deleterious(m_P58012_Leu108Pro), deleterious(m_P00966_Leu206Pro), deleterious(m_O14521_Leu139Pro), deleterious(m_P00813_Gln199Pro), deleterious(m_P12235_Leu98Pro), deleterious(m_Q00266_Leu305Pro), deleterious(m_O94972_Leu76Pro), deleterious(m_Q06710_Gln40Pro), deleterious(m_Q04446_Leu224Pro), deleterious(m_P00439_Gln160Pro), deleterious(m_P07902_Leu226Pro), deleterious(m_P07902_Leu217Pro), deleterious(m_Q06187_Val626Gly), deleterious(m_P00439_Leu212Pro), deleterious(m_P60891_Gln133Pro), deleterious(m_P03951_Leu320Pro), deleterious(m_Q06187_Leu652Pro), deleterious(m_P05186_Gln207Pro), deleterious(m_P01308_Leu35Pro), deleterious(m_P00439_Leu213Pro), deleterious(m_P09417_Trp108Gly), deleterious(m_P30613_Leu73Pro), deleterious(m_P40692_Val185Gly), deleterious(m_P00480_Leu45Pro), deleterious(m_Q06124_Gln514Pro), deleterious(m_P10828_Leu341Pro), deleterious(m_P07196_Gln332Pro), deleterious(m_Q13496_Val364Gly), deleterious(m_P00966_Leu160Pro), deleterious(m_P14410_Val577Gly), deleterious(m_P60891_Leu152Pro), deleterious(m_P50993_Leu764Pro), deleterious(m_Q8IVH4_Leu89Pro), deleterious(m_P11217_Leu116Pro), deleterious(m_P48637_Leu188Pro), deleterious(m_P00492_Leu41Pro), deleterious(m_P06280_Trp47Gly)

+ Negative Examples: deleterious(m_P41567_Leu59Pro), deleterious(m_P00505_Val346Gly), deleterious(m_O75715_Leu85Pro), deleterious(m_P06737_Val698Gly)  
develop  humvar398_6   modif_hydrophobicity(A, hydrophobicity_increase) and conservation_class(A, global_conservation_rank_1) and mut_accessibility(A, intermediate) and stability(A, decrease). deleterious(A)
110 (1.83%) 
5 (0.25%) 
30
Covers:
+ Positive Examples: deleterious(m_P04424_Arg186Gln), deleterious(m_P13569_Arg560Thr), deleterious(m_Q99684_Asn382Ser), deleterious(m_P35557_Gly227Cys), deleterious(m_O43186_Glu80Ala), deleterious(m_P07195_Arg172His), deleterious(m_P60484_Arg173Cys), deleterious(m_P16435_Arg454His), deleterious(m_Q05066_Arg62Gly), deleterious(m_P20823_Arg272His), deleterious(m_P15313_Arg157Cys), deleterious(m_O75695_Arg118Leu), deleterious(m_P43034_Asp317His), deleterious(m_P07101_Arg233His), deleterious(m_P30566_Arg396Cys), deleterious(m_P10275_Asn771His), deleterious(m_P98172_Gly151Val), deleterious(m_Q06124_Asn308Ser), deleterious(m_P39019_Arg62Trp), deleterious(m_P48436_Pro108Leu), deleterious(m_P10275_Pro723Ser), deleterious(m_P43699_Arg213Ser), deleterious(m_Q7Z406_Arg726Ser), deleterious(m_P08100_Pro267Leu), deleterious(m_O15305_Arg141His), deleterious(m_P10275_Pro766Ser), deleterious(m_P11161_Arg359Trp), deleterious(m_P02489_Arg116Cys), deleterious(m_P10275_Arg855His), deleterious(m_P11161_Arg409Trp), deleterious(m_O95292_Pro56Ser), deleterious(m_Q14376_Arg239Trp), deleterious(m_P51648_Asn386Ser), deleterious(m_P15313_Arg124Trp), deleterious(m_O15553_Arg653His), deleterious(m_P28069_Arg172Gln), deleterious(m_P11161_Arg381Cys), deleterious(m_Q16595_Gly130Val), deleterious(m_O75695_Arg118His), deleterious(m_P63261_Pro264Leu), deleterious(m_Q14126_Arg46Gln), deleterious(m_P05166_Pro228Leu), deleterious(m_P10275_Glu772Gly), deleterious(m_Q06710_Arg31His), deleterious(m_P55316_Arg244Cys), deleterious(m_P04198_Arg393Ser), deleterious(m_P10275_Arg855Cys), deleterious(m_Q8WXF7_Arg217Gln), deleterious(m_P10746_Thr62Ala), deleterious(m_Q92947_Gly390Ala), deleterious(m_P08559_Thr231Ala), deleterious(m_P61916_Pro120Ser), deleterious(m_P30566_Arg396His), deleterious(m_P16930_Pro249Thr), deleterious(m_Q9UIF7_Arg238Trp), deleterious(m_Q13950_Thr200Ala), deleterious(m_P35520_Pro88Ser), deleterious(m_Q9H0F7_Gly169Ala), deleterious(m_P36551_Arg328Cys), deleterious(m_Q13950_Arg190Gln), deleterious(m_O43186_Arg90Trp), deleterious(m_P50336_Arg152Cys), deleterious(m_O95409_Arg325Leu), deleterious(m_P31271_Asn372His), deleterious(m_P23760_Ser73Leu), deleterious(m_P49748_Arg366Cys), deleterious(m_P10275_Pro904His), deleterious(m_P25189_Arg98His), deleterious(m_P05107_Asn351Ser), deleterious(m_P40692_Gly67Trp), deleterious(m_P08397_Arg167Gln), deleterious(m_P11161_Arg381His), deleterious(m_Q13950_Thr200Ile), deleterious(m_O14773_Ser475Leu), deleterious(m_Q76LX8_Arg398His), deleterious(m_P04181_Arg154Leu), deleterious(m_P52701_Arg772Trp), deleterious(m_P08397_Arg26Cys), deleterious(m_P10275_Pro904Ser), deleterious(m_P02489_Arg116His), deleterious(m_O75880_Pro174Leu), deleterious(m_P23760_Arg56Leu), deleterious(m_P51149_Asn161Thr), deleterious(m_P11802_Arg24His), deleterious(m_Q9ULV5_Arg119Cys), deleterious(m_Q13950_Arg131Gly), deleterious(m_P10275_Pro682Thr), deleterious(m_P40692_Asn38His), deleterious(m_P49748_Arg366His), deleterious(m_P10828_Arg429Gln), deleterious(m_P08397_Arg26His), deleterious(m_P00492_Asp177Val), deleterious(m_Q06187_Arg520Gln), deleterious(m_P07954_Arg233His), deleterious(m_Q00266_Arg264Cys), deleterious(m_P05186_Arg71His), deleterious(m_P04049_Asp486Gly), deleterious(m_P01241_Arg209His), deleterious(m_Q92979_Asp86Gly), deleterious(m_Q12840_Arg204Gln), deleterious(m_Q99714_Arg130Cys), deleterious(m_Q16595_Arg165Cys), deleterious(m_P39019_Arg101His), deleterious(m_P07315_Arg169Trp), deleterious(m_P13569_Gly480Cys), deleterious(m_P29400_Pro1517Thr), deleterious(m_P10275_Arg752Gln), deleterious(m_P04839_Pro415Leu), deleterious(m_P29965_Gly226Ala), deleterious(m_P08397_Arg195Cys)

+ Negative Examples: deleterious(m_Q9NQX4_Arg172Cys), deleterious(m_P06732_Gly243Ala), deleterious(m_P34913_Arg287Gln), deleterious(m_Q9BPX1_Arg130Trp), deleterious(m_P23368_Pro114Leu)  
develop  humvar398_75   modif_charge(A, charge_unchanged) and conservation_class(A, sub_family_conservation) and freq_at_pos(A, B) and B>=2. deleterious(A)
108 (1.8%) 
4 (0.2%) 
32
Covers:
+ Positive Examples: deleterious(m_Q04771_Gly328Trp), deleterious(m_P40763_Val637Leu), deleterious(m_P00451_Ile405Ser), deleterious(m_P08100_His211Arg), deleterious(m_P00492_Val53Met), deleterious(m_P05186_Arg450His), deleterious(m_P22830_Cys406Ser), deleterious(m_P00740_Val228Leu), deleterious(m_P01008_Leu131Phe), deleterious(m_P00480_Thr264Ile), deleterious(m_P00966_Arg86His), deleterious(m_P08100_Ala164Val), deleterious(m_P45381_Cys152Trp), deleterious(m_P00441_Leu145Phe), deleterious(m_P00451_Ser554Gly), deleterious(m_P35520_Val168Ala), deleterious(m_P00451_Tyr605Ser), deleterious(m_P45381_Arg168His), deleterious(m_P40763_Phe384Ser), deleterious(m_P01241_Gln117Leu), deleterious(m_P08100_Gly51Val), deleterious(m_P00441_Leu9Gln), deleterious(m_P00451_Pro470Leu), deleterious(m_P04792_Pro182Leu), deleterious(m_P00439_Ile224Met), deleterious(m_P04156_Phe198Ser), deleterious(m_P40763_Phe384Leu), deleterious(m_P00451_Gly1869Val), deleterious(m_P00441_Ala90Thr), deleterious(m_P00451_Asp75Glu), deleterious(m_P00480_His117Arg), deleterious(m_P10275_Ala870Val), deleterious(m_P00451_Met721Leu), deleterious(m_P55072_Arg159His), deleterious(m_P10275_Arg840His), deleterious(m_P00451_Ala111Thr), deleterious(m_P54803_Arg531His), deleterious(m_P06280_Cys56Tyr), deleterious(m_P00451_Ile405Phe), deleterious(m_P35520_Ala288Thr), deleterious(m_P38571_His129Arg), deleterious(m_P00966_Pro96Ser), deleterious(m_P40763_Val637Met), deleterious(m_Q9BZ23_Glu322Asp), deleterious(m_P04156_Val180Ile), deleterious(m_P06280_Cys56Phe), deleterious(m_P00480_Tyr183Cys), deleterious(m_P00439_Ala342Thr), deleterious(m_P00439_Asn207Ser), deleterious(m_P00451_Gly92Ala), deleterious(m_P06744_Arg347His), deleterious(m_P00439_Tyr277Cys), deleterious(m_P10746_Gly188Trp), deleterious(m_P00480_Tyr345Cys), deleterious(m_P00451_Tyr450Asn), deleterious(m_P04156_Arg208His), deleterious(m_P35520_Val168Met), deleterious(m_P00451_Met721Ile), deleterious(m_P06280_Cys56Gly), deleterious(m_P06280_Met296Val), deleterious(m_P00441_Ala90Val), deleterious(m_P50897_Val181Leu), deleterious(m_P00441_Ala5Thr), deleterious(m_P25189_Ser78Leu), deleterious(m_P10275_Ala870Gly), deleterious(m_P22830_Cys406Tyr), deleterious(m_P02649_Arg163His), deleterious(m_Q13496_Trp346Ser), deleterious(m_P00480_Arg129His), deleterious(m_Q06187_Cys502Trp), deleterious(m_P25189_Ser78Trp), deleterious(m_P54803_Pro318Ala), deleterious(m_Q92947_Arg383His), deleterious(m_P06280_Met296Ile), deleterious(m_Q06187_Cys502Phe), deleterious(m_P45381_Cys152Tyr), deleterious(m_P05186_Ala399Ser), deleterious(m_P00451_Gly89Val), deleterious(m_P10275_Ser703Cys), deleterious(m_P00441_Leu9Val), deleterious(m_P00740_Val228Phe), deleterious(m_P10275_Val866Leu), deleterious(m_P35520_Ala288Pro), deleterious(m_P21953_His206Arg), deleterious(m_P00441_Leu85Phe), deleterious(m_P00480_Pro225Leu), deleterious(m_P21817_Leu13Val), deleterious(m_P02545_Arg541His), deleterious(m_P00441_Leu145Ser), deleterious(m_Q13496_Trp346Cys), deleterious(m_P41181_Gly100Val), deleterious(m_P00441_Ala5Ser), deleterious(m_P00492_Val53Ala), deleterious(m_P00451_Ser603Ile), deleterious(m_P00441_Leu85Val), deleterious(m_P01008_Leu131Val), deleterious(m_P54803_Met117Leu), deleterious(m_P46100_Cys220Tyr), deleterious(m_P55072_Arg155His), deleterious(m_P10275_Gly743Val), deleterious(m_P00492_Gly16Ser), deleterious(m_P00439_Lys341Arg), deleterious(m_P00451_Pro470Thr), deleterious(m_P50897_Val181Met), deleterious(m_P69892_His78Arg), deleterious(m_P00451_Ala111Val), deleterious(m_P19438_Ser115Gly), deleterious(m_P00480_Pro225Thr)

+ Negative Examples: deleterious(m_P24394_Ile75Leu), deleterious(m_P24394_Ile75Phe), deleterious(m_Q9NZQ9_Asn336Ser), deleterious(m_Q9H4B7_Arg307His)  
develop  humvar398_47   modif_size(A, size_increase) and modif_hydrophobicity(A, hydrophobicity_decrease) and conservation_class(A, sub_family_conservation) and wt_accessibility(A, buried). deleterious(A)
103 (1.72%) 
5 (0.25%) 
33
Covers:
+ Positive Examples: deleterious(m_P00451_Gly1779Arg), deleterious(m_P00451_Ala97Pro), deleterious(m_P08100_His211Arg), deleterious(m_P08100_Cys167Arg), deleterious(m_P00439_Gln304Arg), deleterious(m_P21912_Leu65His), deleterious(m_Q04771_Gly328Glu), deleterious(m_P00492_Met143Lys), deleterious(m_Q9Y4U1_Gln27Arg), deleterious(m_Q9Y3Q4_Ser672Arg), deleterious(m_P06132_Met165Arg), deleterious(m_Q16637_Gln136Glu), deleterious(m_P00451_Gly193Arg), deleterious(m_P22830_Ile71Lys), deleterious(m_P00480_Ala208Thr), deleterious(m_P01185_Gly88Arg), deleterious(m_P08100_Thr4Lys), deleterious(m_P35520_Cys109Arg), deleterious(m_P45381_Cys152Arg), deleterious(m_P50053_Ala43Thr), deleterious(m_P00480_Gly100Asp), deleterious(m_P00747_Gly751Arg), deleterious(m_Q03692_Ser671Pro), deleterious(m_P00451_Val147Asp), deleterious(m_P54803_Gly323Arg), deleterious(m_P08100_Ala164Glu), deleterious(m_P01008_Ser381Pro), deleterious(m_P00441_Ala90Thr), deleterious(m_P05186_Ser445Pro), deleterious(m_P00492_Gly58Arg), deleterious(m_P00480_Met213Lys), deleterious(m_P16615_Gly769Arg), deleterious(m_P00480_Ala140Pro), deleterious(m_Q01968_His414Arg), deleterious(m_Q92947_Cys375Arg), deleterious(m_P22830_Leu182Arg), deleterious(m_P00451_Ser603Arg), deleterious(m_P55809_Gly219Glu), deleterious(m_Q9BZ23_Ala398Thr), deleterious(m_P08100_Thr58Arg), deleterious(m_P00451_Ala111Thr), deleterious(m_P22830_Ser151Pro), deleterious(m_P35520_Ala288Thr), deleterious(m_P38571_His129Arg), deleterious(m_P08100_Gly188Arg), deleterious(m_P00740_His302Arg), deleterious(m_P00492_Gly16Asp), deleterious(m_P41181_Gly100Arg), deleterious(m_Q8WXF7_Ala161Pro), deleterious(m_P06280_Gln279Glu), deleterious(m_P00451_Gly1869Asp), deleterious(m_P54803_Gly286Asp), deleterious(m_P00439_Ala342Thr), deleterious(m_P49768_Ala426Pro), deleterious(m_P00491_Ala174Pro), deleterious(m_Q15582_Leu569Arg), deleterious(m_P07902_Leu289Arg), deleterious(m_P08100_Met207Arg), deleterious(m_P35680_Gly285Asp), deleterious(m_P00441_Ala5Thr), deleterious(m_P08100_Gly90Asp), deleterious(m_P05062_Ala150Pro), deleterious(m_P51648_Ser415Asn), deleterious(m_P46100_Cys220Arg), deleterious(m_Q9Y281_Ala35Thr), deleterious(m_Q92947_Ala293Thr), deleterious(m_P00451_Gly278Arg), deleterious(m_P21817_Leu13Arg), deleterious(m_P04275_Cys1272Arg), deleterious(m_P35520_Ala361Thr), deleterious(m_O43405_Gly88Glu), deleterious(m_P02649_Ala117Thr), deleterious(m_P32929_Gln240Glu), deleterious(m_P21912_Ala43Pro), deleterious(m_P10275_Val866Glu), deleterious(m_P10275_His874Arg), deleterious(m_P61916_Ser67Pro), deleterious(m_Q04771_Gly328Arg), deleterious(m_P00451_Gly130Arg), deleterious(m_P04181_Gln90Glu), deleterious(m_P16615_Gly749Arg), deleterious(m_P08100_Gly51Arg), deleterious(m_P01008_Ser148Pro), deleterious(m_O00255_Val189Glu), deleterious(m_P08100_Leu125Arg), deleterious(m_P08100_Gly188Glu), deleterious(m_P35520_Ala288Pro), deleterious(m_P22830_Met288Lys), deleterious(m_P29033_His73Arg), deleterious(m_P53634_Gly139Arg), deleterious(m_P01008_Ala459Asp), deleterious(m_P00451_Gly89Asp), deleterious(m_P00558_Cys316Arg), deleterious(m_P10828_Cys446Arg), deleterious(m_P00966_Cys19Arg), deleterious(m_P16615_Ala745Asp), deleterious(m_P12271_Met226Lys), deleterious(m_P41181_Gly175Arg), deleterious(m_P16615_Gly23Glu), deleterious(m_P16615_Ala803Thr), deleterious(m_P10275_Gly743Glu), deleterious(m_P45381_Ala305Glu), deleterious(m_Q68CZ1_Ser659Pro)

+ Negative Examples: deleterious(m_Q92854_Ala327Thr), deleterious(m_P17066_Ala150Thr), deleterious(m_P05112_Cys27Arg), deleterious(m_Q96DC8_Ala151Thr), deleterious(m_Q92854_Ala72Thr)  
develop  humvar398_63   g_or_p(A, g_or_p_unchanged) and conservation_class(A, global_conservation_rank_1) and stability(A, increase). deleterious(A)
102 (1.7%) 
4 (0.2%) 
33
Covers:
+ Positive Examples: deleterious(m_P06744_His389Arg), deleterious(m_P48728_Asn145Ile), deleterious(m_P00441_Asn87Ser), deleterious(m_P05186_Arg184Trp), deleterious(m_P00480_Asp175Val), deleterious(m_P29965_Gln174Arg), deleterious(m_P00480_Asp196Tyr), deleterious(m_O15305_Asn216Ile), deleterious(m_P35680_Ser148Trp), deleterious(m_Q92838_His252Tyr), deleterious(m_P00451_His1973Leu), deleterious(m_Q9BZ23_Asn500Ile), deleterious(m_P05186_Asp378Val), deleterious(m_P98172_Cys153Tyr), deleterious(m_P53634_Trp429Cys), deleterious(m_P35914_Cys174Tyr), deleterious(m_O14521_Asp92Tyr), deleterious(m_P28069_Ser179Arg), deleterious(m_P35520_Ala155Val), deleterious(m_P49419_Glu427Gln), deleterious(m_P05156_His418Leu), deleterious(m_P00441_Asp125Val), deleterious(m_Q9UIF7_Tyr176Cys), deleterious(m_P04181_His319Tyr), deleterious(m_P00480_Asp196Val), deleterious(m_Q9Y4Z2_Arg93Leu), deleterious(m_P43246_Asn671Tyr), deleterious(m_P35680_Ser148Leu), deleterious(m_P13569_Ser549Ile), deleterious(m_P48436_Phe154Leu), deleterious(m_P29965_His125Arg), deleterious(m_P31785_Tyr105Cys), deleterious(m_P36894_Cys376Tyr), deleterious(m_P56693_Ser135Thr), deleterious(m_P48436_Lys173Glu), deleterious(m_O95409_Cys335Phe), deleterious(m_P00480_His302Leu), deleterious(m_Q15833_Arg405Trp), deleterious(m_P04181_Tyr55His), deleterious(m_P51843_Lys382Asn), deleterious(m_P00558_Asp315Asn), deleterious(m_P00740_Cys435Tyr), deleterious(m_P13569_Ser549Arg), deleterious(m_O95409_His327Tyr), deleterious(m_P43246_Ser723Phe), deleterious(m_P58335_Cys218Arg), deleterious(m_P51843_Glu377Lys), deleterious(m_P00740_Cys407Ser), deleterious(m_P51649_Cys223Tyr), deleterious(m_P13569_Ser492Phe), deleterious(m_O15305_Asn216Ser), deleterious(m_P01185_Cys92Tyr), deleterious(m_P31271_Gln371Leu), deleterious(m_P31785_Cys231Tyr), deleterious(m_O95409_His286Tyr), deleterious(m_P08559_His292Leu), deleterious(m_P04424_Arg385Cys), deleterious(m_P98172_Met158Ile), deleterious(m_P49768_Cys410Tyr), deleterious(m_P23786_Asp553Asn), deleterious(m_P35680_Arg235Gln), deleterious(m_P09417_His158Tyr), deleterious(m_O43186_Arg41Gln), deleterious(m_P15529_Cys35Tyr), deleterious(m_P00558_Asp285Val), deleterious(m_P14222_Cys279Tyr), deleterious(m_P08100_Cys110Tyr), deleterious(m_Q13351_His299Tyr), deleterious(m_Q92838_His252Leu), deleterious(m_Q01196_Arg174Gln), deleterious(m_P01009_Ser77Phe), deleterious(m_P69892_His64Leu), deleterious(m_Q12948_Ser131Leu), deleterious(m_P69892_His93Tyr), deleterious(m_P48436_Phe112Leu), deleterious(m_Q14353_Met50Leu), deleterious(m_P08235_Ser810Leu), deleterious(m_P35680_Lys164Gln), deleterious(m_P03952_Cys548Tyr), deleterious(m_P48436_His165Tyr), deleterious(m_P35557_Thr228Met), deleterious(m_Q13950_Ser191Asn), deleterious(m_Q92947_Thr429Met), deleterious(m_P19367_Thr680Ser), deleterious(m_P51843_Ala300Val), deleterious(m_O00754_His72Leu), deleterious(m_O43186_Arg41Trp), deleterious(m_O14521_His102Leu), deleterious(m_P35914_Asp42Glu), deleterious(m_P55809_Cys456Phe), deleterious(m_P02655_Lys77Gln), deleterious(m_P60484_Cys105Tyr), deleterious(m_P02656_Thr94Ala), deleterious(m_Q05066_Lys106Ile), deleterious(m_P04424_Gln286Arg), deleterious(m_O14832_Gln176Lys), deleterious(m_P68032_His90Tyr), deleterious(m_P51648_Thr184Met), deleterious(m_P51648_His411Tyr), deleterious(m_P69892_His64Tyr), deleterious(m_O95409_His286Leu), deleterious(m_Q13562_Arg111Leu)

+ Negative Examples: deleterious(m_Q7Z5L0_Thr77Ser), deleterious(m_P09017_Asn178Ser), deleterious(m_P09017_Arg158Leu), deleterious(m_P05154_Ser64Asn)  
develop  humvar398_22   modif_charge(A, charge_decrease) and g_or_p(A, g_or_p_apparition) and wt_accessibility(A, buried). deleterious(A)
100 (1.67%) 
3 (0.15%) 
35
Covers:
+ Positive Examples: deleterious(m_Q01968_Arg500Gly), deleterious(m_P35916_Arg1041Pro), deleterious(m_Q9UGJ0_Arg531Gly), deleterious(m_Q93099_Asp153Gly), deleterious(m_Q06187_Arg28Pro), deleterious(m_P21912_Arg46Gly), deleterious(m_P00451_Glu2018Gly), deleterious(m_Q8WXF7_His247Pro), deleterious(m_P13569_His620Pro), deleterious(m_P53634_Arg272Pro), deleterious(m_P35680_Arg276Gly), deleterious(m_P30301_Glu134Gly), deleterious(m_P30613_Glu387Gly), deleterious(m_P60484_Asp252Gly), deleterious(m_P00451_Asp561Gly), deleterious(m_P06744_Arg75Gly), deleterious(m_P00480_Asp263Gly), deleterious(m_P49747_Asp473Gly), deleterious(m_P54819_Asp165Gly), deleterious(m_O15305_Arg238Gly), deleterious(m_P00451_His1980Pro), deleterious(m_Q7LG56_Glu194Gly), deleterious(m_Q15465_His140Pro), deleterious(m_P00480_Arg141Pro), deleterious(m_Q9BZ23_Arg249Pro), deleterious(m_Q06187_Glu589Gly), deleterious(m_P01185_Glu78Gly), deleterious(m_Q14524_Asp1790Gly), deleterious(m_P29400_Arg1677Pro), deleterious(m_P08100_Arg135Gly), deleterious(m_P38571_His129Pro), deleterious(m_Q8IVH4_Arg359Gly), deleterious(m_P08100_His211Pro), deleterious(m_P43080_Glu155Gly), deleterious(m_Q01968_Glu468Gly), deleterious(m_P25189_Arg98Pro), deleterious(m_P06132_His220Pro), deleterious(m_O00187_Asp120Gly), deleterious(m_P35520_Arg125Pro), deleterious(m_P21953_Arg183Pro), deleterious(m_P51843_Arg425Gly), deleterious(m_P00451_Arg550Gly), deleterious(m_P00441_Asp102Gly), deleterious(m_P06280_His46Pro), deleterious(m_P16615_Glu412Gly), deleterious(m_Q03692_Asp648Gly), deleterious(m_P00451_Asp186Gly), deleterious(m_P28329_Arg482Gly), deleterious(m_P00451_Arg2182Pro), deleterious(m_Q92947_Arg128Gly), deleterious(m_Q13496_His469Pro), deleterious(m_P49747_Asp482Gly), deleterious(m_Q13485_Glu330Gly), deleterious(m_P35914_Asp42Gly), deleterious(m_P00451_Arg2228Gly), deleterious(m_P11172_Arg96Gly), deleterious(m_P08397_Arg225Gly), deleterious(m_P13569_Asp579Gly), deleterious(m_P36897_Asp400Gly), deleterious(m_P23786_Asp213Gly), deleterious(m_O15305_Arg238Pro), deleterious(m_Q92947_Arg138Gly), deleterious(m_P30613_Arg86Pro), deleterious(m_P45381_His21Pro), deleterious(m_P08100_Asp190Gly), deleterious(m_P00480_Arg330Gly), deleterious(m_Q13496_Arg69Pro), deleterious(m_P15056_Glu501Gly), deleterious(m_P00491_Asp128Gly), deleterious(m_P35520_Arg266Gly), deleterious(m_P28069_Glu174Gly), deleterious(m_Q9Y4U1_Arg161Gly), deleterious(m_P02649_Arg163Pro), deleterious(m_P06280_Asp93Gly), deleterious(m_P00439_Arg252Gly), deleterious(m_Q06124_Asp61Gly), deleterious(m_P00451_Glu1894Gly), deleterious(m_Q01968_Asp451Gly), deleterious(m_P48637_Asp219Gly), deleterious(m_P10721_Arg796Gly), deleterious(m_P45381_Glu24Gly), deleterious(m_P08559_Arg263Gly), deleterious(m_P00451_Asp135Gly), deleterious(m_P35270_Arg150Gly), deleterious(m_P55075_Arg116Gly), deleterious(m_P11362_Arg622Gly), deleterious(m_Q06187_Asp521Gly), deleterious(m_P32322_Arg119Gly), deleterious(m_P30613_Arg337Pro), deleterious(m_P00451_Asp2093Gly), deleterious(m_P40692_Arg182Gly), deleterious(m_Q15582_His626Pro), deleterious(m_P07902_Arg333Gly), deleterious(m_P16930_Arg381Gly), deleterious(m_P00451_Arg2228Pro), deleterious(m_Q06187_Arg562Pro), deleterious(m_P11413_Arg198Pro), deleterious(m_Q15465_Arg144Pro), deleterious(m_P00451_His1867Pro), deleterious(m_Q9UBC3_Asp817Gly)

+ Negative Examples: deleterious(m_P16083_Glu29Gly), deleterious(m_O43745_Arg127Pro), deleterious(m_Q9UDX3_Arg124Gly)  
develop  humvar398_109   modif_size(A, size_increase) and modif_polarity(A, polarity_increase) and g_or_p(A, g_or_p_unchanged) and is_in_site(A, yes) and secondary_struc(A, other) and mut_accessibility(A, buried). deleterious(A)
99 (1.65%) 
5 (0.25%) 
36
Covers:
+ Positive Examples: deleterious(m_P43246_Cys697Arg), deleterious(m_P54840_Met491Arg), deleterious(m_P22033_Cys560Tyr), deleterious(m_Q03426_Ala334Thr), deleterious(m_P36551_Leu214Arg), deleterious(m_P06280_Cys94Tyr), deleterious(m_P00966_Ala202Glu), deleterious(m_Q01968_Cys498Tyr), deleterious(m_P05186_Ala179Thr), deleterious(m_P00451_Ala1939Thr), deleterious(m_P00439_Val245Glu), deleterious(m_P40692_Leu155Arg), deleterious(m_P43026_Cys400Tyr), deleterious(m_P00451_Ala723Thr), deleterious(m_P35520_Cys275Tyr), deleterious(m_P00480_Cys303Tyr), deleterious(m_P35914_Cys174Tyr), deleterious(m_Q06187_Ala523Glu), deleterious(m_P01008_Ala436Thr), deleterious(m_P11362_Cys277Tyr), deleterious(m_P00451_Val147Asp), deleterious(m_P08397_Ala219Asp), deleterious(m_P31785_Cys182Arg), deleterious(m_P00451_Val556Asp), deleterious(m_P22033_Leu617Arg), deleterious(m_P00441_Leu39Arg), deleterious(m_P00451_Ile1782Arg), deleterious(m_P00740_Val227Asp), deleterious(m_P00451_Leu217His), deleterious(m_P00451_Leu117Arg), deleterious(m_Q16678_Met132Arg), deleterious(m_P00740_Cys407Arg), deleterious(m_P01112_Ala146Thr), deleterious(m_O43602_Leu178Arg), deleterious(m_P00480_Met213Lys), deleterious(m_P05186_Cys201Tyr), deleterious(m_P22830_Leu182Arg), deleterious(m_P00740_Ala265Thr), deleterious(m_P00451_Ala111Thr), deleterious(m_P35520_Ala288Thr), deleterious(m_P00451_Met2183Arg), deleterious(m_P00451_Ala303Glu), deleterious(m_P51648_Cys237Tyr), deleterious(m_P11413_Ala335Thr), deleterious(m_P00740_Cys435Tyr), deleterious(m_P13716_Ala274Thr), deleterious(m_Q03692_Cys591Arg), deleterious(m_P00451_Leu26Arg), deleterious(m_O43405_Ala119Thr), deleterious(m_Q14353_Cys169Tyr), deleterious(m_P51649_Cys223Tyr), deleterious(m_P00451_Val181Glu), deleterious(m_P05155_Leu481Arg), deleterious(m_P10071_Cys520Tyr), deleterious(m_Q9H3D4_Cys308Tyr), deleterious(m_P06213_Ala1161Thr), deleterious(m_P46100_Cys220Arg), deleterious(m_P21802_Ala648Thr), deleterious(m_P04075_Cys339Tyr), deleterious(m_P21817_Leu13Arg), deleterious(m_Q76LX8_Cys508Tyr), deleterious(m_P04275_Cys1272Arg), deleterious(m_O43918_Cys311Tyr), deleterious(m_Q92947_Leu179Arg), deleterious(m_P21912_Cys196Tyr), deleterious(m_P07902_Met142Lys), deleterious(m_Q01968_Val508Asp), deleterious(m_P21802_Ala628Thr), deleterious(m_P03951_Cys56Arg), deleterious(m_P07686_Ala543Thr), deleterious(m_O14773_Val385Asp), deleterious(m_P00451_Val99Asp), deleterious(m_Q06187_Met477Arg), deleterious(m_P07686_Cys309Tyr), deleterious(m_P06280_Cys378Tyr), deleterious(m_P00451_Leu2185Trp), deleterious(m_P07954_Ala308Thr), deleterious(m_P49768_Ala431Glu), deleterious(m_P20823_Val259Asp), deleterious(m_P00480_Cys303Arg), deleterious(m_P55895_Cys478Tyr), deleterious(m_P11362_Met719Arg), deleterious(m_P01008_Ala459Asp), deleterious(m_P10644_Ala213Asp), deleterious(m_P15918_Cys328Tyr), deleterious(m_P05014_Ala74Thr), deleterious(m_P16930_Cys193Arg), deleterious(m_Q06124_Ala465Thr), deleterious(m_P10828_Cys446Arg), deleterious(m_P22033_Leu347Arg), deleterious(m_P51649_Val487Glu), deleterious(m_P00966_Ala118Thr), deleterious(m_P46100_Cys220Tyr), deleterious(m_P45381_Ala287Thr), deleterious(m_O75695_Cys67Tyr), deleterious(m_P22033_Ala191Glu), deleterious(m_Q9UBV7_Ala186Asp), deleterious(m_P08246_Ala166Thr), deleterious(m_P02675_Leu383Arg)

+ Negative Examples: deleterious(m_P17066_Ala150Thr), deleterious(m_Q6IMI6_Ala88Thr), deleterious(m_Q9P0N9_Leu67Trp), deleterious(m_O43488_Ala142Thr), deleterious(m_Q96I15_Ala175Thr)  
develop  humvar398_95   modif_hydrophobicity(A, hydrophobicity_increase) and modif_polarity(A, polarity_unchanged) and conservation_class(A, global_conservation_rank_1) and secondary_struc(A, helix). deleterious(A)
96 (1.6%) 
4 (0.2%) 
37
Covers:
+ Positive Examples: deleterious(m_P04424_Arg186Gln), deleterious(m_P13569_Arg560Thr), deleterious(m_Q99684_Asn382Ser), deleterious(m_P10721_Gly812Val), deleterious(m_P07195_Arg172His), deleterious(m_Q03426_Asn301Thr), deleterious(m_P51843_Arg425Thr), deleterious(m_P01008_His152Tyr), deleterious(m_P20823_Arg272His), deleterious(m_P07686_Arg505Gln), deleterious(m_P04424_Arg113Gln), deleterious(m_P07101_Arg233His), deleterious(m_Q06187_Ser578Tyr), deleterious(m_P48436_Pro170Leu), deleterious(m_Q13496_Gly402Ala), deleterious(m_P39019_Arg62Gln), deleterious(m_P43699_Arg213Ser), deleterious(m_O14521_Asp92Tyr), deleterious(m_P49748_Lys382Gln), deleterious(m_P39019_Arg56Gln), deleterious(m_Q7Z406_Arg726Ser), deleterious(m_P08100_Pro267Leu), deleterious(m_P10828_Arg316His), deleterious(m_O15305_Arg141His), deleterious(m_P49748_Arg469Gln), deleterious(m_Q16678_Arg390Ser), deleterious(m_P10275_Arg855His), deleterious(m_O14773_Pro202Leu), deleterious(m_P04198_Arg393His), deleterious(m_P35520_Arg121His), deleterious(m_Q12840_Arg280His), deleterious(m_P28069_Arg172Gln), deleterious(m_P32322_Arg251His), deleterious(m_P05166_Pro228Leu), deleterious(m_Q06710_Arg31His), deleterious(m_Q13496_Arg421Gln), deleterious(m_P04198_Arg393Ser), deleterious(m_P51648_Pro121Leu), deleterious(m_P02545_Arg377His), deleterious(m_P11511_Arg365Gln), deleterious(m_P35557_Glu300Gln), deleterious(m_P13569_Arg553Gln), deleterious(m_O95409_Arg325Ser), deleterious(m_P12955_Arg184Gln), deleterious(m_Q92947_Gly390Ala), deleterious(m_P22607_Arg621His), deleterious(m_P30566_Arg396His), deleterious(m_O95409_His327Tyr), deleterious(m_P25445_Arg250Gln), deleterious(m_Q13351_Arg328His), deleterious(m_P35914_Asp42His), deleterious(m_P31271_Asn372His), deleterious(m_Q15833_Arg405Gln), deleterious(m_P05107_Asn351Ser), deleterious(m_P08100_Pro171Leu), deleterious(m_O95409_His286Tyr), deleterious(m_Q9UM73_Arg1275Gln), deleterious(m_P28069_Arg143Gln), deleterious(m_Q9NRR6_Arg435Gln), deleterious(m_P40692_Pro28Leu), deleterious(m_P20823_Arg229Gln), deleterious(m_P09417_His158Tyr), deleterious(m_P10275_Asp732Tyr), deleterious(m_O75880_Pro174Leu), deleterious(m_Q13351_His299Tyr), deleterious(m_Q13496_Gly402Val), deleterious(m_P69892_His93Tyr), deleterious(m_P40692_Asn38His), deleterious(m_P23786_Arg296Gln), deleterious(m_P10828_Arg429Gln), deleterious(m_P35680_Lys164Gln), deleterious(m_P48436_His165Tyr), deleterious(m_P41235_Glu285Gln), deleterious(m_Q9Y4Z2_Arg107Ser), deleterious(m_P41181_Arg187His), deleterious(m_P08397_Arg173Gln), deleterious(m_P43246_Arg359Ser), deleterious(m_P05186_Arg71His), deleterious(m_O14521_Pro81Leu), deleterious(m_P02655_Lys77Gln), deleterious(m_P39019_Pro47Leu), deleterious(m_P01241_Arg209His), deleterious(m_P68032_Arg314His), deleterious(m_Q12840_Arg204Gln), deleterious(m_P39019_Arg101His), deleterious(m_P35680_Arg295His), deleterious(m_P49748_Arg453Gln), deleterious(m_P04424_Arg193Gln), deleterious(m_P35520_Asn228Ser), deleterious(m_Q9ULV5_Arg73His), deleterious(m_P68032_His90Tyr), deleterious(m_P69892_His64Tyr), deleterious(m_P35680_Arg165His), deleterious(m_P10275_Arg752Gln), deleterious(m_P04839_Pro415Leu), deleterious(m_P22033_Arg369His)

+ Negative Examples: deleterious(m_P09326_Glu102Gln), deleterious(m_P10635_Arg365His), deleterious(m_Q14500_Pro156Leu), deleterious(m_P20073_Arg441Gln)  
develop  humvar398_29   modif_hydrophobicity(A, hydrophobicity_decrease) and conservation_class(A, no_conservation_typification) and gain_contact(A, phob) and wt_accessibility(A, buried). deleterious(A)
96 (1.6%) 
5 (0.25%) 
38
Covers:
+ Positive Examples: deleterious(m_P40692_Ser193Pro), deleterious(m_P07902_Ser192Asn), deleterious(m_P04839_Gly408Glu), deleterious(m_P40692_Ala586Pro), deleterious(m_Q13144_Trp628Arg), deleterious(m_P05155_Gly345Arg), deleterious(m_Q03426_Leu39Pro), deleterious(m_P08514_Gly412Arg), deleterious(m_P02545_Thr528Lys), deleterious(m_P51649_Gly268Glu), deleterious(m_P08397_Leu81Pro), deleterious(m_P00451_Gly266Glu), deleterious(m_P00441_Gly86Arg), deleterious(m_P00480_Gly83Arg), deleterious(m_P00451_Ala1939Thr), deleterious(m_P05186_Gly339Arg), deleterious(m_P00451_Ser553Pro), deleterious(m_O14958_Leu167His), deleterious(m_Q03692_Ser600Pro), deleterious(m_Q8WWY3_Ala194Glu), deleterious(m_P03951_Gly263Glu), deleterious(m_P16615_Cys560Arg), deleterious(m_P00451_Gly466Glu), deleterious(m_P02787_Ala477Pro), deleterious(m_P00451_Gly164Asp), deleterious(m_P00451_Gly474Arg), deleterious(m_P04839_Gly408Arg), deleterious(m_P35557_Ala119Asp), deleterious(m_P00451_Ile1782Arg), deleterious(m_P00451_Ser202Arg), deleterious(m_P00451_Gly439Asp), deleterious(m_Q13651_Gly141Arg), deleterious(m_P30613_Gly364Asp), deleterious(m_P06132_Leu161Gln), deleterious(m_P35557_Gly261Arg), deleterious(m_P26367_Ile87Arg), deleterious(m_P00740_Gly351Asp), deleterious(m_P00740_Thr342Lys), deleterious(m_O75369_Gly1834Arg), deleterious(m_P00813_Ala83Asp), deleterious(m_P02649_Ala170Pro), deleterious(m_P13804_Gly116Arg), deleterious(m_P00740_Thr426Pro), deleterious(m_P05155_Val454Glu), deleterious(m_P04629_Leu213Pro), deleterious(m_P31785_Gly232Arg), deleterious(m_P16615_Gly211Asp), deleterious(m_P00480_Gly50Arg), deleterious(m_P35557_Gly261Glu), deleterious(m_O14773_Ser153Pro), deleterious(m_P06280_Ser148Arg), deleterious(m_P00451_Ser176Pro), deleterious(m_P25189_Gly110Asp), deleterious(m_P22033_Gly637Glu), deleterious(m_P00439_Ser87Arg), deleterious(m_P07902_Ala320Thr), deleterious(m_P06280_Gln327Lys), deleterious(m_P24752_Gly183Arg), deleterious(m_P08514_Leu214Pro), deleterious(m_P00813_Gly140Glu), deleterious(m_P54803_Thr668Arg), deleterious(m_Q03426_Gly326Arg), deleterious(m_P06280_Ser148Asn), deleterious(m_P13716_Gly133Arg), deleterious(m_P22033_Thr370Pro), deleterious(m_P03951_Cys56Arg), deleterious(m_O75197_Gly171Arg), deleterious(m_P30613_Gly275Arg), deleterious(m_P22033_Gly623Arg), deleterious(m_O94972_Leu76Pro), deleterious(m_P41181_Ser216Pro), deleterious(m_P05543_Ala133Pro), deleterious(m_Q13496_Ser229Pro), deleterious(m_P00451_Leu725Gln), deleterious(m_P00451_Ser596Pro), deleterious(m_P01008_Cys127Arg), deleterious(m_P00451_Leu327Pro), deleterious(m_P01308_Gly84Arg), deleterious(m_P40692_Leu550Pro), deleterious(m_P06132_Leu282Arg), deleterious(m_P06276_Gly393Arg), deleterious(m_Q16518_Ala393Glu), deleterious(m_P00451_Ser2082Asn), deleterious(m_P05156_Gly243Asp), deleterious(m_Q13285_Leu437Gln), deleterious(m_P22033_Gly637Arg), deleterious(m_P69892_Gly73Arg), deleterious(m_P23786_Gly600Arg), deleterious(m_P22033_Gly703Arg), deleterious(m_P08397_Gly260Asp), deleterious(m_P06132_Gly281Glu), deleterious(m_Q14524_Leu1825Pro), deleterious(m_P26367_Ile87Lys), deleterious(m_P32322_Gly206Arg), deleterious(m_P51649_Val487Glu), deleterious(m_P02545_Thr528Arg)

+ Negative Examples: deleterious(m_Q460N3_Gly606Arg), deleterious(m_Q03426_Ser52Asn), deleterious(m_O60921_Gln147Lys), deleterious(m_P20813_Gly99Glu), deleterious(m_P01889_Ser101Asn)  
develop  humvar398_73   modif_size(A, size_increase) and modif_hydrophobicity(A, hydrophobicity_increase) and g_or_p(A, g_or_p_unchanged) and freq_at_pos(A, B) and B>=2. deleterious(A)
95 (1.58%) 
5 (0.25%) 
39
Covers:
+ Positive Examples: deleterious(m_P69891_Asp74His), deleterious(m_P50570_Ser619Trp), deleterious(m_P08100_Asp190Tyr), deleterious(m_P00451_Ser577Phe), deleterious(m_P07602_Asn215His), deleterious(m_P40692_Ser44Phe), deleterious(m_P25445_Thr270Ile), deleterious(m_P00492_Asp177Tyr), deleterious(m_P00480_Thr264Ile), deleterious(m_P07902_Asp28Tyr), deleterious(m_P10275_Asp695His), deleterious(m_P06280_Asn320Tyr), deleterious(m_P25189_Thr65Ile), deleterious(m_P00480_Asp196Tyr), deleterious(m_Q06187_Asp521His), deleterious(m_P04049_Thr491Ile), deleterious(m_P43246_Ser323Tyr), deleterious(m_P06280_Asn298His), deleterious(m_P35680_Ser148Trp), deleterious(m_P30613_Thr408Ile), deleterious(m_P00451_Thr314Ile), deleterious(m_P25445_Asp260Tyr), deleterious(m_P00740_Thr342Met), deleterious(m_P00451_Asp579His), deleterious(m_P45381_Asp114Tyr), deleterious(m_O15305_Thr237Met), deleterious(m_P00966_Thr389Ile), deleterious(m_P06280_Asp264Tyr), deleterious(m_P05186_Asp294Tyr), deleterious(m_P06280_Asp92Tyr), deleterious(m_P69891_Asp81Tyr), deleterious(m_P29033_Asp50Tyr), deleterious(m_P00451_Asp101His), deleterious(m_Q13509_Asp417His), deleterious(m_P35680_Ser148Leu), deleterious(m_P06276_Asp98His), deleterious(m_P13569_Ser549Ile), deleterious(m_P00451_Asp588Tyr), deleterious(m_P25189_Ser63Phe), deleterious(m_P50570_Ser619Leu), deleterious(m_P10275_Asn705Tyr), deleterious(m_Q8NBP7_Asp374His), deleterious(m_P00451_Asp75Tyr), deleterious(m_P00439_Asp394His), deleterious(m_Q92838_Asp298His), deleterious(m_P49747_Asp361Tyr), deleterious(m_P35914_Asp42His), deleterious(m_Q9H3D4_Asp351His), deleterious(m_P01008_Ser214Tyr), deleterious(m_P02679_Asp356Tyr), deleterious(m_P06280_Asp244His), deleterious(m_P06396_Asp214Tyr), deleterious(m_P00451_Asp561Tyr), deleterious(m_O15118_Asp242His), deleterious(m_P25189_Ser78Leu), deleterious(m_Q13950_Thr200Ile), deleterious(m_P40337_Asp126Tyr), deleterious(m_P00451_Asp561His), deleterious(m_Q92838_Asp298Tyr), deleterious(m_P25189_Ser78Trp), deleterious(m_P00451_Asp2093Tyr), deleterious(m_P00451_Asp135Tyr), deleterious(m_P19438_Thr79Met), deleterious(m_P06280_Asp92His), deleterious(m_P10275_Asp732Tyr), deleterious(m_P02768_Asp389His), deleterious(m_P07902_Ser135Leu), deleterious(m_P00451_Ser392Leu), deleterious(m_Q92838_Thr378Met), deleterious(m_P01009_Ser77Phe), deleterious(m_P08397_Asp61Tyr), deleterious(m_P40692_Asn38His), deleterious(m_P00492_Asp201Tyr), deleterious(m_P00451_Asp186Tyr), deleterious(m_P40692_Asp485His), deleterious(m_P00439_Ser310Phe), deleterious(m_P49747_Thr585Met), deleterious(m_P05106_Asp145Tyr), deleterious(m_Q8NBP7_Asp374Tyr), deleterious(m_P01008_Ser214Phe), deleterious(m_P25189_Thr124Met), deleterious(m_P15976_Asp218Tyr), deleterious(m_P51608_Thr158Met), deleterious(m_P06280_Asp266His), deleterious(m_P00451_Ser603Ile), deleterious(m_P05186_Thr148Ile), deleterious(m_P08709_Asp302His), deleterious(m_P00451_Thr2173Ile), deleterious(m_P08397_Asp99His), deleterious(m_P23760_Asn47His), deleterious(m_P40692_Thr117Met), deleterious(m_P51608_Asp97Tyr), deleterious(m_P00451_Asp1865Tyr), deleterious(m_P51648_Thr184Met), deleterious(m_P35520_Thr262Met)

+ Negative Examples: deleterious(m_P01889_Asp138His), deleterious(m_P22735_Ser755Leu), deleterious(m_P24539_Thr152Met), deleterious(m_P38117_Thr154Met), deleterious(m_Q9P1W8_Ser286Leu)  
develop  humvar398_41   fold(A, 'ATC-like'). deleterious(A)
90 (1.5%) 
0 (0.0%) 
39
Covers:
+ Positive Examples: deleterious(m_P00480_Ala102Glu), deleterious(m_P00480_Leu301Phe), deleterious(m_P00480_Pro220Ala), deleterious(m_P00480_Arg320Leu), deleterious(m_P00480_Thr93Ala), deleterious(m_P00480_Tyr345Asp), deleterious(m_P00480_Ser267Arg), deleterious(m_P00480_His255Pro), deleterious(m_P00480_Lys88Asn), deleterious(m_P00480_Leu201Pro), deleterious(m_P00480_Asp175Val), deleterious(m_P00480_Thr264Ile), deleterious(m_P00480_His182Leu), deleterious(m_P00480_Ala208Thr), deleterious(m_P00480_Asp196Tyr), deleterious(m_P00480_His302Gln), deleterious(m_P00480_Asp263Gly), deleterious(m_P00480_Gly83Arg), deleterious(m_P00480_Tyr176Cys), deleterious(m_P00480_Cys303Tyr), deleterious(m_P00480_Gly100Asp), deleterious(m_P00480_Arg141Pro), deleterious(m_P00480_Glu87Lys), deleterious(m_P00480_Tyr183Asp), deleterious(m_P00480_Gly188Arg), deleterious(m_P00480_Ile172Phe), deleterious(m_P00480_Arg92Gln), deleterious(m_P00480_Asp196Val), deleterious(m_P00480_Thr242Ile), deleterious(m_P00480_Ser203Cys), deleterious(m_P00480_Ile159Thr), deleterious(m_P00480_Gly195Arg), deleterious(m_P00480_Ser90Arg), deleterious(m_P00480_Ser192Arg), deleterious(m_P00480_Pro225Arg), deleterious(m_P00480_Met213Lys), deleterious(m_P00480_Asn161Ser), deleterious(m_P00480_Ala140Pro), deleterious(m_P00480_Met206Arg), deleterious(m_P00480_Met268Thr), deleterious(m_P00480_Leu304Phe), deleterious(m_P00480_His117Arg), deleterious(m_P00480_His202Tyr), deleterious(m_P00480_Leu148Phe), deleterious(m_P00480_His302Leu), deleterious(m_P00480_Glu326Lys), deleterious(m_P00480_Ile160Ser), deleterious(m_P00480_Gly269Glu), deleterious(m_P00480_Tyr183Cys), deleterious(m_P00480_His168Arg), deleterious(m_P00480_Gly83Asp), deleterious(m_P00480_Gly162Arg), deleterious(m_P00480_Gly79Glu), deleterious(m_P00480_Pro305His), deleterious(m_P00480_Glu181Gly), deleterious(m_P00480_Tyr345Cys), deleterious(m_P00480_Arg277Gln), deleterious(m_P00480_Gln180His), deleterious(m_P00480_Arg141Gln), deleterious(m_P00480_Asn198Lys), deleterious(m_P00480_Leu341Pro), deleterious(m_P00480_Thr125Met), deleterious(m_P00480_Arg330Gly), deleterious(m_P00480_Arg94Thr), deleterious(m_P00480_Ala209Val), deleterious(m_P00480_Arg129His), deleterious(m_P00480_Gln216Glu), deleterious(m_P00480_Asp263Asn), deleterious(m_P00480_Ser207Arg), deleterious(m_P00480_Ala336Ser), deleterious(m_P00480_Ala174Pro), deleterious(m_P00480_Ser340Pro), deleterious(m_P00480_Thr247Lys), deleterious(m_P00480_Trp265Leu), deleterious(m_P00480_Gly197Arg), deleterious(m_P00480_Pro225Leu), deleterious(m_P00480_His302Tyr), deleterious(m_P00480_Cys303Arg), deleterious(m_P00480_Leu139Ser), deleterious(m_P00480_Val337Leu), deleterious(m_P00480_His117Leu), deleterious(m_P00480_Thr262Lys), deleterious(m_P00480_Asp126Gly), deleterious(m_P00480_Thr343Lys), deleterious(m_P00480_Leu191Phe), deleterious(m_P00480_His214Tyr), deleterious(m_P00480_Met206Ile), deleterious(m_P00480_Gly188Val), deleterious(m_P00480_Thr178Met), deleterious(m_P00480_Pro225Thr)

+ Negative Examples:  
develop  humvar398_15   modif_hydrophobicity(A, hydrophobicity_increase) and modif_polarity(A, polarity_unchanged) and g_or_p(A, g_or_p_unchanged) and secondary_struc(A, other) and wt_accessibility(A, buried) and mut_accessibility(A, buried). deleterious(A)
94 (1.57%) 
4 (0.2%) 
39
Covers:
+ Positive Examples: deleterious(m_P00747_Arg235His), deleterious(m_P15313_Arg465His), deleterious(m_P08100_Asp190Tyr), deleterious(m_P24752_Asn93Ser), deleterious(m_P00451_Asp1788His), deleterious(m_P07902_Arg333Gln), deleterious(m_P11217_Asn685Tyr), deleterious(m_P08709_Asp403His), deleterious(m_Q16518_Glu417Gln), deleterious(m_Q9UBC3_Arg840Gln), deleterious(m_P00451_Asn1971Thr), deleterious(m_Q13496_Arg69Ser), deleterious(m_Q06187_Arg641His), deleterious(m_Q06187_Asp521His), deleterious(m_P13637_Asp801Tyr), deleterious(m_P00451_Lys1751Gln), deleterious(m_P30613_Arg510Gln), deleterious(m_P28329_Arg560His), deleterious(m_P06280_Asn298His), deleterious(m_P22033_His265Tyr), deleterious(m_Q9ULV0_Arg219His), deleterious(m_P00439_Arg270Ser), deleterious(m_P35914_Arg41Gln), deleterious(m_P16615_Asn39Thr), deleterious(m_P41181_Asn68Ser), deleterious(m_Q13496_Asn189Ser), deleterious(m_P00451_Arg550His), deleterious(m_P49747_Asn453Ser), deleterious(m_P25189_Asn122Ser), deleterious(m_P06280_Asp92Tyr), deleterious(m_P07902_Arg231His), deleterious(m_P00451_Arg2228Gln), deleterious(m_P00451_Asn637Ser), deleterious(m_P22033_His350Tyr), deleterious(m_Q15833_Arg292His), deleterious(m_P05186_Arg246Ser), deleterious(m_Q8WVQ1_Arg300His), deleterious(m_P54840_Asn39Ser), deleterious(m_P49747_Asp408Tyr), deleterious(m_P06280_His46Tyr), deleterious(m_P06213_Arg1158Gln), deleterious(m_P00451_Asn1941Ser), deleterious(m_Q14749_Asn141Ser), deleterious(m_Q16518_Lys294Thr), deleterious(m_P49747_Asp472Tyr), deleterious(m_P48728_Asp276His), deleterious(m_P49747_Asp361Tyr), deleterious(m_Q16678_Asn423Tyr), deleterious(m_P06280_Asn298Ser), deleterious(m_O14832_Asn269His), deleterious(m_O15118_Asp242His), deleterious(m_Q12840_Asn256Ser), deleterious(m_O14832_His220Tyr), deleterious(m_P35680_Arg276Gln), deleterious(m_P40337_Asp126Tyr), deleterious(m_Q13509_Arg62Gln), deleterious(m_P00451_Ser1803Tyr), deleterious(m_P10828_Arg320His), deleterious(m_P08397_Arg116Gln), deleterious(m_P07902_Asn97Ser), deleterious(m_P05186_Arg223Gln), deleterious(m_P30613_Arg488Gln), deleterious(m_P00451_Arg2182His), deleterious(m_P00451_Asp135Tyr), deleterious(m_P06280_Asp92His), deleterious(m_P11362_Arg622Gln), deleterious(m_P00813_Arg156His), deleterious(m_P06280_Asp313Tyr), deleterious(m_P08559_Arg302His), deleterious(m_P40763_His437Tyr), deleterious(m_P00740_Asp410His), deleterious(m_P05166_Arg165Gln), deleterious(m_P40692_Asp485His), deleterious(m_Q06124_Glu69Gln), deleterious(m_P30566_Asp422Tyr), deleterious(m_P43246_His639Tyr), deleterious(m_P06744_Arg472His), deleterious(m_P00451_Asn2148Ser), deleterious(m_P08559_Arg288His), deleterious(m_O14958_Asp307His), deleterious(m_P06280_Asp266His), deleterious(m_P08253_Arg101His), deleterious(m_P43246_Asn127Ser), deleterious(m_P08709_Asp302His), deleterious(m_P49747_Asp342Tyr), deleterious(m_P00451_Asn631Ser), deleterious(m_P08236_His351Tyr), deleterious(m_P07101_Arg337His), deleterious(m_Q15465_Asp171His), deleterious(m_P01008_Asp398His), deleterious(m_P06280_Arg112Ser), deleterious(m_Q16678_Arg444Gln), deleterious(m_P22033_Arg93His), deleterious(m_P51648_His411Tyr)

+ Negative Examples: deleterious(m_Q9UBH0_Asn47Ser), deleterious(m_O95050_Asn246Ser), deleterious(m_Q13822_Asn577Ser), deleterious(m_P06870_Arg77His)  
develop  humvar398_52   modif_charge(A, charge_increase) and modif_polarity(A, polarity_increase) and conservation_class(A, sub_family_conservation). deleterious(A)
94 (1.57%) 
5 (0.25%) 
42
Covers:
+ Positive Examples: deleterious(m_P00451_Gly1779Arg), deleterious(m_P00441_Val8Glu), deleterious(m_P54803_Pro318Arg), deleterious(m_P08100_Cys167Arg), deleterious(m_P21912_Leu65His), deleterious(m_Q04771_Gly328Glu), deleterious(m_P00492_Met143Lys), deleterious(m_P06132_Met165Arg), deleterious(m_P00451_Gly193Arg), deleterious(m_P22830_Ile71Lys), deleterious(m_P01185_Gly88Arg), deleterious(m_P10275_Cys686Arg), deleterious(m_P35520_Cys109Arg), deleterious(m_P45381_Cys152Arg), deleterious(m_P08100_Pro53Arg), deleterious(m_P00480_Gly100Asp), deleterious(m_P00747_Gly751Arg), deleterious(m_P00451_Val147Asp), deleterious(m_P54803_Gly323Arg), deleterious(m_P08100_Ala164Glu), deleterious(m_P00451_Pro470Arg), deleterious(m_P10746_Gly188Arg), deleterious(m_P00492_Gly58Arg), deleterious(m_P00480_Pro225Arg), deleterious(m_P00480_Met213Lys), deleterious(m_P16615_Gly769Arg), deleterious(m_Q92947_Cys375Arg), deleterious(m_P22830_Leu182Arg), deleterious(m_P00451_Gly323Glu), deleterious(m_P36897_Met318Arg), deleterious(m_P55809_Gly219Glu), deleterious(m_P00451_Gly498Arg), deleterious(m_P08100_Gly188Arg), deleterious(m_P46100_Gly175Glu), deleterious(m_P00441_Gly13Arg), deleterious(m_P00492_Gly16Asp), deleterious(m_P41181_Gly100Arg), deleterious(m_P11277_Trp2024Arg), deleterious(m_P00451_Gly1869Asp), deleterious(m_P26367_Leu46Arg), deleterious(m_P54803_Gly286Asp), deleterious(m_P00966_Pro96His), deleterious(m_Q15582_Leu569Arg), deleterious(m_P07902_Leu289Arg), deleterious(m_O95452_Val37Glu), deleterious(m_P51812_Gly431Asp), deleterious(m_P08100_Met207Arg), deleterious(m_P21912_Gly53Arg), deleterious(m_P35680_Gly285Asp), deleterious(m_P01137_Cys225Arg), deleterious(m_P08100_Gly90Asp), deleterious(m_P09417_Trp36Arg), deleterious(m_P46100_Cys220Arg), deleterious(m_P45381_Gly274Arg), deleterious(m_P00451_Gly278Arg), deleterious(m_P21817_Leu13Arg), deleterious(m_P08236_Gly136Arg), deleterious(m_P04275_Cys1272Arg), deleterious(m_P06280_Pro265Arg), deleterious(m_O43405_Gly88Glu), deleterious(m_P00966_Trp179Arg), deleterious(m_P12235_Ala90Asp), deleterious(m_O75712_Gly12Asp), deleterious(m_P10275_Val866Glu), deleterious(m_P07902_Trp167Arg), deleterious(m_P05186_Gly491Arg), deleterious(m_Q04771_Gly328Arg), deleterious(m_P00451_Gly130Arg), deleterious(m_P16615_Gly749Arg), deleterious(m_P08100_Gly51Arg), deleterious(m_O00255_Val189Glu), deleterious(m_P08100_Leu125Arg), deleterious(m_P08100_Gly188Glu), deleterious(m_P21912_Pro131Arg), deleterious(m_P69892_Met56Arg), deleterious(m_P22830_Met288Lys), deleterious(m_P26367_Val126Asp), deleterious(m_P53634_Gly139Arg), deleterious(m_P01008_Ala459Asp), deleterious(m_P00451_Gly89Asp), deleterious(m_P00558_Cys316Arg), deleterious(m_P53634_Val129Glu), deleterious(m_P10828_Cys446Arg), deleterious(m_P00966_Cys19Arg), deleterious(m_P16615_Ala745Asp), deleterious(m_P36894_Cys124Arg), deleterious(m_P22033_Pro95Arg), deleterious(m_P12271_Met226Lys), deleterious(m_P41181_Gly175Arg), deleterious(m_P16615_Gly23Glu), deleterious(m_P10275_Gly743Glu), deleterious(m_O75712_Gly12Arg), deleterious(m_P05186_Gly456Arg), deleterious(m_P45381_Ala305Glu)

+ Negative Examples: deleterious(m_Q7Z3Z3_Cys412Arg), deleterious(m_P00797_Gly217Arg), deleterious(m_P05112_Cys27Arg), deleterious(m_Q6NUN0_Pro352Arg), deleterious(m_P47874_Gly36Arg)  
develop  humvar398_88   modif_charge(A, charge_unchanged) and modif_hydrophobicity(A, hydrophobicity_decrease) and modif_polarity(A, polarity_unchanged) and is_in_site(A, yes) and secondary_struc(A, sheet) and stability(A, decrease). deleterious(A)
93 (1.55%) 
5 (0.25%) 
43
Covers:
+ Positive Examples: deleterious(m_Q92838_Leu293Pro), deleterious(m_Q9UBV7_Leu206Pro), deleterious(m_P05156_His183Arg), deleterious(m_P00439_Leu41Pro), deleterious(m_P08709_Thr241Asn), deleterious(m_O15119_Tyr149Ser), deleterious(m_Q13496_Leu87Pro), deleterious(m_P35916_Leu1044Pro), deleterious(m_P08514_Leu847Pro), deleterious(m_Q92838_Val307Gly), deleterious(m_P08397_Ala122Gly), deleterious(m_P15313_Leu81Pro), deleterious(m_P13804_Val157Gly), deleterious(m_P06744_Leu339Pro), deleterious(m_P00451_Leu1994Pro), deleterious(m_P31785_Leu172Pro), deleterious(m_P42224_Leu600Pro), deleterious(m_O75695_Leu188Pro), deleterious(m_Q93099_Val300Gly), deleterious(m_P16435_Ala284Pro), deleterious(m_P00441_His49Arg), deleterious(m_P08236_Tyr320Ser), deleterious(m_P00387_Leu149Pro), deleterious(m_Q16518_Ala393Gly), deleterious(m_P05186_Phe327Gly), deleterious(m_P35557_Leu164Pro), deleterious(m_P00746_Val213Gly), deleterious(m_Q13950_Ala211Pro), deleterious(m_P11362_Leu245Pro), deleterious(m_Q92838_Val323Gly), deleterious(m_P05062_Leu229Pro), deleterious(m_Q06187_Leu408Pro), deleterious(m_P00480_Ala140Pro), deleterious(m_P00451_Ser2030Asn), deleterious(m_P38571_His129Arg), deleterious(m_P08397_Ala270Gly), deleterious(m_Q13496_Leu228Pro), deleterious(m_P25189_Tyr145Ser), deleterious(m_P54803_Tyr490Asn), deleterious(m_Q14376_Leu183Pro), deleterious(m_P00441_Val149Gly), deleterious(m_P10275_Leu768Pro), deleterious(m_P08100_Tyr178Asn), deleterious(m_P49748_Ala213Pro), deleterious(m_P43246_Val163Gly), deleterious(m_P16473_Leu252Pro), deleterious(m_P16930_Val166Gly), deleterious(m_P06280_Leu131Pro), deleterious(m_P43246_Ala636Pro), deleterious(m_P31371_Ser99Asn), deleterious(m_P43235_Leu309Pro), deleterious(m_P54803_Val566Gly), deleterious(m_P05062_Ala150Pro), deleterious(m_Q5TBB1_His86Arg), deleterious(m_P51159_Leu130Pro), deleterious(m_P30613_Ala115Pro), deleterious(m_P03950_His138Arg), deleterious(m_P30613_Leu155Pro), deleterious(m_P35914_His233Arg), deleterious(m_P08514_Leu214Pro), deleterious(m_P01185_Ala99Pro), deleterious(m_P08397_Leu92Pro), deleterious(m_P00441_His47Arg), deleterious(m_P11597_Leu168Pro), deleterious(m_P21912_Ala43Pro), deleterious(m_P09417_Leu14Pro), deleterious(m_Q15582_His626Arg), deleterious(m_P38571_Leu200Pro), deleterious(m_P14222_Val183Gly), deleterious(m_P43246_Leu173Pro), deleterious(m_P10912_Val173Gly), deleterious(m_Q68CZ1_Ala695Pro), deleterious(m_P05543_Ala133Pro), deleterious(m_Q92793_His1470Arg), deleterious(m_Q16637_Ala111Gly), deleterious(m_P06280_Tyr134Ser), deleterious(m_P08514_Leu86Pro), deleterious(m_Q03692_Leu614Pro), deleterious(m_P29965_Leu195Pro), deleterious(m_O15305_Tyr229Ser), deleterious(m_P13569_Leu633Pro), deleterious(m_P00451_Ser2082Asn), deleterious(m_P08397_Leu278Pro), deleterious(m_P58335_Leu45Pro), deleterious(m_P11172_Val109Gly), deleterious(m_Q9ULV0_Val108Gly), deleterious(m_P06280_Leu89Pro), deleterious(m_P00441_His44Arg), deleterious(m_P35520_Leu456Pro), deleterious(m_P40692_Leu292Pro), deleterious(m_P54803_Tyr567Ser), deleterious(m_P25189_His81Arg), deleterious(m_P43026_Ser475Asn)

+ Negative Examples: deleterious(m_Q9BZP6_Val324Gly), deleterious(m_Q9Y6U3_His61Arg), deleterious(m_Q9NS98_Ser180Asn), deleterious(m_P05161_Ser83Asn), deleterious(m_Q6ISS4_His87Arg)  
develop  humvar398_26   freq_at_pos(A, B) and B>=3 and wt_accessibility(A, accessible). deleterious(A)
89 (1.48%) 
2 (0.1%) 
44
Covers:
+ Positive Examples: deleterious(m_P00439_Met276Ile), deleterious(m_O15553_Lys695Arg), deleterious(m_P69891_Glu7Gln), deleterious(m_P01308_Arg89Cys), deleterious(m_P00451_Arg391His), deleterious(m_P51608_Pro101Ser), deleterious(m_P15918_Arg396Leu), deleterious(m_P02549_Arg28Ser), deleterious(m_P08100_Pro347Ala), deleterious(m_P02545_Arg482Leu), deleterious(m_P19429_Pro82Ser), deleterious(m_Q5S007_Arg1441His), deleterious(m_P35680_Arg295Pro), deleterious(m_P98172_Pro119Ser), deleterious(m_P25445_Asp260Tyr), deleterious(m_P01111_Gln61Lys), deleterious(m_P15918_Arg396His), deleterious(m_P04156_Pro105Leu), deleterious(m_P02545_Arg482Gln), deleterious(m_P36897_Arg487Pro), deleterious(m_P02549_Arg28Cys), deleterious(m_P36897_Arg487Trp), deleterious(m_P42336_His1047Arg), deleterious(m_P02649_Pro102Arg), deleterious(m_P98172_Pro119His), deleterious(m_O15553_Lys695Met), deleterious(m_P01308_Arg89His), deleterious(m_Q12840_Arg280His), deleterious(m_Q13950_Arg131Ser), deleterious(m_P25189_Asp134Gly), deleterious(m_Q5S007_Arg1441Gly), deleterious(m_Q13950_Arg225Leu), deleterious(m_Q13950_Lys218Gln), deleterious(m_P00439_Arg413Pro), deleterious(m_Q8NBP7_Asp374His), deleterious(m_P51608_Pro101Thr), deleterious(m_P00439_Met276Val), deleterious(m_P69892_Lys67Gln), deleterious(m_P00439_Arg176Leu), deleterious(m_P01008_Phe434Ser), deleterious(m_Q9H3D4_Arg318Gln), deleterious(m_P01008_Phe434Cys), deleterious(m_P25445_Asp260Gly), deleterious(m_P51608_Pro101Arg), deleterious(m_P46100_Pro190Ser), deleterious(m_P10828_Pro453His), deleterious(m_P05186_Gly426Asp), deleterious(m_Q13950_Arg225Gln), deleterious(m_P00439_Arg413Ser), deleterious(m_P69892_Lys67Arg), deleterious(m_P00492_Asp201Asn), deleterious(m_Q13950_Lys218Asn), deleterious(m_P69891_Glu7Gly), deleterious(m_P98172_Pro119Thr), deleterious(m_P00480_Arg129His), deleterious(m_Q5S007_Arg1441Cys), deleterious(m_P51608_Pro101Leu), deleterious(m_P08100_Pro347Gln), deleterious(m_P00439_Arg176Pro), deleterious(m_Q9H3D4_Arg318His), deleterious(m_P02549_Arg28His), deleterious(m_P08100_Pro347Arg), deleterious(m_P01111_Gly13Asp), deleterious(m_P02545_Arg482Trp), deleterious(m_Q13950_Arg131Gly), deleterious(m_P01308_Arg89Leu), deleterious(m_P00451_Arg391Pro), deleterious(m_P36897_Arg487Gln), deleterious(m_P00492_Asp201Tyr), deleterious(m_P10828_Pro453Leu), deleterious(m_Q12840_Arg280Cys), deleterious(m_P02549_Arg28Leu), deleterious(m_Q8NBP7_Asp374Tyr), deleterious(m_P15918_Arg396Cys), deleterious(m_P08100_Pro347Ser), deleterious(m_P46100_Pro190Ala), deleterious(m_P08100_Pro347Leu), deleterious(m_P35680_Arg295Cys), deleterious(m_Q15848_Arg112Cys), deleterious(m_Q13950_Lys218Glu), deleterious(m_Q13950_Arg131Cys), deleterious(m_Q12840_Arg280Leu), deleterious(m_P10828_Pro453Thr), deleterious(m_P42336_Glu545Lys), deleterious(m_P35680_Arg295His), deleterious(m_Q13950_Arg225Trp), deleterious(m_P00451_Arg391Cys), deleterious(m_P25189_Asp134Glu), deleterious(m_Q9H3D4_Arg318Cys)

+ Negative Examples: deleterious(m_P24394_Ile75Leu), deleterious(m_P24394_Ile75Phe)  
develop  humvar398_45   modif_charge(A, charge_unchanged) and lost_contact(A, arom). deleterious(A)
92 (1.53%) 
5 (0.25%) 
44
Covers:
+ Positive Examples: deleterious(m_P00439_Tyr386Cys), deleterious(m_Q12809_Phe29Leu), deleterious(m_Q01968_Phe242Ser), deleterious(m_P40763_Tyr657Cys), deleterious(m_P12694_Phe409Cys), deleterious(m_P58012_Trp98Gly), deleterious(m_P00451_Trp401Gly), deleterious(m_Q7Z699_Trp31Cys), deleterious(m_P10275_Phe794Ser), deleterious(m_P46100_Trp222Ser), deleterious(m_P54868_Tyr167Cys), deleterious(m_Q06187_Tyr39Ser), deleterious(m_Q13496_Trp230Cys), deleterious(m_P55316_Phe215Leu), deleterious(m_P53634_Trp39Ser), deleterious(m_Q02763_Tyr897Ser), deleterious(m_P02545_Trp520Ser), deleterious(m_P35914_Phe192Ser), deleterious(m_P00439_Tyr343Cys), deleterious(m_P00451_Tyr605Ser), deleterious(m_P16435_Tyr575Cys), deleterious(m_O15305_Phe172Val), deleterious(m_P21817_Tyr178Cys), deleterious(m_P53634_Trp429Cys), deleterious(m_P06280_Trp162Cys), deleterious(m_P08236_Tyr320Ser), deleterious(m_P10275_Phe856Leu), deleterious(m_P06213_Trp1220Leu), deleterious(m_Q02750_Phe53Ser), deleterious(m_P08236_Tyr320Cys), deleterious(m_P22830_Phe417Ser), deleterious(m_O15553_Tyr688Cys), deleterious(m_P05166_Tyr439Cys), deleterious(m_P16615_Phe675Ser), deleterious(m_P54803_Tyr314Cys), deleterious(m_P31785_Tyr125Asn), deleterious(m_P40763_Phe621Val), deleterious(m_O15305_Phe157Ser), deleterious(m_P00491_Tyr192Cys), deleterious(m_P00451_Phe295Leu), deleterious(m_Q06187_Tyr598Cys), deleterious(m_P04181_Tyr245Cys), deleterious(m_P29033_Trp44Ser), deleterious(m_P36507_Phe57Cys), deleterious(m_P53634_Tyr347Cys), deleterious(m_P35557_Phe150Ser), deleterious(m_P31785_Tyr105Cys), deleterious(m_P06280_Trp95Ser), deleterious(m_P29965_Tyr170Cys), deleterious(m_P00451_Trp532Gly), deleterious(m_P06132_Tyr311Cys), deleterious(m_P35498_Phe1831Ser), deleterious(m_Q13950_Phe187Ser), deleterious(m_P00439_Tyr154Asn), deleterious(m_Q13950_Phe197Ser), deleterious(m_P00451_Tyr492Cys), deleterious(m_Q9Y4U1_Trp157Cys), deleterious(m_P04156_His187Arg), deleterious(m_P15056_Trp531Cys), deleterious(m_P07686_Tyr456Ser), deleterious(m_P15056_Phe468Ser), deleterious(m_P10721_Phe584Cys), deleterious(m_P35498_Trp1812Gly), deleterious(m_P00439_Phe410Ser), deleterious(m_P08236_Trp627Cys), deleterious(m_Q06124_Tyr63Cys), deleterious(m_P21439_Phe165Ile), deleterious(m_P06280_Phe113Ser), deleterious(m_P10721_Phe584Leu), deleterious(m_P29965_Trp140Gly), deleterious(m_P00439_Phe161Ser), deleterious(m_P00451_Trp412Gly), deleterious(m_Q6NVY1_Tyr122Cys), deleterious(m_P16930_Phe62Cys), deleterious(m_P10912_Phe114Ser), deleterious(m_P00451_Phe484Cys), deleterious(m_P00439_Tyr325Cys), deleterious(m_O15305_Tyr229Ser), deleterious(m_P00451_Trp33Gly), deleterious(m_P29033_Trp44Cys), deleterious(m_P10619_Tyr395Cys), deleterious(m_P00740_Trp431Gly), deleterious(m_P03951_Phe301Leu), deleterious(m_P00740_Phe395Leu), deleterious(m_Q01968_Phe463Ser), deleterious(m_Q14353_Trp20Ser), deleterious(m_Q92838_Trp274Gly), deleterious(m_Q06187_Phe559Ser), deleterious(m_Q93099_Trp97Gly), deleterious(m_P51159_Trp73Gly), deleterious(m_P40692_Phe80Val), deleterious(m_P25189_Trp101Cys)

+ Negative Examples: deleterious(m_P04440_Phe38Leu), deleterious(m_Q96DN0_Phe52Leu), deleterious(m_P16442_Phe216Ile), deleterious(m_P23786_Phe352Cys), deleterious(m_P01909_Tyr34Cys)  
develop  humvar398_39   modif_polarity(A, polarity_increase) and g_or_p(A, g_or_p_disparition) and wt_accessibility(A, buried) and mut_accessibility(A, intermediate). deleterious(A)
88 (1.47%) 
5 (0.25%) 
46
Covers:
+ Positive Examples: deleterious(m_Q04771_Gly328Trp), deleterious(m_P06280_Pro146Ser), deleterious(m_P09417_Gly149Arg), deleterious(m_P35557_Gly227Cys), deleterious(m_Q9BZ23_Gly521Arg), deleterious(m_P54803_Pro318Arg), deleterious(m_P00451_Gly2045Glu), deleterious(m_P50336_Gly232Arg), deleterious(m_P05155_Gly345Arg), deleterious(m_Q04771_Gly328Glu), deleterious(m_P08514_Gly412Arg), deleterious(m_P50053_Gly40Arg), deleterious(m_P51649_Gly409Asp), deleterious(m_P32322_Gly206Trp), deleterious(m_P00441_Gly86Arg), deleterious(m_P01185_Gly54Arg), deleterious(m_P00966_Gly117Ser), deleterious(m_P10644_Gly289Trp), deleterious(m_P15259_Gly97Asp), deleterious(m_P00747_Gly751Arg), deleterious(m_P03951_Gly263Glu), deleterious(m_P11413_Gly410Cys), deleterious(m_P05186_Gly120Arg), deleterious(m_P35916_Gly857Arg), deleterious(m_P51857_Pro133Arg), deleterious(m_P05186_Gly63Arg), deleterious(m_P49748_Gly294Glu), deleterious(m_P00451_Gly2028Arg), deleterious(m_P00492_Gly7Asp), deleterious(m_P08559_Gly162Arg), deleterious(m_Q93099_Gly270Arg), deleterious(m_P13569_Gly622Asp), deleterious(m_P45381_Gly123Glu), deleterious(m_P00492_Gly58Arg), deleterious(m_P00441_Gly94Cys), deleterious(m_P06280_Pro409Thr), deleterious(m_P30613_Gly364Asp), deleterious(m_P05156_Gly287Arg), deleterious(m_P53634_Gly300Ser), deleterious(m_P10828_Gly332Arg), deleterious(m_P48728_Gly269Asp), deleterious(m_P00441_Gly94Asp), deleterious(m_P35557_Gly299Arg), deleterious(m_Q02127_Gly152Arg), deleterious(m_P02679_Gly191Arg), deleterious(m_O15305_Gly15Glu), deleterious(m_P31785_Gly232Arg), deleterious(m_P00480_Gly50Arg), deleterious(m_P10721_Gly601Arg), deleterious(m_P11473_Gly46Asp), deleterious(m_P11413_Gly410Asp), deleterious(m_O14773_Gly473Arg), deleterious(m_P69891_Gly26Arg), deleterious(m_Q13485_Gly352Arg), deleterious(m_P16930_Gly337Ser), deleterious(m_P51648_Gly412Arg), deleterious(m_Q13496_Gly402Arg), deleterious(m_P01009_Gly139Ser), deleterious(m_P02545_Gly465Asp), deleterious(m_P46100_Gly249Cys), deleterious(m_P00813_Gly74Cys), deleterious(m_P09417_Gly17Arg), deleterious(m_P04839_Gly389Glu), deleterious(m_P08709_Pro363Arg), deleterious(m_O15553_Gly632Ser), deleterious(m_P21439_Gly535Asp), deleterious(m_Q03426_Gly326Arg), deleterious(m_P04150_Gly679Ser), deleterious(m_P13716_Gly133Arg), deleterious(m_Q9UBC3_Gly663Ser), deleterious(m_P00480_Gly197Arg), deleterious(m_P01308_Gly84Arg), deleterious(m_Q99593_Gly80Arg), deleterious(m_P50897_Gly108Arg), deleterious(m_P08100_Gly89Asp), deleterious(m_P01111_Gly60Glu), deleterious(m_P23786_Gly600Arg), deleterious(m_P22033_Gly703Arg), deleterious(m_P00966_Gly347Arg), deleterious(m_P32322_Gly206Arg), deleterious(m_Q06187_Gly594Arg), deleterious(m_P06744_Gly159Ser), deleterious(m_O14773_Gly77Arg), deleterious(m_P39019_Gly120Arg), deleterious(m_Q92838_Gly381Arg), deleterious(m_Q92947_Gly101Arg), deleterious(m_P00441_Gly148Arg), deleterious(m_P53634_Gly300Asp)

+ Negative Examples: deleterious(m_P04440_Gly114Glu), deleterious(m_P24855_Gly127Arg), deleterious(m_Q6ISS4_Gly78Ser), deleterious(m_P20813_Gly99Glu), deleterious(m_P00505_Gly188Ser)  
develop  humvar398_43   fold(A, 'HIT-like'). deleterious(A)
81 (1.35%) 
0 (0.0%) 
47
Covers:
+ Positive Examples: deleterious(m_P07902_Ser192Asn), deleterious(m_P07902_Gln344Lys), deleterious(m_P07902_Gln252His), deleterious(m_P07902_Met142Val), deleterious(m_P07902_Arg201His), deleterious(m_P07902_Gln212His), deleterious(m_P07902_Gly179Asp), deleterious(m_P07902_Val44Met), deleterious(m_P07902_Arg333Gln), deleterious(m_P07902_Gly55Cys), deleterious(m_P07902_Tyr209Ser), deleterious(m_P07902_Arg148Gln), deleterious(m_P07902_Asp28Tyr), deleterious(m_P07902_Ile198Thr), deleterious(m_P07902_Leu195Pro), deleterious(m_P07902_His319Gln), deleterious(m_P07902_Tyr251Ser), deleterious(m_P07902_Arg148Gly), deleterious(m_P07902_Tyr323His), deleterious(m_P07902_Glu308Lys), deleterious(m_P07902_Asn314Asp), deleterious(m_P07902_Phe194Leu), deleterious(m_P07902_Pro325Leu), deleterious(m_P07902_Arg328His), deleterious(m_P07902_Arg231His), deleterious(m_P07902_His114Leu), deleterious(m_P07902_Gln317His), deleterious(m_P07902_Arg204Pro), deleterious(m_P07902_Thr350Ala), deleterious(m_P07902_Phe294Tyr), deleterious(m_P07902_Arg51Gln), deleterious(m_P07902_Pro324Ser), deleterious(m_P07902_Arg148Trp), deleterious(m_P07902_Glu291Lys), deleterious(m_P07902_Ser45Leu), deleterious(m_P07902_Asp113Asn), deleterious(m_P07902_Trp249Arg), deleterious(m_P07902_Ala199Thr), deleterious(m_P07902_Cys130Tyr), deleterious(m_P07902_Lys334Arg), deleterious(m_P07902_Ser143Leu), deleterious(m_P07902_Leu289Arg), deleterious(m_P07902_His132Tyr), deleterious(m_P07902_Glu203Lys), deleterious(m_P07902_Arg51Leu), deleterious(m_P07902_Arg272Gly), deleterious(m_P07902_Ile32Asn), deleterious(m_P07902_Tyr251Cys), deleterious(m_P07902_Ala320Thr), deleterious(m_P07902_Val44Leu), deleterious(m_P07902_Lys285Asn), deleterious(m_P07902_Gln118His), deleterious(m_P07902_Arg259Trp), deleterious(m_P07902_Asn97Ser), deleterious(m_P07902_Val151Ala), deleterious(m_P07902_Gln317Arg), deleterious(m_P07902_Met142Lys), deleterious(m_P07902_Ser135Leu), deleterious(m_P07902_Trp167Arg), deleterious(m_P07902_Arg258Cys), deleterious(m_P07902_Pro183Thr), deleterious(m_P07902_Tyr209Cys), deleterious(m_P07902_Ile198Met), deleterious(m_P07902_Arg262Pro), deleterious(m_P07902_Phe117Ser), deleterious(m_P07902_Asp98Asn), deleterious(m_P07902_Leu226Pro), deleterious(m_P07902_Leu282Val), deleterious(m_P07902_Leu217Pro), deleterious(m_P07902_Tyr323Asp), deleterious(m_P07902_Arg123Gln), deleterious(m_P07902_Leu74Pro), deleterious(m_P07902_Lys229Asn), deleterious(m_P07902_Val150Leu), deleterious(m_P07902_Met129Thr), deleterious(m_P07902_Arg333Gly), deleterious(m_P07902_Thr138Met), deleterious(m_P07902_Phe171Ser), deleterious(m_P07902_Arg333Trp), deleterious(m_P07902_Lys127Glu), deleterious(m_P07902_Ala81Thr)

+ Negative Examples:  
develop  humvar398_34   modif_charge(A, charge_unchanged) and conservation_class(A, global_conservation_rank_2) and gain_contact(A, phob) and stability(A, decrease). deleterious(A)
83 (1.38%) 
4 (0.2%) 
48
Covers:
+ Positive Examples: deleterious(m_P51857_Pro198Leu), deleterious(m_P19429_Ala157Val), deleterious(m_P38398_Leu1786Pro), deleterious(m_Q13496_Thr197Ile), deleterious(m_P35520_Ala114Val), deleterious(m_P43026_Leu441Pro), deleterious(m_P35557_Val367Met), deleterious(m_P13569_Val562Leu), deleterious(m_P06280_Ala156Thr), deleterious(m_P35557_Gly385Val), deleterious(m_P03950_Val137Ile), deleterious(m_P51649_Thr233Met), deleterious(m_P29400_Cys1678Trp), deleterious(m_P00451_Pro1780Leu), deleterious(m_P60484_His93Arg), deleterious(m_Q99958_Ser125Leu), deleterious(m_P16930_Pro261Leu), deleterious(m_P29033_Val84Met), deleterious(m_O60481_Thr323Met), deleterious(m_O15305_Thr237Met), deleterious(m_P35557_Leu164Pro), deleterious(m_P00439_Pro281Leu), deleterious(m_P06280_Pro259Leu), deleterious(m_Q16637_Ile116Phe), deleterious(m_P10746_Val3Phe), deleterious(m_P06280_Met42Val), deleterious(m_Q04446_Phe257Leu), deleterious(m_P61916_Val39Met), deleterious(m_P45381_Pro280Leu), deleterious(m_P10828_Leu346Phe), deleterious(m_Q16518_Pro470Leu), deleterious(m_P10275_Gly708Val), deleterious(m_P35520_Ile152Met), deleterious(m_P29400_Ser1488Phe), deleterious(m_P10275_Asn705Tyr), deleterious(m_P08100_Gly106Trp), deleterious(m_P06280_Met42Leu), deleterious(m_P54868_Val54Met), deleterious(m_P07902_Cys130Tyr), deleterious(m_P10275_Met749Val), deleterious(m_P35520_Ala331Val), deleterious(m_Q9H2C0_Val195Phe), deleterious(m_P00387_Leu73Pro), deleterious(m_P22830_Pro334Leu), deleterious(m_P00451_Gly1979Val), deleterious(m_P30613_Thr384Met), deleterious(m_P08246_Pro139Leu), deleterious(m_Q9ULV5_Leu114Pro), deleterious(m_P00492_Ile42Phe), deleterious(m_P00740_Gly432Val), deleterious(m_P05107_Pro178Leu), deleterious(m_P06280_Ala156Val), deleterious(m_Q14376_Val94Met), deleterious(m_P10275_Ile737Thr), deleterious(m_O15553_Pro646Leu), deleterious(m_O43918_Val301Met), deleterious(m_P37231_Val318Met), deleterious(m_Q06187_Cys506Tyr), deleterious(m_P38571_Leu200Pro), deleterious(m_P13637_Thr613Met), deleterious(m_Q15465_Cys183Phe), deleterious(m_Q16518_Val287Phe), deleterious(m_P06280_Met187Val), deleterious(m_Q96QS3_Pro353Leu), deleterious(m_P06276_Asn124Tyr), deleterious(m_B7U540_Arg205His), deleterious(m_P26367_Val53Leu), deleterious(m_P26367_Gly18Trp), deleterious(m_Q15465_Val124Met), deleterious(m_Q15465_Cys183Tyr), deleterious(m_Q92838_Gly291Trp), deleterious(m_Q13496_Cys444Tyr), deleterious(m_Q13496_Val227Met), deleterious(m_P10912_Arg229His), deleterious(m_Q9UM73_Thr1151Met), deleterious(m_P00441_Cys7Phe), deleterious(m_P25189_Thr34Ile), deleterious(m_P06280_Ser201Phe), deleterious(m_Q06187_Val535Phe), deleterious(m_P35520_Thr353Met), deleterious(m_P08514_Pro176Leu), deleterious(m_P35520_Thr262Met), deleterious(m_P43026_Ser475Asn)

+ Negative Examples: deleterious(m_Q9NR81_Leu335Val), deleterious(m_P29597_Ala928Val), deleterious(m_Q12959_Pro899Leu), deleterious(m_Q8NHL6_Ala93Thr)  
develop  humvar398_38   modif_size(A, size_decrease) and freq_at_pos(A, B) and B>=2 and secondary_struc(A, helix) and wt_accessibility(A, intermediate) and stability(A, decrease). deleterious(A)
84 (1.4%) 
5 (0.25%) 
48
Covers:
+ Positive Examples: deleterious(m_P08397_His256Asn), deleterious(m_O43186_Glu80Ala), deleterious(m_P05186_Arg272Leu), deleterious(m_P07902_Arg201His), deleterious(m_P04275_Arg1341Gln), deleterious(m_P48436_Met113Val), deleterious(m_P06280_Arg49Ser), deleterious(m_P07902_Tyr209Ser), deleterious(m_P07902_Arg148Gln), deleterious(m_Q16518_Arg91Gln), deleterious(m_P07902_Ile198Thr), deleterious(m_P30566_Arg396Cys), deleterious(m_P02768_Arg242His), deleterious(m_P02768_Arg242Pro), deleterious(m_P00367_Arg318Lys), deleterious(m_Q13501_Met404Val), deleterious(m_P39019_Arg62Gln), deleterious(m_P30613_Arg426Gln), deleterious(m_P07902_Arg148Gly), deleterious(m_P00480_Tyr183Asp), deleterious(m_O15305_Arg141His), deleterious(m_P02768_Asp574Gly), deleterious(m_P30613_Glu427Asp), deleterious(m_P00480_Arg92Gln), deleterious(m_P30613_Arg359Cys), deleterious(m_P10275_Arg855His), deleterious(m_P06132_Arg193Pro), deleterious(m_P35520_Arg336His), deleterious(m_Q99453_Arg141Gln), deleterious(m_P21333_Arg196Gly), deleterious(m_Q06187_Arg544Gly), deleterious(m_P62736_Arg258His), deleterious(m_Q06187_Arg544Lys), deleterious(m_P10275_Arg840His), deleterious(m_P31327_Arg1453Gln), deleterious(m_Q06187_Arg525Pro), deleterious(m_P30613_Arg359His), deleterious(m_P05186_Arg272His), deleterious(m_P48436_Phe112Ser), deleterious(m_Q9BZ23_Glu322Asp), deleterious(m_Q15582_Arg555Gln), deleterious(m_P30613_Asn393Ser), deleterious(m_P10275_Arg855Cys), deleterious(m_Q92947_Arg355His), deleterious(m_O15305_Arg141Cys), deleterious(m_Q13501_Met404Thr), deleterious(m_P00480_Tyr183Cys), deleterious(m_P30566_Arg396His), deleterious(m_P00439_Asn207Ser), deleterious(m_P06744_Arg347His), deleterious(m_P06280_Arg49Pro), deleterious(m_P48436_Met113Thr), deleterious(m_P07902_Arg272Gly), deleterious(m_Q03393_Pro87Ser), deleterious(m_Q06187_Arg525Gly), deleterious(m_P05062_Arg304Gln), deleterious(m_P04181_Arg154Leu), deleterious(m_P10275_Phe754Val), deleterious(m_P00439_Glu205Ala), deleterious(m_P35520_Arg336Cys), deleterious(m_P05186_Arg71Cys), deleterious(m_P10275_Arg840Ser), deleterious(m_P10275_Pro904Ser), deleterious(m_Q06187_Arg525Gln), deleterious(m_P05186_Glu191Gly), deleterious(m_P05186_Arg71Pro), deleterious(m_P00367_Arg318Thr), deleterious(m_Q04446_Arg515His), deleterious(m_P07902_Tyr209Cys), deleterious(m_P07902_Leu226Pro), deleterious(m_P05186_Arg152His), deleterious(m_P62736_Arg258Cys), deleterious(m_Q9BZ23_Glu322Gly), deleterious(m_P05186_Arg71His), deleterious(m_P69892_Lys9Glu), deleterious(m_P30613_Leu73Pro), deleterious(m_P00439_Arg158Gln), deleterious(m_P00439_Asp394Ala), deleterious(m_P54803_Arg79His), deleterious(m_P06744_Arg347Cys), deleterious(m_Q92947_Arg355Cys), deleterious(m_Q9H3D4_Asp351Gly), deleterious(m_P10275_Arg840Gly), deleterious(m_P08397_Asp99Gly)

+ Negative Examples: deleterious(m_Q92698_Arg380Gln), deleterious(m_P00533_Arg521Lys), deleterious(m_Q9UII6_Arg190Gly), deleterious(m_Q9NZQ9_Asn336Ser), deleterious(m_Q9UDX4_Arg214His)  
develop  humvar398_46   modif_hydrophobicity(A, hydrophobicity_decrease) and g_or_p(A, g_or_p_apparition) and conservation_class(A, no_conservation_typification) and secondary_struc(A, helix) and mut_accessibility(A, buried). deleterious(A)
81 (1.35%) 
4 (0.2%) 
50
Covers:
+ Positive Examples: deleterious(m_Q15833_Leu209Pro), deleterious(m_P05166_Leu519Pro), deleterious(m_P08397_Leu254Pro), deleterious(m_P05186_Ala114Gly), deleterious(m_P02768_Leu90Pro), deleterious(m_P00966_Ser79Pro), deleterious(m_P14410_Thr694Pro), deleterious(m_P40692_Ala586Pro), deleterious(m_P00439_Ala395Pro), deleterious(m_Q13496_Leu470Pro), deleterious(m_P00439_Leu194Pro), deleterious(m_P08397_Leu81Pro), deleterious(m_Q15582_Leu518Pro), deleterious(m_P39019_Ala57Pro), deleterious(m_P22830_His386Pro), deleterious(m_P24752_Ala333Pro), deleterious(m_P40692_His329Pro), deleterious(m_P04839_Leu546Pro), deleterious(m_P39019_Leu64Pro), deleterious(m_P10619_Leu236Pro), deleterious(m_Q14749_Leu50Pro), deleterious(m_P22033_Leu518Pro), deleterious(m_P01009_Leu65Pro), deleterious(m_P14410_Leu620Pro), deleterious(m_Q12809_Cys66Gly), deleterious(m_P00439_Ser303Pro), deleterious(m_P00439_Ala322Gly), deleterious(m_P01008_Ser223Pro), deleterious(m_P06280_Ala285Pro), deleterious(m_P35557_Leu309Pro), deleterious(m_P35520_Ala355Pro), deleterious(m_P08397_Leu244Pro), deleterious(m_O43707_Ser262Pro), deleterious(m_Q6VVX0_Leu99Pro), deleterious(m_P35557_Ser131Pro), deleterious(m_P22033_Leu328Pro), deleterious(m_P06276_Leu335Pro), deleterious(m_P02649_Ala170Pro), deleterious(m_P14410_Leu341Pro), deleterious(m_P06276_Thr278Pro), deleterious(m_P00480_Leu63Pro), deleterious(m_P39019_Leu18Pro), deleterious(m_Q9BZ23_Leu563Pro), deleterious(m_P00480_Leu341Pro), deleterious(m_P06744_Ala300Pro), deleterious(m_P14410_Ser594Pro), deleterious(m_P24752_Ala301Pro), deleterious(m_P00813_Leu107Pro), deleterious(m_P43246_Leu187Pro), deleterious(m_Q06124_Gln79Pro), deleterious(m_P10828_Ala268Gly), deleterious(m_P10746_Ser212Pro), deleterious(m_P00966_Leu206Pro), deleterious(m_P22033_Thr370Pro), deleterious(m_P00480_Ser340Pro), deleterious(m_Q00266_Leu305Pro), deleterious(m_O94972_Leu76Pro), deleterious(m_P41181_Ser216Pro), deleterious(m_Q04446_Leu224Pro), deleterious(m_P07954_Ala117Pro), deleterious(m_P10746_Ser47Pro), deleterious(m_P04839_Ser422Pro), deleterious(m_P07902_Leu217Pro), deleterious(m_Q06187_Val626Gly), deleterious(m_Q13424_Ala257Gly), deleterious(m_P15313_Thr275Pro), deleterious(m_P39019_Thr76Pro), deleterious(m_P01308_Leu35Pro), deleterious(m_P00439_Leu213Pro), deleterious(m_P00439_Ser231Pro), deleterious(m_P40692_Val185Gly), deleterious(m_P00480_Leu45Pro), deleterious(m_P54840_Ala339Pro), deleterious(m_P00966_Leu160Pro), deleterious(m_P14410_Val577Gly), deleterious(m_P08397_Thr78Pro), deleterious(m_P60891_Leu152Pro), deleterious(m_P50993_Leu764Pro), deleterious(m_Q8IVH4_Leu89Pro), deleterious(m_P48637_Leu188Pro), deleterious(m_P00451_His1867Pro)

+ Negative Examples: deleterious(m_P08697_Ala98Gly), deleterious(m_O75715_Leu85Pro), deleterious(m_P52789_Ala314Pro), deleterious(m_Q7L576_Ala532Pro)  
develop  humvar398_28   modif_size(A, size_unchanged) and modif_charge(A, charge_unchanged) and is_in_site(A, yes) and secondary_struc(A, other) and wt_accessibility(A, buried). deleterious(A)
81 (1.35%) 
5 (0.25%) 
51
Covers:
+ Positive Examples: deleterious(m_P24386_Gln471Leu), deleterious(m_P54803_Gly194Ala), deleterious(m_P00451_Pro540Thr), deleterious(m_P35557_Gly227Cys), deleterious(m_P00451_Cys2193Gly), deleterious(m_Q06187_Thr33Pro), deleterious(m_Q06187_Ile61Asn), deleterious(m_P00439_Pro362Thr), deleterious(m_P00451_Ala488Gly), deleterious(m_P00451_Gly1942Ala), deleterious(m_P11413_Gly410Cys), deleterious(m_P07225_Cys267Ser), deleterious(m_Q14203_Gly71Ala), deleterious(m_P17050_Ser160Cys), deleterious(m_P43246_Thr552Pro), deleterious(m_P19438_Cys62Gly), deleterious(m_P04181_Gly375Ala), deleterious(m_P10071_Cys515Gly), deleterious(m_P02753_Ile59Asn), deleterious(m_P01185_Cys116Gly), deleterious(m_P00451_Asn713Ile), deleterious(m_P00441_Gly94Cys), deleterious(m_P01241_Cys79Ser), deleterious(m_P43246_Ser323Cys), deleterious(m_P35557_Thr168Pro), deleterious(m_P98172_Cys153Ser), deleterious(m_Q92838_Thr378Pro), deleterious(m_P00451_Ser1858Cys), deleterious(m_P07902_Phe294Tyr), deleterious(m_P05186_Ala51Ser), deleterious(m_P04839_Gly389Ala), deleterious(m_P01308_Gly90Cys), deleterious(m_P06280_Cys223Gly), deleterious(m_P08397_Gln217Leu), deleterious(m_P00740_Cys407Ser), deleterious(m_P19438_Cys99Ser), deleterious(m_O15553_Ser702Cys), deleterious(m_P05106_Ile330Asn), deleterious(m_Q06124_Gly60Ala), deleterious(m_O43602_Gly181Ala), deleterious(m_P11362_Ser332Cys), deleterious(m_Q13496_Pro226Thr), deleterious(m_P22033_Gly215Cys), deleterious(m_P11362_Cys178Ser), deleterious(m_Q9Y4U1_Gly147Ala), deleterious(m_P46100_Gly249Cys), deleterious(m_P22830_Pro192Thr), deleterious(m_P00813_Gly74Cys), deleterious(m_P06132_Ala80Ser), deleterious(m_P06280_Cys94Ser), deleterious(m_P16615_Cys875Gly), deleterious(m_P40337_Ser65Ala), deleterious(m_P00439_Pro225Thr), deleterious(m_Q13496_Ala279Gly), deleterious(m_P01308_Cys43Gly), deleterious(m_P54803_Ala592Ser), deleterious(m_P05186_Ala399Ser), deleterious(m_P05186_Asn478Ile), deleterious(m_Q06187_Pro619Thr), deleterious(m_O15305_Ile132Asn), deleterious(m_P35557_Gly80Ala), deleterious(m_P08236_Gly607Ala), deleterious(m_P00451_Leu725Gln), deleterious(m_O60481_Cys253Ser), deleterious(m_Q06124_Ala72Ser), deleterious(m_O60333_Gln98Leu), deleterious(m_P00451_Cys198Gly), deleterious(m_P00367_Ser270Cys), deleterious(m_P01008_Pro439Thr), deleterious(m_P06132_Ala80Gly), deleterious(m_P16930_Asn16Ile), deleterious(m_Q06124_Ala72Gly), deleterious(m_P00451_Ile2209Asn), deleterious(m_P30613_Ala468Gly), deleterious(m_P06280_Gly260Ala), deleterious(m_Q9UM73_Gly1128Ala), deleterious(m_P10721_Thr847Pro), deleterious(m_P00439_Thr238Pro), deleterious(m_P35557_Ala53Ser), deleterious(m_P49747_Cys387Gly), deleterious(m_P00480_Pro225Thr)

+ Negative Examples: deleterious(m_P08519_Gly4330Ala), deleterious(m_Q8IVS2_Ala303Gly), deleterious(m_Q5IJ48_Gly159Ala), deleterious(m_P06732_Gly243Ala), deleterious(m_P20036_Pro49Thr)  
develop  humvar398_7   modif_charge(A, charge_decrease) and modif_hydrophobicity(A, hydrophobicity_increase) and conservation_class(A, global_conservation_rank_2) and mut_accessibility(A, intermediate). deleterious(A)
81 (1.35%) 
5 (0.25%) 
51
Covers:
+ Positive Examples: deleterious(m_P01138_Arg221Trp), deleterious(m_P10644_Asp183Tyr), deleterious(m_Q03154_Arg353Cys), deleterious(m_P29965_Lys143Thr), deleterious(m_Q13509_Arg262Cys), deleterious(m_Q05066_Arg76Ser), deleterious(m_Q01968_Arg318Cys), deleterious(m_P05106_Asp243Val), deleterious(m_Q99836_Arg196Cys), deleterious(m_P00451_Arg2323Leu), deleterious(m_Q15465_Asp88Val), deleterious(m_Q13509_Arg380Cys), deleterious(m_P29033_Arg184Gln), deleterious(m_P49747_Asp361Val), deleterious(m_P49747_Asp420Ala), deleterious(m_O14958_Arg33Gln), deleterious(m_P29400_Arg1563Gln), deleterious(m_P26367_Arg128Cys), deleterious(m_P26367_Arg26Gly), deleterious(m_P10828_Lys342Ile), deleterious(m_Q16678_Arg523Thr), deleterious(m_Q5TBB1_Lys162Thr), deleterious(m_P21333_Glu82Val), deleterious(m_P10275_Arg710Thr), deleterious(m_P05106_Arg240Trp), deleterious(m_P00966_Glu191Gln), deleterious(m_P18858_Arg771Trp), deleterious(m_P05156_Asp524Val), deleterious(m_Q93099_Glu42Ala), deleterious(m_P30566_Arg303Cys), deleterious(m_Q8IVH4_Arg359Gln), deleterious(m_Q9HBA0_Asp333Gly), deleterious(m_P61457_Arg88Gln), deleterious(m_O14832_Glu197Gln), deleterious(m_P49747_Asp482Gly), deleterious(m_P07951_Glu117Ala), deleterious(m_P07225_Asp245Gly), deleterious(m_P07320_Arg15Cys), deleterious(m_Q03393_Arg16Cys), deleterious(m_P00480_Glu181Gly), deleterious(m_P69892_Arg41Gly), deleterious(m_P06396_Asp214Tyr), deleterious(m_Q9Y2V3_Arg192Gln), deleterious(m_Q03393_Arg25Gln), deleterious(m_P08397_Glu80Gly), deleterious(m_Q8TDP1_Arg69Trp), deleterious(m_P03950_Lys64Ile), deleterious(m_Q06187_Arg525Gly), deleterious(m_Q93099_Arg330Ser), deleterious(m_P05062_Arg304Gln), deleterious(m_P13569_Asp513Gly), deleterious(m_P35520_Asp198Val), deleterious(m_Q92838_Asp298Tyr), deleterious(m_Q9H0P0_Asp137Val), deleterious(m_P35520_Arg336Cys), deleterious(m_Q71U36_Arg264Cys), deleterious(m_P31785_Arg224Trp), deleterious(m_P10275_Asp695Val), deleterious(m_Q06187_Arg525Gln), deleterious(m_P10070_Arg479Gly), deleterious(m_Q16518_Arg515Trp), deleterious(m_Q9BZ23_Arg264Trp), deleterious(m_Q15465_Asp83Val), deleterious(m_P29033_Arg184Trp), deleterious(m_P26367_Arg125Cys), deleterious(m_P58012_Arg103Cys), deleterious(m_P29400_Arg1677Gln), deleterious(m_P06280_Arg100Thr), deleterious(m_O15305_Asp188Gly), deleterious(m_P48165_Arg23Thr), deleterious(m_Q13496_Arg184Leu), deleterious(m_P05062_Arg304Trp), deleterious(m_P49638_Arg221Trp), deleterious(m_P20823_Arg271Trp), deleterious(m_P40692_Arg659Leu), deleterious(m_P00966_Arg157Cys), deleterious(m_P21817_Glu160Gly), deleterious(m_O15273_Arg70Trp), deleterious(m_P35520_Arg379Trp), deleterious(m_P05166_Arg67Ser), deleterious(m_P08397_Asp99Gly)

+ Negative Examples: deleterious(m_Q9H211_Glu456Ala), deleterious(m_Q9H0R5_Arg221Gln), deleterious(m_Q8WXG8_Glu23Ala), deleterious(m_Q9UQ84_Arg93Gly), deleterious(m_Q13576_Arg1052Ile)  
develop  humvar398_68   modif_size(A, size_unchanged) and is_in_site(A, yes) and freq_at_pos(A, B) and B>=2 and wt_accessibility(A, intermediate). deleterious(A)
76 (1.27%) 
3 (0.15%) 
53
Covers:
+ Positive Examples: deleterious(m_P12271_Arg234Trp), deleterious(m_P04049_Asp486Asn), deleterious(m_P01241_Ser134Cys), deleterious(m_P29033_Gly59Ala), deleterious(m_P04156_Asp178Asn), deleterious(m_Q13950_Arg190Trp), deleterious(m_P22830_Cys406Ser), deleterious(m_P00740_Arg449Trp), deleterious(m_P00451_Arg2016Trp), deleterious(m_P00740_Pro333Thr), deleterious(m_P39019_Arg62Trp), deleterious(m_P00451_Arg437Trp), deleterious(m_Q92838_His252Tyr), deleterious(m_P00492_Asp194Asn), deleterious(m_Q14524_Tyr1795His), deleterious(m_P07902_Tyr323His), deleterious(m_P11217_Arg194Trp), deleterious(m_P10275_Asp695Asn), deleterious(m_Q9H3D4_Arg343Trp), deleterious(m_P00480_Asn47Ile), deleterious(m_P30613_Asp331Asn), deleterious(m_P51608_Ser134Cys), deleterious(m_P10275_Tyr763His), deleterious(m_P01112_Gly13Cys), deleterious(m_P00740_Leu383Ile), deleterious(m_Q06187_Cys155Gly), deleterious(m_P11413_Asp58Asn), deleterious(m_P00451_Cys348Ser), deleterious(m_P14222_Arg225Trp), deleterious(m_Q14376_Arg169Trp), deleterious(m_Q15465_Trp117Arg), deleterious(m_P05106_Arg240Trp), deleterious(m_P08397_Ala270Gly), deleterious(m_P07902_Arg148Trp), deleterious(m_P29033_Asp50Asn), deleterious(m_P25189_Ser54Cys), deleterious(m_Q9H3D4_Arg243Trp), deleterious(m_P01308_Cys96Ser), deleterious(m_Q92947_Gly390Ala), deleterious(m_P51608_Arg106Trp), deleterious(m_P01009_Pro386Thr), deleterious(m_P15382_Arg98Trp), deleterious(m_P08397_Asp99Asn), deleterious(m_P01185_Cys98Ser), deleterious(m_P00439_Asn207Asp), deleterious(m_P21333_Arg196Trp), deleterious(m_P06280_Cys56Gly), deleterious(m_P25445_Thr241Pro), deleterious(m_P78330_Asp32Asn), deleterious(m_P48637_Tyr270His), deleterious(m_P08397_His256Tyr), deleterious(m_Q15582_Arg555Trp), deleterious(m_P06280_Cys52Ser), deleterious(m_P52701_Arg772Trp), deleterious(m_P00966_Arg363Trp), deleterious(m_P31327_Arg1453Trp), deleterious(m_P00439_Arg158Trp), deleterious(m_P01112_Gly12Cys), deleterious(m_P30613_Arg426Trp), deleterious(m_Q16518_Arg91Trp), deleterious(m_P40763_Arg382Trp), deleterious(m_P29033_Arg184Trp), deleterious(m_P30613_Gly341Ala), deleterious(m_P48436_His165Tyr), deleterious(m_P07902_Asp98Asn), deleterious(m_O15305_Gly228Cys), deleterious(m_P05062_Arg304Trp), deleterious(m_P25189_Ile135Leu), deleterious(m_P02545_Arg453Trp), deleterious(m_P00451_Asn601Asp), deleterious(m_P54803_Arg396Trp), deleterious(m_P35520_Arg379Trp), deleterious(m_P69892_His64Tyr), deleterious(m_P00451_His113Tyr), deleterious(m_P00451_Pro470Thr), deleterious(m_P01185_Cys98Gly)

+ Negative Examples: deleterious(m_P41218_His357Tyr), deleterious(m_P04440_Ile94Leu), deleterious(m_P04439_Asp101Asn)  
develop  humvar398_97   modif_polarity(A, polarity_increase) and g_or_p(A, g_or_p_disparition) and conservation_class(A, no_conservation_typification) and mut_accessibility(A, buried) and stability(A, decrease). deleterious(A)
77 (1.28%) 
5 (0.25%) 
54
Covers:
+ Positive Examples: deleterious(m_P04839_Gly408Glu), deleterious(m_P60891_Gly306Arg), deleterious(m_P00966_Gly324Ser), deleterious(m_Q92947_Gly354Arg), deleterious(m_Q9NSU2_Gly282Ser), deleterious(m_P21439_Gly983Ser), deleterious(m_P11217_Gly205Ser), deleterious(m_P09417_Gly18Asp), deleterious(m_P08397_Gly24Ser), deleterious(m_P06280_Gly373Ser), deleterious(m_P30613_Gly263Trp), deleterious(m_P51649_Gly268Glu), deleterious(m_P00441_Gly73Ser), deleterious(m_P00480_Gly83Arg), deleterious(m_P08397_Gly280Arg), deleterious(m_P00451_Gly2344Ser), deleterious(m_P08236_Gly572Asp), deleterious(m_P69892_Gly26Glu), deleterious(m_P01116_Gly60Arg), deleterious(m_P48728_Gly47Arg), deleterious(m_P06280_Gly328Arg), deleterious(m_P00439_Gly257Cys), deleterious(m_P43246_Gly162Arg), deleterious(m_P04839_Gly408Arg), deleterious(m_P08397_Gly236Ser), deleterious(m_P15313_Pro346Arg), deleterious(m_P08100_Gly109Arg), deleterious(m_Q13651_Gly141Arg), deleterious(m_P06280_Gly261Asp), deleterious(m_P35557_Gly261Arg), deleterious(m_P08397_Gly216Asp), deleterious(m_O00255_Gly310Asp), deleterious(m_P43246_Gly164Arg), deleterious(m_P00740_Gly351Asp), deleterious(m_O75369_Gly1834Arg), deleterious(m_P05186_Gly75Ser), deleterious(m_P02675_Gly430Asp), deleterious(m_P06280_Pro205Thr), deleterious(m_P13804_Gly116Arg), deleterious(m_O15305_Gly228Arg), deleterious(m_P08397_Gly111Arg), deleterious(m_P01308_Gly90Cys), deleterious(m_P16615_Gly211Asp), deleterious(m_P35557_Gly261Glu), deleterious(m_P00480_Gly83Asp), deleterious(m_Q02127_Gly202Asp), deleterious(m_P08397_Gly335Asp), deleterious(m_P25189_Gly110Asp), deleterious(m_P00451_Pro1844Ser), deleterious(m_P35680_Gly370Ser), deleterious(m_Q9H3D4_Pro348Ser), deleterious(m_P00451_Gly2107Ser), deleterious(m_P06280_Gly183Asp), deleterious(m_P00439_Gly148Ser), deleterious(m_P05107_Gly284Ser), deleterious(m_P24752_Gly183Arg), deleterious(m_P00966_Gly280Arg), deleterious(m_P00813_Gly140Glu), deleterious(m_P05186_Gly334Asp), deleterious(m_O15305_Pro69Ser), deleterious(m_P08236_Pro408Ser), deleterious(m_O75197_Gly171Arg), deleterious(m_P30613_Gly275Arg), deleterious(m_O95452_Gly11Arg), deleterious(m_P06276_Gly393Arg), deleterious(m_P08709_Gly391Ser), deleterious(m_P05129_Gly128Asp), deleterious(m_P05156_Gly243Asp), deleterious(m_P06132_Gly156Asp), deleterious(m_P11413_Pro353Ser), deleterious(m_P08397_Gly260Asp), deleterious(m_P00451_Gly2344Cys), deleterious(m_P06132_Gly281Glu), deleterious(m_P05186_Gly129Arg), deleterious(m_P05186_Gly326Arg), deleterious(m_P00813_Pro297Gln), deleterious(m_Q16518_Pro363Thr)

+ Negative Examples: deleterious(m_Q53FZ2_Pro308Thr), deleterious(m_Q9UK55_Gly271Ser), deleterious(m_P02786_Gly420Ser), deleterious(m_P20036_Pro49Thr), deleterious(m_P04798_Gly45Asp)  
develop  humvar398_101   modif_size(A, size_unchanged) and modif_hydrophobicity(A, hydrophobicity_increase) and conservation_class(A, global_conservation_rank_2). deleterious(A)
73 (1.22%) 
4 (0.2%) 
55
Covers:
+ Positive Examples: deleterious(m_P01138_Arg221Trp), deleterious(m_P54803_Gly194Ala), deleterious(m_P01185_Gly96Cys), deleterious(m_P29033_Gly59Ala), deleterious(m_P00451_Gly2000Ala), deleterious(m_P17661_Asn393Ile), deleterious(m_O15305_Gly208Ala), deleterious(m_P00740_Pro333Thr), deleterious(m_P00441_Gly115Ala), deleterious(m_Q16518_His68Tyr), deleterious(m_P15056_Ser467Ala), deleterious(m_P35453_Ser316Cys), deleterious(m_P22033_His265Tyr), deleterious(m_P00451_Gly1942Ala), deleterious(m_P45381_Pro181Thr), deleterious(m_P49768_Gly384Ala), deleterious(m_P20823_Arg200Trp), deleterious(m_Q18PE1_Gly180Ala), deleterious(m_P05106_Arg119Trp), deleterious(m_P50336_Arg59Trp), deleterious(m_P22033_His350Tyr), deleterious(m_Q15583_Gln236Leu), deleterious(m_P05106_Arg240Trp), deleterious(m_Q05066_Arg133Trp), deleterious(m_Q9BV36_Arg35Trp), deleterious(m_P18858_Arg771Trp), deleterious(m_P10828_Pro447Thr), deleterious(m_P19429_Arg145Trp), deleterious(m_P30613_Gly222Ala), deleterious(m_P25189_Ser54Cys), deleterious(m_Q92838_Gly255Cys), deleterious(m_Q8TDP1_Arg69Trp), deleterious(m_P30613_Arg385Trp), deleterious(m_P35240_Gly197Cys), deleterious(m_P03950_Gln36Leu), deleterious(m_Q9Y4U1_Gly147Ala), deleterious(m_P22830_Pro192Thr), deleterious(m_Q9Y5X4_Arg76Trp), deleterious(m_P08236_Arg216Trp), deleterious(m_P31785_Arg224Trp), deleterious(m_P00439_Pro225Thr), deleterious(m_P15918_Arg314Trp), deleterious(m_Q99593_Arg237Trp), deleterious(m_Q16518_Arg515Trp), deleterious(m_Q9BZ23_Arg264Trp), deleterious(m_P00966_Arg127Trp), deleterious(m_P40692_Gln542Leu), deleterious(m_P07902_Pro183Thr), deleterious(m_P02545_Arg482Trp), deleterious(m_P00740_Pro414Thr), deleterious(m_P10071_Arg625Trp), deleterious(m_Q15067_Gly178Cys), deleterious(m_P08236_Gly607Ala), deleterious(m_P29033_Arg184Trp), deleterious(m_P04792_Arg127Trp), deleterious(m_P30613_Gly341Ala), deleterious(m_P29400_Gly1486Ala), deleterious(m_Q9H4B7_Arg318Trp), deleterious(m_P51843_Asn440Ile), deleterious(m_Q8IWU9_Arg303Trp), deleterious(m_P05062_Arg304Trp), deleterious(m_Q6PHW0_Arg101Trp), deleterious(m_P49638_Arg221Trp), deleterious(m_P29033_Arg75Trp), deleterious(m_P53634_Gln252Leu), deleterious(m_P10828_Pro453Thr), deleterious(m_P20823_Arg271Trp), deleterious(m_P43026_Pro436Thr), deleterious(m_P06280_Gly260Ala), deleterious(m_Q9UM73_Gly1128Ala), deleterious(m_O15273_Arg70Trp), deleterious(m_P35520_Arg379Trp), deleterious(m_Q13950_Arg225Trp)

+ Negative Examples: deleterious(m_P08519_Gly4330Ala), deleterious(m_Q9UNI1_Arg44Trp), deleterious(m_Q5IJ48_Gly159Ala), deleterious(m_P23467_Gly1934Ala)  
develop  humvar398_79   modif_size(A, size_decrease) and modif_hydrophobicity(A, hydrophobicity_unchanged) and modif_polarity(A, polarity_decrease) and g_or_p(A, g_or_p_unchanged) and mut_accessibility(A, buried). deleterious(A)
71 (1.18%) 
5 (0.25%) 
56
Covers:
+ Positive Examples: deleterious(m_P00439_Tyr386Cys), deleterious(m_P00367_Tyr319Cys), deleterious(m_P00451_Tyr2124Cys), deleterious(m_P40763_Tyr657Cys), deleterious(m_P11498_Tyr304Cys), deleterious(m_P25445_Tyr232Cys), deleterious(m_P54868_Tyr167Cys), deleterious(m_P06280_Trp236Leu), deleterious(m_P43699_Trp208Leu), deleterious(m_O15305_Tyr64Cys), deleterious(m_P00439_Tyr343Cys), deleterious(m_P16435_Tyr575Cys), deleterious(m_P00480_Tyr176Cys), deleterious(m_P21817_Tyr178Cys), deleterious(m_P06213_Trp1220Leu), deleterious(m_P32754_Tyr160Cys), deleterious(m_P08236_Tyr320Cys), deleterious(m_P00439_Tyr377Cys), deleterious(m_Q01968_Tyr513Cys), deleterious(m_O15553_Tyr688Cys), deleterious(m_P54803_Tyr314Cys), deleterious(m_Q06187_Trp563Leu), deleterious(m_P00491_Tyr192Cys), deleterious(m_Q06187_Tyr598Cys), deleterious(m_P06276_Tyr61Cys), deleterious(m_P04181_Tyr245Cys), deleterious(m_P00451_Trp1908Leu), deleterious(m_Q93099_Tyr62Cys), deleterious(m_P43246_Tyr98Cys), deleterious(m_Q06124_Tyr279Cys), deleterious(m_P11362_Tyr339Cys), deleterious(m_P00492_Tyr195Cys), deleterious(m_Q06187_Tyr40Cys), deleterious(m_P07225_Tyr266Cys), deleterious(m_P23526_Tyr143Cys), deleterious(m_P00451_Tyr492Cys), deleterious(m_P54803_Tyr335Cys), deleterious(m_P00451_Tyr639Cys), deleterious(m_P09417_Tyr150Cys), deleterious(m_P43080_Tyr99Cys), deleterious(m_Q9H2C0_Tyr89Cys), deleterious(m_P10275_Tyr834Cys), deleterious(m_Q92838_Tyr320Cys), deleterious(m_P22033_Tyr587Cys), deleterious(m_O15305_Tyr76Cys), deleterious(m_P07902_Tyr251Cys), deleterious(m_P10912_Tyr226Cys), deleterious(m_Q92793_Tyr1175Cys), deleterious(m_P25189_Tyr82Cys), deleterious(m_Q06124_Tyr63Cys), deleterious(m_Q16518_Tyr431Cys), deleterious(m_O15305_Tyr106Cys), deleterious(m_P00740_Tyr450Cys), deleterious(m_P10746_Tyr19Cys), deleterious(m_P00451_Tyr2036Cys), deleterious(m_P08100_Tyr178Cys), deleterious(m_Q6NVY1_Tyr122Cys), deleterious(m_P00480_Trp265Leu), deleterious(m_Q03692_Tyr597Cys), deleterious(m_P00439_Tyr325Cys), deleterious(m_P06280_Tyr86Cys), deleterious(m_P45381_Tyr231Cys), deleterious(m_P13569_Tyr569Cys), deleterious(m_P48637_Tyr270Cys), deleterious(m_P01008_Tyr95Cys), deleterious(m_P05106_Tyr141Cys), deleterious(m_P10619_Tyr395Cys), deleterious(m_Q01968_Tyr479Cys), deleterious(m_P00451_Tyr442Cys), deleterious(m_Q13496_Tyr397Cys), deleterious(m_Q02750_Tyr130Cys)

+ Negative Examples: deleterious(m_Q9H306_Trp304Leu), deleterious(m_Q14126_Tyr89Cys), deleterious(m_P40227_Tyr229Cys), deleterious(m_P47944_Tyr30Cys), deleterious(m_Q8IWL3_Tyr73Cys)  
develop  humvar398_96   g_or_p(A, g_or_p_disparition) and is_in_site(A, yes) and conservation_class(A, no_conservation_typification) and gain_contact(A, dc) and mut_accessibility(A, buried). deleterious(A)
66 (1.1%) 
4 (0.2%) 
57
Covers:
+ Positive Examples: deleterious(m_P00966_Gly324Ser), deleterious(m_P22033_Gly312Val), deleterious(m_P00451_Gly164Val), deleterious(m_P09417_Gly18Asp), deleterious(m_P00558_Gly158Val), deleterious(m_P08183_Gly185Val), deleterious(m_P30613_Gly263Trp), deleterious(m_P51649_Gly268Glu), deleterious(m_P00480_Gly83Arg), deleterious(m_P08397_Gly280Arg), deleterious(m_P05186_Gly63Val), deleterious(m_P00451_Gly2344Ser), deleterious(m_P08236_Gly572Asp), deleterious(m_P05186_Gly339Arg), deleterious(m_P01116_Gly60Arg), deleterious(m_P00451_Gly466Glu), deleterious(m_P43246_Gly162Arg), deleterious(m_P22033_Gly203Arg), deleterious(m_P00451_Gly474Arg), deleterious(m_P04839_Gly408Arg), deleterious(m_P00451_Gly2304Val), deleterious(m_P00451_Gly439Asp), deleterious(m_P08100_Gly109Arg), deleterious(m_Q13651_Gly141Arg), deleterious(m_P35670_Gly875Val), deleterious(m_P35557_Gly261Arg), deleterious(m_P43246_Gly164Arg), deleterious(m_O75369_Gly1834Arg), deleterious(m_P30613_Gly165Val), deleterious(m_P05186_Gly75Ser), deleterious(m_P02675_Gly430Asp), deleterious(m_Q12809_Gly47Val), deleterious(m_P13804_Gly116Arg), deleterious(m_P05155_Gly429Arg), deleterious(m_P08397_Gly111Arg), deleterious(m_P16615_Gly211Asp), deleterious(m_P05186_Gly220Val), deleterious(m_P24752_Gly379Val), deleterious(m_P00480_Gly83Asp), deleterious(m_P22033_Gly291Glu), deleterious(m_P25189_Gly110Asp), deleterious(m_P00451_Pro1844Ser), deleterious(m_P35680_Gly370Ser), deleterious(m_P00439_Gly148Ser), deleterious(m_P24752_Gly183Arg), deleterious(m_P00966_Gly280Arg), deleterious(m_P00813_Gly140Glu), deleterious(m_P00966_Gly324Val), deleterious(m_O75197_Gly171Arg), deleterious(m_P30613_Gly275Arg), deleterious(m_O95452_Gly11Arg), deleterious(m_P22033_Gly623Arg), deleterious(m_P05155_Pro489Arg), deleterious(m_P00451_Gly439Ser), deleterious(m_P06276_Gly393Arg), deleterious(m_P05156_Gly243Asp), deleterious(m_P22033_Gly637Arg), deleterious(m_P08397_Gly260Asp), deleterious(m_P00451_Gly2344Cys), deleterious(m_P06132_Gly281Glu), deleterious(m_P05186_Gly129Arg), deleterious(m_P22033_Gly626Cys), deleterious(m_P05186_Gly326Arg), deleterious(m_P00734_Gly601Val), deleterious(m_P00813_Pro297Gln), deleterious(m_P06213_Gly1035Val)

+ Negative Examples: deleterious(m_Q460N3_Gly606Arg), deleterious(m_P05154_Gly94Val), deleterious(m_Q9UK55_Gly271Ser), deleterious(m_Q92901_Pro291Leu)  
develop  humvar398_104   modif_size(A, size_decrease) and modif_charge(A, charge_unchanged) and modif_hydrophobicity(A, hydrophobicity_decrease) and modif_polarity(A, polarity_unchanged) and mut_accessibility(A, intermediate). deleterious(A)
66 (1.1%) 
5 (0.25%) 
58
Covers:
+ Positive Examples: deleterious(m_P11413_Leu323Pro), deleterious(m_P38398_Leu1786Pro), deleterious(m_P29033_Leu79Pro), deleterious(m_P08235_Leu924Pro), deleterious(m_P29033_Leu90Pro), deleterious(m_P07101_Leu236Pro), deleterious(m_P22033_Val633Gly), deleterious(m_Q92947_Leu283Pro), deleterious(m_P07902_Tyr209Ser), deleterious(m_Q13496_Leu87Pro), deleterious(m_P13804_Val157Gly), deleterious(m_P00451_Leu1994Pro), deleterious(m_Q16678_Leu77Pro), deleterious(m_O75695_Leu188Pro), deleterious(m_P00439_Leu248Pro), deleterious(m_P07902_Leu195Pro), deleterious(m_P12694_Tyr438Asn), deleterious(m_P42768_Leu270Pro), deleterious(m_P29033_Leu214Pro), deleterious(m_P07196_Leu336Pro), deleterious(m_P08397_Leu343Pro), deleterious(m_P17661_Leu370Pro), deleterious(m_P53634_Tyr304Asn), deleterious(m_Q06187_Leu408Pro), deleterious(m_P00966_Tyr291Ser), deleterious(m_Q9H0P0_Leu181Pro), deleterious(m_P25189_Tyr145Ser), deleterious(m_P01008_Leu441Pro), deleterious(m_P54803_Tyr490Asn), deleterious(m_P00441_Val149Gly), deleterious(m_P49675_Leu275Pro), deleterious(m_P51843_Val385Gly), deleterious(m_P40337_Tyr156Asn), deleterious(m_Q13950_Leu136Pro), deleterious(m_P11217_Leu292Pro), deleterious(m_P05107_Leu149Pro), deleterious(m_P16930_Val166Gly), deleterious(m_P00451_Leu1771Pro), deleterious(m_P02649_Leu46Pro), deleterious(m_Q9BZ23_Leu413Pro), deleterious(m_P00492_Val8Gly), deleterious(m_O15020_Leu253Pro), deleterious(m_P00451_Leu326Pro), deleterious(m_Q16518_Val452Gly), deleterious(m_P17661_Leu345Pro), deleterious(m_P11413_Leu128Pro), deleterious(m_P00966_Val345Gly), deleterious(m_P11597_Leu168Pro), deleterious(m_O15118_Val231Gly), deleterious(m_O14521_Leu139Pro), deleterious(m_P00451_Val285Gly), deleterious(m_P08514_Leu86Pro), deleterious(m_P40692_Leu588Pro), deleterious(m_O15305_Tyr229Ser), deleterious(m_P13569_Leu633Pro), deleterious(m_P07902_Leu226Pro), deleterious(m_P00439_Leu212Pro), deleterious(m_P03951_Leu320Pro), deleterious(m_P41250_Leu183Pro), deleterious(m_P35520_Leu456Pro), deleterious(m_Q06187_Leu652Pro), deleterious(m_P30613_Leu73Pro), deleterious(m_P17661_Leu385Pro), deleterious(m_P01185_Leu81Pro), deleterious(m_P11217_Leu116Pro), deleterious(m_P00492_Leu41Pro)

+ Negative Examples: deleterious(m_O75747_Val1290Gly), deleterious(m_Q96JF6_Val199Gly), deleterious(m_P00505_Val346Gly), deleterious(m_Q9NWX6_Leu232Pro), deleterious(m_Q9BUD6_Leu40Pro)  
develop  humvar398_59   modif_charge(A, charge_unchanged) and modif_hydrophobicity(A, hydrophobicity_unchanged) and is_in_site(A, yes) and freq_at_pos(A, B) and B>=2 and secondary_struc(A, helix) and wt_accessibility(A, buried) and stability(A, decrease). deleterious(A)
65 (1.08%) 
5 (0.25%) 
59
Covers:
+ Positive Examples: deleterious(m_P30613_Ala394Val), deleterious(m_P06213_Glu1206Asp), deleterious(m_Q06187_Met509Val), deleterious(m_P00480_Leu45Val), deleterious(m_P58012_Leu106Phe), deleterious(m_P13569_Val562Leu), deleterious(m_P00492_Val53Met), deleterious(m_P06280_Trp236Leu), deleterious(m_Q06187_Met509Ile), deleterious(m_P49768_Leu392Val), deleterious(m_P13569_Arg560Lys), deleterious(m_P00480_Tyr176Cys), deleterious(m_P00966_Lys310Arg), deleterious(m_P40692_Arg182Lys), deleterious(m_P06280_Trp162Cys), deleterious(m_P29033_Val84Met), deleterious(m_Q06187_Glu589Asp), deleterious(m_P00480_Ile172Phe), deleterious(m_P08709_Cys254Tyr), deleterious(m_Q14623_Asp100Glu), deleterious(m_P13569_Gly551Ser), deleterious(m_P10275_Leu701Phe), deleterious(m_P23760_Ile59Phe), deleterious(m_P10275_Ala870Val), deleterious(m_P00480_Leu148Phe), deleterious(m_P43246_Met688Ile), deleterious(m_Q06187_Phe644Leu), deleterious(m_P10275_Met742Val), deleterious(m_P00439_Ala309Val), deleterious(m_P04156_Val180Ile), deleterious(m_Q9HBA0_Ile331Phe), deleterious(m_P35520_Arg266Lys), deleterious(m_P00439_Ala259Val), deleterious(m_P35520_Ala331Val), deleterious(m_P08100_Cys110Phe), deleterious(m_P50897_Val181Leu), deleterious(m_P00451_Leu1775Phe), deleterious(m_P00492_Ile42Phe), deleterious(m_Q06124_Glu76Asp), deleterious(m_P08100_Phe220Cys), deleterious(m_P06280_Ala156Val), deleterious(m_Q06187_Cys502Trp), deleterious(m_P00439_Val230Ile), deleterious(m_Q03393_Ile114Val), deleterious(m_Q16595_Leu182Phe), deleterious(m_P69892_Ile76Val), deleterious(m_Q06187_Cys502Phe), deleterious(m_P06280_Trp236Cys), deleterious(m_Q06187_Cys506Tyr), deleterious(m_P43246_Leu93Phe), deleterious(m_P26367_Ile29Val), deleterious(m_P08397_Cys247Phe), deleterious(m_P00439_Ile283Phe), deleterious(m_P00492_Ala50Val), deleterious(m_P10275_Val866Leu), deleterious(m_P26367_Val53Leu), deleterious(m_P00740_Cys382Tyr), deleterious(m_P00439_Ala300Val), deleterious(m_P60484_Cys105Phe), deleterious(m_Q13496_Trp346Cys), deleterious(m_P13569_Val520Phe), deleterious(m_P00492_Val53Ala), deleterious(m_P00480_Met206Ile), deleterious(m_P50897_Val181Met), deleterious(m_P00439_Leu255Val)

+ Negative Examples: deleterious(m_P04440_Met105Val), deleterious(m_P04440_Lys98Arg), deleterious(m_P04440_Met105Ile), deleterious(m_P04798_Ile462Val), deleterious(m_P04440_Ala84Val)  
develop  humvar398_71   modif_size(A, size_increase) and modif_charge(A, charge_unchanged) and modif_hydrophobicity(A, hydrophobicity_decrease) and g_or_p(A, g_or_p_unchanged) and is_in_site(A, yes) and secondary_struc(A, helix) and wt_accessibility(A, buried) and mut_accessibility(A, buried). deleterious(A)
62 (1.03%) 
3 (0.15%) 
60
Covers:
+ Positive Examples: deleterious(m_P12694_Ala253Thr), deleterious(m_P30613_Ala431Thr), deleterious(m_P08100_His211Arg), deleterious(m_P35520_Ser349Asn), deleterious(m_P22033_Ala324Thr), deleterious(m_P00441_Ser135Asn), deleterious(m_P10746_Ala69Thr), deleterious(m_P06280_Ala156Thr), deleterious(m_Q16678_Ala388Thr), deleterious(m_P24752_Ala380Thr), deleterious(m_P20711_Ala275Thr), deleterious(m_P00480_Ala208Thr), deleterious(m_P16615_His943Arg), deleterious(m_Q15582_His572Arg), deleterious(m_P50053_Ala43Thr), deleterious(m_P32754_Ala33Thr), deleterious(m_P48728_His42Arg), deleterious(m_P00451_His1867Arg), deleterious(m_P06276_Ala229Thr), deleterious(m_P35520_Ser352Asn), deleterious(m_P08397_Ala31Thr), deleterious(m_P08559_Ala199Thr), deleterious(m_P05186_Ala348Thr), deleterious(m_Q92947_His403Arg), deleterious(m_P49748_Thr158Asn), deleterious(m_P35520_Thr434Asn), deleterious(m_P39019_Ala135Thr), deleterious(m_P05186_Ala111Thr), deleterious(m_P35520_Ala155Thr), deleterious(m_P06132_Val134Gln), deleterious(m_P35557_Ala188Thr), deleterious(m_P22033_His678Arg), deleterious(m_P01009_Ala84Thr), deleterious(m_P51648_Ser415Asn), deleterious(m_P00439_Ala259Thr), deleterious(m_P08397_Ala252Thr), deleterious(m_Q92947_Ala293Thr), deleterious(m_P54803_Ala263Thr), deleterious(m_P13569_Ala559Thr), deleterious(m_P05186_Ala176Thr), deleterious(m_Q00266_Ser38Asn), deleterious(m_P41181_Ala190Thr), deleterious(m_P35520_Ala361Thr), deleterious(m_P21439_Ala934Thr), deleterious(m_P02649_Ala117Thr), deleterious(m_P02792_Ala96Thr), deleterious(m_P05166_Ala468Thr), deleterious(m_Q05066_Ala113Thr), deleterious(m_P10275_His874Arg), deleterious(m_P35557_Ala259Thr), deleterious(m_P00439_Ala345Thr), deleterious(m_P01009_Ala58Thr), deleterious(m_P00439_Ala322Thr), deleterious(m_P48436_Ala158Thr), deleterious(m_P10828_Ala317Thr), deleterious(m_P29033_His73Arg), deleterious(m_P35557_Ala384Thr), deleterious(m_Q15465_Ala110Thr), deleterious(m_P05186_Ala116Thr), deleterious(m_P16615_Ala803Thr), deleterious(m_Q15582_Ala546Thr), deleterious(m_P00414_Ala200Thr)

+ Negative Examples: deleterious(m_Q16678_Ser206Asn), deleterious(m_Q8TF42_Ala68Thr), deleterious(m_Q15118_Ala134Thr)  
develop  humvar398_2   fold(A, 'HAD-like'). deleterious(A)
61 (1.02%) 
2 (0.1%) 
60
Covers:
+ Positive Examples: deleterious(m_O15305_Glu139Lys), deleterious(m_O15305_Val231Met), deleterious(m_O15305_Glu197Ala), deleterious(m_O15305_Val44Ala), deleterious(m_O15305_Cys9Tyr), deleterious(m_O15305_Phe206Ser), deleterious(m_O15305_Thr226Ser), deleterious(m_O15305_Phe11Cys), deleterious(m_O15305_Phe183Ser), deleterious(m_O15305_Gly208Ala), deleterious(m_O15305_Tyr64Cys), deleterious(m_O15305_Glu151Gly), deleterious(m_O15305_Arg238Gly), deleterious(m_O15305_Asn216Ile), deleterious(m_O15305_Phe172Val), deleterious(m_O15305_Pro131Ala), deleterious(m_O15305_Thr237Met), deleterious(m_O15305_Glu93Ala), deleterious(m_O15305_Arg141His), deleterious(m_O15305_Gly117Arg), deleterious(m_O15305_Cys241Ser), deleterious(m_O15305_Phe157Ser), deleterious(m_O15305_Asp148Asn), deleterious(m_O15305_Arg162Trp), deleterious(m_O15305_Asp223Glu), deleterious(m_O15305_Arg141Cys), deleterious(m_O15305_Gly228Arg), deleterious(m_O15305_Gly15Glu), deleterious(m_O15305_Ile132Thr), deleterious(m_O15305_Ile132Phe), deleterious(m_O15305_Tyr76Cys), deleterious(m_O15305_Arg238Pro), deleterious(m_O15305_Gly214Ser), deleterious(m_O15305_Asn216Ser), deleterious(m_O15305_Phe119Leu), deleterious(m_O15305_Leu104Val), deleterious(m_O15305_Cys192Gly), deleterious(m_O15305_Ile120Thr), deleterious(m_O15305_Tyr106Cys), deleterious(m_O15305_Pro113Leu), deleterious(m_O15305_Asp223Asn), deleterious(m_O15305_Asn101Lys), deleterious(m_O15305_Pro69Ser), deleterious(m_O15305_Gln177His), deleterious(m_O15305_Ala108Val), deleterious(m_O15305_His195Arg), deleterious(m_O15305_Ile132Asn), deleterious(m_O15305_Val129Met), deleterious(m_O15305_Thr237Arg), deleterious(m_O15305_Val67Met), deleterious(m_O15305_His218Leu), deleterious(m_O15305_Asp188Gly), deleterious(m_O15305_Val44Leu), deleterious(m_O15305_Tyr229Ser), deleterious(m_O15305_Pro20Ser), deleterious(m_O15305_Gly228Cys), deleterious(m_O15305_Asp65Tyr), deleterious(m_O15305_Gly176Val), deleterious(m_O15305_Phe144Leu), deleterious(m_O15305_Leu32Arg), deleterious(m_O15305_Asp217Glu)

+ Negative Examples: deleterious(m_P34913_Lys55Arg), deleterious(m_P34913_Arg103Cys)  
develop  humvar398_20   modif_hydrophobicity(A, hydrophobicity_decrease) and modif_polarity(A, polarity_increase) and conservation_class(A, global_conservation_rank_2) and mut_accessibility(A, intermediate). deleterious(A)
62 (1.03%) 
3 (0.15%) 
60
Covers:
+ Positive Examples: deleterious(m_Q92838_Ala349Thr), deleterious(m_P04424_Met382Arg), deleterious(m_P00441_Ile114Thr), deleterious(m_P00451_Gly2045Glu), deleterious(m_P58012_Trp98Arg), deleterious(m_P26367_Ile29Ser), deleterious(m_P07225_Cys241Ser), deleterious(m_Q16678_Ile399Ser), deleterious(m_O15553_Gly678Glu), deleterious(m_P58012_Phe90Ser), deleterious(m_P30613_Gly341Asp), deleterious(m_P50053_Gly40Arg), deleterious(m_P51649_Gly409Asp), deleterious(m_Q05066_Leu101His), deleterious(m_Q15582_Leu527Arg), deleterious(m_P06280_Cys52Arg), deleterious(m_P26367_Ile56Thr), deleterious(m_P01185_Gly54Arg), deleterious(m_P22033_Gly87Glu), deleterious(m_P22033_Phe174Ser), deleterious(m_Q9Y6Q6_Cys175Arg), deleterious(m_P35916_Gly857Arg), deleterious(m_O43405_Trp117Arg), deleterious(m_P32322_Ala257Thr), deleterious(m_P49747_Gly440Arg), deleterious(m_Q93099_Gly270Arg), deleterious(m_P49747_Gly440Glu), deleterious(m_P05156_Gly287Arg), deleterious(m_P00451_Cys348Ser), deleterious(m_P10828_Gly332Arg), deleterious(m_P48728_Gly269Asp), deleterious(m_P29965_Gly144Glu), deleterious(m_P13569_Ala613Thr), deleterious(m_P07225_Ala68Asp), deleterious(m_P01008_Phe434Ser), deleterious(m_P07225_Cys265Arg), deleterious(m_Q16613_Ala129Thr), deleterious(m_P51843_Leu466Arg), deleterious(m_P04839_Val534Asp), deleterious(m_Q13485_Gly352Arg), deleterious(m_P51648_Gly412Arg), deleterious(m_P02545_Gly465Asp), deleterious(m_O15305_Ile120Thr), deleterious(m_P06280_Cys52Ser), deleterious(m_P09417_Gly17Arg), deleterious(m_Q03426_Ala148Thr), deleterious(m_Q03393_Val70Asp), deleterious(m_P29965_Ala123Glu), deleterious(m_Q99593_Gly80Arg), deleterious(m_P00451_Ile2056Asn), deleterious(m_P50897_Gly108Arg), deleterious(m_P60891_Met115Thr), deleterious(m_P06280_Gly85Asp), deleterious(m_Q05066_Ile68Thr), deleterious(m_O14773_Gly77Arg), deleterious(m_P01034_Leu94Gln), deleterious(m_P54577_Gly41Arg), deleterious(m_Q92838_Gly381Arg), deleterious(m_P49768_Ala409Thr), deleterious(m_P98172_Ile62Thr), deleterious(m_P00441_Gly148Arg), deleterious(m_P53634_Gly300Asp)

+ Negative Examples: deleterious(m_O14931_Ala103Thr), deleterious(m_P01909_Ile129Thr), deleterious(m_Q8NHL6_Ala93Thr)  
develop  humvar398_72   modif_size(A, size_increase) and modif_polarity(A, polarity_decrease) and g_or_p(A, g_or_p_unchanged) and is_in_site(A, yes) and conservation_class(A, no_conservation_typification) and mut_accessibility(A, buried). deleterious(A)
64 (1.07%) 
5 (0.25%) 
60
Covers:
+ Positive Examples: deleterious(m_P30613_Ser485Phe), deleterious(m_P22033_Thr230Ile), deleterious(m_P00451_Cys329Phe), deleterious(m_O75197_Thr244Met), deleterious(m_P00451_Thr252Ile), deleterious(m_P25189_Thr65Ile), deleterious(m_P43246_Thr44Met), deleterious(m_P51648_Ser365Leu), deleterious(m_P04049_Thr491Ile), deleterious(m_P11413_Ser188Phe), deleterious(m_P30613_Thr408Ile), deleterious(m_P08397_Thr35Met), deleterious(m_P00740_Thr342Met), deleterious(m_P05186_Ser181Leu), deleterious(m_P51649_Cys93Phe), deleterious(m_P08100_Thr94Ile), deleterious(m_P03951_Cys46Phe), deleterious(m_Q92947_Ser139Leu), deleterious(m_P00451_Ser2088Phe), deleterious(m_P06744_Thr195Ile), deleterious(m_P08709_Thr419Met), deleterious(m_Q06124_Thr73Ile), deleterious(m_P01112_Thr58Ile), deleterious(m_P00451_Ser1965Ile), deleterious(m_P25189_Ser63Phe), deleterious(m_P50570_Ser619Leu), deleterious(m_P28329_Ser498Leu), deleterious(m_P00813_Thr233Ile), deleterious(m_P07902_Ser45Leu), deleterious(m_P11362_Ser685Phe), deleterious(m_Q93099_Ser189Ile), deleterious(m_P16615_Ser495Phe), deleterious(m_Q01968_Ser374Phe), deleterious(m_P06744_Ser278Leu), deleterious(m_P43246_Cys697Phe), deleterious(m_P08397_Thr269Ile), deleterious(m_P05166_Thr428Ile), deleterious(m_P00966_Ser18Leu), deleterious(m_P21439_Ser320Phe), deleterious(m_P00480_Thr44Ile), deleterious(m_P21333_Ser149Phe), deleterious(m_P08397_Ser96Phe), deleterious(m_P00451_Ser189Leu), deleterious(m_P00480_Ser60Leu), deleterious(m_P63261_Thr278Ile), deleterious(m_P21439_Ser346Ile), deleterious(m_P07902_Ser135Leu), deleterious(m_P00966_Thr284Ile), deleterious(m_P08397_Cys247Phe), deleterious(m_P22033_Ser306Phe), deleterious(m_P01116_Thr58Ile), deleterious(m_P40763_Thr622Ile), deleterious(m_P08514_Thr207Ile), deleterious(m_P00439_Ser310Phe), deleterious(m_P01008_Ser214Phe), deleterious(m_P54803_Ser303Phe), deleterious(m_P00439_Thr124Ile), deleterious(m_P24752_Thr297Met), deleterious(m_P00813_Ser291Leu), deleterious(m_Q06187_Ser115Phe), deleterious(m_O75197_Thr253Ile), deleterious(m_Q92947_Ser305Leu), deleterious(m_B7U540_Thr354Met), deleterious(m_P49748_Thr260Met)

+ Negative Examples: deleterious(m_P01833_Thr555Ile), deleterious(m_P08263_Thr19Ile), deleterious(m_O00754_Thr312Ile), deleterious(m_Q9HBL8_Thr23Ile), deleterious(m_P30837_Thr202Ile)  
develop  humvar398_18   modif_hydrophobicity(A, hydrophobicity_decrease) and g_or_p(A, g_or_p_unchanged) and conservation_class(A, sub_family_conservation) and secondary_struc(A, helix) and stability(A, decrease). deleterious(A)
62 (1.03%) 
5 (0.25%) 
64
Covers:
+ Positive Examples: deleterious(m_P41181_Ala147Thr), deleterious(m_P05186_Tyr436His), deleterious(m_P08100_His211Arg), deleterious(m_P08100_Cys167Arg), deleterious(m_P00439_Gln304Arg), deleterious(m_P21912_Leu65His), deleterious(m_P00492_Met143Lys), deleterious(m_P06132_Met165Arg), deleterious(m_P00480_Ala208Thr), deleterious(m_P50053_Ala43Thr), deleterious(m_P29033_Thr86Arg), deleterious(m_P12694_Tyr438Asn), deleterious(m_P16615_Leu65Ser), deleterious(m_P22830_Phe417Ser), deleterious(m_P52333_Leu910Ser), deleterious(m_P00480_Tyr183Asp), deleterious(m_P39019_Phe21Ser), deleterious(m_P08100_Ala164Glu), deleterious(m_P36551_His295Asp), deleterious(m_P06280_Tyr216Asp), deleterious(m_O15305_Phe157Ser), deleterious(m_P06132_Met324Thr), deleterious(m_P06280_Met284Thr), deleterious(m_P08100_Thr58Arg), deleterious(m_Q93099_Ile216Thr), deleterious(m_P35498_Met1852Thr), deleterious(m_P11277_Trp2024Arg), deleterious(m_P35498_Phe1831Ser), deleterious(m_P00439_Tyr154Asn), deleterious(m_P26367_Leu46Arg), deleterious(m_P50897_Leu219Gln), deleterious(m_P21439_Leu591Gln), deleterious(m_Q15582_Leu569Arg), deleterious(m_P07902_Leu289Arg), deleterious(m_O95452_Val37Glu), deleterious(m_P08100_Met207Arg), deleterious(m_P51648_Ser415Asn), deleterious(m_Q05066_Met78Thr), deleterious(m_Q92947_Ala293Thr), deleterious(m_Q13496_Trp346Ser), deleterious(m_P35520_Ala361Thr), deleterious(m_P01137_Tyr81His), deleterious(m_Q92947_Tyr295His), deleterious(m_P02649_Ala117Thr), deleterious(m_P00439_Ile164Thr), deleterious(m_P00439_Phe161Ser), deleterious(m_P32929_Gln240Glu), deleterious(m_P45381_Ile143Thr), deleterious(m_P10275_Val866Glu), deleterious(m_P10275_His874Arg), deleterious(m_P10275_Ile841Ser), deleterious(m_P08100_Leu125Arg), deleterious(m_P22830_Met288Lys), deleterious(m_P26367_Val126Asp), deleterious(m_P29033_His73Arg), deleterious(m_P00966_Cys19Arg), deleterious(m_P16615_Ala745Asp), deleterious(m_P04156_Gln217Arg), deleterious(m_P12271_Met226Lys), deleterious(m_P46100_Cys200Ser), deleterious(m_P16615_Ala803Thr), deleterious(m_P69892_Phe42Ser)

+ Negative Examples: deleterious(m_Q96KN8_Gln214Arg), deleterious(m_Q06520_Ala261Thr), deleterious(m_Q9Y3R4_Ala145Thr), deleterious(m_P06396_Ala129Thr), deleterious(m_P22079_Ala244Thr)  
develop  humvar398_56   modif_size(A, size_increase) and modif_hydrophobicity(A, hydrophobicity_increase) and modif_polarity(A, polarity_unchanged) and is_in_site(A, yes) and secondary_struc(A, other) and mut_accessibility(A, intermediate). deleterious(A)
59 (0.98%) 
3 (0.15%) 
65
Covers:
+ Positive Examples: deleterious(m_P35520_Pro422Leu), deleterious(m_Q9Y5X4_Gly88Val), deleterious(m_P00439_Gly218Val), deleterious(m_P22033_Asn388His), deleterious(m_P31327_Pro1411Leu), deleterious(m_P16930_Gly369Val), deleterious(m_P00439_Asp84Tyr), deleterious(m_P08246_Gly32Val), deleterious(m_P01185_Pro55Leu), deleterious(m_P10275_Asp695His), deleterious(m_P04156_Gly131Val), deleterious(m_P43034_Asp317His), deleterious(m_P00480_Asp196Tyr), deleterious(m_P00441_Gly94Val), deleterious(m_P10275_Asn771His), deleterious(m_P98172_Gly151Val), deleterious(m_P43246_Ser323Tyr), deleterious(m_P00451_Gly2045Val), deleterious(m_P48436_Pro108Leu), deleterious(m_Q14623_Pro46Leu), deleterious(m_P01008_Pro73Leu), deleterious(m_P00439_Pro281Leu), deleterious(m_P00451_Pro470Leu), deleterious(m_P05186_Asp294Tyr), deleterious(m_P00441_Asp126His), deleterious(m_P00451_Pro2067Leu), deleterious(m_P00451_Asp101His), deleterious(m_P06276_Asp98His), deleterious(m_P16930_Pro342Leu), deleterious(m_P01116_Pro34Leu), deleterious(m_O75197_Asp111Tyr), deleterious(m_Q16518_Pro470Leu), deleterious(m_Q9BZ23_Gly219Val), deleterious(m_P01308_Gly47Val), deleterious(m_Q16595_Gly130Val), deleterious(m_P63261_Pro264Leu), deleterious(m_P25189_Asp35Tyr), deleterious(m_Q92838_Asp298His), deleterious(m_P00439_Asp151His), deleterious(m_P13569_Gly458Val), deleterious(m_P06396_Asp214Tyr), deleterious(m_P10275_Pro892Leu), deleterious(m_P00740_Gly432Val), deleterious(m_P05107_Pro178Leu), deleterious(m_P05089_Gly138Val), deleterious(m_Q92838_Asp298Tyr), deleterious(m_O15553_Pro646Leu), deleterious(m_P48637_Gly464Val), deleterious(m_P61626_Asp85His), deleterious(m_P16615_Pro602Leu), deleterious(m_Q01968_Pro799Leu), deleterious(m_P00451_Pro2319Leu), deleterious(m_P15056_Gly466Val), deleterious(m_Q16518_Gly436Val), deleterious(m_O15305_Asp65Tyr), deleterious(m_O00754_Ser453Tyr), deleterious(m_P53420_Pro1572Leu), deleterious(m_P16615_Ser920Tyr), deleterious(m_P07954_Gly282Val)

+ Negative Examples: deleterious(m_P12829_Asn186Tyr), deleterious(m_P05362_Pro352Leu), deleterious(m_P23368_Pro114Leu)  
develop  humvar398_66   modif_size(A, size_increase) and g_or_p(A, g_or_p_apparition) and secondary_struc(A, helix). deleterious(A)
58 (0.97%) 
2 (0.1%) 
65
Covers:
+ Positive Examples: deleterious(m_P17661_Ala337Pro), deleterious(m_P00966_Ser79Pro), deleterious(m_P40692_Ala586Pro), deleterious(m_P00439_Ala395Pro), deleterious(m_Q9H2C0_Ala51Pro), deleterious(m_P11277_Ala2053Pro), deleterious(m_P39019_Ala57Pro), deleterious(m_Q14353_Ala54Pro), deleterious(m_P24752_Ala333Pro), deleterious(m_P08235_Ser805Pro), deleterious(m_P17661_Ala357Pro), deleterious(m_P00387_Ser128Pro), deleterious(m_P51843_Ala300Pro), deleterious(m_Q9BZ23_Ser351Pro), deleterious(m_P00439_Ser303Pro), deleterious(m_P11277_Ser2019Pro), deleterious(m_P51159_Ala152Pro), deleterious(m_P15918_Ser401Pro), deleterious(m_P01008_Ser223Pro), deleterious(m_P06280_Ala285Pro), deleterious(m_P22033_Ala535Pro), deleterious(m_P35520_Ala355Pro), deleterious(m_O43707_Ser262Pro), deleterious(m_P35557_Ser131Pro), deleterious(m_P02649_Ala170Pro), deleterious(m_Q8WXF7_Ala161Pro), deleterious(m_P16615_Ala838Pro), deleterious(m_P49768_Ala426Pro), deleterious(m_Q9Y6K9_Ala323Pro), deleterious(m_P00491_Ala174Pro), deleterious(m_P17661_Ala360Pro), deleterious(m_P39019_Ala17Pro), deleterious(m_P06744_Ala300Pro), deleterious(m_P14410_Ser594Pro), deleterious(m_P24752_Ala301Pro), deleterious(m_P35520_Ala231Pro), deleterious(m_P10746_Ser212Pro), deleterious(m_P21912_Ser163Pro), deleterious(m_P12235_Ala114Pro), deleterious(m_P00480_Ala174Pro), deleterious(m_P00480_Ser340Pro), deleterious(m_P28069_Ala158Pro), deleterious(m_P41181_Ser216Pro), deleterious(m_P01008_Ser148Pro), deleterious(m_P11532_Ala171Pro), deleterious(m_P07954_Ala117Pro), deleterious(m_P10746_Ser47Pro), deleterious(m_P10275_Ser865Pro), deleterious(m_P04839_Ser422Pro), deleterious(m_P00492_Ala50Pro), deleterious(m_P08397_Ala31Pro), deleterious(m_P26367_Ala33Pro), deleterious(m_P05106_Ser778Pro), deleterious(m_P40692_Ala623Pro), deleterious(m_P35713_Ala104Pro), deleterious(m_P00439_Ser231Pro), deleterious(m_P35680_Ser151Pro), deleterious(m_P54840_Ala339Pro)

+ Negative Examples: deleterious(m_P52789_Ala314Pro), deleterious(m_Q7L576_Ala532Pro)  
develop  humvar398_51   g_or_p(A, g_or_p_unchanged) and conservation_class(A, global_conservation_rank_2) and lost_contact(A, phob). deleterious(A)
59 (0.98%) 
4 (0.2%) 
67
Covers:
+ Positive Examples: deleterious(m_Q03154_Arg353Cys), deleterious(m_P00451_Met2007Ile), deleterious(m_P58012_Trp98Arg), deleterious(m_P29965_Lys143Thr), deleterious(m_P10828_Gln340His), deleterious(m_Q16678_Ile399Ser), deleterious(m_P11532_Lys18Asn), deleterious(m_Q00266_Ile322Met), deleterious(m_P22033_Leu281Ser), deleterious(m_Q13496_Ile264Ser), deleterious(m_P10912_Ile171Thr), deleterious(m_Q13509_Arg380Cys), deleterious(m_P00966_Arg157His), deleterious(m_P00439_Arg270Ser), deleterious(m_P30613_Ile314Thr), deleterious(m_P05186_Met62Val), deleterious(m_P60484_His93Arg), deleterious(m_P00966_Glu191Lys), deleterious(m_Q04656_Leu873Arg), deleterious(m_P29965_Leu258Ser), deleterious(m_P35520_Ile152Met), deleterious(m_P10828_Phe459Cys), deleterious(m_Q8IVH4_Arg359Gln), deleterious(m_Q12840_Glu251Lys), deleterious(m_P11217_Lys543Thr), deleterious(m_Q03393_Arg16Cys), deleterious(m_P10828_Met442Val), deleterious(m_P06280_Ile91Thr), deleterious(m_P00492_Ile42Phe), deleterious(m_O15305_Leu104Val), deleterious(m_P03950_Lys64Ile), deleterious(m_P10275_Val889Met), deleterious(m_Q93099_Arg330Ser), deleterious(m_P10275_Phe754Val), deleterious(m_P98172_Leu98Ser), deleterious(m_P01241_Arg42Cys), deleterious(m_O43707_Lys255Glu), deleterious(m_P00813_Arg156Cys), deleterious(m_P35557_Met210Thr), deleterious(m_Q06187_Arg525Gln), deleterious(m_Q9BZ23_Arg264Trp), deleterious(m_P22830_Tyr191His), deleterious(m_P00966_Arg272Cys), deleterious(m_P06280_Met187Val), deleterious(m_Q13496_Arg184Leu), deleterious(m_Q01968_Arg361Ile), deleterious(m_P22748_Arg219Ser), deleterious(m_Q16518_Val473Asp), deleterious(m_P02649_Lys164Gln), deleterious(m_P40692_Arg659Leu), deleterious(m_P13569_Ile618Thr), deleterious(m_Q13461_Arg90Leu), deleterious(m_P02649_Lys164Glu), deleterious(m_P06280_Arg112Ser), deleterious(m_P35520_Lys384Glu), deleterious(m_P35520_Lys384Asn), deleterious(m_Q05066_Val60Ala), deleterious(m_P05166_Arg67Ser), deleterious(m_P23786_Met214Thr)

+ Negative Examples: deleterious(m_P11172_Ile446Val), deleterious(m_Q01995_Asn182Ser), deleterious(m_Q9NQI0_Ile287Val), deleterious(m_Q02742_Ile152Val)  
develop  humvar398_30   modif_polarity(A, polarity_decrease) and conservation_class(A, global_conservation_rank_2) and stability(A, increase). deleterious(A)
59 (0.98%) 
5 (0.25%) 
68
Covers:
+ Positive Examples: deleterious(m_P98172_Thr155Pro), deleterious(m_P10912_Ser244Ile), deleterious(m_P01241_Ser97Phe), deleterious(m_P40692_Ser44Phe), deleterious(m_P39019_Ser59Phe), deleterious(m_P98172_Ser138Phe), deleterious(m_Q15465_Asp88Val), deleterious(m_P00387_Ser128Pro), deleterious(m_P35453_Ser316Cys), deleterious(m_P13804_Thr266Met), deleterious(m_P26367_Arg19Pro), deleterious(m_P31785_Ser241Ile), deleterious(m_P35914_Ser142Phe), deleterious(m_P10828_Lys342Ile), deleterious(m_Q9H161_Arg272Pro), deleterious(m_Q15583_Gln236Leu), deleterious(m_Q7Z406_Ser120Leu), deleterious(m_P21333_Glu82Val), deleterious(m_P35557_Thr168Pro), deleterious(m_P02545_Arg349Leu), deleterious(m_P00451_Tyr1909Cys), deleterious(m_P18858_Arg771Trp), deleterious(m_P05156_Asp524Val), deleterious(m_P25189_Asp134Gly), deleterious(m_P25189_Ser54Cys), deleterious(m_P10746_Thr228Met), deleterious(m_P07951_Glu117Ala), deleterious(m_P68032_Arg97Cys), deleterious(m_P08100_Ser186Pro), deleterious(m_P52952_Tyr191Cys), deleterious(m_P07320_Arg15Cys), deleterious(m_O95409_Arg373Pro), deleterious(m_P01009_Glu288Val), deleterious(m_P08397_Glu80Gly), deleterious(m_Q8TDP1_Arg69Trp), deleterious(m_P30613_Ser376Ile), deleterious(m_P03950_Gln36Leu), deleterious(m_P28069_Glu174Gly), deleterious(m_P29033_Arg184Pro), deleterious(m_O00294_Arg420Pro), deleterious(m_Q13950_Arg228Gly), deleterious(m_Q495M9_Asp458Val), deleterious(m_P10619_Ser90Leu), deleterious(m_Q13148_Asp169Gly), deleterious(m_P25189_Ser54Pro), deleterious(m_P04792_Arg127Trp), deleterious(m_P48436_Arg152Pro), deleterious(m_P10275_Ser865Pro), deleterious(m_P54803_Ser68Phe), deleterious(m_P51843_Asn440Ile), deleterious(m_Q8IWU9_Arg303Trp), deleterious(m_P05062_Arg304Trp), deleterious(m_Q96QS3_Arg332Pro), deleterious(m_P20823_Arg271Trp), deleterious(m_P49768_Ser390Ile), deleterious(m_P00966_Arg157Cys), deleterious(m_P07225_Glu67Ala), deleterious(m_Q06187_Ser592Pro), deleterious(m_P58012_Ser58Leu)

+ Negative Examples: deleterious(m_Q5TGJ6_Thr87Met), deleterious(m_Q8N8V2_Thr14Ile), deleterious(m_Q02539_Thr99Ile), deleterious(m_Q13576_Thr894Ile), deleterious(m_P51161_Thr79Met)  
develop  humvar398_84   modif_size(A, size_decrease) and g_or_p(A, g_or_p_apparition) and is_in_site(A, yes) and conservation_class(A, no_conservation_typification) and lost_contact(A, dc) and wt_accessibility(A, intermediate). deleterious(A)
58 (0.97%) 
5 (0.25%) 
69
Covers:
+ Positive Examples: deleterious(m_P11413_Leu323Pro), deleterious(m_P62736_Arg292Gly), deleterious(m_P22033_Val633Gly), deleterious(m_P21333_Gln170Pro), deleterious(m_P08236_Asp152Gly), deleterious(m_P17900_Arg169Pro), deleterious(m_P00439_Arg261Pro), deleterious(m_P13804_Val157Gly), deleterious(m_P02768_Arg242Pro), deleterious(m_P07902_Leu195Pro), deleterious(m_Q5TBB1_Val185Gly), deleterious(m_P40337_Arg107Gly), deleterious(m_P04181_Arg250Pro), deleterious(m_P07902_Arg148Gly), deleterious(m_P00451_Arg1715Gly), deleterious(m_P02768_Asp574Gly), deleterious(m_O95954_Arg299Pro), deleterious(m_P21333_Arg196Gly), deleterious(m_P01008_Arg425Pro), deleterious(m_P07949_Arg180Pro), deleterious(m_P00966_Arg363Gly), deleterious(m_P01008_Leu441Pro), deleterious(m_P08514_Arg755Pro), deleterious(m_P51608_Asp156Gly), deleterious(m_P49675_Leu275Pro), deleterious(m_P35680_Arg112Pro), deleterious(m_Q92947_Arg227Pro), deleterious(m_P02545_Arg527Pro), deleterious(m_P00451_Arg2016Pro), deleterious(m_P11217_Leu292Pro), deleterious(m_P05107_Leu149Pro), deleterious(m_P55072_Arg95Gly), deleterious(m_P00451_Leu1771Pro), deleterious(m_P00451_Arg1800Gly), deleterious(m_Q16518_Val452Gly), deleterious(m_P21439_Glu395Gly), deleterious(m_P31785_Glu68Gly), deleterious(m_P00451_Glu1848Gly), deleterious(m_P00966_Val345Gly), deleterious(m_P51608_Arg111Gly), deleterious(m_P00439_Glu221Gly), deleterious(m_P51608_Glu137Gly), deleterious(m_P00451_Val285Gly), deleterious(m_P07902_Arg262Pro), deleterious(m_P00439_Gln160Pro), deleterious(m_P08514_Leu86Pro), deleterious(m_P31150_Arg423Pro), deleterious(m_P07902_Leu226Pro), deleterious(m_P00439_Leu212Pro), deleterious(m_P05186_Glu235Gly), deleterious(m_P49675_Glu169Gly), deleterious(m_P00451_Arg2135Pro), deleterious(m_P00451_Arg490Gly), deleterious(m_P00740_Arg294Gly), deleterious(m_P08236_Arg435Pro), deleterious(m_Q01968_Arg457Gly), deleterious(m_Q9H3D4_Asp351Gly), deleterious(m_P11413_Arg439Pro)

+ Negative Examples: deleterious(m_P11217_Arg414Gly), deleterious(m_P28329_Arg222Pro), deleterious(m_Q96PP9_Glu551Gly), deleterious(m_P13747_Arg128Gly), deleterious(m_Q03405_Glu55Gly)  
develop  humvar398_3   modif_charge(A, charge_decrease) and g_or_p(A, g_or_p_unchanged) and is_in_site(A, yes) and secondary_struc(A, helix) and lost_contact(A, hb) and stability(A, decrease). deleterious(A)
57 (0.95%) 
5 (0.25%) 
70
Covers:
+ Positive Examples: deleterious(m_Q9NRR6_Arg512Trp), deleterious(m_P30613_Arg337Gln), deleterious(m_P45381_Arg168Cys), deleterious(m_P60484_Arg173Cys), deleterious(m_P06280_Arg49Ser), deleterious(m_P48637_Arg283Cys), deleterious(m_Q13509_Arg380Cys), deleterious(m_P00367_Arg274Cys), deleterious(m_P30613_Arg504Leu), deleterious(m_P02649_Arg160Cys), deleterious(m_P39019_Arg62Gln), deleterious(m_P43699_Arg213Ser), deleterious(m_Q9NRR6_Arg515Trp), deleterious(m_Q92947_Arg88Cys), deleterious(m_Q92947_Arg294Trp), deleterious(m_P08397_Arg201Trp), deleterious(m_P26367_Arg128Cys), deleterious(m_Q14376_Arg169Trp), deleterious(m_P05166_Arg512Cys), deleterious(m_Q9BV36_Arg35Trp), deleterious(m_P35520_Arg125Trp), deleterious(m_P30613_Arg531Cys), deleterious(m_P11511_Arg365Gln), deleterious(m_Q8IVH4_Arg359Gln), deleterious(m_P11498_Arg156Gln), deleterious(m_P00966_Arg95Ser), deleterious(m_P50336_Arg152Cys), deleterious(m_P29317_Arg721Gln), deleterious(m_P20823_Arg263Cys), deleterious(m_P35557_Arg36Trp), deleterious(m_P02768_Arg434Cys), deleterious(m_P05062_Arg304Gln), deleterious(m_P00439_Arg157Asn), deleterious(m_P62736_Arg185Gln), deleterious(m_P01308_Arg46Gln), deleterious(m_P20823_Arg229Gln), deleterious(m_P02649_Arg154Cys), deleterious(m_P00439_Arg158Trp), deleterious(m_P10275_Arg840Ser), deleterious(m_P15918_Arg314Trp), deleterious(m_Q06187_Arg525Gln), deleterious(m_Q92947_Arg386Gln), deleterious(m_P02649_Arg154Ser), deleterious(m_P29033_Arg143Gln), deleterious(m_P08397_Arg173Gln), deleterious(m_P10275_Arg831Leu), deleterious(m_P21912_Arg230Cys), deleterious(m_Q8WXF7_Arg239Cys), deleterious(m_P49638_Arg59Trp), deleterious(m_Q12840_Arg204Gln), deleterious(m_P00439_Arg158Gln), deleterious(m_Q99714_Arg130Cys), deleterious(m_Q92947_Arg355Cys), deleterious(m_P08559_Arg72Cys), deleterious(m_P10275_Arg774Cys), deleterious(m_P05166_Arg67Ser), deleterious(m_P08397_Arg195Cys)

+ Negative Examples: deleterious(m_P33261_Arg410Cys), deleterious(m_P32320_Lys27Gln), deleterious(m_P16442_Arg199Cys), deleterious(m_Q13576_Arg1052Ile), deleterious(m_Q9UII6_Arg62Gln)  
develop  humvar398_111   modif_size(A, size_increase) and modif_charge(A, charge_unchanged) and conservation_class(A, no_conservation_typification) and secondary_struc(A, other) and gain_contact(A, phob) and mut_accessibility(A, buried). deleterious(A)
54 (0.9%) 
5 (0.25%) 
71
Covers:
+ Positive Examples: deleterious(m_P22033_Cys560Tyr), deleterious(m_P00451_Gly164Val), deleterious(m_P40692_Asp485Glu), deleterious(m_P00558_Gly158Val), deleterious(m_P30613_Gly263Trp), deleterious(m_O15118_Cys177Tyr), deleterious(m_P00451_Ala1939Thr), deleterious(m_P01877_Asp296Glu), deleterious(m_P51648_Ser365Leu), deleterious(m_P05186_Gly63Val), deleterious(m_P00439_Val245Leu), deleterious(m_P11362_Cys277Tyr), deleterious(m_P02787_Ala477Pro), deleterious(m_P51649_Cys93Phe), deleterious(m_P11413_Gly131Val), deleterious(m_P00451_Ala1798Pro), deleterious(m_P06280_Ala97Val), deleterious(m_P00451_Gly2304Val), deleterious(m_P06280_Leu300Phe), deleterious(m_P05186_Cys201Tyr), deleterious(m_P35670_Gly875Val), deleterious(m_P30613_Gly165Val), deleterious(m_P24752_Gly379Val), deleterious(m_O14773_Ser153Pro), deleterious(m_P00451_Val727Phe), deleterious(m_P06744_Ser278Leu), deleterious(m_P43246_Cys697Phe), deleterious(m_P13716_Val275Met), deleterious(m_P06280_Ser297Phe), deleterious(m_P00451_Ile2117Phe), deleterious(m_Q13825_Ala240Val), deleterious(m_Q9H3D4_Cys308Tyr), deleterious(m_P21333_Ser149Phe), deleterious(m_P04075_Cys339Tyr), deleterious(m_P08514_Val329Phe), deleterious(m_Q9UBC3_Ala585Val), deleterious(m_P00451_Ser2192Ile), deleterious(m_P30613_Gly159Val), deleterious(m_P00451_Ser1803Tyr), deleterious(m_P00451_Leu2229Phe), deleterious(m_P06280_Ser148Asn), deleterious(m_P07949_Ser32Leu), deleterious(m_P30613_Val288Leu), deleterious(m_P00966_Thr284Ile), deleterious(m_P00451_Ser596Pro), deleterious(m_P22033_Ser306Phe), deleterious(m_Q13501_Pro387Leu), deleterious(m_P00451_Gly439Val), deleterious(m_Q92947_Val148Ile), deleterious(m_P00439_Thr124Ile), deleterious(m_P01024_Cys1158Trp), deleterious(m_P00966_Val263Met), deleterious(m_P06213_Gly1035Val), deleterious(m_P06280_Gly328Val)

+ Negative Examples: deleterious(m_P01833_Thr555Ile), deleterious(m_Q9Y4X1_Val391Ile), deleterious(m_P01137_Thr263Ile), deleterious(m_P16083_Leu47Phe), deleterious(m_Q8TBK2_Ala445Val)  
develop  humvar398_99   modif_polarity(A, polarity_unchanged) and conservation_class(A, global_conservation_rank_1) and secondary_struc(A, other) and mut_accessibility(A, accessible). deleterious(A)
54 (0.9%) 
5 (0.25%) 
71
Covers:
+ Positive Examples: deleterious(m_P06744_His389Arg), deleterious(m_Q16678_Arg368His), deleterious(m_Q9NVI1_Arg1285Gln), deleterious(m_O95409_Tyr402Asn), deleterious(m_P00492_Asp177Tyr), deleterious(m_P40692_Lys84Glu), deleterious(m_P19429_Lys178Glu), deleterious(m_P49675_Arg217Thr), deleterious(m_P23760_Asn47Lys), deleterious(m_Q03426_Val310Met), deleterious(m_Q9Y5X4_Arg97His), deleterious(m_P28069_Ser179Arg), deleterious(m_P43246_Asn671Tyr), deleterious(m_P21333_Pro207Leu), deleterious(m_P04839_Trp516Cys), deleterious(m_Q01968_Asn354His), deleterious(m_P48436_Lys173Glu), deleterious(m_P04181_Tyr55His), deleterious(m_Q13950_Arg131Ser), deleterious(m_Q13950_Lys218Gln), deleterious(m_P53634_His405Asn), deleterious(m_P13569_Ser549Arg), deleterious(m_P28069_Glu230Lys), deleterious(m_P14854_Arg20His), deleterious(m_P23760_Pro50Leu), deleterious(m_Q13950_Lys218Asn), deleterious(m_P35680_Arg235Gln), deleterious(m_O15305_Pro113Leu), deleterious(m_Q92466_Arg273His), deleterious(m_O43186_Arg41Gln), deleterious(m_Q01196_Arg174Gln), deleterious(m_O43602_Arg159His), deleterious(m_O43918_Pro326Leu), deleterious(m_Q00266_Arg264His), deleterious(m_Q13950_Ser191Asn), deleterious(m_P35557_Glu70Lys), deleterious(m_P15976_Arg216Gln), deleterious(m_P40692_Glu102Lys), deleterious(m_Q04656_Gln924Arg), deleterious(m_Q13950_Lys218Glu), deleterious(m_P20823_Arg203His), deleterious(m_Q14126_Arg49His), deleterious(m_Q06124_Ile309Val), deleterious(m_O15305_Gly176Val), deleterious(m_P23760_Asn47His), deleterious(m_P48165_Arg198Gln), deleterious(m_P23760_Val78Met), deleterious(m_P04424_Gln286Arg), deleterious(m_Q9H161_Arg218Gln), deleterious(m_P53634_His405Arg), deleterious(m_Q13950_Arg193Gln), deleterious(m_P35270_Pro163Leu), deleterious(m_P04181_Arg180Thr), deleterious(m_Q16678_Asp374Asn)

+ Negative Examples: deleterious(m_Q02833_Pro89Ala), deleterious(m_Q9NP86_Thr65Arg), deleterious(m_P82980_Glu70Gln), deleterious(m_Q2M1V0_Arg83Gln), deleterious(m_P01909_Arg64Lys)  
develop  humvar398_102   modif_size(A, size_decrease) and modif_hydrophobicity(A, hydrophobicity_unchanged) and conservation_class(A, global_conservation_rank_1) and secondary_struc(A, helix) and stability(A, decrease). deleterious(A)
53 (0.88%) 
5 (0.25%) 
73
Covers:
+ Positive Examples: deleterious(m_P30566_Met26Leu), deleterious(m_P35916_Arg1041Pro), deleterious(m_Q06187_Met509Val), deleterious(m_P10275_Phe827Val), deleterious(m_P54868_Tyr167Cys), deleterious(m_P06280_Trp236Leu), deleterious(m_P48436_Met113Val), deleterious(m_Q06187_Met509Ile), deleterious(m_P43699_Trp208Leu), deleterious(m_P58012_Met65Val), deleterious(m_P35680_Arg295Pro), deleterious(m_O95409_His286Gln), deleterious(m_P08514_Phe222Leu), deleterious(m_P51843_Trp291Cys), deleterious(m_P13569_Arg560Lys), deleterious(m_P00492_Arg45Lys), deleterious(m_P68032_Met125Val), deleterious(m_Q13501_Met404Val), deleterious(m_A6NCS4_Phe151Leu), deleterious(m_P06280_Trp162Cys), deleterious(m_P10275_Phe856Leu), deleterious(m_P51648_Met328Ile), deleterious(m_P05166_Tyr439Cys), deleterious(m_Q06187_Glu589Asp), deleterious(m_Q15465_His140Gln), deleterious(m_Q05066_Phe67Val), deleterious(m_O14521_Tyr114Cys), deleterious(m_P04181_Tyr245Cys), deleterious(m_Q06187_Arg544Lys), deleterious(m_Q06187_Phe644Leu), deleterious(m_P10275_Met742Val), deleterious(m_Q05066_Ser91Gly), deleterious(m_P09417_Tyr150Cys), deleterious(m_P10275_Tyr834Cys), deleterious(m_P10828_Lys443Glu), deleterious(m_P10912_Val143Ala), deleterious(m_P10746_Tyr19Cys), deleterious(m_P06280_Trp236Cys), deleterious(m_P05186_Arg71Pro), deleterious(m_Q7LG56_Met282Ile), deleterious(m_P28360_Arg196Pro), deleterious(m_Q6NVY1_Tyr122Cys), deleterious(m_P00492_Phe74Leu), deleterious(m_P07902_Tyr209Cys), deleterious(m_P14136_Glu362Asp), deleterious(m_P35520_Met126Val), deleterious(m_P10275_Met787Val), deleterious(m_Q06187_Glu445Asp), deleterious(m_P28069_Phe135Cys), deleterious(m_P23760_Lys85Glu), deleterious(m_O15305_Phe144Leu), deleterious(m_Q13496_Tyr397Cys), deleterious(m_P41181_Trp202Cys)

+ Negative Examples: deleterious(m_P16455_Trp65Cys), deleterious(m_Q9HB55_Met145Ile), deleterious(m_Q8IV50_Ile107Val), deleterious(m_Q8WWF8_Met201Val), deleterious(m_Q12950_Ile152Val)  
develop  humvar398_58   modif_polarity(A, polarity_decrease) and g_or_p(A, g_or_p_unchanged) and is_in_site(A, yes) and secondary_struc(A, other) and lost_contact(A, dc) and wt_accessibility(A, intermediate). deleterious(A)
51 (0.85%) 
5 (0.25%) 
74
Covers:
+ Positive Examples: deleterious(m_P12271_Arg234Trp), deleterious(m_Q15437_Arg701Cys), deleterious(m_P00480_Arg320Leu), deleterious(m_P02679_Arg301Cys), deleterious(m_P08236_Tyr495Cys), deleterious(m_Q13509_Arg262Cys), deleterious(m_Q13950_Arg190Trp), deleterious(m_Q9HBA0_Arg316Cys), deleterious(m_P05186_Arg184Trp), deleterious(m_P00451_Arg437Trp), deleterious(m_P11597_Arg299Cys), deleterious(m_P57796_Arg124Cys), deleterious(m_P21912_Ser100Phe), deleterious(m_P05186_Arg391Cys), deleterious(m_P00451_Thr294Ile), deleterious(m_P00439_Thr278Ala), deleterious(m_P00451_Arg546Trp), deleterious(m_P00451_Arg1888Ile), deleterious(m_P51608_Arg133Cys), deleterious(m_P53634_Arg339Cys), deleterious(m_P06132_Ser219Phe), deleterious(m_Q05066_Tyr127Cys), deleterious(m_P11161_Arg381Cys), deleterious(m_Q13620_Arg572Cys), deleterious(m_P05106_Arg240Trp), deleterious(m_P00451_Arg1800Cys), deleterious(m_P08236_Arg577Leu), deleterious(m_P03951_Arg326Cys), deleterious(m_P05156_Asp524Val), deleterious(m_P53634_Tyr340Cys), deleterious(m_P62736_Arg149Cys), deleterious(m_P54819_Arg103Trp), deleterious(m_P01008_Arg425Cys), deleterious(m_P00451_Ser308Leu), deleterious(m_O75197_Thr173Met), deleterious(m_P49748_Arg366Cys), deleterious(m_O95954_Arg135Cys), deleterious(m_P07902_Arg51Leu), deleterious(m_P30566_Arg194Cys), deleterious(m_P03950_Lys64Ile), deleterious(m_P07320_Glu107Ala), deleterious(m_P00966_Arg363Trp), deleterious(m_Q71U36_Arg264Cys), deleterious(m_P00966_Arg363Leu), deleterious(m_P00966_Arg272Cys), deleterious(m_P45381_Asp249Val), deleterious(m_P00492_Asp177Val), deleterious(m_Q6PHW0_Arg101Trp), deleterious(m_P00451_Asn299Ile), deleterious(m_Q13461_Arg90Leu), deleterious(m_P00740_Glu433Ala)

+ Negative Examples: deleterious(m_Q00526_Thr226Ile), deleterious(m_O00220_Glu228Ala), deleterious(m_O43157_Arg389Trp), deleterious(m_P08174_Arg52Leu), deleterious(m_Q92876_Arg78Trp)  
develop  humvar398_27   modif_charge(A, charge_unchanged) and g_or_p(A, g_or_p_unchanged) and is_in_site(A, yes) and secondary_struc(A, helix) and mut_accessibility(A, buried) and stability(A, increase). deleterious(A)
51 (0.85%) 
5 (0.25%) 
74
Covers:
+ Positive Examples: deleterious(m_P54868_Phe174Leu), deleterious(m_P19878_Ala128Val), deleterious(m_P00441_Ser135Asn), deleterious(m_Q5TBB1_Thr163Ile), deleterious(m_P00439_Ala47Val), deleterious(m_P08100_Ala164Val), deleterious(m_P00813_Ala329Val), deleterious(m_P30613_Ser130Tyr), deleterious(m_P35520_Ala155Val), deleterious(m_P08100_Thr94Ile), deleterious(m_P03951_Cys46Phe), deleterious(m_Q92947_Ser139Leu), deleterious(m_P05186_Ala348Thr), deleterious(m_P48436_Phe154Leu), deleterious(m_Q7Z406_Ser120Leu), deleterious(m_P10746_Ala104Val), deleterious(m_P08236_Ala619Val), deleterious(m_P28329_Ser498Leu), deleterious(m_P06132_Phe229Leu), deleterious(m_P10746_Ala66Val), deleterious(m_P08397_Ala252Val), deleterious(m_O14773_Phe481Cys), deleterious(m_P00966_Ser18Leu), deleterious(m_P21439_Ser320Phe), deleterious(m_P00439_Leu348Val), deleterious(m_P54803_Asn295Thr), deleterious(m_P03950_Gln36Leu), deleterious(m_P00480_Ala209Val), deleterious(m_P06744_Leu487Phe), deleterious(m_P06276_Ala227Val), deleterious(m_P00480_Ser60Leu), deleterious(m_P00439_Thr372Ser), deleterious(m_P08100_Ser127Phe), deleterious(m_P11217_Ala704Val), deleterious(m_P08100_Cys110Tyr), deleterious(m_P21439_Ser346Ile), deleterious(m_P62736_Asn117Thr), deleterious(m_P00439_Leu347Phe), deleterious(m_P35557_Ala259Thr), deleterious(m_P23526_Ala89Val), deleterious(m_Q14353_Met50Leu), deleterious(m_P00439_Ala345Thr), deleterious(m_P03952_Cys548Tyr), deleterious(m_P07902_Leu282Val), deleterious(m_P51843_Ala300Val), deleterious(m_P35914_Asp42Glu), deleterious(m_P06132_Leu195Phe), deleterious(m_P60484_Cys105Tyr), deleterious(m_P49768_Ser390Ile), deleterious(m_Q92947_Ser305Leu), deleterious(m_P22830_Gln139Leu)

+ Negative Examples: deleterious(m_P32856_Ser42Thr), deleterious(m_P23219_Val481Ile), deleterious(m_P08263_Thr19Ile), deleterious(m_P17252_Val568Ile), deleterious(m_O43488_Cys214Tyr)  
develop  humvar398_86   modif_charge(A, charge_decrease) and modif_polarity(A, polarity_decrease) and is_in_site(A, yes) and mut_accessibility(A, intermediate) and stability(A, increase). deleterious(A)
50 (0.83%) 
5 (0.25%) 
76
Covers:
+ Positive Examples: deleterious(m_P00480_His255Pro), deleterious(m_P43246_Lys393Met), deleterious(m_P06744_His20Pro), deleterious(m_P06276_Asp98Gly), deleterious(m_P15976_Asp218Gly), deleterious(m_P05186_Arg184Trp), deleterious(m_Q15465_Asp88Val), deleterious(m_P26367_Arg19Pro), deleterious(m_Q14376_Arg40Cys), deleterious(m_P05014_Glu137Val), deleterious(m_Q9Y4Z2_Arg93Leu), deleterious(m_P10828_Lys342Ile), deleterious(m_P21333_Glu82Val), deleterious(m_P00439_Lys42Ile), deleterious(m_P18858_Arg771Trp), deleterious(m_P05156_Asp524Val), deleterious(m_P05166_Arg44Pro), deleterious(m_P43034_His277Pro), deleterious(m_P07951_Glu117Ala), deleterious(m_P00740_Glu291Val), deleterious(m_P07320_Arg15Cys), deleterious(m_O95409_Arg373Pro), deleterious(m_Q14353_His51Pro), deleterious(m_P63261_Lys118Met), deleterious(m_P08397_Glu80Gly), deleterious(m_Q8TDP1_Arg69Trp), deleterious(m_P04075_Asp129Gly), deleterious(m_P69891_Glu7Gly), deleterious(m_Q5S007_Arg1441Cys), deleterious(m_P29033_Arg184Pro), deleterious(m_O00294_Arg420Pro), deleterious(m_P00439_Glu221Gly), deleterious(m_P02649_Arg43Cys), deleterious(m_P52952_Arg161Pro), deleterious(m_Q92838_His252Leu), deleterious(m_P69892_His64Leu), deleterious(m_P21439_Asp564Gly), deleterious(m_P02768_Asp574Ala), deleterious(m_P23526_Asp86Gly), deleterious(m_P45381_Asp249Val), deleterious(m_P48436_Arg152Pro), deleterious(m_P35240_Glu106Gly), deleterious(m_P05062_Arg304Trp), deleterious(m_O14521_His102Leu), deleterious(m_P00558_Glu252Ala), deleterious(m_P20823_Arg271Trp), deleterious(m_P00480_Asp126Gly), deleterious(m_P00966_Arg157Cys), deleterious(m_P30613_Arg490Trp), deleterious(m_O95409_His286Leu)

+ Negative Examples: deleterious(m_P05187_Arg231Pro), deleterious(m_Q9BUD6_Glu122Ala), deleterious(m_Q03518_Asp697Gly), deleterious(m_P30566_Lys147Met), deleterious(m_P01920_Arg102Gly)  
develop  humvar398_105   modif_size(A, size_increase) and modif_polarity(A, polarity_increase) and g_or_p(A, g_or_p_disparition) and is_in_site(A, yes) and secondary_struc(A, other) and wt_accessibility(A, intermediate) and mut_accessibility(A, intermediate). deleterious(A)
50 (0.83%) 
5 (0.25%) 
76
Covers:
+ Positive Examples: deleterious(m_P01112_Gly13Asp), deleterious(m_O15553_Gly678Glu), deleterious(m_P01112_Gly12Glu), deleterious(m_P00966_Gly14Ser), deleterious(m_Q12809_Gly53Arg), deleterious(m_P11413_Gly447Arg), deleterious(m_P22033_Gly87Glu), deleterious(m_P11182_Gly384Ser), deleterious(m_P29033_Gly59Ser), deleterious(m_P98172_Gly151Ser), deleterious(m_P00439_Gly46Ser), deleterious(m_P25189_Gly93Glu), deleterious(m_P51608_Pro152Arg), deleterious(m_P22033_Gly648Asp), deleterious(m_P41181_Gly180Ser), deleterious(m_P49747_Gly440Arg), deleterious(m_P11362_Gly237Asp), deleterious(m_P00451_Pro470Arg), deleterious(m_P49747_Gly440Glu), deleterious(m_P05186_Gly473Ser), deleterious(m_P15976_Gly208Ser), deleterious(m_P08709_Gly402Glu), deleterious(m_P05106_Gly598Ser), deleterious(m_P22033_Gly630Glu), deleterious(m_P40692_Gly67Trp), deleterious(m_P06132_Gly25Glu), deleterious(m_P00439_Gly239Ser), deleterious(m_Q9Y5Y6_Gly827Arg), deleterious(m_Q06187_Gly613Asp), deleterious(m_P00451_Gly224Trp), deleterious(m_Q15582_Pro551Gln), deleterious(m_P11362_Gly237Ser), deleterious(m_P01116_Pro34Gln), deleterious(m_P00439_Pro314His), deleterious(m_P05106_Gly605Ser), deleterious(m_Q13285_Gly91Ser), deleterious(m_Q14376_Gly302Asp), deleterious(m_P49748_Gly463Glu), deleterious(m_P00740_Pro333His), deleterious(m_P23786_Pro50His), deleterious(m_P11413_Gly163Ser), deleterious(m_P00740_Gly432Ser), deleterious(m_P06280_Gly85Asp), deleterious(m_P08709_Gly216Asp), deleterious(m_P00451_Gly263Ser), deleterious(m_P16442_Gly235Ser), deleterious(m_Q14376_Gly90Glu), deleterious(m_P04275_Gly1324Ser), deleterious(m_P41181_Gly64Arg), deleterious(m_P49748_Gly290Asp)

+ Negative Examples: deleterious(m_O14832_Gly215Ser), deleterious(m_Q9BVJ7_Gly131Ser), deleterious(m_Q14324_Gly52Ser), deleterious(m_P43632_Pro92His), deleterious(m_Q9NWU5_Gly154Ser)  
develop  humvar398_82   modif_size(A, size_unchanged) and modif_polarity(A, polarity_unchanged) and is_in_site(A, yes) and secondary_struc(A, sheet) and wt_accessibility(A, buried) and mut_accessibility(A, buried). deleterious(A)
49 (0.82%) 
4 (0.2%) 
76
Covers:
+ Positive Examples: deleterious(m_P20711_Leu408Ile), deleterious(m_O75197_Asp203Asn), deleterious(m_P00439_Tyr387His), deleterious(m_P08397_Ala122Gly), deleterious(m_O43307_Gly55Ala), deleterious(m_P12955_Asp276Asn), deleterious(m_O15305_Gly208Ala), deleterious(m_Q16518_His68Tyr), deleterious(m_Q06187_Tyr418His), deleterious(m_P05166_Ile430Leu), deleterious(m_Q9Y4U1_Tyr130His), deleterious(m_P01024_Asp549Asn), deleterious(m_P00797_Asp104Asn), deleterious(m_P05186_Gly220Ala), deleterious(m_Q16518_Ala393Gly), deleterious(m_P00451_Tyr155His), deleterious(m_O75096_Asp529Asn), deleterious(m_P00439_Asp415Asn), deleterious(m_P62736_Tyr135His), deleterious(m_P35914_Asp204Asn), deleterious(m_P32189_Asn294Asp), deleterious(m_P02545_Asn456Asp), deleterious(m_P00558_Asp315Asn), deleterious(m_P11413_Tyr70His), deleterious(m_Q03692_Tyr597His), deleterious(m_Q96MS0_Ile66Leu), deleterious(m_Q9NSU2_Asp73Asn), deleterious(m_Q16518_Tyr79His), deleterious(m_P08514_Tyr174His), deleterious(m_P00451_Gly92Ala), deleterious(m_P00441_Asp102Asn), deleterious(m_P16442_Gly268Ala), deleterious(m_O43602_Tyr206His), deleterious(m_P05156_Ile416Leu), deleterious(m_Q16518_His182Tyr), deleterious(m_P43246_Gly162Ala), deleterious(m_P05106_Asp145Asn), deleterious(m_Q16518_Tyr368His), deleterious(m_P35557_Tyr108His), deleterious(m_P05107_Asp128Asn), deleterious(m_Q16637_Ala111Gly), deleterious(m_P30613_Gly557Ala), deleterious(m_P29400_Gly1486Ala), deleterious(m_Q15465_Asp147Asn), deleterious(m_P00480_His302Tyr), deleterious(m_P24752_Gly152Ala), deleterious(m_P13569_Tyr569His), deleterious(m_Q01968_His375Tyr), deleterious(m_P13569_Asp572Asn)

+ Negative Examples: deleterious(m_O60882_Ile169Leu), deleterious(m_Q9H306_Asp447Asn), deleterious(m_P09960_Tyr131His), deleterious(m_O94806_Leu445Ile)  
develop  humvar398_62   modif_polarity(A, polarity_unchanged) and g_or_p(A, g_or_p_apparition) and secondary_struc(A, other) and mut_accessibility(A, buried). deleterious(A)
50 (0.83%) 
5 (0.25%) 
76
Covers:
+ Positive Examples: deleterious(m_P05166_Ala153Pro), deleterious(m_P35520_Leu101Pro), deleterious(m_P50461_Leu44Pro), deleterious(m_P00747_Leu147Pro), deleterious(m_P00451_Ala488Gly), deleterious(m_P00451_Ala303Pro), deleterious(m_P00441_Val15Gly), deleterious(m_Q5TBB1_Val185Gly), deleterious(m_Q06187_Leu542Pro), deleterious(m_O43405_Val66Gly), deleterious(m_P02787_Ala477Pro), deleterious(m_Q9Y4U1_Leu116Pro), deleterious(m_P00451_Ala1798Pro), deleterious(m_P11217_Leu397Pro), deleterious(m_P00451_Leu26Pro), deleterious(m_P06280_Leu32Pro), deleterious(m_P40337_Leu63Pro), deleterious(m_P08236_Leu243Pro), deleterious(m_Q9UBC3_Leu664Pro), deleterious(m_P08235_Leu979Pro), deleterious(m_P00439_Leu311Pro), deleterious(m_P11217_Ala687Pro), deleterious(m_P05155_Leu481Pro), deleterious(m_Q9UBC3_Val726Gly), deleterious(m_Q16518_Leu22Pro), deleterious(m_Q93099_Leu25Pro), deleterious(m_Q06187_Ala622Pro), deleterious(m_P00451_Val220Gly), deleterious(m_P00451_Leu1963Pro), deleterious(m_P00387_Leu73Pro), deleterious(m_P51843_Leu278Pro), deleterious(m_P04181_Ala270Pro), deleterious(m_Q8WWY3_Ala216Pro), deleterious(m_P00451_Leu1777Pro), deleterious(m_P35914_Leu263Pro), deleterious(m_Q13496_Ala279Gly), deleterious(m_P00451_Leu69Pro), deleterious(m_P15056_Leu525Pro), deleterious(m_P00451_Ala2058Pro), deleterious(m_P35520_Ala288Pro), deleterious(m_P30613_Leu374Pro), deleterious(m_P40692_Ala128Pro), deleterious(m_P06132_Ala80Gly), deleterious(m_P07902_Leu74Pro), deleterious(m_Q06124_Ala72Gly), deleterious(m_Q14524_Leu1825Pro), deleterious(m_P30613_Ala468Gly), deleterious(m_P29965_Ala235Pro), deleterious(m_Q16678_Ala115Pro), deleterious(m_P04629_Leu93Pro)

+ Negative Examples: deleterious(m_Q8IVS2_Ala303Gly), deleterious(m_Q9Y2C9_Leu194Pro), deleterious(m_O75594_Val34Gly), deleterious(m_P20853_Val479Gly), deleterious(m_P53621_Val1040Gly)  
develop  humvar398_65   modif_size(A, size_increase) and modif_charge(A, charge_unchanged) and g_or_p(A, g_or_p_unchanged) and conservation_class(A, global_conservation_rank_2) and secondary_struc(A, sheet) and wt_accessibility(A, buried). deleterious(A)
50 (0.83%) 
5 (0.25%) 
76
Covers:
+ Positive Examples: deleterious(m_P25189_Val146Phe), deleterious(m_P00441_Ala146Thr), deleterious(m_P00740_Ser430Thr), deleterious(m_P03950_Val137Ile), deleterious(m_P48637_Asp469Glu), deleterious(m_P10619_Ser51Tyr), deleterious(m_O15553_Ile720Met), deleterious(m_P29400_Cys1678Trp), deleterious(m_P35520_Cys165Tyr), deleterious(m_P05106_Leu143Trp), deleterious(m_P00441_Val119Leu), deleterious(m_Q92743_Val297Met), deleterious(m_P10746_Val3Phe), deleterious(m_P61916_Val39Met), deleterious(m_P29400_Ser1488Phe), deleterious(m_P00387_Ala179Val), deleterious(m_P05186_His381Arg), deleterious(m_P06280_Cys202Tyr), deleterious(m_P07902_Cys130Tyr), deleterious(m_P00813_Ala215Thr), deleterious(m_P06280_Cys202Trp), deleterious(m_P35914_Ile200Phe), deleterious(m_Q15465_Ile84Phe), deleterious(m_P07954_Lys230Arg), deleterious(m_Q13496_Thr186Ile), deleterious(m_P29965_Thr176Ile), deleterious(m_Q15465_Cys183Phe), deleterious(m_Q16518_Val287Phe), deleterious(m_P32754_Ile335Met), deleterious(m_Q92793_His1470Arg), deleterious(m_P06276_Asn124Tyr), deleterious(m_P25189_Asp128Glu), deleterious(m_O15305_Val44Leu), deleterious(m_Q15465_Val124Met), deleterious(m_P49747_Thr585Met), deleterious(m_P08514_Ala139Val), deleterious(m_Q15465_Cys183Tyr), deleterious(m_Q01968_Asn373Tyr), deleterious(m_P25189_Thr124Met), deleterious(m_P35520_Cys370Tyr), deleterious(m_Q13496_Val227Met), deleterious(m_Q9UM73_Thr1151Met), deleterious(m_Q15465_Ser184Leu), deleterious(m_P00441_Cys7Phe), deleterious(m_P05155_Ala458Thr), deleterious(m_P05155_Ala458Val), deleterious(m_P00747_Ala620Thr), deleterious(m_P06280_Ser201Phe), deleterious(m_P10746_Leu4Phe), deleterious(m_Q06187_Val535Phe)

+ Negative Examples: deleterious(m_Q8N8V2_Thr14Ile), deleterious(m_O95716_Val64Ile), deleterious(m_P28065_Val32Ile), deleterious(m_P06737_Val222Ile), deleterious(m_P29597_Ala928Val)  
develop  humvar398_60   modif_size(A, size_unchanged) and modif_charge(A, charge_unchanged) and modif_hydrophobicity(A, hydrophobicity_decrease) and is_in_site(A, yes) and secondary_struc(A, sheet). deleterious(A)
47 (0.78%) 
4 (0.2%) 
81
Covers:
+ Positive Examples: deleterious(m_P08397_Ala55Ser), deleterious(m_P43246_Thr33Pro), deleterious(m_P07315_Thr5Pro), deleterious(m_O75695_Cys108Gly), deleterious(m_P07225_Cys241Ser), deleterious(m_P01185_Cys92Ser), deleterious(m_P21912_Ile127Asn), deleterious(m_P08397_Ala122Gly), deleterious(m_P00740_Cys252Ser), deleterious(m_P29400_Cys1564Ser), deleterious(m_Q16518_Ala393Gly), deleterious(m_P00441_Leu9Gln), deleterious(m_O43602_Ala152Ser), deleterious(m_Q06187_Ile429Asn), deleterious(m_P00439_Cys334Ser), deleterious(m_P00451_Leu594Gln), deleterious(m_P00740_Leu321Gln), deleterious(m_P08397_Ala270Gly), deleterious(m_P30613_Ile310Asn), deleterious(m_P00740_Thr426Pro), deleterious(m_P19438_Cys59Ser), deleterious(m_O14773_Thr353Pro), deleterious(m_Q92838_Ile360Asn), deleterious(m_P10912_Cys56Ser), deleterious(m_P30613_Ile90Asn), deleterious(m_P50461_Cys58Gly), deleterious(m_P11362_Ala167Ser), deleterious(m_P01185_Cys98Ser), deleterious(m_P30613_Ala336Ser), deleterious(m_P14222_Ile224Asn), deleterious(m_P01008_Ile316Asn), deleterious(m_P00451_Cys2345Ser), deleterious(m_P07902_Ile32Asn), deleterious(m_P01225_Cys69Gly), deleterious(m_P00439_Cys265Gly), deleterious(m_O43405_Ile109Asn), deleterious(m_P00439_Ile65Asn), deleterious(m_P01008_Ala416Ser), deleterious(m_P00740_Cys396Ser), deleterious(m_Q16637_Ala111Gly), deleterious(m_P31785_Cys62Gly), deleterious(m_P00441_Ala5Ser), deleterious(m_P25189_Ile89Asn), deleterious(m_P08709_Cys389Gly), deleterious(m_P01034_Leu94Gln), deleterious(m_P01185_Cys98Gly), deleterious(m_Q14203_Thr72Pro)

+ Negative Examples: deleterious(m_P00488_Leu589Gln), deleterious(m_O14967_Ala160Ser), deleterious(m_Q8WUM0_Thr106Pro), deleterious(m_P28332_Thr151Pro)  
develop  humvar398_25   fold(A, 'Serum albumin-like'). deleterious(A)
46 (0.77%) 
3 (0.15%) 
81
Covers:
+ Positive Examples: deleterious(m_P02768_Asp587Asn), deleterious(m_P02768_Lys560Glu), deleterious(m_P02768_Ala344Thr), deleterious(m_P02768_Leu90Pro), deleterious(m_P02768_Lys249Gln), deleterious(m_P02768_Glu143Lys), deleterious(m_P02768_Arg138Gly), deleterious(m_P02768_Lys598Asn), deleterious(m_P02768_His152Arg), deleterious(m_P02768_Asp293Gly), deleterious(m_P02768_Asp338Val), deleterious(m_P02768_Arg242His), deleterious(m_P02768_Arg242Pro), deleterious(m_P02768_Glu357Lys), deleterious(m_P02768_Lys264Glu), deleterious(m_P02768_Lys565Glu), deleterious(m_P02768_Glu525Lys), deleterious(m_P02768_Asp574Gly), deleterious(m_P02768_His27Gln), deleterious(m_P02768_Glu406Lys), deleterious(m_P02768_Val146Glu), deleterious(m_P02768_Glu106Lys), deleterious(m_P02768_Asp87Asn), deleterious(m_P02768_Glu503Lys), deleterious(m_P02768_Glu400Lys), deleterious(m_P02768_Glu378Lys), deleterious(m_P02768_Lys337Asn), deleterious(m_P02768_Glu382Lys), deleterious(m_P02768_Lys396Glu), deleterious(m_P02768_Lys300Asn), deleterious(m_P02768_Asn342Lys), deleterious(m_P02768_Val557Met), deleterious(m_P02768_Asp518Asn), deleterious(m_P02768_Glu594Lys), deleterious(m_P02768_Arg434Cys), deleterious(m_P02768_His27Tyr), deleterious(m_P02768_Asp389Val), deleterious(m_P02768_Lys383Asn), deleterious(m_P02768_Asp389His), deleterious(m_P02768_Asp338Gly), deleterious(m_P02768_Lys597Glu), deleterious(m_P02768_Gln292Arg), deleterious(m_P02768_Asp574Ala), deleterious(m_P02768_Lys584Glu), deleterious(m_P02768_Glu529Lys), deleterious(m_P02768_Glu589Lys)

+ Negative Examples: deleterious(m_P02774_Lys436Thr), deleterious(m_P02774_Asp432Glu), deleterious(m_P02774_Arg445His)  
develop  humvar398_36   modif_polarity(A, polarity_decrease) and g_or_p(A, g_or_p_unchanged) and conservation_class(A, sub_family_conservation) and mut_accessibility(A, intermediate). deleterious(A)
48 (0.8%) 
5 (0.25%) 
81
Covers:
+ Positive Examples: deleterious(m_O75603_Arg47Leu), deleterious(m_P00451_Tyr25Cys), deleterious(m_Q9BZ23_Thr234Ala), deleterious(m_P15382_Thr7Ile), deleterious(m_P00451_Asp101Val), deleterious(m_P21817_Arg163Leu), deleterious(m_P49748_Arg459Trp), deleterious(m_P46100_Arg246Leu), deleterious(m_Q92947_Arg313Trp), deleterious(m_P21912_Ser100Phe), deleterious(m_P05186_Arg391Cys), deleterious(m_P00966_Gln40Leu), deleterious(m_P40763_Arg382Leu), deleterious(m_P00441_Asp91Ala), deleterious(m_P00451_Asp1727Val), deleterious(m_P00480_Tyr183Cys), deleterious(m_P41159_Arg105Trp), deleterious(m_P43026_Arg399Cys), deleterious(m_P00439_Tyr277Cys), deleterious(m_P00480_Tyr345Cys), deleterious(m_P01241_Arg103Cys), deleterious(m_P63261_Lys118Met), deleterious(m_P25189_Ser78Leu), deleterious(m_P10275_Ser759Phe), deleterious(m_P00441_Ser106Leu), deleterious(m_P00451_Tyr24Cys), deleterious(m_P00439_Arg158Trp), deleterious(m_Q03393_Tyr99Cys), deleterious(m_P29033_Ser17Phe), deleterious(m_P05186_Asn478Ile), deleterious(m_P46100_Arg246Cys), deleterious(m_P04792_Ser135Phe), deleterious(m_P04150_Asp641Val), deleterious(m_P40763_Arg382Trp), deleterious(m_P45381_Asp249Val), deleterious(m_P00966_Arg86Cys), deleterious(m_P00439_Tyr414Cys), deleterious(m_P21817_Arg163Cys), deleterious(m_Q15848_Arg112Cys), deleterious(m_P00558_Glu252Ala), deleterious(m_P21817_Arg109Trp), deleterious(m_P43026_Arg438Leu), deleterious(m_P02545_Arg453Trp), deleterious(m_P55072_Arg155Cys), deleterious(m_O43602_Thr123Ile), deleterious(m_P10275_Ser702Ala), deleterious(m_Q92947_Arg383Cys), deleterious(m_P25189_Ser51Phe)

+ Negative Examples: deleterious(m_P31941_Thr19Ala), deleterious(m_P17516_Ser145Cys), deleterious(m_P46734_Arg94Leu), deleterious(m_P16442_Arg199Cys), deleterious(m_Q6UW60_Thr267Met)  
develop  humvar398_19   modif_size(A, size_unchanged) and is_in_site(A, yes) and gain_contact(A, hb). deleterious(A)
40 (0.67%) 
1 (0.05%) 
84
Covers:
+ Positive Examples: deleterious(m_P05156_Asp519Asn), deleterious(m_P01185_Gly96Cys), deleterious(m_P08397_Arg173Trp), deleterious(m_P48728_Asn145Ile), deleterious(m_P05186_Cys489Ser), deleterious(m_P25189_Ser63Cys), deleterious(m_P01008_Trp257Arg), deleterious(m_P05186_Gly220Ala), deleterious(m_P00439_Cys357Gly), deleterious(m_P15056_Asn581Asp), deleterious(m_P98172_Cys153Ser), deleterious(m_P21333_Ala39Gly), deleterious(m_P08397_Ala270Gly), deleterious(m_P05186_Ala51Ser), deleterious(m_Q16518_Tyr79His), deleterious(m_P21439_Trp138Arg), deleterious(m_Q92947_Gly390Ala), deleterious(m_Q9UIF7_Trp128Arg), deleterious(m_P08236_Asp362Asn), deleterious(m_O14832_Trp193Arg), deleterious(m_P19438_Cys99Ser), deleterious(m_O43602_Gly181Ala), deleterious(m_P00451_Cys2345Ser), deleterious(m_P00439_Ala345Ser), deleterious(m_P46100_Gly249Cys), deleterious(m_P06276_Gln546Leu), deleterious(m_P10828_Asn331Asp), deleterious(m_Q9Y5X4_Arg104Trp), deleterious(m_P08709_Asp302Asn), deleterious(m_P00451_Asp1865Asn), deleterious(m_P05186_Ala399Ser), deleterious(m_P40763_Arg382Trp), deleterious(m_P25189_Gly123Cys), deleterious(m_P30613_Gly341Ala), deleterious(m_Q92838_Trp274Arg), deleterious(m_Q9H3D4_Cys347Ser), deleterious(m_P22033_Gly626Cys), deleterious(m_P00451_Asn601Asp), deleterious(m_P40337_Leu198Gln), deleterious(m_P01008_Tyr198His)

+ Negative Examples: deleterious(m_Q2TB90_Trp721Arg)  
develop  humvar398_67   modif_charge(A, charge_increase) and modif_hydrophobicity(A, hydrophobicity_unchanged) and gain_contact(A, dc). deleterious(A)
43 (0.72%) 
5 (0.25%) 
85
Covers:
+ Positive Examples: deleterious(m_P05186_Asn211Asp), deleterious(m_P30613_Asn566Lys), deleterious(m_P08235_Asn770Lys), deleterious(m_P49747_Pro276Arg), deleterious(m_P19429_Asn185Lys), deleterious(m_Q92947_Asn406Lys), deleterious(m_P30613_Asn393Lys), deleterious(m_Q06124_Asn58Lys), deleterious(m_P51857_Pro133Arg), deleterious(m_P51608_Pro152Arg), deleterious(m_P00451_Pro470Arg), deleterious(m_P29033_Asn54Lys), deleterious(m_P00451_Asn631Lys), deleterious(m_P06737_Asn377Lys), deleterious(m_P00451_Asn1941Asp), deleterious(m_P00480_Pro225Arg), deleterious(m_P25189_Asn131Lys), deleterious(m_P22607_Asn540Lys), deleterious(m_P11362_Asn724Lys), deleterious(m_Q15583_Pro192Arg), deleterious(m_P01008_Asn437Lys), deleterious(m_P51608_Pro101Arg), deleterious(m_P00451_Pro2172Arg), deleterious(m_P35520_Asn228Lys), deleterious(m_P04181_Asn89Lys), deleterious(m_P10275_Asn727Lys), deleterious(m_P00451_Ser1799His), deleterious(m_P08100_Pro267Arg), deleterious(m_P10828_Asn331Asp), deleterious(m_P06132_Asn304Lys), deleterious(m_P06280_Pro265Arg), deleterious(m_Q05066_Pro108Arg), deleterious(m_Q03692_Asn617Lys), deleterious(m_P06280_Gln280His), deleterious(m_P05155_Pro489Arg), deleterious(m_P06280_Gln279His), deleterious(m_Q03393_Asn36Lys), deleterious(m_P00439_Pro225Arg), deleterious(m_P22033_Pro95Arg), deleterious(m_P50542_Asn526Lys), deleterious(m_Q13496_Asn180Lys), deleterious(m_Q14896_Asn754Lys), deleterious(m_P00451_Pro1873Arg)

+ Negative Examples: deleterious(m_P20702_Pro517Arg), deleterious(m_Q9UQ72_Asn264Asp), deleterious(m_Q14500_Gln192His), deleterious(m_P13747_Asn98Lys), deleterious(m_Q9HBA9_Asn151Lys)  
develop  humvar398_49   modif_charge(A, charge_increase) and conservation_class(A, global_conservation_rank_2) and secondary_struc(A, other) and wt_accessibility(A, intermediate). deleterious(A)
42 (0.7%) 
5 (0.25%) 
86
Covers:
+ Positive Examples: deleterious(m_P10275_Gly909Arg), deleterious(m_P04424_Met382Arg), deleterious(m_P51649_Gly176Arg), deleterious(m_O15553_Gly678Glu), deleterious(m_Q05066_Leu101His), deleterious(m_P06280_Cys52Arg), deleterious(m_P00441_Gly38Arg), deleterious(m_P22033_Gly87Glu), deleterious(m_P55809_Gly324Glu), deleterious(m_Q13485_Gly386Asp), deleterious(m_Q92947_Ala433Glu), deleterious(m_P02649_Gln99Lys), deleterious(m_O43405_Trp117Arg), deleterious(m_P00480_Gly188Arg), deleterious(m_Q92838_Gln358Glu), deleterious(m_P49747_Gly440Arg), deleterious(m_P21817_Gly165Arg), deleterious(m_P50897_Gly42Glu), deleterious(m_P49747_Gly440Glu), deleterious(m_P00441_Asn140Lys), deleterious(m_P00480_Ser90Arg), deleterious(m_P22033_Gln109Arg), deleterious(m_Q16637_Gly95Arg), deleterious(m_P25189_Asn131Lys), deleterious(m_P22607_Asn540Lys), deleterious(m_Q06187_Tyr476Asp), deleterious(m_P00480_Gly269Glu), deleterious(m_P01008_Asn437Lys), deleterious(m_P02647_Pro27His), deleterious(m_P49768_Gly378Glu), deleterious(m_P10721_Gly664Arg), deleterious(m_P23760_Gly99Asp), deleterious(m_O15305_Gln177His), deleterious(m_Q03393_Val70Asp), deleterious(m_P00740_Pro333His), deleterious(m_P06280_Pro259Arg), deleterious(m_P23786_Pro50His), deleterious(m_P58012_Asn109Lys), deleterious(m_P00387_Gly292Asp), deleterious(m_P12694_Gln190Lys), deleterious(m_P06280_Gly85Asp), deleterious(m_P22033_Asn189Lys)

+ Negative Examples: deleterious(m_O15178_Gly177Asp), deleterious(m_P53602_Asn278His), deleterious(m_P47944_Gly48Asp), deleterious(m_P21399_Gly486Arg), deleterious(m_Q9NP95_Gly116Arg)  
develop  humvar398_16   modif_size(A, size_increase) and is_in_site(A, yes) and gain_contact(A, phob) and lost_contact(A, hb). deleterious(A)
42 (0.7%) 
5 (0.25%) 
86
Covers:
+ Positive Examples: deleterious(m_P01008_Glu269Lys), deleterious(m_P40692_Ser295Thr), deleterious(m_P06744_Thr224Met), deleterious(m_P35520_Ala114Val), deleterious(m_P29965_Gly227Val), deleterious(m_P03950_Val137Ile), deleterious(m_P01008_Leu131Phe), deleterious(m_P39019_Ser59Phe), deleterious(m_P00451_Glu291Lys), deleterious(m_P01877_Asp296Glu), deleterious(m_P00740_Gly412Glu), deleterious(m_P22033_Gly648Asp), deleterious(m_P00451_Gly474Arg), deleterious(m_P05186_Cys201Tyr), deleterious(m_P29400_Ser1488Phe), deleterious(m_P53634_Gly301Val), deleterious(m_P61764_Cys180Tyr), deleterious(m_P19878_Gly78Glu), deleterious(m_P22033_Gly630Glu), deleterious(m_P22033_Gly94Val), deleterious(m_P03950_Cys63Trp), deleterious(m_P05106_Cys400Tyr), deleterious(m_P01185_Cys104Phe), deleterious(m_P00439_Ser87Arg), deleterious(m_P43246_Glu647Lys), deleterious(m_P00451_Cys2040Tyr), deleterious(m_P15529_Cys35Tyr), deleterious(m_Q13950_Ser118Asn), deleterious(m_P08100_Cys110Tyr), deleterious(m_P14222_Gly429Glu), deleterious(m_Q12948_Ser131Leu), deleterious(m_P07686_Cys309Tyr), deleterious(m_P35557_Thr228Met), deleterious(m_P54803_Ser68Phe), deleterious(m_P05156_Gly243Asp), deleterious(m_P00439_Asp129Tyr), deleterious(m_P10275_Glu681Lys), deleterious(m_O95409_Ser272Asn), deleterious(m_P01185_Gly93Trp), deleterious(m_P40692_Thr117Met), deleterious(m_P02545_Thr528Arg), deleterious(m_P43026_Ser475Asn)

+ Negative Examples: deleterious(m_P20711_Pro210Leu), deleterious(m_Q6PEY0_Thr177Met), deleterious(m_P35247_Glu309Lys), deleterious(m_Q9NY33_Glu690Lys), deleterious(m_P17213_Glu216Lys)  
develop  humvar398_81   modif_charge(A, charge_decrease) and modif_polarity(A, polarity_decrease) and is_in_site(A, yes) and conservation_class(A, no_conservation_typification) and freq_at_pos(A, B) and B>=2 and wt_accessibility(A, accessible). deleterious(A)
41 (0.68%) 
5 (0.25%) 
88
Covers:
+ Positive Examples: deleterious(m_P10912_Arg179Cys), deleterious(m_P40692_Arg226Leu), deleterious(m_P01308_Arg89Cys), deleterious(m_P15918_Arg396Leu), deleterious(m_P17661_Arg350Pro), deleterious(m_P55916_Arg70Trp), deleterious(m_P00439_Arg297Cys), deleterious(m_P69891_Asp23Gly), deleterious(m_P00439_Asp222Val), deleterious(m_P00451_Arg48Cys), deleterious(m_Q9NRR6_Arg515Trp), deleterious(m_P00451_Asp579Ala), deleterious(m_Q14896_Arg667Pro), deleterious(m_P11413_Arg459Leu), deleterious(m_P07902_His114Leu), deleterious(m_P69892_Glu126Ala), deleterious(m_O15553_Lys695Met), deleterious(m_Q01968_Arg337Pro), deleterious(m_Q5S007_Arg1441Gly), deleterious(m_P00451_Arg1708Cys), deleterious(m_P00439_Arg176Leu), deleterious(m_P00367_Arg322Cys), deleterious(m_P25445_Asp260Gly), deleterious(m_P21817_Arg44Cys), deleterious(m_P69891_Glu7Gly), deleterious(m_Q5S007_Arg1441Cys), deleterious(m_O00238_Arg486Trp), deleterious(m_P00439_Arg176Pro), deleterious(m_P00740_Arg379Gly), deleterious(m_P01308_Arg89Leu), deleterious(m_Q03154_Arg197Trp), deleterious(m_P00451_Arg391Pro), deleterious(m_P00451_Arg717Leu), deleterious(m_P15918_Arg396Cys), deleterious(m_P03950_Lys41Ile), deleterious(m_P11413_Arg459Pro), deleterious(m_P00740_Arg384Leu), deleterious(m_P16442_Arg176Gly), deleterious(m_P00451_Arg391Cys), deleterious(m_Q01968_Arg337Cys), deleterious(m_Q9H3D4_Arg318Cys)

+ Negative Examples: deleterious(m_Q9UI47_Arg535Cys), deleterious(m_P47989_Arg1296Trp), deleterious(m_P34913_Arg103Cys), deleterious(m_P11511_Arg264Cys), deleterious(m_P01920_Arg102Gly)  
develop  humvar398_77   modif_charge(A, charge_opposite) and conservation_class(A, sub_family_conservation). deleterious(A)
39 (0.65%) 
3 (0.15%) 
88
Covers:
+ Positive Examples: deleterious(m_O00255_Glu260Lys), deleterious(m_P09622_Lys72Glu), deleterious(m_P69892_Lys60Glu), deleterious(m_P35498_Glu1787Lys), deleterious(m_P00451_Glu98Lys), deleterious(m_Q15465_Glu136Lys), deleterious(m_Q15437_Glu109Lys), deleterious(m_P60891_Asp183His), deleterious(m_P69892_Glu102Lys), deleterious(m_P04156_Glu200Lys), deleterious(m_P43080_Glu89Lys), deleterious(m_P08514_Glu355Lys), deleterious(m_P35498_Glu1795Lys), deleterious(m_P22830_Glu178Lys), deleterious(m_P36551_His295Asp), deleterious(m_P00441_Glu22Lys), deleterious(m_P00441_Glu101Lys), deleterious(m_P35520_Glu302Lys), deleterious(m_P10912_Asp170His), deleterious(m_P69892_Glu27Lys), deleterious(m_P00451_Asp101His), deleterious(m_P00451_Glu1723Lys), deleterious(m_P06276_Asp98His), deleterious(m_P54577_Glu196Lys), deleterious(m_P05186_Glu452Lys), deleterious(m_P02647_Glu222Lys), deleterious(m_P00439_Asp151His), deleterious(m_P00441_Glu50Lys), deleterious(m_Q93099_Glu168Lys), deleterious(m_Q13144_Glu650Lys), deleterious(m_P01241_Glu100Lys), deleterious(m_P00451_Asp561His), deleterious(m_Q9Y5X4_Glu121Lys), deleterious(m_P00451_Lys67Glu), deleterious(m_P05186_Glu476Lys), deleterious(m_P16615_Lys683Glu), deleterious(m_P22681_Lys382Glu), deleterious(m_Q16518_Glu102Lys), deleterious(m_P00451_Glu223Lys)

+ Negative Examples: deleterious(m_P27930_Glu292Lys), deleterious(m_Q9UBD3_His28Asp), deleterious(m_P31930_Asp215His)  
develop  humvar398_32   modif_size(A, size_decrease) and modif_charge(A, charge_unchanged) and conservation_class(A, sub_family_conservation) and secondary_struc(A, helix) and mut_accessibility(A, buried). deleterious(A)
38 (0.63%) 
3 (0.15%) 
90
Covers:
+ Positive Examples: deleterious(m_P35498_Phe1808Leu), deleterious(m_P00480_Leu201Pro), deleterious(m_P45381_Arg168His), deleterious(m_O00255_Leu272Pro), deleterious(m_P16615_Leu65Ser), deleterious(m_P52333_Leu910Ser), deleterious(m_P49748_Phe458Leu), deleterious(m_Q92947_Leu407Pro), deleterious(m_O14773_Gln278Pro), deleterious(m_P04156_Thr183Ala), deleterious(m_O15305_Phe157Ser), deleterious(m_P21333_Met102Val), deleterious(m_P06132_Met324Thr), deleterious(m_P00451_Met721Leu), deleterious(m_P06280_Met284Thr), deleterious(m_P10275_Arg840His), deleterious(m_P00966_Pro96Ser), deleterious(m_P35498_Phe1831Ser), deleterious(m_P00439_Tyr154Asn), deleterious(m_P52701_Met492Val), deleterious(m_P08100_Leu131Pro), deleterious(m_P00451_Met721Ile), deleterious(m_P00439_Leu348Val), deleterious(m_P54803_Asn295Thr), deleterious(m_Q05066_Met78Thr), deleterious(m_P02649_Arg163His), deleterious(m_P06132_Phe46Leu), deleterious(m_Q13496_Trp346Ser), deleterious(m_P00439_Ile164Thr), deleterious(m_P00439_Phe161Ser), deleterious(m_P45381_Ile143Thr), deleterious(m_P10275_Ile841Ser), deleterious(m_P06280_Met72Val), deleterious(m_P63261_Val370Ala), deleterious(m_Q13496_Trp346Cys), deleterious(m_P00492_Val53Ala), deleterious(m_P01008_Leu131Val), deleterious(m_P26367_Phe258Ser)

+ Negative Examples: deleterious(m_P41567_Leu59Pro), deleterious(m_P04798_Phe470Val), deleterious(m_Q96HA8_Ile32Val)  
develop  humvar398_92   fold(A, 'TIM beta/alpha-barrel'). deleterious(A)
38 (0.63%) 
3 (0.15%) 
90
Covers:
+ Positive Examples: deleterious(m_P08236_Arg382Cys), deleterious(m_P08236_Tyr495Cys), deleterious(m_P07686_Ser255Arg), deleterious(m_P08236_Arg374Cys), deleterious(m_P07686_Arg505Gln), deleterious(m_P08236_Tyr626His), deleterious(m_P07686_Pro504Ser), deleterious(m_P08236_Tyr508Cys), deleterious(m_P08236_Gly572Asp), deleterious(m_P08236_Arg382His), deleterious(m_Q02127_Asp392Gly), deleterious(m_P07686_Pro417Leu), deleterious(m_P08236_Ala354Val), deleterious(m_Q02127_Gly202Ala), deleterious(m_P08236_Arg577Leu), deleterious(m_Q02127_Gly152Arg), deleterious(m_P08236_Glu540Lys), deleterious(m_P08236_Ala619Val), deleterious(m_Q02127_Arg346Trp), deleterious(m_Q02127_Thr284Ile), deleterious(m_Q02127_Gly202Asp), deleterious(m_P08236_Asp362Asn), deleterious(m_P07686_Tyr456Ser), deleterious(m_P08236_Trp627Cys), deleterious(m_P08236_Lys350Asn), deleterious(m_P08236_Pro408Ser), deleterious(m_P07686_Ala543Thr), deleterious(m_P08236_Arg611Trp), deleterious(m_P07686_Cys534Tyr), deleterious(m_P08236_Gly607Ala), deleterious(m_P07686_Cys309Tyr), deleterious(m_Q02127_Arg199Cys), deleterious(m_P08236_Lys606Asn), deleterious(m_P08236_Arg435Pro), deleterious(m_P08236_His351Tyr), deleterious(m_P08236_Pro364Leu), deleterious(m_Q02127_Arg135Cys), deleterious(m_P08236_Pro415Leu)

+ Negative Examples: deleterious(m_Q12882_Ile543Val), deleterious(m_Q13231_Gln171His), deleterious(m_Q12882_Val732Ile)  
develop  humvar398_48   modif_charge(A, charge_decrease) and modif_polarity(A, polarity_decrease) and g_or_p(A, g_or_p_unchanged) and is_in_site(A, yes) and conservation_class(A, no_conservation_typification) and secondary_struc(A, other) and wt_accessibility(A, intermediate) and stability(A, decrease). deleterious(A)
38 (0.63%) 
5 (0.25%) 
92
Covers:
+ Positive Examples: deleterious(m_P31040_Arg554Trp), deleterious(m_P00480_Arg320Leu), deleterious(m_P01009_Asp280Val), deleterious(m_Q9HBA0_Arg316Cys), deleterious(m_P00451_Asp2307Ala), deleterious(m_P02768_Asp338Val), deleterious(m_P00451_Arg2178Leu), deleterious(m_P00451_Arg2016Trp), deleterious(m_P23786_Arg631Cys), deleterious(m_Q30201_Arg66Cys), deleterious(m_P00480_Arg40Cys), deleterious(m_P22735_Arg764Cys), deleterious(m_P11217_Arg194Trp), deleterious(m_P11597_Arg299Cys), deleterious(m_P06213_Arg1119Trp), deleterious(m_P54803_Arg396Leu), deleterious(m_P00451_Arg1888Ile), deleterious(m_Q92947_Arg94Leu), deleterious(m_P51608_Arg133Cys), deleterious(m_Q9HBA0_Arg315Trp), deleterious(m_Q13620_Arg572Cys), deleterious(m_P00451_Arg1800Cys), deleterious(m_P08236_Arg577Leu), deleterious(m_P03951_Arg326Cys), deleterious(m_P00966_Arg304Trp), deleterious(m_P62736_Arg149Cys), deleterious(m_Q9H3D4_Arg243Trp), deleterious(m_Q9HC23_Arg73Cys), deleterious(m_P30566_Arg194Cys), deleterious(m_P07320_Glu107Ala), deleterious(m_P04275_Arg1308Cys), deleterious(m_P00966_Arg363Trp), deleterious(m_P02768_Asp389Val), deleterious(m_P30613_Arg498Cys), deleterious(m_P00966_Arg363Leu), deleterious(m_P00451_Arg2178Cys), deleterious(m_P54803_Arg396Trp), deleterious(m_P00740_Glu433Ala)

+ Negative Examples: deleterious(m_O00220_Glu228Ala), deleterious(m_Q8TCU6_Arg696Cys), deleterious(m_Q5SRE7_Arg222Trp), deleterious(m_Q9BV79_Arg258Leu), deleterious(m_Q92876_Arg78Trp)  
develop  humvar398_90   modif_charge(A, charge_unchanged) and g_or_p(A, g_or_p_unchanged) and secondary_struc(A, helix) and gain_contact(A, hb). deleterious(A)
38 (0.63%) 
5 (0.25%) 
92
Covers:
+ Positive Examples: deleterious(m_P00480_Thr93Ala), deleterious(m_O95452_Ala88Val), deleterious(m_P35557_Val367Met), deleterious(m_P55789_Arg194His), deleterious(m_P25445_Ile310Ser), deleterious(m_P48436_Ala119Val), deleterious(m_P35680_Ser148Trp), deleterious(m_P32754_Ala33Thr), deleterious(m_P10828_Arg316His), deleterious(m_P36507_Phe57Cys), deleterious(m_P08397_Lys98Arg), deleterious(m_P56693_Ser135Thr), deleterious(m_Q06710_Arg31His), deleterious(m_P21333_Ala128Val), deleterious(m_Q15465_Leu109Phe), deleterious(m_P06744_Thr5Ile), deleterious(m_P06744_Arg273His), deleterious(m_Q8WXF7_Ser259Tyr), deleterious(m_Q03154_Arg393His), deleterious(m_P00439_Ala345Ser), deleterious(m_Q92947_Ala293Thr), deleterious(m_P00480_Ala209Val), deleterious(m_P06280_Ala156Val), deleterious(m_P06276_Gln546Leu), deleterious(m_P43246_Ala600Val), deleterious(m_Q92947_Leu309Trp), deleterious(m_Q16518_Leu341Ser), deleterious(m_P10275_Ile841Ser), deleterious(m_P23526_Ala89Val), deleterious(m_P04156_Val210Ile), deleterious(m_P00439_Tyr325Cys), deleterious(m_P01008_Tyr95Cys), deleterious(m_P55809_Cys456Phe), deleterious(m_P05108_Ala189Val), deleterious(m_P01308_Tyr108Cys), deleterious(m_P43246_Thr564Ala), deleterious(m_Q14353_Trp20Ser), deleterious(m_P40337_Leu198Gln)

+ Negative Examples: deleterious(m_Q9BYT8_Lys372Arg), deleterious(m_P21964_Ala146Val), deleterious(m_O75526_Ala66Val), deleterious(m_P04440_Lys98Arg), deleterious(m_P17516_Leu311Val)  
develop  humvar398_21   modif_size(A, size_increase) and modif_polarity(A, polarity_unchanged) and conservation_class(A, sub_family_conservation) and secondary_struc(A, other) and wt_accessibility(A, buried). deleterious(A)
34 (0.57%) 
2 (0.1%) 
94
Covers:
+ Positive Examples: deleterious(m_P46100_Leu192Phe), deleterious(m_P05186_Ile490Phe), deleterious(m_P00451_Glu98Lys), deleterious(m_P00740_Val228Leu), deleterious(m_P46100_Val194Ile), deleterious(m_P00492_Pro176Leu), deleterious(m_P00439_Ile224Met), deleterious(m_P07902_Pro325Leu), deleterious(m_P00451_Gly1869Val), deleterious(m_P00451_Gly255Val), deleterious(m_P05062_Val222Phe), deleterious(m_Q01968_His414Arg), deleterious(m_P05186_Glu452Lys), deleterious(m_P00451_Ser603Arg), deleterious(m_P00740_His302Arg), deleterious(m_P08100_Gln28His), deleterious(m_P04181_Asn89Lys), deleterious(m_Q93099_Glu168Lys), deleterious(m_P41181_Cys181Trp), deleterious(m_P16615_Gly310Val), deleterious(m_P05089_Gly138Val), deleterious(m_P00451_Asp135Tyr), deleterious(m_P00451_Gly89Val), deleterious(m_P23945_Ala189Val), deleterious(m_P04181_Gln90Glu), deleterious(m_P00740_Val228Phe), deleterious(m_P35520_Ala288Pro), deleterious(m_P00480_Pro225Leu), deleterious(m_Q03393_Val97Met), deleterious(m_Q16518_Glu102Lys), deleterious(m_P16615_Ser920Tyr), deleterious(m_P00451_Glu223Lys), deleterious(m_P25067_Pro575Leu), deleterious(m_P00451_Ala111Val)

+ Negative Examples: deleterious(m_Q8N0V3_Val122Met), deleterious(m_O00206_Leu385Phe)  
develop  humvar398_85   modif_charge(A, charge_decrease) and modif_hydrophobicity(A, hydrophobicity_unchanged) and conservation_class(A, sub_family_conservation). deleterious(A)
37 (0.62%) 
5 (0.25%) 
94
Covers:
+ Positive Examples: deleterious(m_P00439_Arg155Pro), deleterious(m_Q03393_Asp96Asn), deleterious(m_P22033_Asp156Asn), deleterious(m_P04156_Asp178Asn), deleterious(m_P01241_Asp37Asn), deleterious(m_P00558_Asp268Asn), deleterious(m_P51843_Arg267Pro), deleterious(m_P00451_Asp544Asn), deleterious(m_P54803_Asp544Asn), deleterious(m_Q9BZ23_Arg249Pro), deleterious(m_P00492_Arg51Pro), deleterious(m_P55072_Arg155Pro), deleterious(m_P36897_Arg487Pro), deleterious(m_P06132_Arg193Pro), deleterious(m_P02768_His27Gln), deleterious(m_P35520_Asp234Asn), deleterious(m_P35520_Arg125Pro), deleterious(m_P29033_Asp50Asn), deleterious(m_P00439_Arg413Pro), deleterious(m_P02545_Arg453Pro), deleterious(m_P00492_Asp201Asn), deleterious(m_O43602_Lys131Asn), deleterious(m_P43246_Arg524Pro), deleterious(m_P00439_Arg157Asn), deleterious(m_P02649_Arg163Pro), deleterious(m_P04156_Asp202Asn), deleterious(m_Q9Y3Q4_Asp553Asn), deleterious(m_P00491_Arg234Pro), deleterious(m_P00451_Asp478Asn), deleterious(m_P06132_Arg144Pro), deleterious(m_P16615_Asp702Asn), deleterious(m_P07902_Asp98Asn), deleterious(m_Q9UM73_Arg1192Pro), deleterious(m_Q04771_Arg375Pro), deleterious(m_P00451_Lys67Asn), deleterious(m_P11413_Arg198Pro), deleterious(m_P22830_Lys379Asn)

+ Negative Examples: deleterious(m_Q9NP95_Asp206Asn), deleterious(m_Q9H227_Arg213Pro), deleterious(m_P36888_Asp324Asn), deleterious(m_P17066_Asp154Asn), deleterious(m_P12018_Asp76Asn)  
develop  humvar398_31   modif_size(A, size_increase) and modif_charge(A, charge_opposite) and conservation_class(A, global_conservation_rank_2). deleterious(A)
36 (0.6%) 
5 (0.25%) 
96
Covers:
+ Positive Examples: deleterious(m_P43026_Glu491Lys), deleterious(m_P08709_Asp403His), deleterious(m_P68032_Glu101Lys), deleterious(m_P10275_Asp695His), deleterious(m_P02545_Glu358Lys), deleterious(m_O43819_Glu140Lys), deleterious(m_O43602_Asp167His), deleterious(m_P00966_Glu191Lys), deleterious(m_P00441_Asp126His), deleterious(m_O75712_Glu183Lys), deleterious(m_P08100_Glu181Lys), deleterious(m_P21333_Glu254Lys), deleterious(m_Q96KJ9_Glu138Lys), deleterious(m_P08236_Glu540Lys), deleterious(m_P08253_Glu404Lys), deleterious(m_P00480_Glu326Lys), deleterious(m_P61457_Glu97Lys), deleterious(m_P28329_Glu441Lys), deleterious(m_Q12840_Glu251Lys), deleterious(m_Q92838_Asp298His), deleterious(m_P48728_Asp276His), deleterious(m_P11217_Glu349Lys), deleterious(m_P60891_Asp52His), deleterious(m_P10912_Glu62Lys), deleterious(m_Q14623_Glu95Lys), deleterious(m_Q13509_Glu410Lys), deleterious(m_P30613_Glu315Lys), deleterious(m_P29033_Asp66His), deleterious(m_P00740_Asp410His), deleterious(m_P06744_Glu495Lys), deleterious(m_P30613_Asp339His), deleterious(m_P06276_Glu488Lys), deleterious(m_P08709_Asp302His), deleterious(m_P08397_Asp99His), deleterious(m_Q15465_Asp171His), deleterious(m_Q15465_Glu53Lys)

+ Negative Examples: deleterious(m_Q9NP86_Glu140Lys), deleterious(m_Q9UDX3_Glu211Lys), deleterious(m_P32881_Glu137Lys), deleterious(m_Q8N752_Glu177Lys), deleterious(m_P02647_Asp126His)  
develop  humvar398_89   modif_polarity(A, polarity_increase) and conservation_class(A, global_conservation_rank_2) and wt_accessibility(A, accessible). deleterious(A)
34 (0.57%) 
4 (0.2%) 
97
Covers:
+ Positive Examples: deleterious(m_P07954_Phe312Cys), deleterious(m_P19429_Pro82Ser), deleterious(m_P10275_Gly688Glu), deleterious(m_Q13501_Gly425Arg), deleterious(m_P00441_Ile152Thr), deleterious(m_P22033_Phe174Ser), deleterious(m_P15382_Leu51His), deleterious(m_P49768_Pro436Gln), deleterious(m_Q04656_Leu873Arg), deleterious(m_P02649_Pro102Arg), deleterious(m_P35680_Ala241Thr), deleterious(m_Q9UIF7_Gly393Asp), deleterious(m_P29965_Gly144Glu), deleterious(m_Q9GZT9_Pro317Arg), deleterious(m_P26367_Gly73Asp), deleterious(m_P01008_Phe434Ser), deleterious(m_P01008_Phe434Cys), deleterious(m_P61764_Gly544Asp), deleterious(m_P10275_Pro671His), deleterious(m_Q15465_Ile111Asn), deleterious(m_P10828_Pro453His), deleterious(m_P35240_Gly197Cys), deleterious(m_P35670_Gly869Arg), deleterious(m_P07225_Phe72Cys), deleterious(m_P02545_Met371Lys), deleterious(m_P07902_Pro183Thr), deleterious(m_Q02962_Gly76Ser), deleterious(m_P41250_Gly580Arg), deleterious(m_P02647_Val180Glu), deleterious(m_P49768_Pro436Ser), deleterious(m_O15553_Ala744Ser), deleterious(m_P10828_Pro453Thr), deleterious(m_P43026_Pro436Thr), deleterious(m_P07225_Gly52Asp)

+ Negative Examples: deleterious(m_P01909_Gly63Glu), deleterious(m_Q8N9K5_Ile188Thr), deleterious(m_Q8IVI9_Gly473Glu), deleterious(m_O75396_Cys130Arg)  
develop  humvar398_110   modif_size(A, size_decrease) and modif_hydrophobicity(A, hydrophobicity_unchanged) and is_in_site(A, yes) and secondary_struc(A, other) and lost_contact(A, phob) and mut_accessibility(A, intermediate). deleterious(A)
35 (0.58%) 
5 (0.25%) 
97
Covers:
+ Positive Examples: deleterious(m_P10275_Met780Ile), deleterious(m_P10275_Leu821Val), deleterious(m_P09622_Lys72Glu), deleterious(m_P00451_Trp2290Leu), deleterious(m_P00451_Tyr1728Cys), deleterious(m_P53634_Trp429Cys), deleterious(m_P22033_Lys621Asn), deleterious(m_P07902_Phe194Leu), deleterious(m_P00451_Met681Ile), deleterious(m_P11413_Lys386Glu), deleterious(m_Q05066_Tyr127Cys), deleterious(m_P39019_Trp52Cys), deleterious(m_P00451_Tyr1909Cys), deleterious(m_P02675_Arg478Lys), deleterious(m_P53634_Tyr340Cys), deleterious(m_P25189_Lys138Asn), deleterious(m_P23760_Phe45Leu), deleterious(m_Q13496_Lys510Asn), deleterious(m_P00439_Tyr277Cys), deleterious(m_P51149_Lys157Asn), deleterious(m_P00480_Tyr345Cys), deleterious(m_P00451_Phe455Cys), deleterious(m_P00451_Met1966Ile), deleterious(m_P08236_Lys350Asn), deleterious(m_Q06124_Ile282Val), deleterious(m_P98172_Met158Ile), deleterious(m_Q76LX8_Trp390Cys), deleterious(m_P29033_Arg184Pro), deleterious(m_O00294_Arg420Pro), deleterious(m_P31785_Trp240Cys), deleterious(m_P03951_Phe460Val), deleterious(m_P98172_Met158Val), deleterious(m_Q04771_Arg375Pro), deleterious(m_Q05066_Val60Ala), deleterious(m_P00451_Met1966Val)

+ Negative Examples: deleterious(m_Q96C24_Ile420Val), deleterious(m_P33261_Glu92Asp), deleterious(m_Q9Y3V2_Val47Ala), deleterious(m_Q99952_Met193Val), deleterious(m_Q9Y336_Lys100Glu)  
develop  humvar398_103   modif_size(A, size_decrease) and modif_hydrophobicity(A, hydrophobicity_unchanged) and modif_polarity(A, polarity_unchanged) and conservation_class(A, global_conservation_rank_2) and secondary_struc(A, helix). deleterious(A)
35 (0.58%) 
5 (0.25%) 
97
Covers:
+ Positive Examples: deleterious(m_P54868_Phe174Leu), deleterious(m_Q99714_Leu122Val), deleterious(m_P11532_Lys18Asn), deleterious(m_P49768_Leu392Val), deleterious(m_P00492_Leu78Val), deleterious(m_Q03393_Phe100Val), deleterious(m_P40692_Arg182Lys), deleterious(m_Q06187_Met587Leu), deleterious(m_P21439_Arg150Lys), deleterious(m_P06276_Phe502Leu), deleterious(m_Q15436_Phe382Leu), deleterious(m_P40692_Val326Ala), deleterious(m_P43246_Met688Ile), deleterious(m_P15056_Lys499Asn), deleterious(m_P35520_Arg266Lys), deleterious(m_P10275_Met749Val), deleterious(m_P45379_Glu254Asp), deleterious(m_P06280_Leu120Val), deleterious(m_P10828_Met442Val), deleterious(m_O15305_Leu104Val), deleterious(m_P21439_Phe165Ile), deleterious(m_P10275_Phe754Val), deleterious(m_P37231_Phe388Leu), deleterious(m_O43707_Lys255Glu), deleterious(m_Q03393_Ile114Val), deleterious(m_P69892_Phe119Leu), deleterious(m_P26367_Ile29Val), deleterious(m_P06280_Met187Val), deleterious(m_P69892_Lys18Asn), deleterious(m_P15056_Lys499Glu), deleterious(m_P35520_Met391Ile), deleterious(m_P35520_Glu131Asp), deleterious(m_P69892_Lys9Glu), deleterious(m_P69892_Lys66Asn), deleterious(m_P02649_Lys164Glu)

+ Negative Examples: deleterious(m_P54619_Thr89Ser), deleterious(m_Q8NER5_Ile482Val), deleterious(m_Q96DN0_Phe52Leu), deleterious(m_O75439_Glu396Asp), deleterious(m_P15918_Arg449Lys)  
develop  humvar398_83   modif_size(A, size_increase) and modif_charge(A, charge_unchanged) and modif_polarity(A, polarity_unchanged) and conservation_class(A, global_conservation_rank_2) and secondary_struc(A, other) and wt_accessibility(A, intermediate). deleterious(A)
32 (0.53%) 
5 (0.25%) 
100
Covers:
+ Positive Examples: deleterious(m_Q05066_Val60Leu), deleterious(m_P35520_Ala114Val), deleterious(m_P08246_Gly32Val), deleterious(m_P06280_Asp234Glu), deleterious(m_P01185_Pro55Leu), deleterious(m_Q00266_Ile322Met), deleterious(m_P18077_Val33Ile), deleterious(m_P09622_Pro488Leu), deleterious(m_P08397_Ser28Asn), deleterious(m_Q14623_Pro46Leu), deleterious(m_P00439_Pro281Leu), deleterious(m_P12644_Ala346Val), deleterious(m_P06280_Pro259Leu), deleterious(m_P37231_Pro495Leu), deleterious(m_Q14376_Asp69Glu), deleterious(m_Q16518_Pro470Leu), deleterious(m_P00439_Ser350Thr), deleterious(m_Q96QS3_Thr333Asn), deleterious(m_P00441_Gly109Val), deleterious(m_P10275_His917Arg), deleterious(m_Q9BZ23_Ser471Asn), deleterious(m_P00451_Gly1979Val), deleterious(m_P00740_Gly432Val), deleterious(m_P05107_Pro178Leu), deleterious(m_Q14376_Val94Met), deleterious(m_Q13496_Asn481Tyr), deleterious(m_O15553_Pro646Leu), deleterious(m_P48637_Gly464Val), deleterious(m_P00451_Pro262Leu), deleterious(m_P40692_Ala111Val), deleterious(m_P00480_Gly188Val), deleterious(m_P53420_Pro1572Leu)

+ Negative Examples: deleterious(m_P20853_Asp169Glu), deleterious(m_P15918_Asp302Glu), deleterious(m_P12829_Asn186Tyr), deleterious(m_P01031_Gly933Val), deleterious(m_Q6PEY2_Ser101Asn)  
develop  humvar398_57   modif_size(A, size_increase) and modif_hydrophobicity(A, hydrophobicity_unchanged) and modif_polarity(A, polarity_increase) and g_or_p(A, g_or_p_unchanged) and conservation_class(A, no_conservation_typification). deleterious(A)
25 (0.42%) 
2 (0.1%) 
101
Covers:
+ Positive Examples: deleterious(m_P07225_Cys88Tyr), deleterious(m_P22033_Cys560Tyr), deleterious(m_O15305_Cys9Tyr), deleterious(m_P01308_Cys96Tyr), deleterious(m_O15118_Cys177Tyr), deleterious(m_P03951_Cys255Tyr), deleterious(m_Q16518_Cys330Tyr), deleterious(m_P11362_Cys277Tyr), deleterious(m_P00451_Ile522Tyr), deleterious(m_P63316_Cys84Tyr), deleterious(m_P01008_Cys160Tyr), deleterious(m_P05186_Cys201Tyr), deleterious(m_P51648_Cys237Tyr), deleterious(m_Q92947_Cys115Tyr), deleterious(m_Q13873_Cys117Tyr), deleterious(m_Q9H3D4_Cys308Tyr), deleterious(m_O14773_Cys365Tyr), deleterious(m_P04075_Cys339Tyr), deleterious(m_O15118_Cys247Tyr), deleterious(m_Q92947_Leu309Trp), deleterious(m_P00451_Leu2185Trp), deleterious(m_O15118_Cys74Tyr), deleterious(m_P55895_Cys478Tyr), deleterious(m_P00387_Cys204Tyr), deleterious(m_Q13873_Cys60Tyr)

+ Negative Examples: deleterious(m_Q9UII6_Cys156Tyr), deleterious(m_O43488_Cys214Tyr)  
develop  humvar398_93   modif_size(A, size_increase) and modif_charge(A, charge_opposite) and conservation_class(A, no_conservation_typification) and wt_accessibility(A, buried). deleterious(A)
24 (0.4%) 
2 (0.1%) 
102
Covers:
+ Positive Examples: deleterious(m_P08397_Glu250Lys), deleterious(m_P00451_Asp1788His), deleterious(m_P11362_Asp224His), deleterious(m_P08397_Glu223Lys), deleterious(m_Q13496_Glu404Lys), deleterious(m_P06132_Glu167Lys), deleterious(m_P35557_Glu221Lys), deleterious(m_P02768_Glu378Lys), deleterious(m_P06280_Glu341Lys), deleterious(m_P00451_Glu475Lys), deleterious(m_P17050_Glu325Lys), deleterious(m_P00451_Glu1904Lys), deleterious(m_P06280_Glu338Lys), deleterious(m_O15118_Asp242His), deleterious(m_P06132_Glu218Lys), deleterious(m_P05166_Glu168Lys), deleterious(m_P11217_Glu655Lys), deleterious(m_P40692_Asp485His), deleterious(m_P05186_Glu298Lys), deleterious(m_P05186_Glu291Lys), deleterious(m_P54803_Glu130Lys), deleterious(m_P04075_Glu207Lys), deleterious(m_P13637_Glu277Lys), deleterious(m_P01008_Asp398His)

+ Negative Examples: deleterious(m_P01889_Asp138His), deleterious(m_P30711_Glu173Lys)  
develop  humvar398_106   modif_charge(A, charge_unchanged) and modif_hydrophobicity(A, hydrophobicity_increase) and g_or_p(A, g_or_p_unchanged) and conservation_class(A, global_conservation_rank_2) and wt_accessibility(A, intermediate) and stability(A, decrease). deleterious(A)
26 (0.43%) 
5 (0.25%) 
103
Covers:
+ Positive Examples: deleterious(m_P01241_Thr201Ala), deleterious(m_Q03393_Thr106Met), deleterious(m_O60481_Thr323Met), deleterious(m_Q14376_Asn34Ser), deleterious(m_P22607_Asn540Ser), deleterious(m_P07902_Arg328His), deleterious(m_P35520_Arg336His), deleterious(m_O60806_Ser128Phe), deleterious(m_P30613_Asn393Ser), deleterious(m_P10828_Thr426Ile), deleterious(m_P15382_Ser74Leu), deleterious(m_Q92793_Thr1447Ile), deleterious(m_P16871_Thr66Ile), deleterious(m_P30613_Thr384Met), deleterious(m_P21583_Asn36Ser), deleterious(m_P08236_Asn339Ser), deleterious(m_Q13496_Asn481Tyr), deleterious(m_P00451_Arg2323His), deleterious(m_Q13509_Arg262His), deleterious(m_Q04446_Arg515His), deleterious(m_P07225_Thr78Met), deleterious(m_P10912_Arg229His), deleterious(m_P49748_Arg456His), deleterious(m_P00966_Thr119Ile), deleterious(m_Q9GZT9_Arg371His), deleterious(m_Q92947_Thr416Ile)

+ Negative Examples: deleterious(m_P21583_Thr54Ala), deleterious(m_P12829_Asn186Tyr), deleterious(m_P17066_Asn153Ser), deleterious(m_Q03519_Thr665Ala), deleterious(m_P05534_Arg205His)  
develop  humvar398_98   modif_charge(A, charge_unchanged) and modif_polarity(A, polarity_unchanged) and g_or_p(A, g_or_p_unchanged) and conservation_class(A, global_conservation_rank_2) and wt_accessibility(A, accessible) and stability(A, decrease). deleterious(A)
23 (0.38%) 
4 (0.2%) 
104
Covers:
+ Positive Examples: deleterious(m_P19429_Ala157Val), deleterious(m_P13569_Ile601Phe), deleterious(m_P55789_Arg194His), deleterious(m_P10275_Val684Ile), deleterious(m_Q03393_Asn52Ser), deleterious(m_P80404_Arg220Lys), deleterious(m_P60484_His93Arg), deleterious(m_Q92793_Arg1664His), deleterious(m_Q06124_Phe285Leu), deleterious(m_P43246_Ala714Val), deleterious(m_Q93099_Arg225His), deleterious(m_P16871_Ile138Val), deleterious(m_Q15465_Ile111Phe), deleterious(m_P69892_Lys67Arg), deleterious(m_P58012_His104Arg), deleterious(m_P21439_Phe165Ile), deleterious(m_O43918_Val301Met), deleterious(m_Q6KF10_Lys424Arg), deleterious(m_B7U540_Arg205His), deleterious(m_Q96QS3_Arg332His), deleterious(m_O95409_His404Arg), deleterious(m_P19429_Arg192His), deleterious(m_P04198_Arg394His)

+ Negative Examples: deleterious(m_Q6P5R6_Val97Phe), deleterious(m_Q6ECI4_Lys254Arg), deleterious(m_Q7Z2G1_Arg123His), deleterious(m_Q8IUH4_Lys99Arg)  
develop  humvar398_100   modif_hydrophobicity(A, hydrophobicity_decrease) and modif_polarity(A, polarity_decrease) and is_in_site(A, yes) and secondary_struc(A, other) and wt_accessibility(A, intermediate). deleterious(A)
23 (0.38%) 
5 (0.25%) 
105
Covers:
+ Positive Examples: deleterious(m_P50897_Thr75Pro), deleterious(m_Q03426_His20Pro), deleterious(m_Q15465_Trp117Gly), deleterious(m_P05107_Ser138Pro), deleterious(m_Q8IXL7_Cys89Gly), deleterious(m_P54840_Ser483Pro), deleterious(m_Q06187_Cys155Gly), deleterious(m_P05155_Thr394Pro), deleterious(m_P43034_His277Pro), deleterious(m_P08236_Cys38Gly), deleterious(m_P06280_Cys56Gly), deleterious(m_P25445_Thr241Pro), deleterious(m_P05129_Ser119Pro), deleterious(m_P00439_Thr418Pro), deleterious(m_P25189_Ser54Pro), deleterious(m_P26367_Thr63Pro), deleterious(m_P16615_Ser186Pro), deleterious(m_Q06187_Thr117Pro), deleterious(m_P05106_His306Pro), deleterious(m_O60260_Thr351Pro), deleterious(m_P01008_Ser323Pro), deleterious(m_P98172_Gln115Pro), deleterious(m_Q68CZ1_Thr615Pro)

+ Negative Examples: deleterious(m_P11464_Thr43Pro), deleterious(m_P52815_Ser105Pro), deleterious(m_Q9NYZ4_Ser170Pro), deleterious(m_P06731_Gln137Pro), deleterious(m_P36952_Ser176Pro)  
develop  humvar398_94   modif_size(A, size_increase) and fold(A, 'NAD(P)-binding Rossmann-fold domains'). deleterious(A)
20 (0.33%) 
3 (0.15%) 
106
Covers:
+ Positive Examples: deleterious(m_P11413_His32Arg), deleterious(m_P11413_Glu156Lys), deleterious(m_P11413_Val394Leu), deleterious(m_P11413_Gly447Arg), deleterious(m_P11413_Ser188Phe), deleterious(m_P51659_Gly16Ser), deleterious(m_P11413_Val291Met), deleterious(m_P11413_Gly131Val), deleterious(m_P11413_Cys385Arg), deleterious(m_P11413_Glu317Lys), deleterious(m_P11413_Ala335Thr), deleterious(m_P11413_Asp282His), deleterious(m_P11413_Gly410Asp), deleterious(m_P11413_Val213Leu), deleterious(m_P11413_Leu342Phe), deleterious(m_P11413_Gly163Ser), deleterious(m_P11413_Val68Met), deleterious(m_P11413_Glu398Lys), deleterious(m_P35270_Pro163Leu), deleterious(m_P07195_Ser129Arg)

+ Negative Examples: deleterious(m_Q9BY49_Glu149Lys), deleterious(m_P53004_Ala3Thr), deleterious(m_P23368_Gly450Glu)  
develop  humvar398_74   modif_charge(A, charge_unchanged) and is_in_site(A, yes) and conservation_class(A, no_conservation_typification) and secondary_struc(A, other) and lost_contact(A, hb) and mut_accessibility(A, intermediate). deleterious(A)
20 (0.33%) 
3 (0.15%) 
106
Covers:
+ Positive Examples: deleterious(m_P11413_Leu323Pro), deleterious(m_P08246_Val177Phe), deleterious(m_P22033_Val633Gly), deleterious(m_P62736_Arg39His), deleterious(m_P30613_Thr477Ala), deleterious(m_P25189_Asp90Glu), deleterious(m_P00734_Arg431His), deleterious(m_P00451_Arg2178His), deleterious(m_P02675_Arg478Lys), deleterious(m_P08709_Thr332Met), deleterious(m_O15553_Val726Ala), deleterious(m_Q9NRR6_Arg563His), deleterious(m_P00451_Arg503His), deleterious(m_P07949_Arg231His), deleterious(m_P11413_Arg387His), deleterious(m_O15553_Met680Ile), deleterious(m_P00451_Val285Gly), deleterious(m_P08514_Gln778Pro), deleterious(m_P11413_Arg454His), deleterious(m_O95409_Ser272Asn)

+ Negative Examples: deleterious(m_Q07444_Cys155Ser), deleterious(m_P47712_Arg651Lys), deleterious(m_P78324_Arg54His)  
develop  humvar398_76   modif_size(A, size_decrease) and modif_hydrophobicity(A, hydrophobicity_unchanged) and conservation_class(A, sub_family_conservation) and lost_contact(A, dc). deleterious(A)
19 (0.32%) 
4 (0.2%) 
108
Covers:
+ Positive Examples: deleterious(m_P60891_Glu43Asp), deleterious(m_P51843_Arg267Pro), deleterious(m_P09622_Lys72Glu), deleterious(m_P69892_Lys60Glu), deleterious(m_P00441_Leu107Val), deleterious(m_Q9BZ23_Arg249Pro), deleterious(m_P00441_Val88Ala), deleterious(m_P08559_Phe205Leu), deleterious(m_P00439_Leu348Val), deleterious(m_P22830_Met267Ile), deleterious(m_P43246_Arg524Pro), deleterious(m_P00439_Arg157Asn), deleterious(m_P02649_Arg163Pro), deleterious(m_P00491_Arg234Pro), deleterious(m_P06132_Arg144Pro), deleterious(m_Q9UM73_Arg1192Pro), deleterious(m_Q04771_Arg375Pro), deleterious(m_P10912_Glu242Asp), deleterious(m_P35520_Met173Val)

+ Negative Examples: deleterious(m_Q9H777_Met355Val), deleterious(m_Q9H227_Arg213Pro), deleterious(m_P04798_Phe470Val), deleterious(m_Q96HA8_Ile32Val)  
develop  humvar398_91   modif_size(A, size_increase) and modif_charge(A, charge_unchanged) and modif_hydrophobicity(A, hydrophobicity_increase) and g_or_p(A, g_or_p_disparition) and conservation_class(A, no_conservation_typification) and secondary_struc(A, other) and mut_accessibility(A, accessible) and stability(A, decrease). deleterious(A)
20 (0.33%) 
5 (0.25%) 
108
Covers:
+ Positive Examples: deleterious(m_P05543_Pro383Leu), deleterious(m_P00966_Gly362Val), deleterious(m_Q03692_Gly618Val), deleterious(m_P04275_Pro1266Leu), deleterious(m_P04156_Pro105Leu), deleterious(m_P26367_Gly64Val), deleterious(m_Q12809_Pro72Gln), deleterious(m_P54803_Pro400Leu), deleterious(m_P00439_Gly337Val), deleterious(m_P35520_Pro49Leu), deleterious(m_P17302_Pro283Leu), deleterious(m_P51608_Pro101Leu), deleterious(m_P08100_Pro347Gln), deleterious(m_P00813_Pro274Leu), deleterious(m_P04156_Pro102Leu), deleterious(m_P05186_Gly249Val), deleterious(m_P06280_Gly144Val), deleterious(m_Q15465_Pro26Leu), deleterious(m_P13569_Gly544Val), deleterious(m_P00740_Gly363Trp)

+ Negative Examples: deleterious(m_Q9H3Y6_Pro452Leu), deleterious(m_P28329_Pro299Leu), deleterious(m_O60934_Pro266Leu), deleterious(m_P07357_Pro575Leu), deleterious(m_Q9Y2Z4_Gly191Val)  
develop  humvar398_87   modif_size(A, size_unchanged) and g_or_p(A, g_or_p_unchanged) and is_in_site(A, no) and secondary_struc(A, helix). deleterious(A)
16 (0.27%) 
3 (0.15%) 
110
Covers:
+ Positive Examples: deleterious(m_P49748_Arg613Trp), deleterious(m_Q9Y6K9_Asp311Asn), deleterious(m_P02549_Arg41Trp), deleterious(m_P19429_Asp196Asn), deleterious(m_P30566_Arg374Trp), deleterious(m_P06280_Asp244Asn), deleterious(m_P06280_Ile242Asn), deleterious(m_P45379_Asn281Ile), deleterious(m_P04424_Arg456Trp), deleterious(m_P02549_Arg34Trp), deleterious(m_P13569_Asp651Asn), deleterious(m_P21359_Ala1785Ser), deleterious(m_Q15437_Arg14Trp), deleterious(m_Q13285_Leu437Gln), deleterious(m_Q14524_Cys1850Ser), deleterious(m_Q13509_Asp417Asn)

+ Negative Examples: deleterious(m_O00754_Ala481Ser), deleterious(m_Q9NVI1_Cys742Ser), deleterious(m_O15527_Asp322Asn)  
develop  humvar398_64   modif_hydrophobicity(A, hydrophobicity_unchanged) and is_in_site(A, no) and secondary_struc(A, helix) and mut_accessibility(A, buried). deleterious(A)
15 (0.25%) 
5 (0.25%) 
111
Covers:
+ Positive Examples: deleterious(m_P40692_Val506Ala), deleterious(m_Q9NSU2_Gly282Ser), deleterious(m_P06280_Gly373Ser), deleterious(m_Q9UQ90_Ala510Val), deleterious(m_P13637_Phe780Leu), deleterious(m_P40692_Leu724Met), deleterious(m_Q9UBC3_Val818Met), deleterious(m_P08397_Gly236Ser), deleterious(m_P06280_Asn320Lys), deleterious(m_P09417_Phe212Cys), deleterious(m_P22033_Tyr587Cys), deleterious(m_P06280_Gln280His), deleterious(m_P06280_Ile289Phe), deleterious(m_O14773_Val277Met), deleterious(m_P05543_Ser43Thr)

+ Negative Examples: deleterious(m_P78417_Ala236Val), deleterious(m_Q15024_Val274Leu), deleterious(m_P46734_Val339Met), deleterious(m_Q9Y2C9_Val327Met), deleterious(m_P17516_Leu311Val)  
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help How to interpret the rules



Statistic

  Descriptor Description and comments Frequence in
set of rules
 conservation_class  Conservation in the alignment
55 (11.60%) 
 secondary_struc  In a secondary structure element? (helix, sheet, no)
49 (10.34%) 
 modif_size  Size modification. Value: size_increase (+) / size_decrease (-) / size_unchanged (=)
44 (9.28%) 
 modif_charge  Charge modification. Value: charge_increase (+) / charge_decrease (-) / charge_unchanged (=) / charge_opposite (!=)
41 (8.65%) 
 wt_accessibility  Accessibility of the wild type residue.
38 (8.02%) 
 modif_hydrophobicity  Hydrophobicity modification. Value: hydrophobicity_increase (+) / hydrophobicity_decrease (-) / hydrophobicity_unchanged (=)
38 (8.02%) 
 g_or_p  Glycine or Proline loss or apparition. Value: g_or_p_apparition (+) / g_or_p_disparition (-) / g_or_p_unchanged(=)
38 (8.02%) 
 modif_polarity  Polarity modification. Value: polarity_increase (+) / polarity_decrease (-) / polarity_unchanged (=)
37 (7.81%) 
 mut_accessibility  Accessibility of the mutant residue.
35 (7.38%) 
10 
 is_in_site  In an annoted site?
30 (6.33%) 
11 
 stability  The change in protein relative stability upon mutation.
24 (5.06%) 
12 
 freq_at_pos  Number of known mutations at this position.
16 (3.38%) 
13 
 lost_contact  Contacts between:
- the wild type residue and its direct 3D neighbors, based on the wild type 3D model
- the mutant residue and its direct 3D neighbors, based on the mutant 3D model
are computed and compared.
11 (2.32%) 
14 
 gain_contact  Contacts between:
- the wild type residue and its direct 3D neighbors, based on the wild type 3D model
- the mutant residue and its direct 3D neighbors, based on the mutant 3D model
are computed and compared.
11 (2.32%) 
15 
 fold  Identification of related proteins at the fold level using SCOP classification
7 (1.48%)