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Gene Protein AA change dbSNP Phenotype Chain Detail
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1 MLH1 P40692 p.Arg18Cys - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
1 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Ile19Phe rs63750648 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
1 (D)
N
4 MLH1 P40692 p.Ala21Val rs63750706 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
1 (D)
D ( Predicted by rules : 1 2 )
4 MLH1 P40692 p.Gly22Ala rs41295280 variant of unknown significance
3na3
A
Detail
0.01 (D)
1 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Ile25Phe - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
1 (D)
N
4 MLH1 P40692 p.Arg27Gln rs138705565 variant of unknown significance
3na3
A
Detail
(-)
(-)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Pro28Leu - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
1 (D)
D ( Predicted by rules : 1 2 3 4 )
6 MLH1 P40692 p.Ala29Ser rs63750656 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.51 (T)
0.82 (D)
N
7 MLH1 P40692 p.Ile32Val rs2020872 variant of unknown significance
3na3
A
Detail
0.68 (T)
0.002 (N)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Met35Asn - Mismatch repair cancer syndrome (MMRCS) [MIM:276300]
3na3
A
Detail
0.00 (D)
0.987 (D)
D ( Predicted by rules : 1 2 )
4 MLH1 P40692 p.Met35Arg - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
0.967 (D)
D ( Predicted by rules : 1 2 3 4 )
6 MLH1 P40692 p.Met35Lys - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
0.987 (D)
D ( Predicted by rules : 1 2 3 4 )
6 MLH1 P40692 p.Asn38His rs63750580 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
1 (D)
D ( Predicted by rules : 1 2 3 4 )
6 MLH1 P40692 p.Asn38Asp rs63750580 variant of unknown significance
3na3
A
Detail
0.02 (D)
1 (D)
D ( Predicted by rules : 1 2 )
4 MLH1 P40692 p.Asp41Gly - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.02 (D)
1 (D)
N
5 MLH1 P40692 p.Ser44Phe rs121912957 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
0.999 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Gln48His rs147342421 variant of unknown significance
3na3
A
Detail
(-)
(-)
N
4 MLH1 P40692 p.Gln62Lys - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.41 (T)
0.984 (D)
N
5 MLH1 P40692 p.Asp63Glu - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.02 (D)
1 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Asn64Ser rs63750952 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.01 (D)
1 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Gly67Trp rs121912959 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
1 (D)
D ( Predicted by rules : 1 2 3 4 5 6 7 )
9 MLH1 P40692 p.Gly67Glu rs121912966 COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 2 [MIM:120436#0029]
3na3
A
Detail
0.00 (D)
1 (D)
D ( Predicted by rules : 1 2 3 4 5 6 )
8 MLH1 P40692 p.Gly67Arg - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
1 (D)
D ( Predicted by rules : 1 2 3 4 5 )
7 MLH1 P40692 p.Ile68Asn - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
1 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Arg69Lys - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.77 (T)
0.65 (D)
N
4 MLH1 P40692 p.Cys77Arg - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.04 (D)
1 (D)
D ( Predicted by rules : 1 2 3 )
5 MLH1 P40692 p.Phe80Val - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.04 (D)
1 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Lys84Glu rs63750641 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
1 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Phe88Leu rs182963667 variant of unknown significance
3na3
A
Detail
(-)
(-)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Ser93Gly rs78852840 variant of unknown significance
3na3
A
Detail
0.26 (T)
0.021 (N)
N
4 MLH1 P40692 p.Gly101Asp - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
1 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Glu102Lys - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.02 (D)
1 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Ile107Arg - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
1 (D)
D ( Predicted by rules : 1 2 )
4 MLH1 P40692 p.His109Gln rs63749803 variant of unknown significance
3na3
A
Detail
(-)
(-)
N
5 MLH1 P40692 p.Ala111Val - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
0.999 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Thr117Arg - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
0.991 (D)
D ( Predicted by rules : 1 2 3 4 5 )
7 MLH1 P40692 p.Thr117Met rs121912961 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
0.999 (D)
D ( Predicted by rules : 1 2 3 4 5 6 7 )
9 MLH1 P40692 p.Ala128Pro - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.02 (D)
0.999 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Asp132His rs121912963 variant of unknown significance
3na3
A
Detail
0.03 (D)
1 (D)
D ( Predicted by rules : 1 2 )
4 MLH1 P40692 p.Gln149His rs63750638 variant of unknown significance
3na3
A
Detail
(-)
(-)
N
5 MLH1 P40692 p.Leu155Arg - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
1 (D)
D ( Predicted by rules : 1 2 3 4 5 )
7 MLH1 P40692 p.Ala160Val rs63749924 variant of unknown significance
3na3
A
Detail
(-)
(-)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Arg182Gly - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
0.999 (D)
D ( Predicted by rules : 1 2 3 )
5 MLH1 P40692 p.Arg182Lys - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.38 (T)
0.056 (N)
D ( Predicted by rules : 1 2 3 )
5 MLH1 P40692 p.Val185Leu - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.54 (T)
0 (N)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Val185Gly - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
0.515 (D)
D ( Predicted by rules : 1 2 3 )
5 MLH1 P40692 p.Ser193Pro - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.09 (T)
0.876 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Glu199Gln rs63749887 variant of unknown significance
3na3
A
Detail
(-)
(-)
N
4 MLH1 P40692 p.Asn209Ser rs150478207 variant of unknown significance
3na3
A
Detail
(-)
(-)
N
5 MLH1 P40692 p.Thr212Ala rs149196672 variant of unknown significance
3na3
A
Detail
(-)
(-)
N
6 MLH1 P40692 p.Val213Leu rs2308317 variant of unknown significance
3na3
A
Detail
(-)
(-)
N
7 MLH1 P40692 p.Val213Met rs2308317 variant of unknown significance
3na3
A
Detail
0.23 (T)
0.048 (N)
N
8 MLH1 P40692 p.Arg217Cys rs4986984 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.16 (T)
1 (D)
D ( Predicted by rules : 1 2 )
4 MLH1 P40692 p.Arg217Gly - variant of unknown significance
3na3
A
Detail
0.35 (T)
0.671 (D)
D ( Predicted by rules : 1 2 )
4 MLH1 P40692 p.Ile219Leu rs1799977 variant of unknown significance
3na3
A
Detail
(-)
(-)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Ile219Phe rs1799977 variant of unknown significance
3na3
A
Detail
(-)
(-)
N
4 MLH1 P40692 p.Ile219Val rs1799977 variant of unknown significance
3na3
A
Detail
0.49 (T)
0.005 (N)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Arg226Leu - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.15 (T)
1 (D)
N
4 MLH1 P40692 p.Gly232Val rs149302013 variant of unknown significance
3na3
A
Detail
(-)
(-)
N
5 MLH1 P40692 p.Glu234Gly - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.37 (T)
0.349 (N)
N
6 MLH1 P40692 p.Gly244Val - variant of unknown significance
3na3
A
Detail
0.03 (D)
0.999 (D)
D ( Predicted by rules : 1 2 3 4 )
6 MLH1 P40692 p.Gly244Asp - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
1 (D)
D ( Predicted by rules : 1 2 3 )
5 MLH1 P40692 p.Ser247Pro - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.02 (D)
0.914 (D)
N
6 MLH1 P40692 p.Ser247Ala rs104894996 variant of unknown significance
3na3
A
Detail
(-)
(-)
N
7 MLH1 P40692 p.Leu259Ser rs56250509 variant of unknown significance
3na3
A
Detail
(-)
(-)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Leu260Phe rs63750642 variant of unknown significance
3na3
A
Detail
(-)
(-)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Asn263Thr rs104894997 variant of unknown significance
3na3
A
Detail
(-)
(-)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.His264Tyr - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.09 (T)
0.987 (D)
N
4 MLH1 P40692 p.His264Asp rs35338630 variant of unknown significance
3na3
A
Detail
(-)
(-)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Arg265His - variant of unknown significance
3na3
A
Detail
0.00 (D)
1 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Glu268Gly rs63750650 variant of unknown significance
3na3
A
Detail
(-)
(-)
N
4 MLH1 P40692 p.Ala282Gly - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.40 (T)
0.601 (D)
N
5 MLH1 P40692 p.Leu292Pro - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.07 (T)
0.968 (D)
D ( Predicted by rules : 1 2 3 )
5 MLH1 P40692 p.Ser295Thr - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.23 (T)
0.968 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Asp304Val - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
1 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Pro309Ser - variant of unknown significance
3na3
A
Detail
0.00 (D)
1 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.His315Tyr rs151119913 variant of unknown significance
3na3
A
Detail
(-)
(-)
N
4 MLH1 P40692 p.Ser321Ile rs63750286 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.18 (T)
0.601 (D)
N
5 MLH1 P40692 p.Arg325Gln rs63750268 variant of unknown significance
3na3
A
Detail
0.65 (T)
0.855 (D)
N
6 MLH1 P40692 p.Val326Ala rs63751049 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.00 (D)
0.587 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.His329Pro rs63750710 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3na3
A
Detail
0.20 (T)
0.556 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Asn338Ser - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
Detail
1.00 (T)
0.037 (N)
N
4 MLH1 P40692 p.Ser340Phe rs191257018 variant of unknown significance
Detail
(-)
(-)
N
5 MLH1 P40692 p.Thr364Ala rs63749864 variant of unknown significance
Detail
(-)
(-)
N
6 MLH1 P40692 p.Tyr379Cys rs143009528 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
Detail
0.18 (T)
0.904 (D)
N
7 MLH1 P40692 p.His381Tyr rs63750557 variant of unknown significance
Detail
(-)
(-)
N
8 MLH1 P40692 p.Met383Thr rs141344760 variant of unknown significance
Detail
(-)
(-)
N
9 MLH1 P40692 p.Val384Asp rs63750447 variant of unknown significance
Detail
0.01 (D)
1 (D)
N
10 MLH1 P40692 p.Arg385Pro rs63750430 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
Detail
0.07 (T)
1 (D)
N
11 MLH1 P40692 p.Arg385Cys rs63750760 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
Detail
0.00 (D)
1 (D)
N
12 MLH1 P40692 p.Arg385His rs63750430 variant of unknown significance
Detail
(-)
(-)
N
13 MLH1 P40692 p.Arg389Gln rs63750361 variant of unknown significance
Detail
(-)
(-)
N
14 MLH1 P40692 p.Leu400Val rs63751485 variant of unknown significance
Detail
(-)
(-)
N
15 MLH1 P40692 p.Ser406Asn rs41294980 variant of unknown significance
Detail
0.53 (T)
0.012 (N)
N
16 MLH1 P40692 p.Gln409Pro rs104895000 variant of unknown significance
Detail
(-)
(-)
N
17 MLH1 P40692 p.Thr413Ile rs63750766 variant of unknown significance
Detail
(-)
(-)
N
18 MLH1 P40692 p.Asp418Glu rs63751440 variant of unknown significance
Detail
(-)
(-)
N
19 MLH1 P40692 p.Ser420Cys rs63751179 variant of unknown significance
Detail
(-)
(-)
N
20 MLH1 P40692 p.Glu433Gln rs63750443 variant of unknown significance
Detail
(-)
(-)
N
21 MLH1 P40692 p.Pro435Leu rs63751414 variant of unknown significance
Detail
(-)
(-)
N
22 MLH1 P40692 p.Ala441Thr rs63750365 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
Detail
0.58 (T)
0 (N)
N
23 MLH1 P40692 p.Lys443Gln rs34213726 variant of unknown significance
Detail
0.58 (T)
0 (N)
N
24 MLH1 P40692 p.Thr452Ser rs34285587 variant of unknown significance
Detail
(-)
(-)
N
25 MLH1 P40692 p.Gly454Arg rs63750527 variant of unknown significance
Detail
(-)
(-)
N
26 MLH1 P40692 p.Met458Lys rs63750390 variant of unknown significance
Detail
(-)
(-)
N
27 MLH1 P40692 p.Arg474Gln - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.60 (T)
0.803 (D)
N
28 MLH1 P40692 p.Arg474Gly rs147939838 variant of unknown significance
3rbn
A
Detail
(-)
(-)
N
29 MLH1 P40692 p.Asp485Glu rs63750956 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
1.00 (T)
0 (N)
D ( Predicted by rules : 1 2 )
4 MLH1 P40692 p.Asp485His rs63750314 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.12 (T)
0 (N)
D ( Predicted by rules : 1 2 3 4 )
6 MLH1 P40692 p.Ala492Thr rs63751145 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.56 (T)
0.046 (N)
N
7 MLH1 P40692 p.Pro496Leu rs63750226 variant of unknown significance
3rbn
A
Detail
(-)
(-)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Pro496Arg rs63750226 variant of unknown significance
3rbn
A
Detail
(-)
(-)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Leu503Phe rs145679961 variant of unknown significance
3rbn
A
Detail
(-)
(-)
N
4 MLH1 P40692 p.Val506Ala rs63749909 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.18 (T)
0.714 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Gln542Leu - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.00 (D)
1 (D)
D ( Predicted by rules : 1 2 )
4 MLH1 P40692 p.Gln542Pro - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.00 (D)
1 (D)
D ( Predicted by rules : 1 2 )
4 MLH1 P40692 p.Leu549Pro - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.05 (D)
1 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Leu550Pro - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.01 (D)
0.989 (D)
D ( Predicted by rules : 1 2 )
4 MLH1 P40692 p.Asn551Thr - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.05 (T)
0.992 (D)
N
5 MLH1 P40692 p.Leu559Arg rs63750059 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.02 (D)
0.999 (D)
D ( Predicted by rules : 1 2 )
4 MLH1 P40692 p.Ile565Phe - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.03 (D)
0.974 (D)
N
5 MLH1 P40692 p.Leu574Pro - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.16 (T)
0.999 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Ser577Leu rs56185292 variant of unknown significance
3rbn
A
Detail
(-)
(-)
N
4 MLH1 P40692 p.Glu578Gly rs121912960 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.24 (T)
0.012 (N)
N
5 MLH1 P40692 p.Pro581Leu rs78038339 variant of unknown significance
3rbn
A
Detail
(-)
(-)
N
6 MLH1 P40692 p.Leu582Val rs186577970 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.63 (T)
0.922 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Ala586Pro - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.11 (T)
0.984 (D)
D ( Predicted by rules : 1 2 3 )
5 MLH1 P40692 p.Leu588Pro - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.04 (D)
1 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Ala589Asp - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.06 (T)
1 (D)
D ( Predicted by rules : 1 2 )
4 MLH1 P40692 p.Asp601Gly rs63750718 variant of unknown significance
3rbn
A
Detail
(-)
(-)
N
5 MLH1 P40692 p.Pro603Arg rs63750876 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.51 (T)
0.997 (D)
N
6 MLH1 P40692 p.Leu607His rs41295284 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.15 (T)
1 (D)
N
7 MLH1 P40692 p.Ala608Thr rs147928948 variant of unknown significance
3rbn
A
Detail
(-)
(-)
N
8 MLH1 P40692 p.Ile611Thr rs141688321 variant of unknown significance
3rbn
A
Detail
(-)
(-)
N
9 MLH1 P40692 p.Lys618Ala rs35502531 variant of unknown significance
3rbn
A
Detail
0.16 (T)
1 (D)
N
10 MLH1 P40692 p.Lys618Thr rs63750449 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.15 (T)
1 (D)
N
11 MLH1 P40692 p.Lys618Arg rs63750449 variant of unknown significance
3rbn
A
Detail
(-)
(-)
N
12 MLH1 P40692 p.Lys618Ter rs35001569 variant of unknown significance
Detail
(-)
(-)
N
13 MLH1 P40692 p.Lys618Glu rs35001569 variant of unknown significance
3rbn
A
Detail
(-)
(-)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Leu622His rs63750693 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.00 (D)
1 (D)
D ( Predicted by rules : 1 2 3 )
5 MLH1 P40692 p.Leu622Pro rs63750693 variant of unknown significance
3rbn
A
Detail
(-)
(-)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Ala623Pro - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.33 (T)
0.69 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Phe626Ser rs63750153 variant of unknown significance
3rbn
A
Detail
(-)
(-)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Ser627Thr rs63750846 variant of unknown significance
3rbn
A
Detail
(-)
(-)
N
4 MLH1 P40692 p.Asp631Ala rs63750240 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.77 (T)
0.97 (D)
N
5 MLH1 P40692 p.Gly634Arg rs63750830 variant of unknown significance
3rbn
A
Detail
(-)
(-)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Asn635Lys rs63751047 variant of unknown significance
3rbn
A
Detail
(-)
(-)
N
4 MLH1 P40692 p.Asn635Ser rs63751270 variant of unknown significance
3rbn
A
Detail
(-)
(-)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Leu636Pro rs63750825 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.03 (D)
1 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Gly638Ter rs63750549 variant of unknown significance
Detail
(-)
(-)
N
4 MLH1 P40692 p.Gly638Arg rs63750549 variant of unknown significance
3rbn
A
Detail
(-)
(-)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Pro640Thr rs63749792 variant of unknown significance
3rbn
A
Detail
(-)
(-)
D ( Predicted by rules : 1 2 )
4 MLH1 P40692 p.Pro640Ser rs63749792 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.01 (D)
1 (D)
D ( Predicted by rules : 1 2 3 )
5 MLH1 P40692 p.Tyr646Cys rs35045067 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.05 (D)
1 (D)
D ( Predicted by rules : 1 2 )
4 MLH1 P40692 p.Val647Met rs63750109 variant of unknown significance
3rbn
A
Detail
(-)
(-)
N
5 MLH1 P40692 p.Pro648Ser rs63750899 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.01 (D)
1 (D)
D ( Predicted by rules : 1 2 3 4 )
6 MLH1 P40692 p.Pro648Leu rs63750610 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.00 (D)
1 (D)
D ( Predicted by rules : 1 2 3 4 )
6 MLH1 P40692 p.Leu653Arg rs63751202 variant of unknown significance
3rbn
A
Detail
(-)
(-)
D ( Predicted by rules : 1 2 )
4 MLH1 P40692 p.Pro654Leu rs63750726 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.58 (T)
1 (D)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Ile655Thr rs63751225 variant of unknown significance
3rbn
A
Detail
(-)
(-)
N
4 MLH1 P40692 p.Ile655Val rs55907433 variant of unknown significance
3rbn
A
Detail
0.50 (T)
0 (N)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Arg659Gln rs63749900 variant of unknown significance
3rbn
A
Detail
0.06 (T)
1 (D)
D ( Predicted by rules : 1 2 )
4 MLH1 P40692 p.Arg659Leu rs63749900 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.07 (T)
1 (D)
D ( Predicted by rules : 1 2 3 )
5 MLH1 P40692 p.Arg659Pro rs63749900 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.03 (D)
1 (D)
D ( Predicted by rules : 1 2 )
4 MLH1 P40692 p.Thr662Pro rs63750975 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.34 (T)
0.987 (D)
N
5 MLH1 P40692 p.Asp667Gly rs63751162 variant of unknown significance
3rbn
A
Detail
(-)
(-)
N
6 MLH1 P40692 p.Glu668Lys rs63750292 variant of unknown significance
3rbn
A
Detail
(-)
(-)
N
7 MLH1 P40692 p.Leu676Arg rs63750242 variant of unknown significance
3rbn
A
Detail
(-)
(-)
D ( Predicted by rules : 1 2 )
4 MLH1 P40692 p.Cys680Gly rs63750809 variant of unknown significance
3rbn
A
Detail
(-)
(-)
N
5 MLH1 P40692 p.Ala681Val rs63750864 variant of unknown significance
3rbn
A
Detail
(-)
(-)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Ala681Thr rs63750217 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.09 (T)
0.757 (D)
D ( Predicted by rules : 1 2 )
4 MLH1 P40692 p.Arg687Trp - Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.02 (D)
1 (D)
N
5 MLH1 P40692 p.Gln689Arg - variant of unknown significance
3rbn
A
Detail
0.36 (T)
0.106 (N)
N
6 MLH1 P40692 p.Gln689Lys rs41542214 variant of unknown significance
3rbn
A
Detail
(-)
(-)
N
7 MLH1 P40692 p.Glu694Ala rs145565670 variant of unknown significance
3rbn
A
Detail
(-)
(-)
N
8 MLH1 P40692 p.Gln701Lys rs75756294 variant of unknown significance
3rbn
A
Detail
0.91 (T)
0.153 (N)
N
9 MLH1 P40692 p.Val716Met rs35831931 variant of unknown significance
3rbn
A
Detail
0.10 (T)
0.997 (D)
N
10 MLH1 P40692 p.His718Tyr rs2020873 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.23 (T)
0.998 (D)
D ( Predicted by rules : 1 2 )
4 MLH1 P40692 p.Leu724Met rs63749875 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.45 (T)
0.212 (N)
D ( Predicted by rules : 1 )
3 MLH1 P40692 p.Arg725Gly rs138584384 variant of unknown significance
3rbn
A
Detail
(-)
(-)
N
4 MLH1 P40692 p.His727Leu rs104895002 variant of unknown significance
3rbn
A
Detail
(-)
(-)
N
5 MLH1 P40692 p.Ile728Phe rs143279525 variant of unknown significance
3rbn
A
Detail
(-)
(-)
N
6 MLH1 P40692 p.Leu729Val rs1800149 variant of unknown significance
3rbn
A
Detail
0.82 (T)
0 (N)
N
7 MLH1 P40692 p.Gly738Glu rs148317871 variant of unknown significance
3rbn
A
Detail
(-)
(-)
N
8 MLH1 P40692 p.Lys751Arg rs140195825 Hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]
3rbn
A
Detail
0.62 (T)
0.024 (N)
N